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The map label for this gene is msrAB [H]

Identifier: 123966727

GI number: 123966727

Start: 1328783

End: 1329388

Strand: Reverse

Name: msrAB [H]

Synonym: P9515_14941

Alternate gene names: 123966727

Gene position: 1329388-1328783 (Counterclockwise)

Preceding gene: 123966728

Following gene: 123966724

Centisome position: 78.01

GC content: 32.34

Gene sequence:

>606_bases
ATGACTTATTTTTTCTCACTAATTATTGTATTTTCAATAATAGTAAATCCTATAAATACTTTCGCTGAAGAAGTAACCCT
CGCTGGAGGATGTTTTTGGTGTTTAGAGCATGATTTAGAGTCATTAAAAGGGGTTAATTCAGTTATTAGTGGATACTCCG
GAGGGAATTTACAAAACCCTACTTATGAAAATCATGATGGACACCAAGAAGTTGTTTTAGTAGATTATGACTCTGAAGAG
GTGGCTTTATCAGAAATATACAGAATATACCTAAGAAATATTGATCCACTTGATGGAGAAGGTCAATTTTGCGATAGAGG
GAACTCTTATAGACCTGTAATTTTTTTTGAAACTTCAGATGAAAAGAATGAAGCAAGTAAATCCCTCCTTTCTGCTTCAA
AAGAATTAGGCGTCAAATTAGAACAAATTAATGTTGAACTAAAACCAAAAAGTCAGTTTTGGGAAGCGGAGGATTATCAT
CAAGATTTTGCTATTAGGAATGAATTAAAATATAAGTTCTATAGATTCTCTTGTGGCAGAGATCAGAAATTAGATAAAAT
ATGGAAAGACAATGCTAGATCAATGAATGCTTGGTCTCAAGAATAA

Upstream 100 bases:

>100_bases
GGTTATGCTCAATTAAAGAAAGAGTTAGGACAACAAGGTGTGGCCAAAAGAGCTGCTGAAGAGATTATTAATTCTTTAAT
TTGATGCTTATAATTGAAAA

Downstream 100 bases:

>100_bases
TTATTTATTATCTTGACGTTTATTTTTAATCCATTGGACTAAAGTTTTAACTCCGAATCCTGTAGCTCCTAAGGGGTTAA
TTCCTTTACTTTTGTCAGTC

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 201; Mature: 200

Protein sequence:

>201_residues
MTYFFSLIIVFSIIVNPINTFAEEVTLAGGCFWCLEHDLESLKGVNSVISGYSGGNLQNPTYENHDGHQEVVLVDYDSEE
VALSEIYRIYLRNIDPLDGEGQFCDRGNSYRPVIFFETSDEKNEASKSLLSASKELGVKLEQINVELKPKSQFWEAEDYH
QDFAIRNELKYKFYRFSCGRDQKLDKIWKDNARSMNAWSQE

Sequences:

>Translated_201_residues
MTYFFSLIIVFSIIVNPINTFAEEVTLAGGCFWCLEHDLESLKGVNSVISGYSGGNLQNPTYENHDGHQEVVLVDYDSEE
VALSEIYRIYLRNIDPLDGEGQFCDRGNSYRPVIFFETSDEKNEASKSLLSASKELGVKLEQINVELKPKSQFWEAEDYH
QDFAIRNELKYKFYRFSCGRDQKLDKIWKDNARSMNAWSQE
>Mature_200_residues
TYFFSLIIVFSIIVNPINTFAEEVTLAGGCFWCLEHDLESLKGVNSVISGYSGGNLQNPTYENHDGHQEVVLVDYDSEEV
ALSEIYRIYLRNIDPLDGEGQFCDRGNSYRPVIFFETSDEKNEASKSLLSASKELGVKLEQINVELKPKSQFWEAEDYHQ
DFAIRNELKYKFYRFSCGRDQKLDKIWKDNARSMNAWSQE

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=163, Percent_Identity=31.9018404907975, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI6912516, Length=163, Percent_Identity=31.9018404907975, Blast_Score=85, Evalue=5e-17,
Organism=Escherichia coli, GI1790665, Length=151, Percent_Identity=32.4503311258278, Blast_Score=81, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17533973, Length=149, Percent_Identity=28.1879194630872, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24664627, Length=153, Percent_Identity=26.797385620915, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 23226; Mature: 23095

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYFFSLIIVFSIIVNPINTFAEEVTLAGGCFWCLEHDLESLKGVNSVISGYSGGNLQNP
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
TYENHDGHQEVVLVDYDSEEVALSEIYRIYLRNIDPLDGEGQFCDRGNSYRPVIFFETSD
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCC
EKNEASKSLLSASKELGVKLEQINVELKPKSQFWEAEDYHQDFAIRNELKYKFYRFSCGR
CHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCC
DQKLDKIWKDNARSMNAWSQE
CHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TYFFSLIIVFSIIVNPINTFAEEVTLAGGCFWCLEHDLESLKGVNSVISGYSGGNLQNP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
TYENHDGHQEVVLVDYDSEEVALSEIYRIYLRNIDPLDGEGQFCDRGNSYRPVIFFETSD
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCC
EKNEASKSLLSASKELGVKLEQINVELKPKSQFWEAEDYHQDFAIRNELKYKFYRFSCGR
CHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCC
DQKLDKIWKDNARSMNAWSQE
CHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]