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The map label for this gene is mfnA [H]

Identifier: 124027121

GI number: 124027121

Start: 210735

End: 211841

Strand: Direct

Name: mfnA [H]

Synonym: Hbut_0224

Alternate gene names: 124027121

Gene position: 210735-211841 (Clockwise)

Preceding gene: 124027120

Following gene: 124027125

Centisome position: 12.64

GC content: 58.81

Gene sequence:

>1107_bases
TTGGAGTGGCTGCGTGGGGGCAGTTGGGAGGAGGTAGCAAGGGAGCTGGGGGAGCTGCGTGCTGGAGAACCTAGTCCGTG
CCGTGTTGCAGGTAGCACTGTTGCAGAACCTTTGCCTGTTGCACGTAGGGCTTACAGCCTCTATGCAGATGTGAATCTTA
ACGATCCTGCTTCGTGGCCTAGTGTGACAAAGCTCCTGGAGGGTATTTCTAGGGTCCTCGAGGAACTCAGGCTTGGTCAT
CGCTGGCTCGTTGCTGTAAGTGGTGGCAGCGAGGCAGTATTGACGGGTCTCTACATTGCGAGAGAGTATACGCGGGGCAG
GGTGGTTGTAGCGTCTAGTGCTGCCCATGCATCCGTGCTAAAGGCTGCCCGTGTCCTGGGCATGGAGGTTAAGCTTGTGC
AGGTGGACTCTAGGCTGAGGATAGACCTCTACGCCCTGGAGAAGACGTTGAGGGGAGTTCAGAATGTTGCTGCTATCGTT
GCGACAGCAGGTGTCACTGATAACGGTGCTGTGGATCCAGTTAGGGATGTGGCCAAGCTTGCCTGGGAGCATGGTGCAGT
AGTGTATGTGGACGCTGCTTTTGGCGGCCTACCACTCCTAGGGTTGGGGAGCACCGAGACAGTATTGCCCCGTGGCGGCC
CCGCCCTAGCCGGGATAGACTTCCACAAGCACGTAGCACCTCCGCCATCCTCCATACTTGTATCAAACACAGCGGAGCTT
AGGGACTACATAGTGTTCCCCGCGCCCTACATGCCCTTGGGGAGGCAGGAGACGCTACTCTGGACCCGGCCAGCATCGGG
CCTAGCAGCAGCCTATGCAGCCCTTAGGGCACTAGGAGCCAGTGGCGTTGGAGAGCTAGCAAGATACCTCTACAGGCTAG
CCTCGAAGCTGGCATCCATCCTCGAGCAGCGGGGTGTAGAGTTGTTGTCGCCTCTCGATACGCCTCTCGTGGCCTTTCGG
CCCCCAAGTGTGGAGGGGGCGTTGAAGAGGCTGAGAAGGAGAGGCTGGATACTCTACCCCTCCAGGCTTCCCGGCATACT
GCGCTACGTAGCAAAGTGGTGCCACGAGCCCGGAGACGTGGAGGAGATAGCGGAGGCGGTAGCCTAG

Upstream 100 bases:

>100_bases
CCAGTGGACTAGCTCAACAAGCTGTAGTGTTCCATACGTAGCAAGCTGTGGAGAGGCCTCTTACCCCAAAGACTACTATG
GGCTACTGGGGGGTTTAGCT

Downstream 100 bases:

>100_bases
ACAAAGGCGTCCATGCTACGATATATCACGTACATGGAGTAGACGGCTAACACGAGTGCAGCAGCAGAGACGGCGAGTAT
AGCTCCGACCACTACATAGG

Product: decarboxylase

Products: NA

Alternate protein names: TDC [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MEWLRGGSWEEVARELGELRAGEPSPCRVAGSTVAEPLPVARRAYSLYADVNLNDPASWPSVTKLLEGISRVLEELRLGH
RWLVAVSGGSEAVLTGLYIAREYTRGRVVVASSAAHASVLKAARVLGMEVKLVQVDSRLRIDLYALEKTLRGVQNVAAIV
ATAGVTDNGAVDPVRDVAKLAWEHGAVVYVDAAFGGLPLLGLGSTETVLPRGGPALAGIDFHKHVAPPPSSILVSNTAEL
RDYIVFPAPYMPLGRQETLLWTRPASGLAAAYAALRALGASGVGELARYLYRLASKLASILEQRGVELLSPLDTPLVAFR
PPSVEGALKRLRRRGWILYPSRLPGILRYVAKWCHEPGDVEEIAEAVA

Sequences:

>Translated_368_residues
MEWLRGGSWEEVARELGELRAGEPSPCRVAGSTVAEPLPVARRAYSLYADVNLNDPASWPSVTKLLEGISRVLEELRLGH
RWLVAVSGGSEAVLTGLYIAREYTRGRVVVASSAAHASVLKAARVLGMEVKLVQVDSRLRIDLYALEKTLRGVQNVAAIV
ATAGVTDNGAVDPVRDVAKLAWEHGAVVYVDAAFGGLPLLGLGSTETVLPRGGPALAGIDFHKHVAPPPSSILVSNTAEL
RDYIVFPAPYMPLGRQETLLWTRPASGLAAAYAALRALGASGVGELARYLYRLASKLASILEQRGVELLSPLDTPLVAFR
PPSVEGALKRLRRRGWILYPSRLPGILRYVAKWCHEPGDVEEIAEAVA
>Mature_368_residues
MEWLRGGSWEEVARELGELRAGEPSPCRVAGSTVAEPLPVARRAYSLYADVNLNDPASWPSVTKLLEGISRVLEELRLGH
RWLVAVSGGSEAVLTGLYIAREYTRGRVVVASSAAHASVLKAARVLGMEVKLVQVDSRLRIDLYALEKTLRGVQNVAAIV
ATAGVTDNGAVDPVRDVAKLAWEHGAVVYVDAAFGGLPLLGLGSTETVLPRGGPALAGIDFHKHVAPPPSSILVSNTAEL
RDYIVFPAPYMPLGRQETLLWTRPASGLAAAYAALRALGASGVGELARYLYRLASKLASILEQRGVELLSPLDTPLVAFR
PPSVEGALKRLRRRGWILYPSRLPGILRYVAKWCHEPGDVEEIAEAVA

Specific function: Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine [H]

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31982936, Length=332, Percent_Identity=25.6024096385542, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17543922, Length=370, Percent_Identity=25.4054054054054, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25148342, Length=336, Percent_Identity=24.4047619047619, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115
- InterPro:   IPR020931 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.25 [H]

Molecular weight: Translated: 39554; Mature: 39554

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEWLRGGSWEEVARELGELRAGEPSPCRVAGSTVAEPLPVARRAYSLYADVNLNDPASWP
CCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCHHCCCCHHHHHHHEEEEECCCCCCCCCH
SVTKLLEGISRVLEELRLGHRWLVAVSGGSEAVLTGLYIAREYTRGRVVVASSAAHASVL
HHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHH
KAARVLGMEVKLVQVDSRLRIDLYALEKTLRGVQNVAAIVATAGVTDNGAVDPVRDVAKL
HHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
AWEHGAVVYVDAAFGGLPLLGLGSTETVLPRGGPALAGIDFHKHVAPPPSSILVSNTAEL
HHHCCCEEEEECCCCCCCEEECCCCCEECCCCCCCEECCCHHHCCCCCCCCEEECCHHHH
RDYIVFPAPYMPLGRQETLLWTRPASGLAAAYAALRALGASGVGELARYLYRLASKLASI
HHEEECCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LEQRGVELLSPLDTPLVAFRPPSVEGALKRLRRRGWILYPSRLPGILRYVAKWCHEPGDV
HHHCCHHHHCCCCCCEEEECCCCHHHHHHHHHHCCCEEECHHCHHHHHHHHHHCCCCCCH
EEIAEAVA
HHHHHHHC
>Mature Secondary Structure
MEWLRGGSWEEVARELGELRAGEPSPCRVAGSTVAEPLPVARRAYSLYADVNLNDPASWP
CCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCHHCCCCHHHHHHHEEEEECCCCCCCCCH
SVTKLLEGISRVLEELRLGHRWLVAVSGGSEAVLTGLYIAREYTRGRVVVASSAAHASVL
HHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHH
KAARVLGMEVKLVQVDSRLRIDLYALEKTLRGVQNVAAIVATAGVTDNGAVDPVRDVAKL
HHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
AWEHGAVVYVDAAFGGLPLLGLGSTETVLPRGGPALAGIDFHKHVAPPPSSILVSNTAEL
HHHCCCEEEEECCCCCCCEEECCCCCEECCCCCCCEECCCHHHCCCCCCCCEEECCHHHH
RDYIVFPAPYMPLGRQETLLWTRPASGLAAAYAALRALGASGVGELARYLYRLASKLASI
HHEEECCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LEQRGVELLSPLDTPLVAFRPPSVEGALKRLRRRGWILYPSRLPGILRYVAKWCHEPGDV
HHHCCHHHHCCCCCCEEEECCCCHHHHHHHHHHCCCEEECHHCHHHHHHHHHHCCCCCCH
EEIAEAVA
HHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA