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The map label for this gene is lysA [H]

Identifier: 123966414

GI number: 123966414

Start: 1037731

End: 1039104

Strand: Direct

Name: lysA [H]

Synonym: P9515_11811

Alternate gene names: 123966414

Gene position: 1037731-1039104 (Clockwise)

Preceding gene: 123966408

Following gene: 123966415

Centisome position: 60.89

GC content: 32.1

Gene sequence:

>1374_bases
ATGAATGAAAAAATTTCTTTTTTAAAAAATAAAATAAATTTAAGTAGTCCTAACAAAAATATTGTACCTATAACTACCAA
TATTGACATTACCGAAAAGTTAAATATTGGTGGTTGTTCTATTGAAGATTTGGTAAAAAAATACGAATCGCCTTTATATA
TATTGGATGAAATCACTTTAAGAAATTCCTGTAGAGCTTACAAAAAAGCATTAGAAAAATATTATCGAGGAGTGTCCCTA
CCAATATATGCCTCTAAAGCAAATAGTTCATTATTTATGAGTAATCTGGTAGCTTCAGAGGGATTTGGTCTTGATGCAGT
TTCAGAAGGTGAATTACTGACTGCTTTAAAAGGGGGAGTGCCAAATGAAAAAATTGTTTTTCATGGAAATAATAAATCTG
ATAAGGAAATTGCATTTGCCATAAAAAATAAAATCAAAGTAATTGTAGATAATGAACATGACCTTAAAAGACTAGAAGAA
ATATCTAATTCATTAAATTTTGATCTAGAAATAATGATTAGATTTACCCCGGGAATAGAATGCCATACCCATGAATACAT
AAGAACCGGTTCTTTTGATAGCAAGTTTGGCTTTGGAATTGAGTCTCTAACTAAGTTATTCGGAGTGATAATCAAAACCA
AGCACCTAAAATTAATTGGATTACATGCTCATATAGGTTCTCAGATCTTTGAACTTGAACCACATAAAGATCTCGGAGAG
ATAATGGTAAATGTTATGCTCCAAGCTAAAAAGTTTGGCCACAACATAAAAGAACTAAATGTCGGAGGTGGATTAGGAAT
TAAATATACCCAGGAAGATGATCCTCCTTCCATTGATGAGTGGATCAAAACAGTTTCTTCATCCATTGAACAAGCTTGTA
AAAAAAATAAATTAGATTTACCTTTACTTATGTGTGAGCCTGGGAGATCAATAGTTTCTACCGCTGGGGTAACAATATAC
AAAATTGGCTCATTTAAAGAAATTCCTGGGATAAGGACATACCTATCAGTTGATGGTGGCATGAGTGATAATCCCAGGCC
AATCACATATCAATCTAATTATTCTGCTTGTTTAGTAAATGACCCTTTAAATATTAATTCCAAAAATAAATATACTGTTG
CGGGTAAGCATTGTGAGTCTGGAGACGTTTTATTTAAGGAAATTGAACTAGGTAAATGTAAAACAGGTGATTTGATTTGT
GTTTTTGGTACTGGCGCATACAATAATTCAATGAGTTCTAATTACAACAGAATTCCTAAACCTGCTGCTGTTTTAGTTTG
TAATGGGGAAGCAGAAATAATTCAAAAAAGAGAAAGTCCACATGATCTTCTTAAAAACGATGTCTTACCCGATCGCTTTA
TCAATCAAAGTTAG

Upstream 100 bases:

>100_bases
AATCATTAAATTAATTATTGTCTCTTATAGTAATTTTAAAATTAAATTAATAATAGAAGTTCTGAAAGTTGTAGAATGAT
TTTATGTGAAAAGAGAACCT

Downstream 100 bases:

>100_bases
GTACATTTAAATAAATTAAATTTTAATGTGAATTTTTGGGGGTTTATAAACTTAAAGTTTTTATTAGATGTATTATTTGC
AGCTGGATTTGGACTTTTAT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MNEKISFLKNKINLSSPNKNIVPITTNIDITEKLNIGGCSIEDLVKKYESPLYILDEITLRNSCRAYKKALEKYYRGVSL
PIYASKANSSLFMSNLVASEGFGLDAVSEGELLTALKGGVPNEKIVFHGNNKSDKEIAFAIKNKIKVIVDNEHDLKRLEE
ISNSLNFDLEIMIRFTPGIECHTHEYIRTGSFDSKFGFGIESLTKLFGVIIKTKHLKLIGLHAHIGSQIFELEPHKDLGE
IMVNVMLQAKKFGHNIKELNVGGGLGIKYTQEDDPPSIDEWIKTVSSSIEQACKKNKLDLPLLMCEPGRSIVSTAGVTIY
KIGSFKEIPGIRTYLSVDGGMSDNPRPITYQSNYSACLVNDPLNINSKNKYTVAGKHCESGDVLFKEIELGKCKTGDLIC
VFGTGAYNNSMSSNYNRIPKPAAVLVCNGEAEIIQKRESPHDLLKNDVLPDRFINQS

Sequences:

>Translated_457_residues
MNEKISFLKNKINLSSPNKNIVPITTNIDITEKLNIGGCSIEDLVKKYESPLYILDEITLRNSCRAYKKALEKYYRGVSL
PIYASKANSSLFMSNLVASEGFGLDAVSEGELLTALKGGVPNEKIVFHGNNKSDKEIAFAIKNKIKVIVDNEHDLKRLEE
ISNSLNFDLEIMIRFTPGIECHTHEYIRTGSFDSKFGFGIESLTKLFGVIIKTKHLKLIGLHAHIGSQIFELEPHKDLGE
IMVNVMLQAKKFGHNIKELNVGGGLGIKYTQEDDPPSIDEWIKTVSSSIEQACKKNKLDLPLLMCEPGRSIVSTAGVTIY
KIGSFKEIPGIRTYLSVDGGMSDNPRPITYQSNYSACLVNDPLNINSKNKYTVAGKHCESGDVLFKEIELGKCKTGDLIC
VFGTGAYNNSMSSNYNRIPKPAAVLVCNGEAEIIQKRESPHDLLKNDVLPDRFINQS
>Mature_457_residues
MNEKISFLKNKINLSSPNKNIVPITTNIDITEKLNIGGCSIEDLVKKYESPLYILDEITLRNSCRAYKKALEKYYRGVSL
PIYASKANSSLFMSNLVASEGFGLDAVSEGELLTALKGGVPNEKIVFHGNNKSDKEIAFAIKNKIKVIVDNEHDLKRLEE
ISNSLNFDLEIMIRFTPGIECHTHEYIRTGSFDSKFGFGIESLTKLFGVIIKTKHLKLIGLHAHIGSQIFELEPHKDLGE
IMVNVMLQAKKFGHNIKELNVGGGLGIKYTQEDDPPSIDEWIKTVSSSIEQACKKNKLDLPLLMCEPGRSIVSTAGVTIY
KIGSFKEIPGIRTYLSVDGGMSDNPRPITYQSNYSACLVNDPLNINSKNKYTVAGKHCESGDVLFKEIELGKCKTGDLIC
VFGTGAYNNSMSSNYNRIPKPAAVLVCNGEAEIIQKRESPHDLLKNDVLPDRFINQS

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=431, Percent_Identity=28.3062645011601, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1789307, Length=280, Percent_Identity=25.3571428571429, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24586474, Length=398, Percent_Identity=23.8693467336683, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 50700; Mature: 50700

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEKISFLKNKINLSSPNKNIVPITTNIDITEKLNIGGCSIEDLVKKYESPLYILDEITL
CCCHHHHHHHHCCCCCCCCCEEEEEECCCEEEECCCCCCCHHHHHHHHCCCEEEEEEHHH
RNSCRAYKKALEKYYRGVSLPIYASKANSSLFMSNLVASEGFGLDAVSEGELLTALKGGV
HHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCC
PNEKIVFHGNNKSDKEIAFAIKNKIKVIVDNEHDLKRLEEISNSLNFDLEIMIRFTPGIE
CCCEEEEECCCCCCCCEEEEEECCEEEEECCCHHHHHHHHHHHHCCCEEEEEEEECCCCE
CHTHEYIRTGSFDSKFGFGIESLTKLFGVIIKTKHLKLIGLHAHIGSQIFELEPHKDLGE
ECCCHHEECCCCCCCCCCCHHHHHHHHHHHHEECCEEEEEEEHHHCCEEEEECCCCCHHH
IMVNVMLQAKKFGHNIKELNVGGGLGIKYTQEDDPPSIDEWIKTVSSSIEQACKKNKLDL
HHHHHHHHHHHHCCCCEEEECCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
PLLMCEPGRSIVSTAGVTIYKIGSFKEIPGIRTYLSVDGGMSDNPRPITYQSNYSACLVN
EEEEECCCCHHHHHCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCEEEEE
DPLNINSKNKYTVAGKHCESGDVLFKEIELGKCKTGDLICVFGTGAYNNSMSSNYNRIPK
CCCCCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCC
PAAVLVCNGEAEIIQKRESPHDLLKNDVLPDRFINQS
CEEEEEECCCHHHHHCCCCHHHHHHHCCCCCHHCCCC
>Mature Secondary Structure
MNEKISFLKNKINLSSPNKNIVPITTNIDITEKLNIGGCSIEDLVKKYESPLYILDEITL
CCCHHHHHHHHCCCCCCCCCEEEEEECCCEEEECCCCCCCHHHHHHHHCCCEEEEEEHHH
RNSCRAYKKALEKYYRGVSLPIYASKANSSLFMSNLVASEGFGLDAVSEGELLTALKGGV
HHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCC
PNEKIVFHGNNKSDKEIAFAIKNKIKVIVDNEHDLKRLEEISNSLNFDLEIMIRFTPGIE
CCCEEEEECCCCCCCCEEEEEECCEEEEECCCHHHHHHHHHHHHCCCEEEEEEEECCCCE
CHTHEYIRTGSFDSKFGFGIESLTKLFGVIIKTKHLKLIGLHAHIGSQIFELEPHKDLGE
ECCCHHEECCCCCCCCCCCHHHHHHHHHHHHEECCEEEEEEEHHHCCEEEEECCCCCHHH
IMVNVMLQAKKFGHNIKELNVGGGLGIKYTQEDDPPSIDEWIKTVSSSIEQACKKNKLDL
HHHHHHHHHHHHCCCCEEEECCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
PLLMCEPGRSIVSTAGVTIYKIGSFKEIPGIRTYLSVDGGMSDNPRPITYQSNYSACLVN
EEEEECCCCHHHHHCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCEEEEE
DPLNINSKNKYTVAGKHCESGDVLFKEIELGKCKTGDLICVFGTGAYNNSMSSNYNRIPK
CCCCCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCC
PAAVLVCNGEAEIIQKRESPHDLLKNDVLPDRFINQS
CEEEEEECCCHHHHHCCCCHHHHHHHCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]