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The map label for this gene is dnaA

Identifier: 123965864

GI number: 123965864

Start: 562236

End: 563627

Strand: Direct

Name: dnaA

Synonym: P9515_06291

Alternate gene names: 123965864

Gene position: 562236-563627 (Clockwise)

Preceding gene: 123965861

Following gene: 123965866

Centisome position: 32.99

GC content: 34.27

Gene sequence:

>1392_bases
GTGCAAGCAACCAATCCTATTTGGGCAGAAGTTCAACAATTACTTCAAAAAAATTTAAGTAAACCTTCCTTCGAAACTTG
GATAAGGCCAGCTAAATTTAATTGTTTTGAAAATGGCTTGTTAACTTTGATTACTCCAAATAACTTTACAAGTGATTGGC
TTAGAAAAAATTATAGTGAAACTATTGAAAAAGCTGCAGAAGAAATTTGTGGACATAATGTAAAGGTGATTTTTAAGTCT
GAAAATAATGTCAACAACAATTCAAATATTCCTGACACCGTTAGCCAACAAAGTATTAAATCTCAGACAAGGTCTATTTC
TACAAGTCAAGGGAATAATACAAATAATAGAACAAAAAAATCTCATTCTTTAAATATACGTTATGTATTTAAAAGATTTG
TTGTTGGTCCTAACAGTAGAATGGCTCATGCCGCAGCTTTAGCTGTCGCAGAATCTCCGGGGAGAGAATTTAACCCGTTA
TTTATTTGTGGTGGAGTTGGTCTTGGTAAGACCCACTTAATGCAGGCAATTGGTCATTACAGAGTGGAAATTGATCCTGA
AGCGAAAGTTTTATATGTTTCAACAGAAACTTTTAGTAGTGATTTGATTCAATCTATAAGAAAAGATGGAATGCATGTCT
TTAAAAATAAATACAGATCAGTAGATCTACTATTAATTGACGATATTCAATTTTTGGAGGGCAAGGAATATACCCAAGAA
GAATTTTTTAATACTTTCAATGCTTTGTATGAAGCTGGTAAACAAATTGTTATTGCAAGTGATAGGCCTCCTAGTCAGAT
TCCTAAATTACAAGAAAGGCTGATCTCTAGATTTTCAATGGGATTAATAGCAGATATTCAACCTCCTGATATTGAGACAA
GAATGGCAATTCTGCAGAAAAAAGCTGAACAAGAAAGAATGAATCTTCCAAGAGATTTGGTTCAATTTATCGCAGGAAGA
TTCTCTTCAAATATTCGGGAATTAGAGGGTGCTTTTACTAGAGCCGTTGCATTCGCATCAATAACAGGCTTACCTATGAC
AGTTCAATCAATTGCTCCAATGCTTGATCCAAATAGTGTTGGAGTAGTCGTAACGCCAAAGCAGGTAATAAAAAAGGTCT
CAGACTTCTTTTCAGTAACAGCTGAAGAATTAGTTAGTTCAAGCAGACGAAAGCCAGTTAGTCAGGCAAGGCAAATAGGC
ATGTATCTTATGAGGCAAGGGACTAATTTGAGCCTTCCAAAAATTGGAGATGAATTTGGAGGTAAAGATCATACCACGGT
TATGTATGCTATCGAGCAAGTGGAAAAAAAATTGTCAAGTGATCCAAATGTTGCAAGTCAAGTTCAAAAAATAAAAGATC
TTCTTCAAATTGATTCAAGAAAAAATTTATGA

Upstream 100 bases:

>100_bases
TGCGCATTGTTAATAAATTTTAAATTTATCGTGATCTTGCGATTTGAGAATGACCAATTAATAAATCCCTACTAGATTAA
ATGTCTATTGAATAAATTTA

Downstream 100 bases:

>100_bases
TCTTTGATTTAATTTGAATTTCGAAGGGTCTTGATCATATCGATGTGTAACTGGAATCTTATCAGTTTTGGAATTAACAT
TAGGTGACCCTATTTTATTT

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MQATNPIWAEVQQLLQKNLSKPSFETWIRPAKFNCFENGLLTLITPNNFTSDWLRKNYSETIEKAAEEICGHNVKVIFKS
ENNVNNNSNIPDTVSQQSIKSQTRSISTSQGNNTNNRTKKSHSLNIRYVFKRFVVGPNSRMAHAAALAVAESPGREFNPL
FICGGVGLGKTHLMQAIGHYRVEIDPEAKVLYVSTETFSSDLIQSIRKDGMHVFKNKYRSVDLLLIDDIQFLEGKEYTQE
EFFNTFNALYEAGKQIVIASDRPPSQIPKLQERLISRFSMGLIADIQPPDIETRMAILQKKAEQERMNLPRDLVQFIAGR
FSSNIRELEGAFTRAVAFASITGLPMTVQSIAPMLDPNSVGVVVTPKQVIKKVSDFFSVTAEELVSSSRRKPVSQARQIG
MYLMRQGTNLSLPKIGDEFGGKDHTTVMYAIEQVEKKLSSDPNVASQVQKIKDLLQIDSRKNL

Sequences:

