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The map label for this gene is rnc [H]

Identifier: 123967024

GI number: 123967024

Start: 1578477

End: 1579226

Strand: Direct

Name: rnc [H]

Synonym: P9515_17911

Alternate gene names: 123967024

Gene position: 1578477-1579226 (Clockwise)

Preceding gene: 123967021

Following gene: 123967026

Centisome position: 92.62

GC content: 29.6

Gene sequence:

>750_bases
ATGAATAACGTTATTGAAAAAAAAAGGACTGAACAAATTATTCAGTTTTTGAATTCGCTAGATATTGACTCAAAAAGATT
TTTTGAAATTATAAACAAAAAAGATCAATTGATAATTTGTACTTTCAATGAAGCATTAACCCACTCTTCAGCAGATAAAA
TAGTTAATTATGAAAAATTAGAATTCTTTGGCGATGCTGTTCTCAGATTATCGGCATCAGATTTCATAGAAAGAAAATAT
AAAAACATGAGTGTTGGAAATAGATCAGAACTCAGATCTCAGCTAGTAAGTGATGAATGGTTAACTGAATTAGGTAAAAA
AATCTTTATCGAAAAAGTTATAGTTAAAGGTCCAAAAGCAATTGGTGACGAAAATTCAAAAGACACTATAATCGCAGAAA
CTAGCGAAGCATTAATAGGAGCAATATATAAATGTTTTAACTCAATACATGAAGTCAATATTTGGTTAGACAATTTTTGG
GAAAAAGATGCAGAATTATATTTAAAAGCCCCACATAAATATAATGCCAAGTCAGCGTTACAAGAATGGTGTCAAAAGCA
TGGGTTTGATTTACCTATTTATAAGATATATGAGGTGTCATCAAGTCACGGGGATCCAAAAAGATTTTCTTGTGACATAT
ATCTTAATGGATCTAAAGAAGCCAGTAGTTTCGGTAATTCTCACAAAAAGGCTGAAAAAAATGCCGCAACTATTTTAATA
GAAAAAATTTTTCAGAAAGAACAAAACTAA

Upstream 100 bases:

>100_bases
AAGTAATTCCAGTCCTAGATAGATGATTGCCCATCTTAATTACGATGAACAGAACCCGGCTTATGACCTGCTTTCTAATT
AATGAAAACATCTAATCTAT

Downstream 100 bases:

>100_bases
TTCCTCAAACTAGTTCTAAATTATTTAATTTAAATGTTACGAGCTTATCCCAATTTCCTCCTTCAAAAAGAACTGCAGCT
TTTTTTTTGGTTACTCTCTG

Product: putative ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III 2; RNase III 2 [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MNNVIEKKRTEQIIQFLNSLDIDSKRFFEIINKKDQLIICTFNEALTHSSADKIVNYEKLEFFGDAVLRLSASDFIERKY
KNMSVGNRSELRSQLVSDEWLTELGKKIFIEKVIVKGPKAIGDENSKDTIIAETSEALIGAIYKCFNSIHEVNIWLDNFW
EKDAELYLKAPHKYNAKSALQEWCQKHGFDLPIYKIYEVSSSHGDPKRFSCDIYLNGSKEASSFGNSHKKAEKNAATILI
EKIFQKEQN

Sequences:

>Translated_249_residues
MNNVIEKKRTEQIIQFLNSLDIDSKRFFEIINKKDQLIICTFNEALTHSSADKIVNYEKLEFFGDAVLRLSASDFIERKY
KNMSVGNRSELRSQLVSDEWLTELGKKIFIEKVIVKGPKAIGDENSKDTIIAETSEALIGAIYKCFNSIHEVNIWLDNFW
EKDAELYLKAPHKYNAKSALQEWCQKHGFDLPIYKIYEVSSSHGDPKRFSCDIYLNGSKEASSFGNSHKKAEKNAATILI
EKIFQKEQN
>Mature_249_residues
MNNVIEKKRTEQIIQFLNSLDIDSKRFFEIINKKDQLIICTFNEALTHSSADKIVNYEKLEFFGDAVLRLSASDFIERKY
KNMSVGNRSELRSQLVSDEWLTELGKKIFIEKVIVKGPKAIGDENSKDTIIAETSEALIGAIYKCFNSIHEVNIWLDNFW
EKDAELYLKAPHKYNAKSALQEWCQKHGFDLPIYKIYEVSSSHGDPKRFSCDIYLNGSKEASSFGNSHKKAEKNAATILI
EKIFQKEQN

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Escherichia coli, GI1788920, Length=222, Percent_Identity=27.4774774774775, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17506883, Length=189, Percent_Identity=25.9259259259259, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI193202651, Length=189, Percent_Identity=25.9259259259259, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 28687; Mature: 28687

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS50137 DS_RBD ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNVIEKKRTEQIIQFLNSLDIDSKRFFEIINKKDQLIICTFNEALTHSSADKIVNYEKL
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCHHHHCCCHHHHHHHHHH
EFFGDAVLRLSASDFIERKYKNMSVGNRSELRSQLVSDEWLTELGKKIFIEKVIVKGPKA
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
IGDENSKDTIIAETSEALIGAIYKCFNSIHEVNIWLDNFWEKDAELYLKAPHKYNAKSAL
CCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHH
QEWCQKHGFDLPIYKIYEVSSSHGDPKRFSCDIYLNGSKEASSFGNSHKKAEKNAATILI
HHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEEECCCCHHHHCCCHHHHHHHHHHHHHH
EKIFQKEQN
HHHHHHCCC
>Mature Secondary Structure
MNNVIEKKRTEQIIQFLNSLDIDSKRFFEIINKKDQLIICTFNEALTHSSADKIVNYEKL
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCHHHHCCCHHHHHHHHHH
EFFGDAVLRLSASDFIERKYKNMSVGNRSELRSQLVSDEWLTELGKKIFIEKVIVKGPKA
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
IGDENSKDTIIAETSEALIGAIYKCFNSIHEVNIWLDNFWEKDAELYLKAPHKYNAKSAL
CCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHH
QEWCQKHGFDLPIYKIYEVSSSHGDPKRFSCDIYLNGSKEASSFGNSHKKAEKNAATILI
HHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEEECCCCHHHHCCCHHHHHHHHHHHHHH
EKIFQKEQN
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]