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The map label for this gene is 124028414

Identifier: 124028414

GI number: 124028414

Start: 1577444

End: 1579375

Strand: Direct

Name: 124028414

Synonym: Hbut_1568

Alternate gene names: NA

Gene position: 1577444-1579375 (Clockwise)

Preceding gene: 124028413

Following gene: 124028416

Centisome position: 94.62

GC content: 49.07

Gene sequence:

>1932_bases
TTGAAGAAGATAGCATTGACAATAATGGAGCAACTTACACCCAAGTACATACAAGTTTCGAGAATAGAGTTTGAAGGACC
CGAAATAGCAATCTATGTCAGAAACCCGAAGGCGCTAGCAGAGCATCCCGAGGTTGCAAAGGAGATAGCTAAGAAGCTAA
AGAAGAGGATAGTAATAAGGACAGATCCCTCTGTCCGGAGGAGCGAGAAGGAGACAATAGAGGTTATCAAGAACCTTGTT
CCGCCCGAAGCCGGCATAAAGGAGATAAAGTTTGATCACGTACTCGGTGAGGTCATAATTAAGGCTGAAAAGGTTGGTCT
AGTATATGGCAAGGGCCAATCAATATATAATAAAGTACTCGCCGAGACAGGCTGGCGCATGAACGTTGTAAGAATACCGC
CAGTAGACCCTAAAGATTTAAGCACACTCAACAAAATCATAGATTACATGTTGTCCCAGAGTAGCTATCGTCTAGAGTTT
CTCCGCAGCAGCGGCGAGAGAATACACCGTGGTGTAATCTTCGAAAACCGCTATGTAAGGATAACAGCTCTTGGTGGCTT
CATGGAGGTGGGCCGCTCAGCAATACTCATAGAGACCAGCGAGAGCAAGATCCTCCTGGACGTTGGCATAAACCCGAGTG
GCATCGGCTACAACCTATACCCCCGTCTGGACATAGACCAACTCAACCTCGAGGAACTAGATGCCGTTGTGGTTACACAC
GCGCATCTAGACCACATAGGCCTCGTACCTTACCTGTTCAAGTATGGTTACCGGGGTCCTGTCTACGCGACAAAGCCCAC
CCGAGACCTAATGGTTCTACTACTCCTAGACCTTCTCGACATAATGCAGCGTAGCGGCCAGAAGCCGCCCTACACGCAAC
AAGAAGTTAAGAAGATGATACTACACACCATACCCCTCGACTACGGCGAGGTCACCGACATAGCTCCAGATATGAAGCTA
ACCTTCTACAATGCAGGCCACATACTAGGCTCAGCAATAGCACACATCCACATAGGCGAAGGCCTACACAACATAGTCTA
TACAGGCGACTTCAAGTTTGGCCGCACAAGACTCCTAGATAAAGCCCATACAGAGTTCCCGAGAGTCGAGACACTCATCA
TGGAGAGTACTTATGGCGACCGCGACCAGCCACGCAGGGATGAGGCAGAACTAGAACTCATAAGCGTTATAAGTAAAACC
ATAGCTCGTAGGGGCAAGGTGCTAATCCCAGTCATGGCTGTTGGAAGGGCACAAGAAATACTCTTAGTGCTCGTTGATGC
TCTTAGGAAGAAATTGTTACCACCAGAAACAAAGATCTACATTGACGGCAGCATAAAGGAGGTAACAGCTATCCACCTAA
CCTACCCAGAACTCCTCTCAGCACAAGTTAGGGCAAGGATACTGCGCGGCGAAAATCCGTTCGACCACGAGAACATAGTA
CGGGTGGAAGGTAGACAGATGAGGGAAGACATAGCAAAGAGCGACGAGCCTGGAGTAATACTGGCAACAGCAGGTATGCT
GACTGGTGGCCCCTCGGTAGAGTACTTGCGCCTATTAGCACCAGATCCACGTAACGTACTGGTATTTGTTAGCTACCAGG
CTAAGGGTACGCTGGGTAGGCGTATACTTGACGGCGAACGCGAAATAACAATGGTTGACGAGGAGGGCAAGCCACAGCTC
GTGAGAATACAGATGGAGGTAAAGTCTATAGATGGGTTCTCTGGCCACTCAGACCGCCGTCAGCTCCTAGCATTCCTGGC
CAATATGAAGCCTAAGCCAAAGAACATAATACTGAACCATGGCGAACCTCAGTCAATCCACGCGCTTGCAGAGACTATTA
GGCGTAGAGCCCGCCATCTAGGTCTTCCCGAAGACATCAGAGTCTACACACCAACGATACTTGACACCCTCCATATTGCC
GGTGTAGCCTAG

Upstream 100 bases:

>100_bases
AGCAGATGCTGTGCCTCCAATAGGCAGTTTAAGCAAAACACTTCACCCAACTTGCCTCAACGAGTAGGAGGTGTAACAGC
CATTGTATAAGCGTAATGAG

Downstream 100 bases:

>100_bases
TACTCATAGCCTCTCAGCTATTTTCCAGTACCTGTCACCCACGTAGTGGAGCCTTCTCGAAACCCTGCCCTTCTCCATAC
CAGGAATATCCTTGCTAGAG

Product: exonuclease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 643; Mature: 643

Protein sequence:

>643_residues
MKKIALTIMEQLTPKYIQVSRIEFEGPEIAIYVRNPKALAEHPEVAKEIAKKLKKRIVIRTDPSVRRSEKETIEVIKNLV
PPEAGIKEIKFDHVLGEVIIKAEKVGLVYGKGQSIYNKVLAETGWRMNVVRIPPVDPKDLSTLNKIIDYMLSQSSYRLEF
LRSSGERIHRGVIFENRYVRITALGGFMEVGRSAILIETSESKILLDVGINPSGIGYNLYPRLDIDQLNLEELDAVVVTH
AHLDHIGLVPYLFKYGYRGPVYATKPTRDLMVLLLLDLLDIMQRSGQKPPYTQQEVKKMILHTIPLDYGEVTDIAPDMKL
TFYNAGHILGSAIAHIHIGEGLHNIVYTGDFKFGRTRLLDKAHTEFPRVETLIMESTYGDRDQPRRDEAELELISVISKT
IARRGKVLIPVMAVGRAQEILLVLVDALRKKLLPPETKIYIDGSIKEVTAIHLTYPELLSAQVRARILRGENPFDHENIV
RVEGRQMREDIAKSDEPGVILATAGMLTGGPSVEYLRLLAPDPRNVLVFVSYQAKGTLGRRILDGEREITMVDEEGKPQL
VRIQMEVKSIDGFSGHSDRRQLLAFLANMKPKPKNIILNHGEPQSIHALAETIRRRARHLGLPEDIRVYTPTILDTLHIA
GVA

Sequences:

>Translated_643_residues
MKKIALTIMEQLTPKYIQVSRIEFEGPEIAIYVRNPKALAEHPEVAKEIAKKLKKRIVIRTDPSVRRSEKETIEVIKNLV
PPEAGIKEIKFDHVLGEVIIKAEKVGLVYGKGQSIYNKVLAETGWRMNVVRIPPVDPKDLSTLNKIIDYMLSQSSYRLEF
LRSSGERIHRGVIFENRYVRITALGGFMEVGRSAILIETSESKILLDVGINPSGIGYNLYPRLDIDQLNLEELDAVVVTH
AHLDHIGLVPYLFKYGYRGPVYATKPTRDLMVLLLLDLLDIMQRSGQKPPYTQQEVKKMILHTIPLDYGEVTDIAPDMKL
TFYNAGHILGSAIAHIHIGEGLHNIVYTGDFKFGRTRLLDKAHTEFPRVETLIMESTYGDRDQPRRDEAELELISVISKT
IARRGKVLIPVMAVGRAQEILLVLVDALRKKLLPPETKIYIDGSIKEVTAIHLTYPELLSAQVRARILRGENPFDHENIV
RVEGRQMREDIAKSDEPGVILATAGMLTGGPSVEYLRLLAPDPRNVLVFVSYQAKGTLGRRILDGEREITMVDEEGKPQL
VRIQMEVKSIDGFSGHSDRRQLLAFLANMKPKPKNIILNHGEPQSIHALAETIRRRARHLGLPEDIRVYTPTILDTLHIA
GVA
>Mature_643_residues
MKKIALTIMEQLTPKYIQVSRIEFEGPEIAIYVRNPKALAEHPEVAKEIAKKLKKRIVIRTDPSVRRSEKETIEVIKNLV
PPEAGIKEIKFDHVLGEVIIKAEKVGLVYGKGQSIYNKVLAETGWRMNVVRIPPVDPKDLSTLNKIIDYMLSQSSYRLEF
LRSSGERIHRGVIFENRYVRITALGGFMEVGRSAILIETSESKILLDVGINPSGIGYNLYPRLDIDQLNLEELDAVVVTH
AHLDHIGLVPYLFKYGYRGPVYATKPTRDLMVLLLLDLLDIMQRSGQKPPYTQQEVKKMILHTIPLDYGEVTDIAPDMKL
TFYNAGHILGSAIAHIHIGEGLHNIVYTGDFKFGRTRLLDKAHTEFPRVETLIMESTYGDRDQPRRDEAELELISVISKT
IARRGKVLIPVMAVGRAQEILLVLVDALRKKLLPPETKIYIDGSIKEVTAIHLTYPELLSAQVRARILRGENPFDHENIV
RVEGRQMREDIAKSDEPGVILATAGMLTGGPSVEYLRLLAPDPRNVLVFVSYQAKGTLGRRILDGEREITMVDEEGKPQL
VRIQMEVKSIDGFSGHSDRRQLLAFLANMKPKPKNIILNHGEPQSIHALAETIRRRARHLGLPEDIRVYTPTILDTLHIA
GVA

Specific function: Unknown

COG id: COG1782

COG function: function code R; Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI7706427, Length=443, Percent_Identity=31.6027088036117, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI33300633, Length=469, Percent_Identity=28.997867803838, Blast_Score=206, Evalue=7e-53,
Organism=Homo sapiens, GI34101288, Length=386, Percent_Identity=25.3886010362694, Blast_Score=101, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI32566029, Length=457, Percent_Identity=30.1969365426696, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI32564696, Length=451, Percent_Identity=26.8292682926829, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17559452, Length=379, Percent_Identity=23.4828496042216, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323307, Length=473, Percent_Identity=28.7526427061311, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24648013, Length=459, Percent_Identity=32.0261437908497, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI21358523, Length=446, Percent_Identity=30.4932735426009, Blast_Score=208, Evalue=8e-54,
Organism=Drosophila melanogaster, GI21358013, Length=380, Percent_Identity=23.6842105263158, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR004087
- InterPro:   IPR019975
- InterPro:   IPR004044
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF07650 KH_2; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 72506; Mature: 72506

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIALTIMEQLTPKYIQVSRIEFEGPEIAIYVRNPKALAEHPEVAKEIAKKLKKRIVIR
CCHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEECCHHHHCCHHHHHHHHHHHHHCEEEE
TDPSVRRSEKETIEVIKNLVPPEAGIKEIKFDHVLGEVIIKAEKVGLVYGKGQSIYNKVL
CCCCHHHCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHH
AETGWRMNVVRIPPVDPKDLSTLNKIIDYMLSQSSYRLEFLRSSGERIHRGVIFENRYVR
HCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHCCEEEECCEEE
ITALGGFMEVGRSAILIETSESKILLDVGINPSGIGYNLYPRLDIDQLNLEELDAVVVTH
EEEECCHHHCCCCEEEEEECCCEEEEEECCCCCCCCEEECCCCCCCCCCHHHHHEEEEEE
AHLDHIGLVPYLFKYGYRGPVYATKPTRDLMVLLLLDLLDIMQRSGQKPPYTQQEVKKMI
HHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
LHTIPLDYGEVTDIAPDMKLTFYNAGHILGSAIAHIHIGEGLHNIVYTGDFKFGRTRLLD
HHHCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHEEEECCCCCCCEEECCCCCCHHHHHH
KAHTEFPRVETLIMESTYGDRDQPRRDEAELELISVISKTIARRGKVLIPVMAVGRAQEI
HHHCCCCCHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHH
LLVLVDALRKKLLPPETKIYIDGSIKEVTAIHLTYPELLSAQVRARILRGENPFDHENIV
HHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEEECHHHHHHHHHHHHHCCCCCCCCCCEE
RVEGRQMREDIAKSDEPGVILATAGMLTGGPSVEYLRLLAPDPRNVLVFVSYQAKGTLGR
EECCHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCCCH
RILDGEREITMVDEEGKPQLVRIQMEVKSIDGFSGHSDRRQLLAFLANMKPKPKNIILNH
HHCCCCCEEEEECCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEC
GEPQSIHALAETIRRRARHLGLPEDIRVYTPTILDTLHIAGVA
CCCHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHCCCC
>Mature Secondary Structure
MKKIALTIMEQLTPKYIQVSRIEFEGPEIAIYVRNPKALAEHPEVAKEIAKKLKKRIVIR
CCHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEECCHHHHCCHHHHHHHHHHHHHCEEEE
TDPSVRRSEKETIEVIKNLVPPEAGIKEIKFDHVLGEVIIKAEKVGLVYGKGQSIYNKVL
CCCCHHHCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHH
AETGWRMNVVRIPPVDPKDLSTLNKIIDYMLSQSSYRLEFLRSSGERIHRGVIFENRYVR
HCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHCCEEEECCEEE
ITALGGFMEVGRSAILIETSESKILLDVGINPSGIGYNLYPRLDIDQLNLEELDAVVVTH
EEEECCHHHCCCCEEEEEECCCEEEEEECCCCCCCCEEECCCCCCCCCCHHHHHEEEEEE
AHLDHIGLVPYLFKYGYRGPVYATKPTRDLMVLLLLDLLDIMQRSGQKPPYTQQEVKKMI
HHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
LHTIPLDYGEVTDIAPDMKLTFYNAGHILGSAIAHIHIGEGLHNIVYTGDFKFGRTRLLD
HHHCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHEEEECCCCCCCEEECCCCCCHHHHHH
KAHTEFPRVETLIMESTYGDRDQPRRDEAELELISVISKTIARRGKVLIPVMAVGRAQEI
HHHCCCCCHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHH
LLVLVDALRKKLLPPETKIYIDGSIKEVTAIHLTYPELLSAQVRARILRGENPFDHENIV
HHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEEECHHHHHHHHHHHHHCCCCCCCCCCEE
RVEGRQMREDIAKSDEPGVILATAGMLTGGPSVEYLRLLAPDPRNVLVFVSYQAKGTLGR
EECCHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCCCH
RILDGEREITMVDEEGKPQLVRIQMEVKSIDGFSGHSDRRQLLAFLANMKPKPKNIILNH
HHCCCCCEEEEECCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEC
GEPQSIHALAETIRRRARHLGLPEDIRVYTPTILDTLHIAGVA
CCCHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]