>Translated_463_residues
MQATNPIWAEVQQLLQKNLSKPSFETWIRPAKFNCFENGLLTLITPNNFTSDWLRKNYSETIEKAAEEICGHNVKVIFKS
ENNVNNNSNIPDTVSQQSIKSQTRSISTSQGNNTNNRTKKSHSLNIRYVFKRFVVGPNSRMAHAAALAVAESPGREFNPL
FICGGVGLGKTHLMQAIGHYRVEIDPEAKVLYVSTETFSSDLIQSIRKDGMHVFKNKYRSVDLLLIDDIQFLEGKEYTQE
EFFNTFNALYEAGKQIVIASDRPPSQIPKLQERLISRFSMGLIADIQPPDIETRMAILQKKAEQERMNLPRDLVQFIAGR
FSSNIRELEGAFTRAVAFASITGLPMTVQSIAPMLDPNSVGVVVTPKQVIKKVSDFFSVTAEELVSSSRRKPVSQARQIG
MYLMRQGTNLSLPKIGDEFGGKDHTTVMYAIEQVEKKLSSDPNVASQVQKIKDLLQIDSRKNL
>Mature_463_residues
MQATNPIWAEVQQLLQKNLSKPSFETWIRPAKFNCFENGLLTLITPNNFTSDWLRKNYSETIEKAAEEICGHNVKVIFKS
ENNVNNNSNIPDTVSQQSIKSQTRSISTSQGNNTNNRTKKSHSLNIRYVFKRFVVGPNSRMAHAAALAVAESPGREFNPL
FICGGVGLGKTHLMQAIGHYRVEIDPEAKVLYVSTETFSSDLIQSIRKDGMHVFKNKYRSVDLLLIDDIQFLEGKEYTQE
EFFNTFNALYEAGKQIVIASDRPPSQIPKLQERLISRFSMGLIADIQPPDIETRMAILQKKAEQERMNLPRDLVQFIAGR
FSSNIRELEGAFTRAVAFASITGLPMTVQSIAPMLDPNSVGVVVTPKQVIKKVSDFFSVTAEELVSSSRRKPVSQARQIG
MYLMRQGTNLSLPKIGDEFGGKDHTTVMYAIEQVEKKLSSDPNVASQVQKIKDLLQIDSRKNL

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=446, Percent_Identity=39.0134529147982, Blast_Score=323, Evalue=1e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_PROM5 (A2BVM7)

Other databases:

- EMBL:   CP000552
- RefSeq:   YP_001010945.1
- ProteinModelPortal:   A2BVM7
- STRING:   A2BVM7
- GeneID:   4719637
- GenomeReviews:   CP000552_GR
- KEGG:   pmc:P9515_06291
- eggNOG:   COG0593
- HOGENOM:   HBG695666
- OMA:   DEVAFLI
- ProtClustDB:   PRK00149
- BioCyc:   PMAR167542:P9515ORF_0665-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 52037; Mature: 52037

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQATNPIWAEVQQLLQKNLSKPSFETWIRPAKFNCFENGLLTLITPNNFTSDWLRKNYSE
CCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHCCCCEEEECCCCCCHHHHHCCHHH
TIEKAAEEICGHNVKVIFKSENNVNNNSNIPDTVSQQSIKSQTRSISTSQGNNTNNRTKK
HHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCH
SHSLNIRYVFKRFVVGPNSRMAHAAALAVAESPGREFNPLFICGGVGLGKTHLMQAIGHY
HHCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHCE
RVEIDPEAKVLYVSTETFSSDLIQSIRKDGMHVFKNKYRSVDLLLIDDIQFLEGKEYTQE
EEEECCCCEEEEEECCHHHHHHHHHHHHCCHHHHHHHHCCEEEEEECCHHHHCCCCHHHH
EFFNTFNALYEAGKQIVIASDRPPSQIPKLQERLISRFSMGLIADIQPPDIETRMAILQK
HHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHH
KAEQERMNLPRDLVQFIAGRFSSNIRELEGAFTRAVAFASITGLPMTVQSIAPMLDPNSV
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHCCCCCCCCC
GVVVTPKQVIKKVSDFFSVTAEELVSSSRRKPVSQARQIGMYLMRQGTNLSLPKIGDEFG
EEEECHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHCC
GKDHTTVMYAIEQVEKKLSSDPNVASQVQKIKDLLQIDSRKNL
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQATNPIWAEVQQLLQKNLSKPSFETWIRPAKFNCFENGLLTLITPNNFTSDWLRKNYSE
CCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHCCCCEEEECCCCCCHHHHHCCHHH
TIEKAAEEICGHNVKVIFKSENNVNNNSNIPDTVSQQSIKSQTRSISTSQGNNTNNRTKK
HHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCH
SHSLNIRYVFKRFVVGPNSRMAHAAALAVAESPGREFNPLFICGGVGLGKTHLMQAIGHY
HHCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHCE
RVEIDPEAKVLYVSTETFSSDLIQSIRKDGMHVFKNKYRSVDLLLIDDIQFLEGKEYTQE
EEEECCCCEEEEEECCHHHHHHHHHHHHCCHHHHHHHHCCEEEEEECCHHHHCCCCHHHH
EFFNTFNALYEAGKQIVIASDRPPSQIPKLQERLISRFSMGLIADIQPPDIETRMAILQK
HHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHH
KAEQERMNLPRDLVQFIAGRFSSNIRELEGAFTRAVAFASITGLPMTVQSIAPMLDPNSV
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHCCCCCCCCC
GVVVTPKQVIKKVSDFFSVTAEELVSSSRRKPVSQARQIGMYLMRQGTNLSLPKIGDEFG
EEEECHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHCC
GKDHTTVMYAIEQVEKKLSSDPNVASQVQKIKDLLQIDSRKNL
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA