Click here to switch to the map view.

The map label for this gene is srpG [H]

Identifier: 123965703

GI number: 123965703

Start: 416790

End: 417776

Strand: Reverse

Name: srpG [H]

Synonym: P9515_04681

Alternate gene names: 123965703

Gene position: 417776-416790 (Counterclockwise)

Preceding gene: 123965704

Following gene: 123965697

Centisome position: 24.51

GC content: 37.99

Gene sequence:

>987_bases
ATGGCAAAAATTTATGAGGACAACAGCTTTGCTATTGGAAACACTCCATTAGTAAAATTAAAGTCAGTTACTAAAAATGC
TAAAGCTACTGTACTAGCAAAAATTGAAGGAAGGAATCCTGCCTATAGTGTTAAATGCAGAATTGGTGCAAACATGATCT
GGGACGCTGAGAAAAGCGGGAAACTCACAAAAGATAAAACAATTGTTGAGCCTACATCTGGAAACACTGGAATTGCCCTA
GCTTTTACTGCTTCAGCAAGAGGTTATAAGTTAATCCTTACTATGCCAGAATCTATGTCGATAGAAAGAAGAAGAGTGAT
GGCAGTATTAGGGGCTGAAATTGTTTTAACAGAGGCTTCAAAAGGTATGCCAGGAGCAATTGCTAAAGCCAAAGAGATTG
CGGAAAGCAATCCCTCTCAATATTTTATGCCAGGTCAGTTTGATAATCCAGCAAACCCAGAAATTCATTTTAAAACAACT
GGGCCTGAAATTTGGGATGATTGCGATGGTGCAATTGATGTTTTAGTTGCAGGAGTTGGAACAGGTGGAACAATAACAGG
AGTCTCAAGATACATTAAACAAGAAAAGGGTAAAAATATTACTTCTGTAGCAGTTGAACCATCTCATAGTCCTGTTATTA
CTCAGACACTTAATGGAGAGGAAGTGAAATCAGGACCACATAAAATTCAAGGAATAGGGGCAGGATTTATCCCTAAAAAT
CTTGATTTATCAATTGTTGACAAAGTTGAACAGGTTACAAACGATGAATCTATAGAAATGGCTTTAAGATTGGCTAAAGA
GGAAGGCTTGCTCGTTGGTATATCTTGCGGAGCTGCTGCTGCTGCTGCTGTTAAATTAGCTGAACAAGATGAATATGCAG
GCAAGACTATTGTCGTTGTTCTTCCTGATTTAGCGGAAAGATATTTATCATCAATAATGTTTACTGAAGTCCCAAGCGGC
ATAATTGAGGAACCAATTAACGCTTAA

Upstream 100 bases:

>100_bases
ATTAAATAATTTTTAAATCCCTAGTATTTACCGTATAGAAACTTATATACTCTTTTTACGAAAAATAGTTAATATTAAAA
TATATTTTCTTAAAACATAA

Downstream 100 bases:

>100_bases
AAATATTATTTCTCCAGAAATGAATCTGGTGAAATATACATAGCATCGCCATAAGAGAAAAATCTAAATTTTTCTTTTGT
GGCTTTTTTATATAGATCTA

Product: O-acetylserine (thiol)-lyase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MAKIYEDNSFAIGNTPLVKLKSVTKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKSGKLTKDKTIVEPTSGNTGIAL
AFTASARGYKLILTMPESMSIERRRVMAVLGAEIVLTEASKGMPGAIAKAKEIAESNPSQYFMPGQFDNPANPEIHFKTT
GPEIWDDCDGAIDVLVAGVGTGGTITGVSRYIKQEKGKNITSVAVEPSHSPVITQTLNGEEVKSGPHKIQGIGAGFIPKN
LDLSIVDKVEQVTNDESIEMALRLAKEEGLLVGISCGAAAAAAVKLAEQDEYAGKTIVVVLPDLAERYLSSIMFTEVPSG
IIEEPINA

Sequences:

>Translated_328_residues
MAKIYEDNSFAIGNTPLVKLKSVTKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKSGKLTKDKTIVEPTSGNTGIAL
AFTASARGYKLILTMPESMSIERRRVMAVLGAEIVLTEASKGMPGAIAKAKEIAESNPSQYFMPGQFDNPANPEIHFKTT
GPEIWDDCDGAIDVLVAGVGTGGTITGVSRYIKQEKGKNITSVAVEPSHSPVITQTLNGEEVKSGPHKIQGIGAGFIPKN
LDLSIVDKVEQVTNDESIEMALRLAKEEGLLVGISCGAAAAAAVKLAEQDEYAGKTIVVVLPDLAERYLSSIMFTEVPSG
IIEEPINA
>Mature_327_residues
AKIYEDNSFAIGNTPLVKLKSVTKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKSGKLTKDKTIVEPTSGNTGIALA
FTASARGYKLILTMPESMSIERRRVMAVLGAEIVLTEASKGMPGAIAKAKEIAESNPSQYFMPGQFDNPANPEIHFKTTG
PEIWDDCDGAIDVLVAGVGTGGTITGVSRYIKQEKGKNITSVAVEPSHSPVITQTLNGEEVKSGPHKIQGIGAGFIPKNL
DLSIVDKVEQVTNDESIEMALRLAKEEGLLVGISCGAAAAAAVKLAEQDEYAGKTIVVVLPDLAERYLSSIMFTEVPSGI
IEEPINA

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=316, Percent_Identity=40.1898734177215, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI295821200, Length=316, Percent_Identity=40.1898734177215, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI4557415, Length=316, Percent_Identity=40.1898734177215, Blast_Score=207, Evalue=1e-53,
Organism=Escherichia coli, GI1788754, Length=318, Percent_Identity=64.7798742138365, Blast_Score=399, Evalue=1e-113,
Organism=Escherichia coli, GI2367138, Length=305, Percent_Identity=39.344262295082, Blast_Score=203, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17535051, Length=307, Percent_Identity=49.5114006514658, Blast_Score=284, Evalue=5e-77,
Organism=Caenorhabditis elegans, GI115535073, Length=315, Percent_Identity=51.4285714285714, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17562970, Length=313, Percent_Identity=44.7284345047923, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI32566674, Length=307, Percent_Identity=45.6026058631922, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17561720, Length=323, Percent_Identity=45.5108359133127, Blast_Score=250, Evalue=8e-67,
Organism=Caenorhabditis elegans, GI32566672, Length=223, Percent_Identity=43.0493273542601, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17534315, Length=316, Percent_Identity=40.5063291139241, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI25147552, Length=312, Percent_Identity=37.5, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17561716, Length=138, Percent_Identity=41.304347826087, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321594, Length=318, Percent_Identity=36.4779874213836, Blast_Score=179, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6321449, Length=323, Percent_Identity=33.1269349845201, Blast_Score=138, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24643623, Length=323, Percent_Identity=37.4613003095975, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI20129101, Length=323, Percent_Identity=37.4613003095975, Blast_Score=164, Evalue=9e-41,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34832; Mature: 34701

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIYEDNSFAIGNTPLVKLKSVTKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKSG
CCEEEECCCEEECCCCEEEEECCCCCCCEEEEEEEECCCCCEEEEEEECCCEEECCCCCC
KLTKDKTIVEPTSGNTGIALAFTASARGYKLILTMPESMSIERRRVMAVLGAEIVLTEAS
CCCCCCEEEECCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHCCEEEEEECC
KGMPGAIAKAKEIAESNPSQYFMPGQFDNPANPEIHFKTTGPEIWDDCDGAIDVLVAGVG
CCCCCHHHHHHHHHHCCCCCEECCCCCCCCCCCEEEEEECCCCHHHCCCCCEEEEEECCC
TGGTITGVSRYIKQEKGKNITSVAVEPSHSPVITQTLNGEEVKSGPHKIQGIGAGFIPKN
CCCHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCHHCCCCCEEEECCCCCCCCC
LDLSIVDKVEQVTNDESIEMALRLAKEEGLLVGISCGAAAAAAVKLAEQDEYAGKTIVVV
CCHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCCCEEEEE
LPDLAERYLSSIMFTEVPSGIIEEPINA
CCHHHHHHHHHHHHHHCCCHHHCCCCCC
>Mature Secondary Structure 
AKIYEDNSFAIGNTPLVKLKSVTKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKSG
CEEEECCCEEECCCCEEEEECCCCCCCEEEEEEEECCCCCEEEEEEECCCEEECCCCCC
KLTKDKTIVEPTSGNTGIALAFTASARGYKLILTMPESMSIERRRVMAVLGAEIVLTEAS
CCCCCCEEEECCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHCCEEEEEECC
KGMPGAIAKAKEIAESNPSQYFMPGQFDNPANPEIHFKTTGPEIWDDCDGAIDVLVAGVG
CCCCCHHHHHHHHHHCCCCCEECCCCCCCCCCCEEEEEECCCCHHHCCCCCEEEEEECCC
TGGTITGVSRYIKQEKGKNITSVAVEPSHSPVITQTLNGEEVKSGPHKIQGIGAGFIPKN
CCCHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCHHCCCCCEEEECCCCCCCCC
LDLSIVDKVEQVTNDESIEMALRLAKEEGLLVGISCGAAAAAAVKLAEQDEYAGKTIVVV
CCHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCCCEEEEE
LPDLAERYLSSIMFTEVPSGIIEEPINA
CCHHHHHHHHHHHHHHCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7603442 [H]