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The map label for this gene is ubiB [C]

Identifier: 123965473

GI number: 123965473

Start: 220177

End: 221844

Strand: Reverse

Name: ubiB [C]

Synonym: P9515_02381

Alternate gene names: 123965473

Gene position: 221844-220177 (Counterclockwise)

Preceding gene: 123965474

Following gene: 123965471

Centisome position: 13.02

GC content: 32.25

Gene sequence:

>1668_bases
ATGAGTAATCATAAATTAAAAAATAGAATACAAAAAATCAAAAGAAGCTTTCTTATTTGGAAAACACTTATTTTACTTTT
AGTCAATTTATGGATAGATAATTTAAAAACTAAAATTTTTCAAACTAACAAAGATAAAAATAAAAAAGTTCAAATAAAAA
GAGCTAGGTGGTTTACTAATCAATTAATTGATCTTGGTTCTGCCTTTATCAAAATTGGTCAGCTATTGTCGGCAAGACCT
GATTTAATTCCTAATACTTGGATACAAGAATTATCAAAGTTACAAGATCAAGTTCCTCAGTTTTCATATACAAAAGTTGA
GGAAATTATCAAAACCGAACTCGGGCAGAAATTCTCAGAAATTAACAAAATTAATGATTTGCCAATTGGATCAGCTTCTT
TAGCTCAAGTTCATAGAGCGACTTTGAGAAATGGGAAAGAAGTTGTATTTAAAGTTCAAAGACCCAATCTTAAGCAATTA
TTCATAATCGATTTGAACATAATGCAACAAATTGCTTTTGTACTGCAAAAGAATAGGAATTGGAGTCGTGGAAGAAATTG
GGTTGATATAGCAAAAGAGTGCAGAAAAGTTCTGATGAAAGAACTAGATTTTAAATGTGAAGCACAGTATGCCGCAAGAT
TTAGACAACAATTTCTTGATGATGATAATGTAGAAGTCCCTGAAGTTATTTGGGACTTGAGTAGTGACAAAGTCCTTTGT
CTTAGTTATTTAGAAGGTATAAAAATAAGTGATATTGAAAAATTAAAGTCTAAGAACATTGACTTACCTAAGATTGCCGA
AATAGGTGCAATTAGCTATCTGAAACAACTAGTAAATTATGGTTTTTTTCATGCTGATCCTCATCCTGGGAATTTAGCCG
TTTCAAATTCAGGCAAATTAATCTTTTATGATTTTGGGATGATGGGCAATATTTCAAATAACCTACAAGTCAGATTGGGA
TCTATGGTTCAATCAGCAGCATTGAGAGATGCATCTTCACTTGTCACTCAACTACAACAAGCAGGCTTGATCTCCAAAGA
TATAGATGTTGGACCAGTAAGAAGATTAGTTAGATTAATGCTAAAAGAAGCTTTAACTCCTCCATTCAGCCCAAAAATTA
TCGAAAAACTATCTGGGGATTTATATGAACTTGTTTATGAAACTCCTTTTCAACTACCAGTGGATTTAATTTTTGTGATG
AGAGCACTATCAACTTTTGAAGGAGTTGGTAGAATGTTAGACCCAGGGTTTAACCTTGTATCAATTACTAAGCCTTATCT
AATTGACCTCATGACTTCTAATAATCAATCACCAAACGATTTAATTAACCAATTCGGGAGACAAGTTGGTGAATTAGGTT
CAAAGGCTGTAGGCATCCCAAAAAGAATTGATGAGAGTTTAGAGAGATTAGAGCAGGGTGATTTACAACTTCAAATAAGG
ATGGGAGAATCTGACAGGCAATTTAAGAAAATGTTTACTGCACAAAAATCATTAGGACATTCAATTCTTATGGGAAGCCT
TACAATAGCATCAGCTTTACTTGTGACTAAGAACCAAAATAATTTAGCTATTTTACCTTTATTATTTGCAGCACCAATAA
GTATTGATTGGATAAAATGTCAACTAAACATGAGAAAAGGTTCAAGAATAGACAAGCTCAAGAAGTAG

Upstream 100 bases:

>100_bases
AATCTTATAAAGATCCAAACTTAAATGAAGTTTTAAAAGAGATACAAGAAATACAAGAAAAAATTGAAAAATTCAATATG
AAAATGAATAATACAATTTA

Downstream 100 bases:

>100_bases
CAATAATCTAATCTTATATATTTTTTGGACCTAATCCTAAATCCCCAGCAAATCTAGCTTGGTTCCCTAACTCTTCCTCA
ATCCTTAGGAGTCTATTATA

Product: putative kinase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 555; Mature: 554

Protein sequence:

>555_residues
MSNHKLKNRIQKIKRSFLIWKTLILLLVNLWIDNLKTKIFQTNKDKNKKVQIKRARWFTNQLIDLGSAFIKIGQLLSARP
DLIPNTWIQELSKLQDQVPQFSYTKVEEIIKTELGQKFSEINKINDLPIGSASLAQVHRATLRNGKEVVFKVQRPNLKQL
FIIDLNIMQQIAFVLQKNRNWSRGRNWVDIAKECRKVLMKELDFKCEAQYAARFRQQFLDDDNVEVPEVIWDLSSDKVLC
LSYLEGIKISDIEKLKSKNIDLPKIAEIGAISYLKQLVNYGFFHADPHPGNLAVSNSGKLIFYDFGMMGNISNNLQVRLG
SMVQSAALRDASSLVTQLQQAGLISKDIDVGPVRRLVRLMLKEALTPPFSPKIIEKLSGDLYELVYETPFQLPVDLIFVM
RALSTFEGVGRMLDPGFNLVSITKPYLIDLMTSNNQSPNDLINQFGRQVGELGSKAVGIPKRIDESLERLEQGDLQLQIR
MGESDRQFKKMFTAQKSLGHSILMGSLTIASALLVTKNQNNLAILPLLFAAPISIDWIKCQLNMRKGSRIDKLKK

Sequences:

>Translated_555_residues
MSNHKLKNRIQKIKRSFLIWKTLILLLVNLWIDNLKTKIFQTNKDKNKKVQIKRARWFTNQLIDLGSAFIKIGQLLSARP
DLIPNTWIQELSKLQDQVPQFSYTKVEEIIKTELGQKFSEINKINDLPIGSASLAQVHRATLRNGKEVVFKVQRPNLKQL
FIIDLNIMQQIAFVLQKNRNWSRGRNWVDIAKECRKVLMKELDFKCEAQYAARFRQQFLDDDNVEVPEVIWDLSSDKVLC
LSYLEGIKISDIEKLKSKNIDLPKIAEIGAISYLKQLVNYGFFHADPHPGNLAVSNSGKLIFYDFGMMGNISNNLQVRLG
SMVQSAALRDASSLVTQLQQAGLISKDIDVGPVRRLVRLMLKEALTPPFSPKIIEKLSGDLYELVYETPFQLPVDLIFVM
RALSTFEGVGRMLDPGFNLVSITKPYLIDLMTSNNQSPNDLINQFGRQVGELGSKAVGIPKRIDESLERLEQGDLQLQIR
MGESDRQFKKMFTAQKSLGHSILMGSLTIASALLVTKNQNNLAILPLLFAAPISIDWIKCQLNMRKGSRIDKLKK
>Mature_554_residues
SNHKLKNRIQKIKRSFLIWKTLILLLVNLWIDNLKTKIFQTNKDKNKKVQIKRARWFTNQLIDLGSAFIKIGQLLSARPD
LIPNTWIQELSKLQDQVPQFSYTKVEEIIKTELGQKFSEINKINDLPIGSASLAQVHRATLRNGKEVVFKVQRPNLKQLF
IIDLNIMQQIAFVLQKNRNWSRGRNWVDIAKECRKVLMKELDFKCEAQYAARFRQQFLDDDNVEVPEVIWDLSSDKVLCL
SYLEGIKISDIEKLKSKNIDLPKIAEIGAISYLKQLVNYGFFHADPHPGNLAVSNSGKLIFYDFGMMGNISNNLQVRLGS
MVQSAALRDASSLVTQLQQAGLISKDIDVGPVRRLVRLMLKEALTPPFSPKIIEKLSGDLYELVYETPFQLPVDLIFVMR
ALSTFEGVGRMLDPGFNLVSITKPYLIDLMTSNNQSPNDLINQFGRQVGELGSKAVGIPKRIDESLERLEQGDLQLQIRM
GESDRQFKKMFTAQKSLGHSILMGSLTIASALLVTKNQNNLAILPLLFAAPISIDWIKCQLNMRKGSRIDKLKK

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=305, Percent_Identity=27.8688524590164, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI41393593, Length=354, Percent_Identity=27.4011299435028, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI217035081, Length=224, Percent_Identity=27.6785714285714, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI27363457, Length=276, Percent_Identity=25, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI217416386, Length=228, Percent_Identity=25.8771929824561, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI34147522, Length=289, Percent_Identity=25.6055363321799, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI2367309, Length=544, Percent_Identity=26.4705882352941, Blast_Score=155, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17559152, Length=278, Percent_Identity=32.0143884892086, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI32565180, Length=254, Percent_Identity=26.3779527559055, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323282, Length=248, Percent_Identity=29.8387096774194, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6321319, Length=293, Percent_Identity=26.2798634812287, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6325148, Length=432, Percent_Identity=22.2222222222222, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24662575, Length=403, Percent_Identity=28.7841191066998, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI22024280, Length=286, Percent_Identity=30.0699300699301, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI18859849, Length=258, Percent_Identity=25.5813953488372, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 63209; Mature: 63078

Theoretical pI: Translated: 10.31; Mature: 10.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EEECCCCCCHHHCCC
>Mature Secondary Structure 
SNHKLKNRIQKIKRSFLIWKTLILLLVNLWIDNLKTKIFQTNKDKNKKVQIKRARWFTN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHH
QLIDLGSAFIKIGQLLSARPDLIPNTWIQELSKLQDQVPQFSYTKVEEIIKTELGQKFSE
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
INKINDLPIGSASLAQVHRATLRNGKEVVFKVQRPNLKQLFIIDLNIMQQIAFVLQKNRN
HHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEHHHHHHHHHHHHCCCC
WSRGRNWVDIAKECRKVLMKELDFKCEAQYAARFRQQFLDDDNVEVPEVIWDLSSDKVLC
CCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEH
LSYLEGIKISDIEKLKSKNIDLPKIAEIGAISYLKQLVNYGFFHADPHPGNLAVSNSGKL
HHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEECCCCE
IFYDFGMMGNISNNLQVRLGSMVQSAALRDASSLVTQLQQAGLISKDIDVGPVRRLVRLM
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
LKEALTPPFSPKIIEKLSGDLYELVYETPFQLPVDLIFVMRALSTFEGVGRMLDPGFNLV
HHHHCCCCCCHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEE
SITKPYLIDLMTSNNQSPNDLINQFGRQVGELGSKAVGIPKRIDESLERLEQGDLQLQIR
EECCCHHEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEE
MGESDRQFKKMFTAQKSLGHSILMGSLTIASALLVTKNQNNLAILPLLFAAPISIDWIKC
ECCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHEECCCCCEEEEHHHHHCCCCEEEEEE
QLNMRKGSRIDKLKK
EEECCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]