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The map label for this gene is dfrA [H]

Identifier: 123966784

GI number: 123966784

Start: 1370567

End: 1371535

Strand: Direct

Name: dfrA [H]

Synonym: P9515_15511

Alternate gene names: 123966784

Gene position: 1370567-1371535 (Clockwise)

Preceding gene: 123966783

Following gene: 123966785

Centisome position: 80.42

GC content: 33.44

Gene sequence:

>969_bases
TTGCACTGCATCCATGAGCTCCTAAAAGAAGGTTATATCGTAAAAGGATCTCTTAGAAATATGAAAAGAGCAGAGGAAGT
AAGAAAATCTCTTAAGATAGATTCAGAAAATCATAAGCTGGAATTTTGTAAACTTGACCTTCTACATGATGAGGGTTGGG
ATGAAGCAGCCTTTGATTGTGATTATCTTCTTCATGTCGCATCTCCTTTTACTATCGCAGAACCAAAAAGAGAATCTCTT
CTAATCAATCCTGCATTGGAAGGTACTATAAGGGCATTAAATGCTTCAAAAAAATCCTCTAAAGTCAAAAAAGTTGTTCT
AACTTCTTCAATGGCGGCAATTGCTTATGGACATGATAAGCAGTTATGTACGCCTCAAGACTGGACAGACACAACAAAAA
ACGTCGGCGCTTATGTAAAAAGTAAAACAATTGCAGAGAAAGCTGCATGGGATTTTGTTCATAATGACAATGATCATTCT
TTTTCAATGACAACTATTAATCCTGGAATGGTTTTCGGTCCACTGCTCAGCGATGATATTGATGGGGCTTCGGCAGAACT
TCTTTCAAAAATGATTAATGGTAAATTCCCGGCATTACCAGATGCTTATTTTACTGTCGTTGATGTAAGAGATGTCGCTA
AGTTGCATGTCGATTCTCTTAGAAATAATAAAAGTGATAATAAAAGAATTATTGCGACTTCTCCCCAAGGGATAAATATC
ATGAAAATTTCAAAAATTTTAAGAAAAAATGGTTATACAAAAACACCTCAAAAATTTATCCCAACAAAAATGATAAATTC
TCTTGCGTCTTTTAATAAAGAGATGAAAAGTATGGCTAATATGGTTAATAGAGGTTCTTATGGTGCTGATATTTCAGAAA
CTATTTCTATATTTAATTGGGAACCAATTTCACTAGAAAAAACATTAATTGATATGGGTAATTCTTTAAAACAAATTTCA
ACCAAATAA

Upstream 100 bases:

>100_bases
TTATTTATTTATGTAGCCTAAAGAATCATAATAAAAGTAGGCATAAAATAAAATTATTTTGGAAAAAGTTTTAGTTACTG
GAGCATCTGGGTTTATTGCT

Downstream 100 bases:

>100_bases
ACCAATAACATGGTTATAGCCATAGTTTTCGTATATCTTAAATTTATAACTTTACCACGATAATTTTTAACTCGACTATC
CTATCTATAGAGAATCAAAG

Product: dihydroflavonol-4-reductase

Products: NA

Alternate protein names: DFR; Dihydrokaempferol 4-reductase [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MHCIHELLKEGYIVKGSLRNMKRAEEVRKSLKIDSENHKLEFCKLDLLHDEGWDEAAFDCDYLLHVASPFTIAEPKRESL
LINPALEGTIRALNASKKSSKVKKVVLTSSMAAIAYGHDKQLCTPQDWTDTTKNVGAYVKSKTIAEKAAWDFVHNDNDHS
FSMTTINPGMVFGPLLSDDIDGASAELLSKMINGKFPALPDAYFTVVDVRDVAKLHVDSLRNNKSDNKRIIATSPQGINI
MKISKILRKNGYTKTPQKFIPTKMINSLASFNKEMKSMANMVNRGSYGADISETISIFNWEPISLEKTLIDMGNSLKQIS
TK

Sequences:

>Translated_322_residues
MHCIHELLKEGYIVKGSLRNMKRAEEVRKSLKIDSENHKLEFCKLDLLHDEGWDEAAFDCDYLLHVASPFTIAEPKRESL
LINPALEGTIRALNASKKSSKVKKVVLTSSMAAIAYGHDKQLCTPQDWTDTTKNVGAYVKSKTIAEKAAWDFVHNDNDHS
FSMTTINPGMVFGPLLSDDIDGASAELLSKMINGKFPALPDAYFTVVDVRDVAKLHVDSLRNNKSDNKRIIATSPQGINI
MKISKILRKNGYTKTPQKFIPTKMINSLASFNKEMKSMANMVNRGSYGADISETISIFNWEPISLEKTLIDMGNSLKQIS
TK
>Mature_322_residues
MHCIHELLKEGYIVKGSLRNMKRAEEVRKSLKIDSENHKLEFCKLDLLHDEGWDEAAFDCDYLLHVASPFTIAEPKRESL
LINPALEGTIRALNASKKSSKVKKVVLTSSMAAIAYGHDKQLCTPQDWTDTTKNVGAYVKSKTIAEKAAWDFVHNDNDHS
FSMTTINPGMVFGPLLSDDIDGASAELLSKMINGKFPALPDAYFTVVDVRDVAKLHVDSLRNNKSDNKRIIATSPQGINI
MKISKILRKNGYTKTPQKFIPTKMINSLASFNKEMKSMANMVNRGSYGADISETISIFNWEPISLEKTLIDMGNSLKQIS
TK

Specific function: Unknown

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroflavonol-4-reductase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI71987463, Length=323, Percent_Identity=38.390092879257, Blast_Score=198, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6320750, Length=256, Percent_Identity=33.59375, Blast_Score=122, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6324421, Length=262, Percent_Identity=33.587786259542, Blast_Score=105, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6321281, Length=257, Percent_Identity=31.1284046692607, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321399, Length=257, Percent_Identity=31.9066147859922, Blast_Score=100, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR017829
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =1.1.1.219 [H]

Molecular weight: Translated: 35971; Mature: 35971

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHCIHELLKEGYIVKGSLRNMKRAEEVRKSLKIDSENHKLEFCKLDLLHDEGWDEAAFDC
CHHHHHHHHCCEEEECHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCCHHHHH
DYLLHVASPFTIAEPKRESLLINPALEGTIRALNASKKSSKVKKVVLTSSMAAIAYGHDK
HHHHHHCCCCEECCCCCCCEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCC
QLCTPQDWTDTTKNVGAYVKSKTIAEKAAWDFVHNDNDHSFSMTTINPGMVFGPLLSDDI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEECCHHCCCC
DGASAELLSKMINGKFPALPDAYFTVVDVRDVAKLHVDSLRNNKSDNKRIIATSPQGINI
CCHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCH
MKISKILRKNGYTKTPQKFIPTKMINSLASFNKEMKSMANMVNRGSYGADISETISIFNW
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCC
EPISLEKTLIDMGNSLKQISTK
CCCCHHHHHHHHCCHHHHHCCC
>Mature Secondary Structure
MHCIHELLKEGYIVKGSLRNMKRAEEVRKSLKIDSENHKLEFCKLDLLHDEGWDEAAFDC
CHHHHHHHHCCEEEECHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCCHHHHH
DYLLHVASPFTIAEPKRESLLINPALEGTIRALNASKKSSKVKKVVLTSSMAAIAYGHDK
HHHHHHCCCCEECCCCCCCEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCC
QLCTPQDWTDTTKNVGAYVKSKTIAEKAAWDFVHNDNDHSFSMTTINPGMVFGPLLSDDI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEECCHHCCCC
DGASAELLSKMINGKFPALPDAYFTVVDVRDVAKLHVDSLRNNKSDNKRIIATSPQGINI
CCHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCH
MKISKILRKNGYTKTPQKFIPTKMINSLASFNKEMKSMANMVNRGSYGADISETISIFNW
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCC
EPISLEKTLIDMGNSLKQISTK
CCCCHHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]