Click here to switch to the map view.

The map label for this gene is lpxA [H]

Identifier: 123966729

GI number: 123966729

Start: 1330580

End: 1331422

Strand: Reverse

Name: lpxA [H]

Synonym: P9515_14961

Alternate gene names: 123966729

Gene position: 1331422-1330580 (Counterclockwise)

Preceding gene: 123966730

Following gene: 123966728

Centisome position: 78.13

GC content: 34.88

Gene sequence:

>843_bases
ATGGAGATTAAAAATACCAAACGAAATCCAGATTTTCGAGGTGCGAGAGTGCACCCCAATGCAGTTGTCGATTCAAGTGC
AGAATTGCATGATGGAGTTTCTATCGCTAGTGGAGCTATCGTTGGACCAAACGTAATAATAGAATCAGGCACCAAAATAG
GATCTAATGCTGTAATTGAAGGGAAAACCAAAATAGGTAAAGATAATAAAGTTTTTCCAAATGTTTTTATAGGACTTGAG
CCCCAAGACCTTAAATATCAAGGTGCATCTACGGAGGTGATTATTGGAGATAACAATACATTTAGAGAGTGCGTAACTAT
TAATAAGGCAACTGACGAAGGAGAAAAAACAATTATTGGGAATAATAATTTATTAATGGCATACACTCATATTGGTCATA
ATTGCGTACTTGGTAATGGGATTGTTTTATCAAATAGTGTCCAGGTTGCTGGTCATGTAAAAATTGAAGATAATGCAATT
ATTGGAGGTTGTTTAGGTATTCATCAATTTGTACATGTGGGATATCTCGCAATGATTGGAGGAATGACAAGAGTAGATAG
AGACGTTCCTCCTTTTTGCTTGGCAGAAGGACATCCTGGTAGATTGAGAGGTTTAAATAGAGTAGGAATTAAGAGGAGTG
GGCTGATGGAAAATGAAGAATTTGATTTGAAATTATTGCAAAATACATGGAATCTTTTATTTAAGTCTAATGATGTAATT
TCTATTTCATTGGGTATGGCGATGAAAGGAAAATTAGATATTTCTTCTGCTAAACTTTGTGAATTTGTAAAAGATTCAAT
ATCAAAGCAAAGAAGAGGACCAATGCCTTCCGTTAATTTATGA

Upstream 100 bases:

>100_bases
ATTAAAAGACAAAGGTTTGGGAAGGTAAAAGGTGAAGCACATGTTGATGGGAAATTAGTTTGCTCAGGCGAATTGATGTT
TTCATTAGTTGATTAATAAA

Downstream 100 bases:

>100_bases
ATAAAAAGATATTCATAAGTACTGGAGAAGTTTCAGGAGATTTACATGGAAGTTTATTAGCTAATGCATTATTTAATGAG
GCTGAAAAACGTTCTGTTAA

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MEIKNTKRNPDFRGARVHPNAVVDSSAELHDGVSIASGAIVGPNVIIESGTKIGSNAVIEGKTKIGKDNKVFPNVFIGLE
PQDLKYQGASTEVIIGDNNTFRECVTINKATDEGEKTIIGNNNLLMAYTHIGHNCVLGNGIVLSNSVQVAGHVKIEDNAI
IGGCLGIHQFVHVGYLAMIGGMTRVDRDVPPFCLAEGHPGRLRGLNRVGIKRSGLMENEEFDLKLLQNTWNLLFKSNDVI
SISLGMAMKGKLDISSAKLCEFVKDSISKQRRGPMPSVNL

Sequences:

>Translated_280_residues
MEIKNTKRNPDFRGARVHPNAVVDSSAELHDGVSIASGAIVGPNVIIESGTKIGSNAVIEGKTKIGKDNKVFPNVFIGLE
PQDLKYQGASTEVIIGDNNTFRECVTINKATDEGEKTIIGNNNLLMAYTHIGHNCVLGNGIVLSNSVQVAGHVKIEDNAI
IGGCLGIHQFVHVGYLAMIGGMTRVDRDVPPFCLAEGHPGRLRGLNRVGIKRSGLMENEEFDLKLLQNTWNLLFKSNDVI
SISLGMAMKGKLDISSAKLCEFVKDSISKQRRGPMPSVNL
>Mature_280_residues
MEIKNTKRNPDFRGARVHPNAVVDSSAELHDGVSIASGAIVGPNVIIESGTKIGSNAVIEGKTKIGKDNKVFPNVFIGLE
PQDLKYQGASTEVIIGDNNTFRECVTINKATDEGEKTIIGNNNLLMAYTHIGHNCVLGNGIVLSNSVQVAGHVKIEDNAI
IGGCLGIHQFVHVGYLAMIGGMTRVDRDVPPFCLAEGHPGRLRGLNRVGIKRSGLMENEEFDLKLLQNTWNLLFKSNDVI
SISLGMAMKGKLDISSAKLCEFVKDSISKQRRGPMPSVNL

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=229, Percent_Identity=40.6113537117904, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI1786376, Length=250, Percent_Identity=28.4, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: NA

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 30228; Mature: 30228

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKNTKRNPDFRGARVHPNAVVDSSAELHDGVSIASGAIVGPNVIIESGTKIGSNAVIE
CCCCCCCCCCCCCCCEECCCCEECCCCHHHCCCEECCCCEECCCEEEECCCCCCCCCEEE
GKTKIGKDNKVFPNVFIGLEPQDLKYQGASTEVIIGDNNTFRECVTINKATDEGEKTIIG
CCCCCCCCCCCCCEEEEECCCCCCEECCCCEEEEECCCCCEEEEEEEECCCCCCCEEEEC
NNNLLMAYTHIGHNCVLGNGIVLSNSVQVAGHVKIEDNAIIGGCLGIHQFVHVGYLAMIG
CCCEEEEEEECCCEEEEECCEEEECCEEEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHC
GMTRVDRDVPPFCLAEGHPGRLRGLNRVGIKRSGLMENEEFDLKLLQNTWNLLFKSNDVI
CCHHHCCCCCCEEEECCCCHHHCCCHHCCCCCCCCCCCCCCHHHHHHHHHHEEEECCCEE
SISLGMAMKGKLDISSAKLCEFVKDSISKQRRGPMPSVNL
EEEECEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MEIKNTKRNPDFRGARVHPNAVVDSSAELHDGVSIASGAIVGPNVIIESGTKIGSNAVIE
CCCCCCCCCCCCCCCEECCCCEECCCCHHHCCCEECCCCEECCCEEEECCCCCCCCCEEE
GKTKIGKDNKVFPNVFIGLEPQDLKYQGASTEVIIGDNNTFRECVTINKATDEGEKTIIG
CCCCCCCCCCCCCEEEEECCCCCCEECCCCEEEEECCCCCEEEEEEEECCCCCCCEEEEC
NNNLLMAYTHIGHNCVLGNGIVLSNSVQVAGHVKIEDNAIIGGCLGIHQFVHVGYLAMIG
CCCEEEEEEECCCEEEEECCEEEECCEEEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHC
GMTRVDRDVPPFCLAEGHPGRLRGLNRVGIKRSGLMENEEFDLKLLQNTWNLLFKSNDVI
CCHHHCCCCCCEEEECCCCHHHCCCHHCCCCCCCCCCCCCCHHHHHHHHHHEEEECCCEE
SISLGMAMKGKLDISSAKLCEFVKDSISKQRRGPMPSVNL
EEEECEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA