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The map label for this gene is lpxB [H]

Identifier: 123966728

GI number: 123966728

Start: 1329405

End: 1330583

Strand: Reverse

Name: lpxB [H]

Synonym: P9515_14951

Alternate gene names: 123966728

Gene position: 1330583-1329405 (Counterclockwise)

Preceding gene: 123966729

Following gene: 123966727

Centisome position: 78.08

GC content: 29.52

Gene sequence:

>1179_bases
ATGAATAAAAAGATATTCATAAGTACTGGAGAAGTTTCAGGAGATTTACATGGAAGTTTATTAGCTAATGCATTATTTAA
TGAGGCTGAAAAACGTTCTGTTAATTTAAAAATATATGGCTTGGGTGGGGAAAGGATGAGAAAAGAGGGTGTAGAAATTT
TACAAGATACTACTTCAATAAGTGCTATTGGTATTTGGGAGGCTTTGCCACTCATCATTCCTACAATAAAAATACAAAAA
AAATTTTATAAATCACTTAAAAACTTTTCCCCGAATTGCTTAATATTAATTGACTATATGGGTCCTAATATTAAAATTGG
ACGACAATTAAAAATTGAGAAGAATAAAATCCCAATTTATTATTATATCGCTCCTCAAGAGTGGGCTTGGCGAGTTGGGA
ATAATTCGACGACGGATCTTATAAGTTTTTCTGATAGAATTTTTGCAATTTTTAAACAAGAAGCAAATTTTTATAAAAGA
AGAGGCGGTAATGTTTTATGGATTGGACATCCAATGATCGATCTTATAAAAAAACTACCTACTAAAAAAGAATCTAGAAA
AATTCTTGAACTTCGTGCAAATGAAAATATTTTACTATTAATGCCAGCATCAAGACCTCAAGAATTAAGATATGTTCTAC
CCGTTTTTATGCAGGCAGCCAGAAAATTACAACAAAAATATCCAAATCTAATCGTTTATATCCCATCGTGTAGAGCTGTT
TTTGATGCTAAATTCGAACAAGCTTTAGATAAATACAAAGTTAAAGGAAAGGTAGTATCTCAAAAAGATATCGATAAATT
TAAAACTCATATTTATTCATTAAGTAAATTAGCCTTATGTAAATCAGGAACGGTAAATATGGAATTGGCTTTATATGGGA
TACCTCAAATCGTTGGATATAGAGTGAGTAGAGTTACAGCATTTATTGCAAAAAAGATTCTCAATTTCAAAGTGAAATTT
ATTTCGCCAGTAAATTTATTAGTTAAAAAGTTAATTATTCCTGAATTCGTTCAAAAAGAATTTGATGTAAAAAAAATATA
CGATAAAGCTTGTCTGGTTATAGATCAAAAATCAGAAAAAGCAAAAATCTTAAAAGGTTATGCTCAATTAAAGAAAGAGT
TAGGACAACAAGGTGTGGCCAAAAGAGCTGCTGAAGAGATTATTAATTCTTTAATTTGA

Upstream 100 bases:

>100_bases
CGATGAAAGGAAAATTAGATATTTCTTCTGCTAAACTTTGTGAATTTGTAAAAGATTCAATATCAAAGCAAAGAAGAGGA
CCAATGCCTTCCGTTAATTT

Downstream 100 bases:

>100_bases
TGCTTATAATTGAAAAATGACTTATTTTTTCTCACTAATTATTGTATTTTCAATAATAGTAAATCCTATAAATACTTTCG
CTGAAGAAGTAACCCTCGCT

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MNKKIFISTGEVSGDLHGSLLANALFNEAEKRSVNLKIYGLGGERMRKEGVEILQDTTSISAIGIWEALPLIIPTIKIQK
KFYKSLKNFSPNCLILIDYMGPNIKIGRQLKIEKNKIPIYYYIAPQEWAWRVGNNSTTDLISFSDRIFAIFKQEANFYKR
RGGNVLWIGHPMIDLIKKLPTKKESRKILELRANENILLLMPASRPQELRYVLPVFMQAARKLQQKYPNLIVYIPSCRAV
FDAKFEQALDKYKVKGKVVSQKDIDKFKTHIYSLSKLALCKSGTVNMELALYGIPQIVGYRVSRVTAFIAKKILNFKVKF
ISPVNLLVKKLIIPEFVQKEFDVKKIYDKACLVIDQKSEKAKILKGYAQLKKELGQQGVAKRAAEEIINSLI

Sequences:

>Translated_392_residues
MNKKIFISTGEVSGDLHGSLLANALFNEAEKRSVNLKIYGLGGERMRKEGVEILQDTTSISAIGIWEALPLIIPTIKIQK
KFYKSLKNFSPNCLILIDYMGPNIKIGRQLKIEKNKIPIYYYIAPQEWAWRVGNNSTTDLISFSDRIFAIFKQEANFYKR
RGGNVLWIGHPMIDLIKKLPTKKESRKILELRANENILLLMPASRPQELRYVLPVFMQAARKLQQKYPNLIVYIPSCRAV
FDAKFEQALDKYKVKGKVVSQKDIDKFKTHIYSLSKLALCKSGTVNMELALYGIPQIVGYRVSRVTAFIAKKILNFKVKF
ISPVNLLVKKLIIPEFVQKEFDVKKIYDKACLVIDQKSEKAKILKGYAQLKKELGQQGVAKRAAEEIINSLI
>Mature_392_residues
MNKKIFISTGEVSGDLHGSLLANALFNEAEKRSVNLKIYGLGGERMRKEGVEILQDTTSISAIGIWEALPLIIPTIKIQK
KFYKSLKNFSPNCLILIDYMGPNIKIGRQLKIEKNKIPIYYYIAPQEWAWRVGNNSTTDLISFSDRIFAIFKQEANFYKR
RGGNVLWIGHPMIDLIKKLPTKKESRKILELRANENILLLMPASRPQELRYVLPVFMQAARKLQQKYPNLIVYIPSCRAV
FDAKFEQALDKYKVKGKVVSQKDIDKFKTHIYSLSKLALCKSGTVNMELALYGIPQIVGYRVSRVTAFIAKKILNFKVKF
ISPVNLLVKKLIIPEFVQKEFDVKKIYDKACLVIDQKSEKAKILKGYAQLKKELGQQGVAKRAAEEIINSLI

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=344, Percent_Identity=28.1976744186047, Blast_Score=143, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 44791; Mature: 44791

Theoretical pI: Translated: 10.46; Mature: 10.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKIFISTGEVSGDLHGSLLANALFNEAEKRSVNLKIYGLGGERMRKEGVEILQDTTSI
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCEEEEEEEECCHHHHHHHHHHHHHHCCCC
SAIGIWEALPLIIPTIKIQKKFYKSLKNFSPNCLILIDYMGPNIKIGRQLKIEKNKIPIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEECCEEEEECCCCCEE
YYIAPQEWAWRVGNNSTTDLISFSDRIFAIFKQEANFYKRRGGNVLWIGHPMIDLIKKLP
EEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHCC
TKKESRKILELRANENILLLMPASRPQELRYVLPVFMQAARKLQQKYPNLIVYIPSCRAV
CCCHHHHHHEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHH
FDAKFEQALDKYKVKGKVVSQKDIDKFKTHIYSLSKLALCKSGTVNMELALYGIPQIVGY
HHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHH
RVSRVTAFIAKKILNFKVKFISPVNLLVKKLIIPEFVQKEFDVKKIYDKACLVIDQKSEK
HHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEEECCCHH
AKILKGYAQLKKELGQQGVAKRAAEEIINSLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKKIFISTGEVSGDLHGSLLANALFNEAEKRSVNLKIYGLGGERMRKEGVEILQDTTSI
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCEEEEEEEECCHHHHHHHHHHHHHHCCCC
SAIGIWEALPLIIPTIKIQKKFYKSLKNFSPNCLILIDYMGPNIKIGRQLKIEKNKIPIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEECCEEEEECCCCCEE
YYIAPQEWAWRVGNNSTTDLISFSDRIFAIFKQEANFYKRRGGNVLWIGHPMIDLIKKLP
EEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHCC
TKKESRKILELRANENILLLMPASRPQELRYVLPVFMQAARKLQQKYPNLIVYIPSCRAV
CCCHHHHHHEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHH
FDAKFEQALDKYKVKGKVVSQKDIDKFKTHIYSLSKLALCKSGTVNMELALYGIPQIVGY
HHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHH
RVSRVTAFIAKKILNFKVKFISPVNLLVKKLIIPEFVQKEFDVKKIYDKACLVIDQKSEK
HHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEEECCCHH
AKILKGYAQLKKELGQQGVAKRAAEEIINSLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA