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The map label for this gene is gor [H]

Identifier: 123965866

GI number: 123965866

Start: 564913

End: 566277

Strand: Direct

Name: gor [H]

Synonym: P9515_06311

Alternate gene names: 123965866

Gene position: 564913-566277 (Clockwise)

Preceding gene: 123965864

Following gene: 123965868

Centisome position: 33.15

GC content: 32.09

Gene sequence:

>1365_bases
TTGGAATTTGAATTTGATTTAATTGTTGTTGGCGCTGGTTCCGGCGGTTTGGCCGCTGCAAAGCGCGCTGCAAGTTATGG
AGCAAAAGTTGCAATAATAGAAGTTAATAAGATTGGTGGAACTTGTGTTCTTCGAGGTTGTGTTCCCAAAAAACTGATGG
TTTATGCTGCCAATAATAGAAGGAATATGGTTTCTGCTGAAGGGTATGGACTAATAAATAAAGAAATAACTTTTAATTCT
AGTGTGTTACTAAAAAACGTTAGAGAAGAAGTATCTAGATTGAGTCACATACATTCAAACTCTTTAAAAAAATTAAACGT
GACAGTTTTTGAAGGCTTAGGAAGATTTAAAAATCAAAATACAGTAGAAGTGGTTTGTCCAAAAACAAGAAACATTTTAA
GAAAAGTAAGCGCTAATAAAGTTCTTATTTCGGTGGGTGGTAAACCCAAAAAACTAGAAATTCCAGGGGTAGATTTAGCA
TGGAGTAGTGATGATATTTTTGAATTGCAAGATTTTCCTAAAACATTATTAATAGTTGGTGGAGGCTATATTGCATGTGA
ATTTGCATCTATTTTTAAAAACTTAGGTACTGAGGTTATACAAATAATTAGAGGTCAGAACTTGCTAAGTGGATTTGACA
AAGATTTGTCAGAATGTTTGAAAAAATCAATGACCTCTTTGGGCATAGATTTAAAATTTAATAATCAATTAAAGTCTATA
AAAAAAATTAAGGGAAAACTACAGTCGACTTTAGTATCAGGAAGTAAATTTTTAACCAATAATATACTTATTGCAACTGG
ACGAGAGCCTGCTCTCAAAGAATTGCATTTAGATACTTTAAATCTTAAAATGGATGGTATTTATTTAGATGTTAATGAAG
TTAATCAGACAAGTAATTCCAATATATTTGCGATTGGAGATATAATCAAGAGGCCAAATTTAACCCCAGTAGCAATAGAA
CAAGGGAGGGTTTTCGCCGATAATTATTTTGCTGATCGTAGAAGAAAAGTTAACTATCAAAATATTCCTAAGGCAGTGTT
TACTATCCCAGAGATTTCAACCGTTGGACTTAGTGAGGAAGAGGCAACAGAAATTTACTCGGAATTAAATATAAAAATTT
TCAAATGTAGTTTTACTCCTATGTCCAACACCTTTAAAAAAAACAAATCTAAATGTATGTTAAAACTTGTGGTCAACAAA
AAAAATGATAAGATTTTAGGCTGCCATATGTTTGGTGAAGCAGCATCTGAGATTATTCAAATGGTTTCAGTCTCTTTAAA
TGCAGGAATAACTAAAAAGGATTTTGATAATACTATGGCTTTGCATCCAACTATTTCAGAGGAATTTGTAACTATGTATG
GCTGA

Upstream 100 bases:

>100_bases
ATCAATTTCAAATTTACTTAAATCTGCCCAACTCAAAACTTTATTCATTATTTGATATTAGACTTCGTTATAAGGATATA
ATATATGTTTTAAAAAGATT

Downstream 100 bases:

>100_bases
TGAAATTATCTTCTAGATGTTTTTAACTTTTCTTGTGTAAAAAGATATACTGTGAATAAAGAAAAATAAATAAAAATACA
CACCCTCAATTGATAGAGAT

Product: glutathione reductase (NADPH)

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MEFEFDLIVVGAGSGGLAAAKRAASYGAKVAIIEVNKIGGTCVLRGCVPKKLMVYAANNRRNMVSAEGYGLINKEITFNS
SVLLKNVREEVSRLSHIHSNSLKKLNVTVFEGLGRFKNQNTVEVVCPKTRNILRKVSANKVLISVGGKPKKLEIPGVDLA
WSSDDIFELQDFPKTLLIVGGGYIACEFASIFKNLGTEVIQIIRGQNLLSGFDKDLSECLKKSMTSLGIDLKFNNQLKSI
KKIKGKLQSTLVSGSKFLTNNILIATGREPALKELHLDTLNLKMDGIYLDVNEVNQTSNSNIFAIGDIIKRPNLTPVAIE
QGRVFADNYFADRRRKVNYQNIPKAVFTIPEISTVGLSEEEATEIYSELNIKIFKCSFTPMSNTFKKNKSKCMLKLVVNK
KNDKILGCHMFGEAASEIIQMVSVSLNAGITKKDFDNTMALHPTISEEFVTMYG

Sequences:

>Translated_454_residues
MEFEFDLIVVGAGSGGLAAAKRAASYGAKVAIIEVNKIGGTCVLRGCVPKKLMVYAANNRRNMVSAEGYGLINKEITFNS
SVLLKNVREEVSRLSHIHSNSLKKLNVTVFEGLGRFKNQNTVEVVCPKTRNILRKVSANKVLISVGGKPKKLEIPGVDLA
WSSDDIFELQDFPKTLLIVGGGYIACEFASIFKNLGTEVIQIIRGQNLLSGFDKDLSECLKKSMTSLGIDLKFNNQLKSI
KKIKGKLQSTLVSGSKFLTNNILIATGREPALKELHLDTLNLKMDGIYLDVNEVNQTSNSNIFAIGDIIKRPNLTPVAIE
QGRVFADNYFADRRRKVNYQNIPKAVFTIPEISTVGLSEEEATEIYSELNIKIFKCSFTPMSNTFKKNKSKCMLKLVVNK
KNDKILGCHMFGEAASEIIQMVSVSLNAGITKKDFDNTMALHPTISEEFVTMYG
>Mature_454_residues
MEFEFDLIVVGAGSGGLAAAKRAASYGAKVAIIEVNKIGGTCVLRGCVPKKLMVYAANNRRNMVSAEGYGLINKEITFNS
SVLLKNVREEVSRLSHIHSNSLKKLNVTVFEGLGRFKNQNTVEVVCPKTRNILRKVSANKVLISVGGKPKKLEIPGVDLA
WSSDDIFELQDFPKTLLIVGGGYIACEFASIFKNLGTEVIQIIRGQNLLSGFDKDLSECLKKSMTSLGIDLKFNNQLKSI
KKIKGKLQSTLVSGSKFLTNNILIATGREPALKELHLDTLNLKMDGIYLDVNEVNQTSNSNIFAIGDIIKRPNLTPVAIE
QGRVFADNYFADRRRKVNYQNIPKAVFTIPEISTVGLSEEEATEIYSELNIKIFKCSFTPMSNTFKKNKSKCMLKLVVNK
KNDKILGCHMFGEAASEIIQMVSVSLNAGITKKDFDNTMALHPTISEEFVTMYG

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=465, Percent_Identity=38.494623655914, Blast_Score=291, Evalue=9e-79,
Organism=Homo sapiens, GI148277065, Length=480, Percent_Identity=33.3333333333333, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI33519430, Length=480, Percent_Identity=33.3333333333333, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI33519428, Length=480, Percent_Identity=33.3333333333333, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI33519426, Length=480, Percent_Identity=33.3333333333333, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI148277071, Length=480, Percent_Identity=33.3333333333333, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI291045266, Length=477, Percent_Identity=31.2368972746331, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI22035672, Length=458, Percent_Identity=30.3493449781659, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI91199540, Length=465, Percent_Identity=27.741935483871, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI291045268, Length=477, Percent_Identity=28.5115303983228, Blast_Score=169, Evalue=6e-42,
Organism=Escherichia coli, GI1789915, Length=435, Percent_Identity=37.0114942528736, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI87082354, Length=456, Percent_Identity=27.4122807017544, Blast_Score=191, Evalue=6e-50,
Organism=Escherichia coli, GI1786307, Length=461, Percent_Identity=26.8980477223427, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI87081717, Length=459, Percent_Identity=25.0544662309368, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17557007, Length=473, Percent_Identity=36.3636363636364, Blast_Score=274, Evalue=9e-74,
Organism=Caenorhabditis elegans, GI71983429, Length=456, Percent_Identity=37.0614035087719, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI71983419, Length=456, Percent_Identity=37.0614035087719, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI71982272, Length=482, Percent_Identity=32.3651452282158, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI32565766, Length=463, Percent_Identity=28.0777537796976, Blast_Score=167, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6325166, Length=469, Percent_Identity=36.8869936034115, Blast_Score=275, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6321091, Length=466, Percent_Identity=26.6094420600858, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6325240, Length=469, Percent_Identity=25.3731343283582, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI17737741, Length=475, Percent_Identity=35.3684210526316, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI24640549, Length=472, Percent_Identity=33.0508474576271, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24640553, Length=472, Percent_Identity=33.0508474576271, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24640551, Length=472, Percent_Identity=33.0508474576271, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI21358499, Length=461, Percent_Identity=27.9826464208243, Blast_Score=162, Evalue=5e-40,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 50094; Mature: 50094

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFEFDLIVVGAGSGGLAAAKRAASYGAKVAIIEVNKIGGTCVLRGCVPKKLMVYAANNR
CCEEEEEEEEECCCCCHHHHHHHHHCCCEEEEEEEECCCCEEEEECCCCCEEEEEEECCC
RNMVSAEGYGLINKEITFNSSVLLKNVREEVSRLSHIHSNSLKKLNVTVFEGLGRFKNQN
CCEEECCCCEEEECEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCC
TVEVVCPKTRNILRKVSANKVLISVGGKPKKLEIPGVDLAWSSDDIFELQDFPKTLLIVG
EEEEECCCHHHHHHHHCCCEEEEEECCCCCEEECCCEEEEECCCCCEECCCCCCEEEEEE
GGYIACEFASIFKNLGTEVIQIIRGQNLLSGFDKDLSECLKKSMTSLGIDLKFNNQLKSI
CCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCEEEEECHHHHHH
KKIKGKLQSTLVSGSKFLTNNILIATGREPALKELHLDTLNLKMDGIYLDVNEVNQTSNS
HHHHHHHHHHHHCCCEEEECCEEEEECCCCHHHHHCCEEEEEEEEEEEEEHHHCCCCCCC
NIFAIGDIIKRPNLTPVAIEQGRVFADNYFADRRRKVNYQNIPKAVFTIPEISTVGLSEE
CEEEEEHHHCCCCCCEEEEECCEEEECCHHHHHHHCCCCCCCCHHEEECCCCEECCCCHH
EATEIYSELNIKIFKCSFTPMSNTFKKNKSKCMLKLVVNKKNDKILGCHMFGEAASEIIQ
HHHHHHHHCCEEEEEEECCCCCHHHHCCCCEEEEEEEEECCCCEEEEEEHHHHHHHHHHH
MVSVSLNAGITKKDFDNTMALHPTISEEFVTMYG
HHHHHHCCCCCCCCCCCEEEECCCCCCCHHEECC
>Mature Secondary Structure
MEFEFDLIVVGAGSGGLAAAKRAASYGAKVAIIEVNKIGGTCVLRGCVPKKLMVYAANNR
CCEEEEEEEEECCCCCHHHHHHHHHCCCEEEEEEEECCCCEEEEECCCCCEEEEEEECCC
RNMVSAEGYGLINKEITFNSSVLLKNVREEVSRLSHIHSNSLKKLNVTVFEGLGRFKNQN
CCEEECCCCEEEECEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCC
TVEVVCPKTRNILRKVSANKVLISVGGKPKKLEIPGVDLAWSSDDIFELQDFPKTLLIVG
EEEEECCCHHHHHHHHCCCEEEEEECCCCCEEECCCEEEEECCCCCEECCCCCCEEEEEE
GGYIACEFASIFKNLGTEVIQIIRGQNLLSGFDKDLSECLKKSMTSLGIDLKFNNQLKSI
CCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCEEEEECHHHHHH
KKIKGKLQSTLVSGSKFLTNNILIATGREPALKELHLDTLNLKMDGIYLDVNEVNQTSNS
HHHHHHHHHHHHCCCEEEECCEEEEECCCCHHHHHCCEEEEEEEEEEEEEHHHCCCCCCC
NIFAIGDIIKRPNLTPVAIEQGRVFADNYFADRRRKVNYQNIPKAVFTIPEISTVGLSEE
CEEEEEHHHCCCCCCEEEEECCEEEECCHHHHHHHCCCCCCCCHHEEECCCCEECCCCHH
EATEIYSELNIKIFKCSFTPMSNTFKKNKSKCMLKLVVNKKNDKILGCHMFGEAASEIIQ
HHHHHHHHCCEEEEEEECCCCCHHHHCCCCEEEEEEEEECCCCEEEEEEHHHHHHHHHHH
MVSVSLNAGITKKDFDNTMALHPTISEEFVTMYG
HHHHHHCCCCCCCCCCCEEEECCCCCCCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7559423; 11759840 [H]