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The map label for this gene is yciC [H]

Identifier: 123966360

GI number: 123966360

Start: 982425

End: 983783

Strand: Direct

Name: yciC [H]

Synonym: P9515_11271

Alternate gene names: 123966360

Gene position: 982425-983783 (Clockwise)

Preceding gene: 123966359

Following gene: 123966361

Centisome position: 57.65

GC content: 35.84

Gene sequence:

>1359_bases
ATGAGTATTAACGAAAGAGTTCCCGTTACAATCCTTACAGGATTCTTAGGTTCAGGTAAGACAACTCTCCTAAATAGAAT
TTTAAGCGAAGAACATGGTAAGCGAATAGCCGTTATTGAGAACGAATATGGAGAAGTTGGAATTGACCAAGGATTGGTAA
TAAACGCCGATGAAGAAGTATTTGAAATGTCTAATGGTTGCATTTGTTGTACTGTTCGAGGAGATCTTATTAGAGTCCTT
GGTAATTTGATGAAAAGAAGGGATAAGTTTGACTATGTTTTAGTTGAAACCACTGGATTAGCAGACCCAGGTCCCGTTGC
TCAAACATTTTTTATGGATGAAGAAATCAGTTCTGAATTTATACTTGATGGAATTGTTACTTTAGTTGATGCAGCTCATA
TTGATCAACAACTTGGACGAAGTGATGAGAGTTCTGAACAAGTTGCATTTGCAGATGTCCTAGTTCTTAATAAAACTGAT
TTAGTCTCAGATGAAGCTCTTAATAGCCTTGAATCAAGATTAAGGGACATGAATCGAATGACTCGTATTATTCGAGCGGA
GAATGCACAGGTACCTATTAATACAGTCTTAAATCTTAGTGCCTTCGATCTTGATCAAATTCTAAAGCGTAGACCAACTT
TTTTAGAACCTGAATATCCTTTTGAATGGTCAGGAGTTTATGATGTTGAGTCTGGAAAATATGAATTAACACTTGAAGAT
GGGCCTGATCCTGAAATGTCATTAGTAGCTTTTGCTAATCAAGGAGTCAGTGAGCAAGAATTAAAAGAGGGTGCTGAAGC
TTCTGTAAGACTTTATGCTGAAAAAGCTAAAAACCTAGAGCCTGGAAATACCATTCCATATGATGAGCATGTAAGTCTCA
AATTAGAAGAGAAAGGTACTAAATCTTTTATTTTGGTAGTAGAAAGATCTTCAAAAGTTGGTTTGTTTACACAACATACT
GCTGAAGAATTTGAAATGAAAGTACTAAAAGTAGATGACAAAAAAAACATAAGGGAAATTCCTTTAAAAAAAGAGAGGAA
CTGGGTAGCAGAGCATGAACATGATGACGAAGTTGGATCAATCGCAATAGAACGTTTTGGAGATGTTGATCCTGAAAAGT
TAAATACATGGATGGGAAGACTTCTTTCTGAGAAAGGGGTTGATATATTCAGGACAAAAGGTTTTATAAGTTATTCTGGT
AATCCACGCCGAATAGTCTTTCAAGGAGTTCATATGTTATTTACTGCTCAGCCAGATAAAGAATGGGGTAATGAACCTCG
TAGAAATCAACTTGTATTTATTGGCAGAAATCTTAATGAAAAAGAGATGCAGGAGGGATTTGATAAGTGCCTGATATAG

Upstream 100 bases:

>100_bases
GGATTCTCTCTCAAATTAATTTTTTATAAATAACGGTTTTCATTATCATTATTGATTAACATATATTTGTTAGTCATCAA
TCAAGAAAACTATTAAAAAG

Downstream 100 bases:

>100_bases
AACCGTTTAACCCTAGAGGGATGTTTCATGAGGGCTGGTCTGCTGAAGTTGAAGATTATGCAATAGTTTGTGGTTGGGCT
TTAGGAGGAAAACTTTTTAT

Product: cobalamin synthesis protein/P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MSINERVPVTILTGFLGSGKTTLLNRILSEEHGKRIAVIENEYGEVGIDQGLVINADEEVFEMSNGCICCTVRGDLIRVL
GNLMKRRDKFDYVLVETTGLADPGPVAQTFFMDEEISSEFILDGIVTLVDAAHIDQQLGRSDESSEQVAFADVLVLNKTD
LVSDEALNSLESRLRDMNRMTRIIRAENAQVPINTVLNLSAFDLDQILKRRPTFLEPEYPFEWSGVYDVESGKYELTLED
GPDPEMSLVAFANQGVSEQELKEGAEASVRLYAEKAKNLEPGNTIPYDEHVSLKLEEKGTKSFILVVERSSKVGLFTQHT
AEEFEMKVLKVDDKKNIREIPLKKERNWVAEHEHDDEVGSIAIERFGDVDPEKLNTWMGRLLSEKGVDIFRTKGFISYSG
NPRRIVFQGVHMLFTAQPDKEWGNEPRRNQLVFIGRNLNEKEMQEGFDKCLI

Sequences:

>Translated_452_residues
MSINERVPVTILTGFLGSGKTTLLNRILSEEHGKRIAVIENEYGEVGIDQGLVINADEEVFEMSNGCICCTVRGDLIRVL
GNLMKRRDKFDYVLVETTGLADPGPVAQTFFMDEEISSEFILDGIVTLVDAAHIDQQLGRSDESSEQVAFADVLVLNKTD
LVSDEALNSLESRLRDMNRMTRIIRAENAQVPINTVLNLSAFDLDQILKRRPTFLEPEYPFEWSGVYDVESGKYELTLED
GPDPEMSLVAFANQGVSEQELKEGAEASVRLYAEKAKNLEPGNTIPYDEHVSLKLEEKGTKSFILVVERSSKVGLFTQHT
AEEFEMKVLKVDDKKNIREIPLKKERNWVAEHEHDDEVGSIAIERFGDVDPEKLNTWMGRLLSEKGVDIFRTKGFISYSG
NPRRIVFQGVHMLFTAQPDKEWGNEPRRNQLVFIGRNLNEKEMQEGFDKCLI
>Mature_451_residues
SINERVPVTILTGFLGSGKTTLLNRILSEEHGKRIAVIENEYGEVGIDQGLVINADEEVFEMSNGCICCTVRGDLIRVLG
NLMKRRDKFDYVLVETTGLADPGPVAQTFFMDEEISSEFILDGIVTLVDAAHIDQQLGRSDESSEQVAFADVLVLNKTDL
VSDEALNSLESRLRDMNRMTRIIRAENAQVPINTVLNLSAFDLDQILKRRPTFLEPEYPFEWSGVYDVESGKYELTLEDG
PDPEMSLVAFANQGVSEQELKEGAEASVRLYAEKAKNLEPGNTIPYDEHVSLKLEEKGTKSFILVVERSSKVGLFTQHTA
EEFEMKVLKVDDKKNIREIPLKKERNWVAEHEHDDEVGSIAIERFGDVDPEKLNTWMGRLLSEKGVDIFRTKGFISYSGN
PRRIVFQGVHMLFTAQPDKEWGNEPRRNQLVFIGRNLNEKEMQEGFDKCLI

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=212, Percent_Identity=44.811320754717, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI126722884, Length=212, Percent_Identity=44.811320754717, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI146231952, Length=212, Percent_Identity=44.811320754717, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI148727351, Length=212, Percent_Identity=44.3396226415094, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI223941779, Length=200, Percent_Identity=44, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI223941776, Length=198, Percent_Identity=44.4444444444444, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI119120938, Length=136, Percent_Identity=49.2647058823529, Blast_Score=145, Evalue=6e-35,
Organism=Escherichia coli, GI87082430, Length=213, Percent_Identity=40.8450704225352, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1788499, Length=184, Percent_Identity=30.9782608695652, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6324356, Length=224, Percent_Identity=33.9285714285714, Blast_Score=144, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 51127; Mature: 50995

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSINERVPVTILTGFLGSGKTTLLNRILSEEHGKRIAVIENEYGEVGIDQGLVINADEEV
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEECCCHHH
FEMSNGCICCTVRGDLIRVLGNLMKRRDKFDYVLVETTGLADPGPVAQTFFMDEEISSEF
HHCCCCEEEEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHEEECHHHHHHH
ILDGIVTLVDAAHIDQQLGRSDESSEQVAFADVLVLNKTDLVSDEALNSLESRLRDMNRM
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
TRIIRAENAQVPINTVLNLSAFDLDQILKRRPTFLEPEYPFEWSGVYDVESGKYELTLED
HHHHHHCCCCCCHHHHEECCCCCHHHHHHCCCCCCCCCCCCCCCCEEEECCCEEEEEECC
GPDPEMSLVAFANQGVSEQELKEGAEASVRLYAEKAKNLEPGNTIPYDEHVSLKLEEKGT
CCCCCEEEEEEECCCCCHHHHHCCCHHHEEEEEHHHCCCCCCCCCCCCCCEEEEEECCCC
KSFILVVERSSKVGLFTQHTAEEFEMKVLKVDDKKNIREIPLKKERNWVAEHEHDDEVGS
CEEEEEEECCCCCCEEECCCHHHHEEEEEEECCCCCHHHCCCCCCCCCCCCCCCCCHHHH
IAIERFGDVDPEKLNTWMGRLLSEKGVDIFRTKGFISYSGNPRRIVFQGVHMLFTAQPDK
HHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEECCEEEECCCCCEEEEECEEEEEEECCCH
EWGNEPRRNQLVFIGRNLNEKEMQEGFDKCLI
HHCCCCCCCEEEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SINERVPVTILTGFLGSGKTTLLNRILSEEHGKRIAVIENEYGEVGIDQGLVINADEEV
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEECCCHHH
FEMSNGCICCTVRGDLIRVLGNLMKRRDKFDYVLVETTGLADPGPVAQTFFMDEEISSEF
HHCCCCEEEEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHEEECHHHHHHH
ILDGIVTLVDAAHIDQQLGRSDESSEQVAFADVLVLNKTDLVSDEALNSLESRLRDMNRM
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
TRIIRAENAQVPINTVLNLSAFDLDQILKRRPTFLEPEYPFEWSGVYDVESGKYELTLED
HHHHHHCCCCCCHHHHEECCCCCHHHHHHCCCCCCCCCCCCCCCCEEEECCCEEEEEECC
GPDPEMSLVAFANQGVSEQELKEGAEASVRLYAEKAKNLEPGNTIPYDEHVSLKLEEKGT
CCCCCEEEEEEECCCCCHHHHHCCCHHHEEEEEHHHCCCCCCCCCCCCCCEEEEEECCCC
KSFILVVERSSKVGLFTQHTAEEFEMKVLKVDDKKNIREIPLKKERNWVAEHEHDDEVGS
CEEEEEEECCCCCCEEECCCHHHHEEEEEEECCCCCHHHCCCCCCCCCCCCCCCCCHHHH
IAIERFGDVDPEKLNTWMGRLLSEKGVDIFRTKGFISYSGNPRRIVFQGVHMLFTAQPDK
HHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEECCEEEECCCCCEEEEECEEEEEEECCCH
EWGNEPRRNQLVFIGRNLNEKEMQEGFDKCLI
HHCCCCCCCEEEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]