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The map label for this gene is ahpC [C]

Identifier: 124027125

GI number: 124027125

Start: 215755

End: 216453

Strand: Direct

Name: ahpC [C]

Synonym: Hbut_0228

Alternate gene names: 124027125

Gene position: 215755-216453 (Clockwise)

Preceding gene: 124027121

Following gene: 124027126

Centisome position: 12.94

GC content: 52.07

Gene sequence:

>699_bases
ATGCCTCTACAAGCTCCATCCATTGGAGAGAAGTTCCCAGAAATCGAGGTAATGACAACCCATGGCAAGATAAAGCTGCC
AGACCATTTTAGGGGTAAGTGGTTCGTGTTATTTAGCCATCCAGCAGACTTCACGCCGGTCTGCACCACAGAGTTCGTAG
CTTTTGCCAAGAGGTACGAGGACTTCAAGAAGCTCAACACAGAACTCATCGGCTTAAGCGTTGACAGCACCTTCAGCCAC
ATTAAGTGGGCTGAGTGGATCAAGGAGAAGCTAGGCGTGGAAATACCATTCCCGATAATCGCCGATCCAACCGGCGAGGT
TGCAAAGAAGCTAGGGCTCCTACATGCTCAGAGCAGCACGGCAACCGTACGCGCTGTATTCGTGGTAGACGATAAGGGTG
TTGTGAGAGCTATCCTCTACTACCCGCAAGAGGTTGGCAGAAACATTGACGAGATATTGAGGCTGATAGAGAGCCTCCAG
ATAAGCGACAAGTACGGCCGCGCCATCCCGGCAAACTGGCCAAACAACGAGCTAATCGGCGACAACTTGATAGTACCGCC
TGCAGCTACGGTACAGGAGGCCGAGGAGAGACTAAAGAAGTTCAAGTGCTTCGACTGGTGGTTCTGCTACGAGGACAAGG
CAACAGCCGAGGAGAAGGAGCTAGCCAGGAAGTTCCTCAAGCGCGTTGCTAACTGCTAG

Upstream 100 bases:

>100_bases
TATAGTCTTCCACCCATGTTTCAGGGCCAATAGACATAAAAACCAGAAGCAATTTCTTACTAGTAGCAAAATCGGAGAGA
AGGTTCGGGGTGTACGAGTT

Downstream 100 bases:

>100_bases
TAAACACCTTCAATCCCATAATGAAGCTGGTTAAATCGCTATTTTTTAACCGCCACTACTTCCATACCGCACCCGCATGC
TCTACGACTCCCACCCCACT

Product: peroxiredoxin family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 231

Protein sequence:

>232_residues
MPLQAPSIGEKFPEIEVMTTHGKIKLPDHFRGKWFVLFSHPADFTPVCTTEFVAFAKRYEDFKKLNTELIGLSVDSTFSH
IKWAEWIKEKLGVEIPFPIIADPTGEVAKKLGLLHAQSSTATVRAVFVVDDKGVVRAILYYPQEVGRNIDEILRLIESLQ
ISDKYGRAIPANWPNNELIGDNLIVPPAATVQEAEERLKKFKCFDWWFCYEDKATAEEKELARKFLKRVANC

Sequences:

>Translated_232_residues
MPLQAPSIGEKFPEIEVMTTHGKIKLPDHFRGKWFVLFSHPADFTPVCTTEFVAFAKRYEDFKKLNTELIGLSVDSTFSH
IKWAEWIKEKLGVEIPFPIIADPTGEVAKKLGLLHAQSSTATVRAVFVVDDKGVVRAILYYPQEVGRNIDEILRLIESLQ
ISDKYGRAIPANWPNNELIGDNLIVPPAATVQEAEERLKKFKCFDWWFCYEDKATAEEKELARKFLKRVANC
>Mature_231_residues
PLQAPSIGEKFPEIEVMTTHGKIKLPDHFRGKWFVLFSHPADFTPVCTTEFVAFAKRYEDFKKLNTELIGLSVDSTFSHI
KWAEWIKEKLGVEIPFPIIADPTGEVAKKLGLLHAQSSTATVRAVFVVDDKGVVRAILYYPQEVGRNIDEILRLIESLQI
SDKYGRAIPANWPNNELIGDNLIVPPAATVQEAEERLKKFKCFDWWFCYEDKATAEEKELARKFLKRVANC

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI5453549, Length=159, Percent_Identity=41.5094339622642, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI4505591, Length=180, Percent_Identity=40.5555555555556, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI32455266, Length=180, Percent_Identity=40.5555555555556, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI32455264, Length=180, Percent_Identity=40.5555555555556, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI32189392, Length=163, Percent_Identity=40.4907975460123, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI4758638, Length=202, Percent_Identity=38.1188118811881, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI5802974, Length=147, Percent_Identity=36.0544217687075, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI32483377, Length=147, Percent_Identity=36.734693877551, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI33188454, Length=63, Percent_Identity=53.968253968254, Blast_Score=75, Evalue=4e-14,
Organism=Escherichia coli, GI1786822, Length=147, Percent_Identity=34.0136054421769, Blast_Score=94, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17554494, Length=200, Percent_Identity=32.5, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI25153706, Length=202, Percent_Identity=32.1782178217822, Blast_Score=117, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI32565831, Length=178, Percent_Identity=36.5168539325843, Blast_Score=117, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI193204376, Length=178, Percent_Identity=36.5168539325843, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6319407, Length=202, Percent_Identity=44.5544554455446, Blast_Score=158, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6323613, Length=175, Percent_Identity=33.7142857142857, Blast_Score=104, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320661, Length=147, Percent_Identity=33.3333333333333, Blast_Score=96, Evalue=4e-21,
Organism=Drosophila melanogaster, GI17975518, Length=202, Percent_Identity=40.5940594059406, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24652434, Length=202, Percent_Identity=40.5940594059406, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24652436, Length=202, Percent_Identity=40.5940594059406, Blast_Score=144, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24581278, Length=193, Percent_Identity=42.4870466321244, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI17738015, Length=206, Percent_Identity=35.4368932038835, Blast_Score=128, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17157991, Length=151, Percent_Identity=41.0596026490066, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24641739, Length=151, Percent_Identity=41.0596026490066, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24656348, Length=174, Percent_Identity=37.3563218390805, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI17864676, Length=174, Percent_Identity=37.3563218390805, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI21357347, Length=145, Percent_Identity=36.551724137931, Blast_Score=114, Evalue=5e-26,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): TDXH_HYPBU (A2BJD9)

Other databases:

- EMBL:   CP000493
- RefSeq:   YP_001012445.1
- ProteinModelPortal:   A2BJD9
- SMR:   A2BJD9
- STRING:   A2BJD9
- GeneID:   4782634
- GenomeReviews:   CP000493_GR
- KEGG:   hbu:Hbut_0228
- eggNOG:   arNOG04373
- HOGENOM:   HBG493509
- OMA:   EVKTTHG
- PhylomeDB:   A2BJD9
- ProtClustDB:   CLSK964488
- BioCyc:   HBUT415426:HBUT_0228-MONOMER
- HAMAP:   MF_00401
- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR022915
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA; SSF52833 Thiordxn-like_fd

EC number: =1.11.1.15

Molecular weight: Translated: 26470; Mature: 26339

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS51352 THIOREDOXIN_2

Important sites: ACT_SITE 48-48

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLQAPSIGEKFPEIEVMTTHGKIKLPDHFRGKWFVLFSHPADFTPVCTTEFVAFAKRYE
CCCCCCCCCCCCCCEEEEECCCEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHH
DFKKLNTELIGLSVDSTFSHIKWAEWIKEKLGVEIPFPIIADPTGEVAKKLGLLHAQSST
HHHHHCHHEEEEECCCHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHCCCCC
ATVRAVFVVDDKGVVRAILYYPQEVGRNIDEILRLIESLQISDKYGRAIPANWPNNELIG
CEEEEEEEECCCHHHHHHHHCCHHHCCCHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCC
DNLIVPPAATVQEAEERLKKFKCFDWWFCYEDKATAEEKELARKFLKRVANC
CCEECCCCHHHHHHHHHHHHCCHHEEEEEECCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PLQAPSIGEKFPEIEVMTTHGKIKLPDHFRGKWFVLFSHPADFTPVCTTEFVAFAKRYE
CCCCCCCCCCCCCEEEEECCCEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHH
DFKKLNTELIGLSVDSTFSHIKWAEWIKEKLGVEIPFPIIADPTGEVAKKLGLLHAQSST
HHHHHCHHEEEEECCCHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHCCCCC
ATVRAVFVVDDKGVVRAILYYPQEVGRNIDEILRLIESLQISDKYGRAIPANWPNNELIG
CEEEEEEEECCCHHHHHHHHCCHHHCCCHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCC
DNLIVPPAATVQEAEERLKKFKCFDWWFCYEDKATAEEKELARKFLKRVANC
CCEECCCCHHHHHHHHHHHHCCHHEEEEEECCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA