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The map label for this gene is fcl [C]

Identifier: 123966633

GI number: 123966633

Start: 1237333

End: 1238295

Strand: Reverse

Name: fcl [C]

Synonym: P9515_14001

Alternate gene names: 123966633

Gene position: 1238295-1237333 (Counterclockwise)

Preceding gene: 123966643

Following gene: 123966632

Centisome position: 72.66

GC content: 29.6

Gene sequence:

>963_bases
ATGCTTATAAAACAAAAGACTAAAATTTTTATTGCCGGTCATAATGGAATGCTTGGTTCATCATTACTTAGGAAATTTAA
AGATCAAAATATATATGAAGTTATTACGGTAGATAAAAAAGATCTCGATTTAAGGAATCAAATTGATGTTAATAATTTTA
TAGGTATCCATAAACCTGATAAAATTATTCTTTCTGCAGCAAAAGTTGGAGGGATTCAAGCTAACCAAAATTTTAAATGC
GAATTTCTATATGACAACCTTATGATTCAAACTAATATAATTGATGCTGCTGCTAAAAATAATACTAAAACTTTAGTTTT
TATTGGAAGTTCATGCATTTACCCTAGAGAATCTGAACAACCAATAAAGGAGAATTACCTTTTGACTGGATTATTAGAAC
CTACAAATGAACCATATGCGTTAGCAAAAATTGTAGGTTTAAAATTAGCTAAGCTTTATGCAGAAAAATATAACATACAA
TGTATTTGTCCTATGTTTTGCAATCTATATGGGAATAATGATAATTTTGATTTAATAAATTCACATGTCTTGTCTTCTCT
CGTTCGGAAATTTGTCGATGCGGTTGATAACTCAATAGGAAAAGTAGAATTATGGGGAAGCGGTGAAGTTTTCAGAGAGT
TTTTAAATGTAGAGGATGCAGTAGATGCAATAATTTTGCTTTTAGAAAAATATAAATCAAATGATCATATTAATGTTGGT
TCTGGTGAAGAAATCAAGATATGTGAACTTGCATCAAAGATCGCAGGTCTTACTGGGTTTGAAGGTGAAATTATTTGGGA
CGAATCTAAACCTGATGGAACACCGCACAAATTACTGGACGTTTCAAAAATTTCAAAACTTGGTTTCAAACCTAAAATCA
ATCTGGATGATGGATTAGTTTCCACCATAAATTCATATAAAGCTTTAAAATTAAATGAAGAAATTAATAATAAGAAGCAA
TGA

Upstream 100 bases:

>100_bases
ATCCAAATATATTACGAAATAAATACTTGATTAACTATATTAAATATTTTTAAAATGCTACATTATCATTAAAATTATTA
AAGAAATATTTAAACTAAAT

Downstream 100 bases:

>100_bases
TTCCTCTTATGAAAGATACATTTATAGAAGAATATAAAACAAAGTTAGCTTTATCTGAATTCATATTATCTTCCAATAAG
CTAAGTATGGGAATAAAATG

Product: putative fucose synthetase

Products: GDP-4-dehydro-6-deoxy-D-mannose; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MLIKQKTKIFIAGHNGMLGSSLLRKFKDQNIYEVITVDKKDLDLRNQIDVNNFIGIHKPDKIILSAAKVGGIQANQNFKC
EFLYDNLMIQTNIIDAAAKNNTKTLVFIGSSCIYPRESEQPIKENYLLTGLLEPTNEPYALAKIVGLKLAKLYAEKYNIQ
CICPMFCNLYGNNDNFDLINSHVLSSLVRKFVDAVDNSIGKVELWGSGEVFREFLNVEDAVDAIILLLEKYKSNDHINVG
SGEEIKICELASKIAGLTGFEGEIIWDESKPDGTPHKLLDVSKISKLGFKPKINLDDGLVSTINSYKALKLNEEINNKKQ

Sequences:

>Translated_320_residues
MLIKQKTKIFIAGHNGMLGSSLLRKFKDQNIYEVITVDKKDLDLRNQIDVNNFIGIHKPDKIILSAAKVGGIQANQNFKC
EFLYDNLMIQTNIIDAAAKNNTKTLVFIGSSCIYPRESEQPIKENYLLTGLLEPTNEPYALAKIVGLKLAKLYAEKYNIQ
CICPMFCNLYGNNDNFDLINSHVLSSLVRKFVDAVDNSIGKVELWGSGEVFREFLNVEDAVDAIILLLEKYKSNDHINVG
SGEEIKICELASKIAGLTGFEGEIIWDESKPDGTPHKLLDVSKISKLGFKPKINLDDGLVSTINSYKALKLNEEINNKKQ
>Mature_320_residues
MLIKQKTKIFIAGHNGMLGSSLLRKFKDQNIYEVITVDKKDLDLRNQIDVNNFIGIHKPDKIILSAAKVGGIQANQNFKC
EFLYDNLMIQTNIIDAAAKNNTKTLVFIGSSCIYPRESEQPIKENYLLTGLLEPTNEPYALAKIVGLKLAKLYAEKYNIQ
CICPMFCNLYGNNDNFDLINSHVLSSLVRKFVDAVDNSIGKVELWGSGEVFREFLNVEDAVDAIILLLEKYKSNDHINVG
SGEEIKICELASKIAGLTGFEGEIIWDESKPDGTPHKLLDVSKISKLGFKPKINLDDGLVSTINSYKALKLNEEINNKKQ

Specific function: Putative nucleotide sugar epimerase/dehydrogenase [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fucose synthase family [H]

Homologues:

Organism=Homo sapiens, GI4507709, Length=282, Percent_Identity=26.5957446808511, Blast_Score=111, Evalue=9e-25,
Organism=Homo sapiens, GI7657641, Length=234, Percent_Identity=23.0769230769231, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1788365, Length=310, Percent_Identity=43.8709677419355, Blast_Score=276, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17554428, Length=285, Percent_Identity=27.0175438596491, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI19922778, Length=308, Percent_Identity=28.5714285714286, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: 1.1.1.271

Molecular weight: Translated: 35818; Mature: 35818

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIKQKTKIFIAGHNGMLGSSLLRKFKDQNIYEVITVDKKDLDLRNQIDVNNFIGIHKPD
CCCCCCEEEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHEECCCCCC
KIILSAAKVGGIQANQNFKCEFLYDNLMIQTNIIDAAAKNNTKTLVFIGSSCIYPRESEQ
CEEEEHHHHCCEECCCCEEEEEEECCEEEEEEEEHHHCCCCCEEEEEECCCCCCCCCCCC
PIKENYLLTGLLEPTNEPYALAKIVGLKLAKLYAEKYNIQCICPMFCNLYGNNDNFDLIN
CHHHCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECHHHEECCCCCCHHHHH
SHVLSSLVRKFVDAVDNSIGKVELWGSGEVFREFLNVEDAVDAIILLLEKYKSNDHINVG
HHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHCHHHHHHHHHHHHHHHCCCCCEECC
SGEEIKICELASKIAGLTGFEGEIIWDESKPDGTPHKLLDVSKISKLGFKPKINLDDGLV
CCCEEEHHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHH
STINSYKALKLNEEINNKKQ
HHHCCCEEEEECHHHCCCCC
>Mature Secondary Structure
MLIKQKTKIFIAGHNGMLGSSLLRKFKDQNIYEVITVDKKDLDLRNQIDVNNFIGIHKPD
CCCCCCEEEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHEECCCCCC
KIILSAAKVGGIQANQNFKCEFLYDNLMIQTNIIDAAAKNNTKTLVFIGSSCIYPRESEQ
CEEEEHHHHCCEECCCCEEEEEEECCEEEEEEEEHHHCCCCCEEEEEECCCCCCCCCCCC
PIKENYLLTGLLEPTNEPYALAKIVGLKLAKLYAEKYNIQCICPMFCNLYGNNDNFDLIN
CHHHCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECHHHEECCCCCCHHHHH
SHVLSSLVRKFVDAVDNSIGKVELWGSGEVFREFLNVEDAVDAIILLLEKYKSNDHINVG
HHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHCHHHHHHHHHHHHHHHCCCCCEECC
SGEEIKICELASKIAGLTGFEGEIIWDESKPDGTPHKLLDVSKISKLGFKPKINLDDGLV
CCCEEEHHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHH
STINSYKALKLNEEINNKKQ
HHHCCCEEEEECHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GDP-L-fucose; NADP+

Specific reaction: GDP-L-fucose + NADP+ = GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]