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The map label for this gene is pyrC [H]

Identifier: 123965868

GI number: 123965868

Start: 567470

End: 568519

Strand: Direct

Name: pyrC [H]

Synonym: P9515_06331

Alternate gene names: 123965868

Gene position: 567470-568519 (Clockwise)

Preceding gene: 123965866

Following gene: 123965870

Centisome position: 33.3

GC content: 30.95

Gene sequence:

>1050_bases
TTGAAAGATTTAACTATATTAAAGCCTGATGATTGGCATTTACATTTAAGAGAGGGAATTGTTTTAAAAAATATAATTAA
GTTTAGCTCCGAGTTTTTTGGCAGAGCTATTGTGATGCCAAATACCAAAAACCCAATAACATCTATAAATAAATGTATAT
CTTATAAAAAATCTATTTCTGAAGGATTACCTGAAAATTCAAAGTTTGAGCCATTAATGACGATATATCTTACGGATGAA
ACAATAAAAGATGAATTAATAGAAGGATTTAAAAATGATGTTTTCTTCGCAGCTAAATTATATCCTGCTAATGCGACAAC
AAACTCCAGTCAGGGCGTAAAAAAAATAGAAAATCTTTATGAAATTTTTGAAGTTATGGAAGAACTTGGAATGCCTCTTT
TAATCCATGGAGAAGTGACTGATCCTAAAGTTGATATTTTTGATAGGGAAGTGGTTTTTATAGATAAAGAACTTTTACCT
CTAATACAAAGATTTCCAAAGTTAAAGATTGTTTTAGAACACATAACCACCTCTTATGCTGTTTCTTTTGTCCAAGAGAA
TAATTTAGGCGCTACTATTACACCACATCATTTACATATAAATAGGAATGCAATGTTCTTTGGAGGATTAAATAGTGACT
TTTACTGTCTACCAGTCGCTAAAAGGGAAAATAATAGAATTGCTTTAAGGAAAGCTGCTACTAGTGGAAAAAAATGTTTT
TTCTTAGGCACAGATTCTGCCCCCCATTTGAGACAGTGGAAAGCTTTTTGCGGTTGTGCAGGTATTTTTAATTCACCAGT
TGCAATAGAAAGCTACATCCAAGTTTTTGATGAGGAGGATTCACTGGATCAATTCGAAAAATTTGCAAGCTTGAATGGTC
CTAATTTTTATAATTTGCCTGTAAATAAAGAAAAAATAAGATTAGTATCTAAATCAAATGAAATCCCAAAATTTATTGAA
GTAATTGATAATAATAAGGTTGTTGGGCAAATAAAACCATTTCATGCAGGTGAAATACTAAACTGGCAAGTTGAAGGGAT
TGTGAATTAA

Upstream 100 bases:

>100_bases
AGACTTATTTAAATGATTATATCTTTAATTTATTCAATAATTATCTTAAAACTATTGTCAAAATTTATTTGCTGTTAAAA
TAGATTAAATAATTAAAATT

Downstream 100 bases:

>100_bases
ATCTAATCTAACCACTCAAGAAAAGTTAAAATTCCCAAATTCTTATTGGTTAAATGTATTAATATCTACCAAGTTCAAAA
GCTCAAGTTACTTTTAGAAG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MKDLTILKPDDWHLHLREGIVLKNIIKFSSEFFGRAIVMPNTKNPITSINKCISYKKSISEGLPENSKFEPLMTIYLTDE
TIKDELIEGFKNDVFFAAKLYPANATTNSSQGVKKIENLYEIFEVMEELGMPLLIHGEVTDPKVDIFDREVVFIDKELLP
LIQRFPKLKIVLEHITTSYAVSFVQENNLGATITPHHLHINRNAMFFGGLNSDFYCLPVAKRENNRIALRKAATSGKKCF
FLGTDSAPHLRQWKAFCGCAGIFNSPVAIESYIQVFDEEDSLDQFEKFASLNGPNFYNLPVNKEKIRLVSKSNEIPKFIE
VIDNNKVVGQIKPFHAGEILNWQVEGIVN

Sequences:

>Translated_349_residues
MKDLTILKPDDWHLHLREGIVLKNIIKFSSEFFGRAIVMPNTKNPITSINKCISYKKSISEGLPENSKFEPLMTIYLTDE
TIKDELIEGFKNDVFFAAKLYPANATTNSSQGVKKIENLYEIFEVMEELGMPLLIHGEVTDPKVDIFDREVVFIDKELLP
LIQRFPKLKIVLEHITTSYAVSFVQENNLGATITPHHLHINRNAMFFGGLNSDFYCLPVAKRENNRIALRKAATSGKKCF
FLGTDSAPHLRQWKAFCGCAGIFNSPVAIESYIQVFDEEDSLDQFEKFASLNGPNFYNLPVNKEKIRLVSKSNEIPKFIE
VIDNNKVVGQIKPFHAGEILNWQVEGIVN
>Mature_349_residues
MKDLTILKPDDWHLHLREGIVLKNIIKFSSEFFGRAIVMPNTKNPITSINKCISYKKSISEGLPENSKFEPLMTIYLTDE
TIKDELIEGFKNDVFFAAKLYPANATTNSSQGVKKIENLYEIFEVMEELGMPLLIHGEVTDPKVDIFDREVVFIDKELLP
LIQRFPKLKIVLEHITTSYAVSFVQENNLGATITPHHLHINRNAMFFGGLNSDFYCLPVAKRENNRIALRKAATSGKKCF
FLGTDSAPHLRQWKAFCGCAGIFNSPVAIESYIQVFDEEDSLDQFEKFASLNGPNFYNLPVNKEKIRLVSKSNEIPKFIE
VIDNNKVVGQIKPFHAGEILNWQVEGIVN

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=345, Percent_Identity=50.4347826086956, Blast_Score=358, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6323452, Length=360, Percent_Identity=34.7222222222222, Blast_Score=178, Evalue=1e-45,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 39690; Mature: 39690

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDLTILKPDDWHLHLREGIVLKNIIKFSSEFFGRAIVMPNTKNPITSINKCISYKKSIS
CCCCEEECCCCCEEEECCCHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHH
EGLPENSKFEPLMTIYLTDETIKDELIEGFKNDVFFAAKLYPANATTNSSQGVKKIENLY
HCCCCCCCCCEEEEEEEECHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCHHHHHHHHHH
EIFEVMEELGMPLLIHGEVTDPKVDIFDREVVFIDKELLPLIQRFPKLKIVLEHITTSYA
HHHHHHHHCCCCEEEECCCCCCCEEEECCEEEEECHHHHHHHHHCCHHHHHHHHHHHHHH
VSFVQENNLGATITPHHLHINRNAMFFGGLNSDFYCLPVAKRENNRIALRKAATSGKKCF
EEEEEECCCCCEECCEEEEEECCEEEEECCCCCEEEEEECCCCCCEEEEEEECCCCCEEE
FLGTDSAPHLRQWKAFCGCAGIFNSPVAIESYIQVFDEEDSLDQFEKFASLNGPNFYNLP
EEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEECC
VNKEKIRLVSKSNEIPKFIEVIDNNKVVGQIKPFHAGEILNWQVEGIVN
CCHHHEEEEECCCCCCHHHHHHCCCEEEEEECCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MKDLTILKPDDWHLHLREGIVLKNIIKFSSEFFGRAIVMPNTKNPITSINKCISYKKSIS
CCCCEEECCCCCEEEECCCHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHH
EGLPENSKFEPLMTIYLTDETIKDELIEGFKNDVFFAAKLYPANATTNSSQGVKKIENLY
HCCCCCCCCCEEEEEEEECHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCHHHHHHHHHH
EIFEVMEELGMPLLIHGEVTDPKVDIFDREVVFIDKELLPLIQRFPKLKIVLEHITTSYA
HHHHHHHHCCCCEEEECCCCCCCEEEECCEEEEECHHHHHHHHHCCHHHHHHHHHHHHHH
VSFVQENNLGATITPHHLHINRNAMFFGGLNSDFYCLPVAKRENNRIALRKAATSGKKCF
EEEEEECCCCCEECCEEEEEECCEEEEECCCCCEEEEEECCCCCCEEEEEEECCCCCEEE
FLGTDSAPHLRQWKAFCGCAGIFNSPVAIESYIQVFDEEDSLDQFEKFASLNGPNFYNLP
EEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEECC
VNKEKIRLVSKSNEIPKFIEVIDNNKVVGQIKPFHAGEILNWQVEGIVN
CCHHHEEEEECCCCCCHHHHHHCCCEEEEEECCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA