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The map label for this gene is paaJ [C]

Identifier: 124028375

GI number: 124028375

Start: 1535405

End: 1536559

Strand: Direct

Name: paaJ [C]

Synonym: Hbut_1528

Alternate gene names: 124028375

Gene position: 1535405-1536559 (Clockwise)

Preceding gene: 124028374

Following gene: 124028376

Centisome position: 92.1

GC content: 58.96

Gene sequence:

>1155_bases
ATGCCTCGAGTCTACGTAGCCGGAGTCGGGATGACAAAGATCGACCGTCACTACGACAAGGGTATCCTGGACCTAGCAGC
CGAGGCCGCCTTTAGAGCCATAGACGACGCAGGAATCAAACCCGATGCTGTGATTGTTACGAGCATGCTTGCGAGCAAGC
TACAGGAGCAGGACAATCTTGGCGCCTACGTAGCTGCTGGACTGGGGCTGCGCTACAGACCCGCACTACATGTTGAAGCT
GCCTGCGGCAGCGGAGGCGCTGGCGTTTACACGGGGTTTGCCTTGATACGTTCGGGGCTCGTAGATTCTGTGCTGGTTGT
TGGCGTTGAGAAGATGACTGATTACCCGACAGCCATTGTCACCGCTGGCTTGGCGCAGGCTGCCGACGCAGAGTACGAAC
TCTATTACGGGGCCACGTTTACCGGACTCAACGCACTCATGATGAGGTATTATATGGAGAAGTACGGGGTTACAAGGGAC
GAGATGAGCGAGTGGCCAGTAATGATGCACGAGAACGCCCTCAGCAACCCATACGCACAGATAAGGAGGAGGATAACGAG
GGAGGACGTGGCTCGCAGCCAGGTGATAGCTGATCCGATAAGACTGCTTGACAGCAGCCCCATAGGTGATGGCGCTGCAG
CCGTCCTACTAGTCTCGGAGGATGCCGCGAAGAGGCTGCCCGAGAAACCCATCGTCGAGATAGCCGGTGCTGGACTGGCC
GTGGACACCGTGGAGCTTAGCAATAGGGAGATTCTCGACGGCATGCCTGCCGCTAGGAAGGCTGCCGAGCAGGCTTACCG
TATGGCAGGGGTGGAGCCAAGCAAGATAGACGTCATGGAGATCCATGACGCGTTCACGATAAACGCGATACTGCTATTGG
AGGAGCTAGGCTTTGCGGAGAAGGGCAGGGCGGCTAAGCTAGTAGCTGAGGGCCGCTTCCACCCAGGCGATAGGCCGACG
GCAAACCCGAGCGGAGGCCTCAAGGCCCGCGGCCACCCAGTAGGCGCAACCGGTGTCTACCAGGTAGCAGAGGTGACGAT
GCAGCTGCGCGGCGACTTCCCCGGCGTAAAGGTCGATGGCGCCGAGGTAGGCTTAGCAGTTAACGTTGGTGGCGACGGCT
CGACGGTTTCAGCCCTAGTCCTCAGACGCGCCTAG

Upstream 100 bases:

>100_bases
GACTACGTGAACTGGAAGCGCTATATAGACTATGCTATGCACGCACGCATGCGCAAGCTCTATGACAGAAGACCCGTCTA
GTCGTGGCGGGGTGATGATT

Downstream 100 bases:

>100_bases
CCCATATCACTGTGAAGGGTGTATATCCATGACCATAAGCATGCACATATCCCCGGCTAGGATATGGCGTGAGCGAATCT
ACAGGTACAGACTTGTTGGC

Product: Acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MPRVYVAGVGMTKIDRHYDKGILDLAAEAAFRAIDDAGIKPDAVIVTSMLASKLQEQDNLGAYVAAGLGLRYRPALHVEA
ACGSGGAGVYTGFALIRSGLVDSVLVVGVEKMTDYPTAIVTAGLAQAADAEYELYYGATFTGLNALMMRYYMEKYGVTRD
EMSEWPVMMHENALSNPYAQIRRRITREDVARSQVIADPIRLLDSSPIGDGAAAVLLVSEDAAKRLPEKPIVEIAGAGLA
VDTVELSNREILDGMPAARKAAEQAYRMAGVEPSKIDVMEIHDAFTINAILLLEELGFAEKGRAAKLVAEGRFHPGDRPT
ANPSGGLKARGHPVGATGVYQVAEVTMQLRGDFPGVKVDGAEVGLAVNVGGDGSTVSALVLRRA

Sequences:

>Translated_384_residues
MPRVYVAGVGMTKIDRHYDKGILDLAAEAAFRAIDDAGIKPDAVIVTSMLASKLQEQDNLGAYVAAGLGLRYRPALHVEA
ACGSGGAGVYTGFALIRSGLVDSVLVVGVEKMTDYPTAIVTAGLAQAADAEYELYYGATFTGLNALMMRYYMEKYGVTRD
EMSEWPVMMHENALSNPYAQIRRRITREDVARSQVIADPIRLLDSSPIGDGAAAVLLVSEDAAKRLPEKPIVEIAGAGLA
VDTVELSNREILDGMPAARKAAEQAYRMAGVEPSKIDVMEIHDAFTINAILLLEELGFAEKGRAAKLVAEGRFHPGDRPT
ANPSGGLKARGHPVGATGVYQVAEVTMQLRGDFPGVKVDGAEVGLAVNVGGDGSTVSALVLRRA
>Mature_383_residues
PRVYVAGVGMTKIDRHYDKGILDLAAEAAFRAIDDAGIKPDAVIVTSMLASKLQEQDNLGAYVAAGLGLRYRPALHVEAA
CGSGGAGVYTGFALIRSGLVDSVLVVGVEKMTDYPTAIVTAGLAQAADAEYELYYGATFTGLNALMMRYYMEKYGVTRDE
MSEWPVMMHENALSNPYAQIRRRITREDVARSQVIADPIRLLDSSPIGDGAAAVLLVSEDAAKRLPEKPIVEIAGAGLAV
DTVELSNREILDGMPAARKAAEQAYRMAGVEPSKIDVMEIHDAFTINAILLLEELGFAEKGRAAKLVAEGRFHPGDRPTA
NPSGGLKARGHPVGATGVYQVAEVTMQLRGDFPGVKVDGAEVGLAVNVGGDGSTVSALVLRRA

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=391, Percent_Identity=31.4578005115089, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI302344760, Length=391, Percent_Identity=30.690537084399, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI302344767, Length=317, Percent_Identity=32.1766561514196, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI302344762, Length=391, Percent_Identity=30.4347826086957, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI55956775, Length=355, Percent_Identity=28.7323943661972, Blast_Score=121, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17537653, Length=388, Percent_Identity=30.9278350515464, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI19921506, Length=394, Percent_Identity=31.4720812182741, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24585051, Length=394, Percent_Identity=31.2182741116751, Blast_Score=174, Evalue=8e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 40733; Mature: 40602

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRVYVAGVGMTKIDRHYDKGILDLAAEAAFRAIDDAGIKPDAVIVTSMLASKLQEQDNL
CCEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
GAYVAAGLGLRYRPALHVEAACGSGGAGVYTGFALIRSGLVDSVLVVGVEKMTDYPTAIV
CEEEHHCCCCEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
TAGLAQAADAEYELYYGATFTGLNALMMRYYMEKYGVTRDEMSEWPVMMHENALSNPYAQ
HHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHCCEEEECCCCCCHHHH
IRRRITREDVARSQVIADPIRLLDSSPIGDGAAAVLLVSEDAAKRLPEKPIVEIAGAGLA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECHHHHHCCCCCHHHHCCCCEE
VDTVELSNREILDGMPAARKAAEQAYRMAGVEPSKIDVMEIHDAFTINAILLLEELGFAE
EEEEECCCCHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCC
KGRAAKLVAEGRFHPGDRPTANPSGGLKARGHPVGATGVYQVAEVTMQLRGDFPGVKVDG
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECC
AEVGLAVNVGGDGSTVSALVLRRA
CEEEEEEEECCCCCHHHHHHEECC
>Mature Secondary Structure 
PRVYVAGVGMTKIDRHYDKGILDLAAEAAFRAIDDAGIKPDAVIVTSMLASKLQEQDNL
CEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
GAYVAAGLGLRYRPALHVEAACGSGGAGVYTGFALIRSGLVDSVLVVGVEKMTDYPTAIV
CEEEHHCCCCEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
TAGLAQAADAEYELYYGATFTGLNALMMRYYMEKYGVTRDEMSEWPVMMHENALSNPYAQ
HHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHCCEEEECCCCCCHHHH
IRRRITREDVARSQVIADPIRLLDSSPIGDGAAAVLLVSEDAAKRLPEKPIVEIAGAGLA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECHHHHHCCCCCHHHHCCCCEE
VDTVELSNREILDGMPAARKAAEQAYRMAGVEPSKIDVMEIHDAFTINAILLLEELGFAE
EEEEECCCCHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCC
KGRAAKLVAEGRFHPGDRPTANPSGGLKARGHPVGATGVYQVAEVTMQLRGDFPGVKVDG
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECC
AEVGLAVNVGGDGSTVSALVLRRA
CEEEEEEEECCCCCHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]