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The map label for this gene is icd [H]

Identifier: 123967016

GI number: 123967016

Start: 1568400

End: 1569824

Strand: Direct

Name: icd [H]

Synonym: P9515_17831

Alternate gene names: 123967016

Gene position: 1568400-1569824 (Clockwise)

Preceding gene: 123967010

Following gene: 123967021

Centisome position: 92.03

GC content: 36.42

Gene sequence:

>1425_bases
ATGCCTAAATTTGAAAAATTAAATTTACCTTCAGAAGGGGAGTTAATTACTTTTAATCACGGCAAGCCTAATGTTCCCAA
TAATCCCATCGTTCCATATATAAGAGGAGACGGAACTGGGGTAGATATATGGCCAGCTAGCCGACTAGTTCTTGATGAAG
CAATAAAAAAAAGCTATGGAGATGAAAGAAAAATTAATTGGTTCAAAGTATATGCAGGTGATGAAGCGTGTGAAATATAT
GGAACTTATAACTATTTACCCCAAGATACTATTGAAGCTATAAAACACTTTGGAGTTGCAATCAAAGGCCCATTAACAAC
TCCCGTTGGAGGGGGGATTAGATCTTTAAATGTTGCACTAAGACAAATTTTTGATTTATATAGTTGTGTCAGACCATGCA
AATACTATTCAGGCACTCCTAGTCCTCATAAAAATCCGCAAAATTTGGACGTAATTGTTTATAGAGAAAATACAGAGGAT
ATTTATATGGGTATTGAGTGGGAATCTGATGATGATACTTGCGTTGATTTAATAAATCACTTAAATAATGTGGTCATTCC
TAGTAGCAAAAATCTAAAAAACAGATCAATACCCAACGGTTCAAGCATTGGGATCAAACCTGTTAGTAAACTTGGCAGCC
AAAGGCATATCAGAAAGGCTATAGAACATGCAAAAAGATTGTCAGGTGACAAAAAGCATGTAACTCTTGTTCATAAGGGC
AATATCATGAAATATACCGAAGGCGCCTTTAGAGATTGGGGATATGAATTAGCAGTAAATGAATTCCGATCTGATTGTAT
TACCGAAAGAGAAAGCTGGATTTTAGACAATATTCAAAAATTTCCAGAAATTACAATTGAAAATAATGCCAGAATGATTG
AACCTGGCTACGACAAACTAACAAGTAATAAACAATTTTTTATTTGCGAAGAAATAAAGGAAGTAATAGCCTCTATTTCC
AATACTCATGGAGATAATAAATGGAAAAAACTCGTCATGGTTGATGATCGTATAGCTGATAGCATTTTCCAGCAAATCCA
AACCCGACCTCAAGAATATTCAATTCTCGCGACCTTGAACTTAAACGGAGATTATATTTCTGATGCCGCAGCTGCAATAG
TAGGTGGCTTAGGTATGGCCCCCGGAGCAAATATTGGTGATCATGCCGCGATTTTTGAAGCAACACATGGAACCGCTCCT
AAGCATGCCGGATTAAACAAAATTAATCCGGGCTCAGTAATTCTTAGTGGAGTAATGATGCTTGAATATTTTGGATGGGA
AGAGGCAGCGAATCTAATAACTTCTGGGATTAGTAGAGCTATTGAAGAAAAAAAAGTTACCTATGATCTGGCCCGATTAA
TGGAACCAAAGGTAGAACCACTCTCATGCAGTGGTTTTGCTGAAGCAATTATCTCAAATTTTTAA

Upstream 100 bases:

>100_bases
TTGAATAATTCATTTCTAACTTACAAAAAATATTCTAAATTTCAATTTAAGATATCTAGTAATCTAATTTATTAATTTTA
TTTCTATTAATTCAAGAGCT

Downstream 100 bases:

>100_bases
TTATAAGAGTTTTTTATTTTCTAAAATTTTCCATACGGTTACCAATGACTCTTGGCTGCCAATATTTCCTGGAAAGGTAA
CTATTGGAAGATTCTCTTCA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MPKFEKLNLPSEGELITFNHGKPNVPNNPIVPYIRGDGTGVDIWPASRLVLDEAIKKSYGDERKINWFKVYAGDEACEIY
GTYNYLPQDTIEAIKHFGVAIKGPLTTPVGGGIRSLNVALRQIFDLYSCVRPCKYYSGTPSPHKNPQNLDVIVYRENTED
IYMGIEWESDDDTCVDLINHLNNVVIPSSKNLKNRSIPNGSSIGIKPVSKLGSQRHIRKAIEHAKRLSGDKKHVTLVHKG
NIMKYTEGAFRDWGYELAVNEFRSDCITERESWILDNIQKFPEITIENNARMIEPGYDKLTSNKQFFICEEIKEVIASIS
NTHGDNKWKKLVMVDDRIADSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDHAAIFEATHGTAP
KHAGLNKINPGSVILSGVMMLEYFGWEEAANLITSGISRAIEEKKVTYDLARLMEPKVEPLSCSGFAEAIISNF

Sequences:

>Translated_474_residues
MPKFEKLNLPSEGELITFNHGKPNVPNNPIVPYIRGDGTGVDIWPASRLVLDEAIKKSYGDERKINWFKVYAGDEACEIY
GTYNYLPQDTIEAIKHFGVAIKGPLTTPVGGGIRSLNVALRQIFDLYSCVRPCKYYSGTPSPHKNPQNLDVIVYRENTED
IYMGIEWESDDDTCVDLINHLNNVVIPSSKNLKNRSIPNGSSIGIKPVSKLGSQRHIRKAIEHAKRLSGDKKHVTLVHKG
NIMKYTEGAFRDWGYELAVNEFRSDCITERESWILDNIQKFPEITIENNARMIEPGYDKLTSNKQFFICEEIKEVIASIS
NTHGDNKWKKLVMVDDRIADSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDHAAIFEATHGTAP
KHAGLNKINPGSVILSGVMMLEYFGWEEAANLITSGISRAIEEKKVTYDLARLMEPKVEPLSCSGFAEAIISNF
>Mature_473_residues
PKFEKLNLPSEGELITFNHGKPNVPNNPIVPYIRGDGTGVDIWPASRLVLDEAIKKSYGDERKINWFKVYAGDEACEIYG
TYNYLPQDTIEAIKHFGVAIKGPLTTPVGGGIRSLNVALRQIFDLYSCVRPCKYYSGTPSPHKNPQNLDVIVYRENTEDI
YMGIEWESDDDTCVDLINHLNNVVIPSSKNLKNRSIPNGSSIGIKPVSKLGSQRHIRKAIEHAKRLSGDKKHVTLVHKGN
IMKYTEGAFRDWGYELAVNEFRSDCITERESWILDNIQKFPEITIENNARMIEPGYDKLTSNKQFFICEEIKEVIASISN
THGDNKWKKLVMVDDRIADSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDHAAIFEATHGTAPK
HAGLNKINPGSVILSGVMMLEYFGWEEAANLITSGISRAIEEKKVTYDLARLMEPKVEPLSCSGFAEAIISNF

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178838, Length=379, Percent_Identity=26.1213720316623, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI4758582, Length=353, Percent_Identity=26.628895184136, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI5031777, Length=228, Percent_Identity=29.8245614035088, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1787381, Length=469, Percent_Identity=48.6140724946695, Blast_Score=440, Evalue=1e-124,
Organism=Escherichia coli, GI87081683, Length=142, Percent_Identity=33.0985915492958, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788101, Length=145, Percent_Identity=28.2758620689655, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71986051, Length=237, Percent_Identity=31.2236286919831, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17505779, Length=134, Percent_Identity=32.089552238806, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25144293, Length=110, Percent_Identity=34.5454545454545, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324709, Length=461, Percent_Identity=28.4164859002169, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322097, Length=429, Percent_Identity=27.5058275058275, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324291, Length=250, Percent_Identity=28.4, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24643268, Length=367, Percent_Identity=30.5177111716621, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24643270, Length=366, Percent_Identity=30.6010928961749, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24661184, Length=126, Percent_Identity=40.4761904761905, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI161078639, Length=108, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161078637, Length=108, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161078633, Length=108, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24650122, Length=108, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161078635, Length=108, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 52794; Mature: 52662

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKFEKLNLPSEGELITFNHGKPNVPNNPIVPYIRGDGTGVDIWPASRLVLDEAIKKSYG
CCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCEEEECCCHHHHHHHHHHHHCC
DERKINWFKVYAGDEACEIYGTYNYLPQDTIEAIKHFGVAIKGPLTTPVGGGIRSLNVAL
CCCCCEEEEEEECCCEEEEEECCCCCCHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHH
RQIFDLYSCVRPCKYYSGTPSPHKNPQNLDVIVYRENTEDIYMGIEWESDDDTCVDLINH
HHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCHHHHHHHHH
LNNVVIPSSKNLKNRSIPNGSSIGIKPVSKLGSQRHIRKAIEHAKRLSGDKKHVTLVHKG
HCCEECCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEECC
NIMKYTEGAFRDWGYELAVNEFRSDCITERESWILDNIQKFPEITIENNARMIEPGYDKL
CEEEECCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEECCCCHHH
TSNKQFFICEEIKEVIASISNTHGDNKWKKLVMVDDRIADSIFQQIQTRPQEYSILATLN
CCCCCEEEHHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHCCCCCEEEEEEEE
LNGDYISDAAAAIVGGLGMAPGANIGDHAAIFEATHGTAPKHAGLNKINPGSVILSGVMM
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
LEYFGWEEAANLITSGISRAIEEKKVTYDLARLMEPKVEPLSCSGFAEAIISNF
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
PKFEKLNLPSEGELITFNHGKPNVPNNPIVPYIRGDGTGVDIWPASRLVLDEAIKKSYG
CCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCEEEECCCHHHHHHHHHHHHCC
DERKINWFKVYAGDEACEIYGTYNYLPQDTIEAIKHFGVAIKGPLTTPVGGGIRSLNVAL
CCCCCEEEEEEECCCEEEEEECCCCCCHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHH
RQIFDLYSCVRPCKYYSGTPSPHKNPQNLDVIVYRENTEDIYMGIEWESDDDTCVDLINH
HHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCHHHHHHHHH
LNNVVIPSSKNLKNRSIPNGSSIGIKPVSKLGSQRHIRKAIEHAKRLSGDKKHVTLVHKG
HCCEECCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEECC
NIMKYTEGAFRDWGYELAVNEFRSDCITERESWILDNIQKFPEITIENNARMIEPGYDKL
CEEEECCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEECCCCHHH
TSNKQFFICEEIKEVIASISNTHGDNKWKKLVMVDDRIADSIFQQIQTRPQEYSILATLN
CCCCCEEEHHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHCCCCCEEEEEEEE
LNGDYISDAAAAIVGGLGMAPGANIGDHAAIFEATHGTAPKHAGLNKINPGSVILSGVMM
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
LEYFGWEEAANLITSGISRAIEEKKVTYDLARLMEPKVEPLSCSGFAEAIISNF
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8763933; 8905231; 1730247 [H]