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The map label for this gene is cmk [H]

Identifier: 123967010

GI number: 123967010

Start: 1563472

End: 1565001

Strand: Direct

Name: cmk [H]

Synonym: P9515_17771

Alternate gene names: 123967010

Gene position: 1563472-1565001 (Clockwise)

Preceding gene: 123967004

Following gene: 123967016

Centisome position: 91.74

GC content: 28.17

Gene sequence:

>1530_bases
GTGAACAAGATAATAAGAAAAATAGAAGAACTTGAAGAATGGCGCCGCCACCTTAAAAGTGATATTAATTTTATACCAAC
TATGGGTAATCTGCATTATGGTCATCAAAAATTAATATCCACAGCAAAAAGTTCAAATTGCAATATTAACTTAGTAAGTA
TTTTTGTGAATCCACTTCAATTTGATAGTAAAAAAGATCTTAAAAGCTACCCAAAAACTGTTGATAAAGATATTGAAATT
GCTTTTTCTACTGGCACAGATGTAATTTTTATTCCTAATACCATTGATATCTATCCCCCAAATAATAAAAGTATTAGTTA
TCTGAAAGCTTCTAAAGAACTATCTTCAGCATTATGTGGCATTACAAGAAAAGGTCATTTTGATGGAGTTTGTACTGTTA
TTTATAGATTACTAAAACTTATACAGCCAAAAAATCTTTATTTAGGAGAAAAAGACTGGCAGCAGCTATTAATCTTGAAA
AACCTAGTATCAGAAAAAAAATTAAACATCAATATTTTATCTATTCCGACCCAAAGAGATTCTGATGGTATCCCATTTAG
TTCACGTAACAATCTTTTATCTAAAAATGAAAAAACAATTGTAAAATTTTTTTCAAATGAACTAGTCCATTCACAAAAAG
TTTTTAAAAAGGATAAAAAGATTGAATTAAATCAAATTATCAAAAAGCTACAATCTAAAAATATTTCTATTGAATATTTA
GAACATCTAAACGCTTATAGCTTGAAAAAAGTACAAAAGGAAGATAATATTTCGATTTTAGCTGGTGCGATAAAATGTGG
AAAAACAAGATTAATTGATCACGTTTTTCTTATGAAAAGAAATCCAATTATTGCGATTGATGGACCAGCAGGTTCAGGGA
AAAGTACCATAACAAAATTAATTGCAAAGAAGTTAAAGTTTTTATATTTAGACACTGGAGCAATGTATAGAGCACTAAGT
TGGCTTTTAATAAAAGAAAAGATTGACTATAATGAAAAATCTGAATTGAACAAAATCCTTAGTAATGTATCTATAATTTT
CAAAACAAATTCTATTTCCCACCAGGATGTATTCATAAATAAATTTTGTGTAACTGAAGAAATTCGTTCGCAAAAAATAA
GTTCTATTGTTTCTAAAATTTCATCAATAAAAGAAATTAGAGATTTTTTAGTGAAAGAACAAAGAAAAATTGGAGAATCA
GGAGGATTAGTAGCTGAAGGAAGAGACATCGGATCAACAGTTTTTCCTGATGCAGAAATTAAAATATACTTAACTGCTAG
TATTGAGGAAAGAGCGAAAAGAAGAAAGTCTGAACTAGATATCAGAGGTTCAAAAGAGATTGACTTTAATCAATTAAAAG
AACTTATAAGGAAAAGAGATTTGGATGATTCTACTAGAGAAATTTCCCCACTCACTAAAGCAAAGGGCGCAATTGAACTG
ATCACTGACGGATATTCTATAAATGAAGTCGTAGAAAAAATTATTAATATTTACAATTTCAAAATTCCTAAAGAGATTCA
AATTGAATAA

Upstream 100 bases:

>100_bases
TCCATGAAGTAAAAATGATAGAATTGTCCTATATAGATGTTCCTCCGTAGATCGCTTTTGTCCAGTAATTATTTATTAAA
TAGATTTATTTTTTAAAAAA

Downstream 100 bases:

>100_bases
CTCAACAAATCGTATTCAAGAAGCCACTTACAGAGTCTTCTAAGATATCAAGGACGTGATCAAATCCATCATCGCCGCCA
AAATAAGGATCAGGCACTTC

Product: bifunctional pantoate ligase/cytidylate kinase

Products: NA

Alternate protein names: Pantoate--beta-alanine ligase; Pantoate-activating enzyme; Pantothenate synthetase; Cytidylate kinase; CK; Cytidine monophosphate kinase; CMP kinase [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MNKIIRKIEELEEWRRHLKSDINFIPTMGNLHYGHQKLISTAKSSNCNINLVSIFVNPLQFDSKKDLKSYPKTVDKDIEI
AFSTGTDVIFIPNTIDIYPPNNKSISYLKASKELSSALCGITRKGHFDGVCTVIYRLLKLIQPKNLYLGEKDWQQLLILK
NLVSEKKLNINILSIPTQRDSDGIPFSSRNNLLSKNEKTIVKFFSNELVHSQKVFKKDKKIELNQIIKKLQSKNISIEYL
EHLNAYSLKKVQKEDNISILAGAIKCGKTRLIDHVFLMKRNPIIAIDGPAGSGKSTITKLIAKKLKFLYLDTGAMYRALS
WLLIKEKIDYNEKSELNKILSNVSIIFKTNSISHQDVFINKFCVTEEIRSQKISSIVSKISSIKEIRDFLVKEQRKIGES
GGLVAEGRDIGSTVFPDAEIKIYLTASIEERAKRRKSELDIRGSKEIDFNQLKELIRKRDLDDSTREISPLTKAKGAIEL
ITDGYSINEVVEKIINIYNFKIPKEIQIE

Sequences:

>Translated_509_residues
MNKIIRKIEELEEWRRHLKSDINFIPTMGNLHYGHQKLISTAKSSNCNINLVSIFVNPLQFDSKKDLKSYPKTVDKDIEI
AFSTGTDVIFIPNTIDIYPPNNKSISYLKASKELSSALCGITRKGHFDGVCTVIYRLLKLIQPKNLYLGEKDWQQLLILK
NLVSEKKLNINILSIPTQRDSDGIPFSSRNNLLSKNEKTIVKFFSNELVHSQKVFKKDKKIELNQIIKKLQSKNISIEYL
EHLNAYSLKKVQKEDNISILAGAIKCGKTRLIDHVFLMKRNPIIAIDGPAGSGKSTITKLIAKKLKFLYLDTGAMYRALS
WLLIKEKIDYNEKSELNKILSNVSIIFKTNSISHQDVFINKFCVTEEIRSQKISSIVSKISSIKEIRDFLVKEQRKIGES
GGLVAEGRDIGSTVFPDAEIKIYLTASIEERAKRRKSELDIRGSKEIDFNQLKELIRKRDLDDSTREISPLTKAKGAIEL
ITDGYSINEVVEKIINIYNFKIPKEIQIE
>Mature_509_residues
MNKIIRKIEELEEWRRHLKSDINFIPTMGNLHYGHQKLISTAKSSNCNINLVSIFVNPLQFDSKKDLKSYPKTVDKDIEI
AFSTGTDVIFIPNTIDIYPPNNKSISYLKASKELSSALCGITRKGHFDGVCTVIYRLLKLIQPKNLYLGEKDWQQLLILK
NLVSEKKLNINILSIPTQRDSDGIPFSSRNNLLSKNEKTIVKFFSNELVHSQKVFKKDKKIELNQIIKKLQSKNISIEYL
EHLNAYSLKKVQKEDNISILAGAIKCGKTRLIDHVFLMKRNPIIAIDGPAGSGKSTITKLIAKKLKFLYLDTGAMYRALS
WLLIKEKIDYNEKSELNKILSNVSIIFKTNSISHQDVFINKFCVTEEIRSQKISSIVSKISSIKEIRDFLVKEQRKIGES
GGLVAEGRDIGSTVFPDAEIKIYLTASIEERAKRRKSELDIRGSKEIDFNQLKELIRKRDLDDSTREISPLTKAKGAIEL
ITDGYSINEVVEKIINIYNFKIPKEIQIE

Specific function: Pantothenate biosynthesis; last step. [C]

COG id: COG0283

COG function: function code F; Cytidylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786325, Length=278, Percent_Identity=33.0935251798561, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1787139, Length=221, Percent_Identity=35.7466063348416, Blast_Score=153, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6322046, Length=209, Percent_Identity=35.8851674641148, Blast_Score=130, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003136
- InterPro:   IPR011994
- InterPro:   IPR003721
- InterPro:   IPR014729 [H]

Pfam domain/function: PF02224 Cytidylate_kin; PF02569 Pantoate_ligase [H]

EC number: =6.3.2.1; =2.7.4.14 [H]

Molecular weight: Translated: 58136; Mature: 58136

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIIRKIEELEEWRRHLKSDINFIPTMGNLHYGHQKLISTAKSSNCNINLVSIFVNPLQ
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCC
FDSKKDLKSYPKTVDKDIEIAFSTGTDVIFIPNTIDIYPPNNKSISYLKASKELSSALCG
CCCHHHHHHCCHHCCCCEEEEEECCCCEEEECCEEEEECCCCCCCHHHHHHHHHHHHHHC
ITRKGHFDGVCTVIYRLLKLIQPKNLYLGEKDWQQLLILKNLVSEKKLNINILSIPTQRD
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCC
SDGIPFSSRNNLLSKNEKTIVKFFSNELVHSQKVFKKDKKIELNQIIKKLQSKNISIEYL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHH
EHLNAYSLKKVQKEDNISILAGAIKCGKTRLIDHVFLMKRNPIIAIDGPAGSGKSTITKL
HHCCHHHHHHHHCCCCCEEEEHHHHCCHHHHHHHHHHEECCCEEEEECCCCCCHHHHHHH
IAKKLKFLYLDTGAMYRALSWLLIKEKIDYNEKSELNKILSNVSIIFKTNSISHQDVFIN
HHHHHHEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEEEECCCCCCHHHHH
KFCVTEEIRSQKISSIVSKISSIKEIRDFLVKEQRKIGESGGLVAEGRDIGSTVFPDAEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCEE
KIYLTASIEERAKRRKSELDIRGSKEIDFNQLKELIRKRDLDDSTREISPLTKAKGAIEL
EEEEEECHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHCHHHHCCCCEEE
ITDGYSINEVVEKIINIYNFKIPKEIQIE
EECCCCHHHHHHHHHHHHCCCCCCEEECC
>Mature Secondary Structure
MNKIIRKIEELEEWRRHLKSDINFIPTMGNLHYGHQKLISTAKSSNCNINLVSIFVNPLQ
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCC
FDSKKDLKSYPKTVDKDIEIAFSTGTDVIFIPNTIDIYPPNNKSISYLKASKELSSALCG
CCCHHHHHHCCHHCCCCEEEEEECCCCEEEECCEEEEECCCCCCCHHHHHHHHHHHHHHC
ITRKGHFDGVCTVIYRLLKLIQPKNLYLGEKDWQQLLILKNLVSEKKLNINILSIPTQRD
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCC
SDGIPFSSRNNLLSKNEKTIVKFFSNELVHSQKVFKKDKKIELNQIIKKLQSKNISIEYL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHH
EHLNAYSLKKVQKEDNISILAGAIKCGKTRLIDHVFLMKRNPIIAIDGPAGSGKSTITKL
HHCCHHHHHHHHCCCCCEEEEHHHHCCHHHHHHHHHHEECCCEEEEECCCCCCHHHHHHH
IAKKLKFLYLDTGAMYRALSWLLIKEKIDYNEKSELNKILSNVSIIFKTNSISHQDVFIN
HHHHHHEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEEEECCCCCCHHHHH
KFCVTEEIRSQKISSIVSKISSIKEIRDFLVKEQRKIGESGGLVAEGRDIGSTVFPDAEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCEE
KIYLTASIEERAKRRKSELDIRGSKEIDFNQLKELIRKRDLDDSTREISPLTKAKGAIEL
EEEEEECHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHCHHHHCCCCEEE
ITDGYSINEVVEKIINIYNFKIPKEIQIE
EECCCCHHHHHHHHHHHHCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]