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The map label for this gene is iscS [H]

Identifier: 123966202

GI number: 123966202

Start: 863372

End: 864406

Strand: Reverse

Name: iscS [H]

Synonym: P9515_09691

Alternate gene names: 123966202

Gene position: 864406-863372 (Counterclockwise)

Preceding gene: 123966203

Following gene: 123966201

Centisome position: 50.72

GC content: 27.73

Gene sequence:

>1035_bases
ATGTATCTTGAAAAAACAAGACAAAAAATAGCCGAAATTTTAAATGCTGAGATTGAGGATATTATTTTTACTTCTGGTTC
ATCTGAGTCAACATCAATTGTCTTTAGTAATCTTTCTGATAGATATAAAAGAGGGAGAGTTGTAATCTCTAAAGTTGAAC
ATCAAGCCACAATTATTTCAGCAAATAAACTTAAACGAAAAGGCTGGGATATTTATGAATGGCCTGTCAATCACGATGGA
ATAATAAATATTTCGGAAGTAGATGAGGTAATTAAAAATAATACAAATCTTGTCTCGATTATTTGGGGTCAAAGTGAGAT
TGGAAGTTTACAACCAGTTCAATTAATAGGAACTAAATGTAAAGAGTTAGATATTTTATTTCATATCGACGGGACTCAGA
TTCTGAGCAATGGTATTTTTAATTGGAAAGAACTTAAATGTGATCTATTAAGTTTATCAGCACATAAATTTGGAGGTCCT
AAAGGTATCGGTTTACTTCTGACTAATTCAAAATCTAGATCTTTTTTAAAAAATAAGGACATATCACTTACTCAAGAATA
TCAAATAAGGCAAGGTACAACTCCTCTTCCTTTAATAGCTGGAATGTATCAATCTATAAAAAATATCAAGGGTAGAATTA
GTTTTAGTTCAGATAAAACAGTATTTGATTTAAACAAAAATGAAATACTAAAAAACTACTTTATAAGCAAAATAAATAAT
ATACCAAATATTAAAATAACTGGTAGTTATACTCAAAGACTTCCTAATCATATATCATTTATTTTATTTAATTCTCAACG
TGAGCCTATAAAAGCTTATAAAGTTATTAATTACATGTCTGATAATAATGTTGAAATTAGTAGTGGTAGTGCTTGTTCAA
GCTCGTCAGGTAAACCTAGTCAAATTCTTGAGAATATGGGATATGATAGTAATCAACTTTATTCAAATATTCGTGTTAGT
TTAGGATCTATGAATAAAAAATCTGATTTAGATAGACTGTTTGAATTAATTCAAAATTGTATAAAAAAATTCTAA

Upstream 100 bases:

>100_bases
AACGCCATTATCTAAAAATGTATTAAAAAAAATAAACTCTACTTACAATAATTTTTGGAATAATTCATCTTCAACTTATA
AATCTGGGATTAAATGTGCA

Downstream 100 bases:

>100_bases
TGACTAATAGCTATATACTTCCAAAGGATCTTAATGATGCCTTAAAAAATATGGAAAGTGCAATAATTTCTAGTTTAAAA
AATTCAAATAGTAGATTCAC

Product: class-V aminotransferase family cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MYLEKTRQKIAEILNAEIEDIIFTSGSSESTSIVFSNLSDRYKRGRVVISKVEHQATIISANKLKRKGWDIYEWPVNHDG
IINISEVDEVIKNNTNLVSIIWGQSEIGSLQPVQLIGTKCKELDILFHIDGTQILSNGIFNWKELKCDLLSLSAHKFGGP
KGIGLLLTNSKSRSFLKNKDISLTQEYQIRQGTTPLPLIAGMYQSIKNIKGRISFSSDKTVFDLNKNEILKNYFISKINN
IPNIKITGSYTQRLPNHISFILFNSQREPIKAYKVINYMSDNNVEISSGSACSSSSGKPSQILENMGYDSNQLYSNIRVS
LGSMNKKSDLDRLFELIQNCIKKF

Sequences:

>Translated_344_residues
MYLEKTRQKIAEILNAEIEDIIFTSGSSESTSIVFSNLSDRYKRGRVVISKVEHQATIISANKLKRKGWDIYEWPVNHDG
IINISEVDEVIKNNTNLVSIIWGQSEIGSLQPVQLIGTKCKELDILFHIDGTQILSNGIFNWKELKCDLLSLSAHKFGGP
KGIGLLLTNSKSRSFLKNKDISLTQEYQIRQGTTPLPLIAGMYQSIKNIKGRISFSSDKTVFDLNKNEILKNYFISKINN
IPNIKITGSYTQRLPNHISFILFNSQREPIKAYKVINYMSDNNVEISSGSACSSSSGKPSQILENMGYDSNQLYSNIRVS
LGSMNKKSDLDRLFELIQNCIKKF
>Mature_344_residues
MYLEKTRQKIAEILNAEIEDIIFTSGSSESTSIVFSNLSDRYKRGRVVISKVEHQATIISANKLKRKGWDIYEWPVNHDG
IINISEVDEVIKNNTNLVSIIWGQSEIGSLQPVQLIGTKCKELDILFHIDGTQILSNGIFNWKELKCDLLSLSAHKFGGP
KGIGLLLTNSKSRSFLKNKDISLTQEYQIRQGTTPLPLIAGMYQSIKNIKGRISFSSDKTVFDLNKNEILKNYFISKINN
IPNIKITGSYTQRLPNHISFILFNSQREPIKAYKVINYMSDNNVEISSGSACSSSSGKPSQILENMGYDSNQLYSNIRVS
LGSMNKKSDLDRLFELIQNCIKKF

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=344, Percent_Identity=28.7790697674419, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI156713448, Length=376, Percent_Identity=24.2021276595745, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI48994898, Length=341, Percent_Identity=29.9120234604106, Blast_Score=175, Evalue=3e-45,
Organism=Escherichia coli, GI1787970, Length=353, Percent_Identity=23.2294617563739, Blast_Score=88, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI25143064, Length=345, Percent_Identity=28.1159420289855, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17533177, Length=343, Percent_Identity=25.6559766763848, Blast_Score=79, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6319831, Length=342, Percent_Identity=28.0701754385965, Blast_Score=167, Evalue=2e-42,
Organism=Drosophila melanogaster, GI20129463, Length=342, Percent_Identity=30.1169590643275, Blast_Score=162, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 38844; Mature: 38844

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLEKTRQKIAEILNAEIEDIIFTSGSSESTSIVFSNLSDRYKRGRVVISKVEHQATIIS
CCHHHHHHHHHHHHCCCHHHEEEECCCCCCCEEEECCHHHHHHCCCEEEEEHHHHEEEEE
ANKLKRKGWDIYEWPVNHDGIINISEVDEVIKNNTNLVSIIWGQSEIGSLQPVQLIGTKC
HHHHHHCCCCEEECCCCCCCEEEHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHCCCC
KELDILFHIDGTQILSNGIFNWKELKCDLLSLSAHKFGGPKGIGLLLTNSKSRSFLKNKD
CEEEEEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHCCC
ISLTQEYQIRQGTTPLPLIAGMYQSIKNIKGRISFSSDKTVFDLNKNEILKNYFISKINN
CCEEHHHHCCCCCCCHHHHHHHHHHHHHHCCEEEECCCCEEEECCHHHHHHHHHHHHHCC
IPNIKITGSYTQRLPNHISFILFNSQREPIKAYKVINYMSDNNVEISSGSACSSSSGKPS
CCCEEEECHHHHHCCCCEEEEEECCCCCCHHHHHHHHEECCCCEEECCCCCCCCCCCCHH
QILENMGYDSNQLYSNIRVSLGSMNKKSDLDRLFELIQNCIKKF
HHHHHCCCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYLEKTRQKIAEILNAEIEDIIFTSGSSESTSIVFSNLSDRYKRGRVVISKVEHQATIIS
CCHHHHHHHHHHHHCCCHHHEEEECCCCCCCEEEECCHHHHHHCCCEEEEEHHHHEEEEE
ANKLKRKGWDIYEWPVNHDGIINISEVDEVIKNNTNLVSIIWGQSEIGSLQPVQLIGTKC
HHHHHHCCCCEEECCCCCCCEEEHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHCCCC
KELDILFHIDGTQILSNGIFNWKELKCDLLSLSAHKFGGPKGIGLLLTNSKSRSFLKNKD
CEEEEEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHCCC
ISLTQEYQIRQGTTPLPLIAGMYQSIKNIKGRISFSSDKTVFDLNKNEILKNYFISKINN
CCEEHHHHCCCCCCCHHHHHHHHHHHHHHCCEEEECCCCEEEECCHHHHHHHHHHHHHCC
IPNIKITGSYTQRLPNHISFILFNSQREPIKAYKVINYMSDNNVEISSGSACSSSSGKPS
CCCEEEECHHHHHCCCCEEEEEECCCCCCHHHHHHHHEECCCCEEECCCCCCCCCCCCHH
QILENMGYDSNQLYSNIRVSLGSMNKKSDLDRLFELIQNCIKKF
HHHHHCCCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA