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The map label for this gene is pepB [H]

Identifier: 123969064

GI number: 123969064

Start: 1311615

End: 1313087

Strand: Direct

Name: pepB [H]

Synonym: A9601_15321

Alternate gene names: 123969064

Gene position: 1311615-1313087 (Clockwise)

Preceding gene: 123969063

Following gene: 123969073

Centisome position: 78.55

GC content: 34.08

Gene sequence:

>1473_bases
ATGCAATTTTCCACATTCCAAACAAATCTAGATAACTGGCAAGGTGCTTCATTAATTTTTGGAGTTCTAGAGGAAGAAAT
TGCAAGCCAACTTGAAAACATAAAATTTGTTGTTGACCCAAAATTATTACTAAAAAAAGTTACTCAAAAAAAATTCAAAG
GAGAAAAAGGAAAAACTTTAAGCTTTGAATTTTTAGATCAAAAATTAGAAACTTTAATCATAGTTGGTCTTGGCAAATCA
AAAGACCTAAACAAAAGTGATATAGAAAACTCTATAGGAAATCTAGTTAGGAAAACTGTTGATAAAAATGCAAAAATCAG
CATCTTGCTACCTTGGGAATTAATAAATTCACAACTAGAGATAACTAAACTAGCAGAATCAGCCAGATTATCTGCCTATA
AGGACAATAGATTTAATAAGAAAAAAGATGAAAAGAAAGTTCTTAAAGAAATAGAGTTTTTGAATTTAAAACAATTTGAG
AATATTAGCTTTGAAGAGACAGCACAAATATGTGAAGGTGTAGAACTAGCTAGAAAACTTGTAGCCGCCCCTCCAAATAG
TCTTACACCTCAGGAAATGTCTTTACAAGCTTCTAAAATAGCTAAAGATCATGGTTTGGAAGTAAAAATTTTAGAGGCAA
AAGATTGTGAAGATTTAGAAATGGGTGCATATTTAGCTGTAGCAAAAGGTTCTGATCTAGATCCTAAATTTATACATCTT
ACTTTGAAGTCAGAGGGGCCTATAAAAGAAAAGATTGCACTTGTTGGGAAGGGTTTAACCTTTGATTCTGGAGGGTACAA
TCTGAAAGTAGGAGCCTCTCAAATTGAAATGATGAAATATGATATGGGAGGAAGCGCTGCAGTTTTAGGAGCAGCAAAAG
CACTTGGAGCAATAAAACCAAAGGGATTAGAAATTCATTTTATTGTGGCAGCTTGCGAAAACATGATAAATGGATCTGCT
GTTCATCCTGGAGATGTAGTTAAAGCATCAAATGGTAAGACAATTGAAATAAATAATACTGATGCAGAGGGTAGGCTCAC
ATTAGCTGATGCTTTAACTTATGCATCCAATTTAAACCCCGATTCAATAATAGATCTTGCCACTTTAACAGGAGCTATCG
TTGTTGCATTAGGGAATGATGTAGCTGGATTCTGGAGCAATAATGATGATCTAGCAAATGACCTAAAAGCTGCATCAGCC
CAGTCTGGAGAAAAATTATGGCAAATGCCTTTACAAAAATCTTATAAAGAAGGGTTAAAGTCTCATATAGCTGACATGAA
AAATACAGGCCCTAGAGCAGGTGGGTCAATAACTGCGGCTTTGTTTCTAGAGGAATTCTTTGATTCAGAGATTAAATGGG
CTCATATTGATATTGCTGGGACTTGTTGGACTGATAAGAATAAAGGAATTAATCCATCAGGTGCAACCGGTTTTGGAGTT
AAAACTCTTGTTCAATGGATTAAAAATAAATAA

Upstream 100 bases:

>100_bases
ACTGATATATTTATGGTTACCACCTTTTAATAAAGAAACTCGAGATAGGTGGGCAACTACTTTCACAAACAACTAAAAGT
TAATTAAATCCATTTAACAA

Downstream 100 bases:

>100_bases
CTATATTTAAATCATTCATTCCAAATATTTATCGATCTAGCGTTATCACCCCATAATTTATCCAACCTTTGATCTCTACC
ACATGAGAATCTATAGAATT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MQFSTFQTNLDNWQGASLIFGVLEEEIASQLENIKFVVDPKLLLKKVTQKKFKGEKGKTLSFEFLDQKLETLIIVGLGKS
KDLNKSDIENSIGNLVRKTVDKNAKISILLPWELINSQLEITKLAESARLSAYKDNRFNKKKDEKKVLKEIEFLNLKQFE
NISFEETAQICEGVELARKLVAAPPNSLTPQEMSLQASKIAKDHGLEVKILEAKDCEDLEMGAYLAVAKGSDLDPKFIHL
TLKSEGPIKEKIALVGKGLTFDSGGYNLKVGASQIEMMKYDMGGSAAVLGAAKALGAIKPKGLEIHFIVAACENMINGSA
VHPGDVVKASNGKTIEINNTDAEGRLTLADALTYASNLNPDSIIDLATLTGAIVVALGNDVAGFWSNNDDLANDLKAASA
QSGEKLWQMPLQKSYKEGLKSHIADMKNTGPRAGGSITAALFLEEFFDSEIKWAHIDIAGTCWTDKNKGINPSGATGFGV
KTLVQWIKNK

Sequences:

>Translated_490_residues
MQFSTFQTNLDNWQGASLIFGVLEEEIASQLENIKFVVDPKLLLKKVTQKKFKGEKGKTLSFEFLDQKLETLIIVGLGKS
KDLNKSDIENSIGNLVRKTVDKNAKISILLPWELINSQLEITKLAESARLSAYKDNRFNKKKDEKKVLKEIEFLNLKQFE
NISFEETAQICEGVELARKLVAAPPNSLTPQEMSLQASKIAKDHGLEVKILEAKDCEDLEMGAYLAVAKGSDLDPKFIHL
TLKSEGPIKEKIALVGKGLTFDSGGYNLKVGASQIEMMKYDMGGSAAVLGAAKALGAIKPKGLEIHFIVAACENMINGSA
VHPGDVVKASNGKTIEINNTDAEGRLTLADALTYASNLNPDSIIDLATLTGAIVVALGNDVAGFWSNNDDLANDLKAASA
QSGEKLWQMPLQKSYKEGLKSHIADMKNTGPRAGGSITAALFLEEFFDSEIKWAHIDIAGTCWTDKNKGINPSGATGFGV
KTLVQWIKNK
>Mature_490_residues
MQFSTFQTNLDNWQGASLIFGVLEEEIASQLENIKFVVDPKLLLKKVTQKKFKGEKGKTLSFEFLDQKLETLIIVGLGKS
KDLNKSDIENSIGNLVRKTVDKNAKISILLPWELINSQLEITKLAESARLSAYKDNRFNKKKDEKKVLKEIEFLNLKQFE
NISFEETAQICEGVELARKLVAAPPNSLTPQEMSLQASKIAKDHGLEVKILEAKDCEDLEMGAYLAVAKGSDLDPKFIHL
TLKSEGPIKEKIALVGKGLTFDSGGYNLKVGASQIEMMKYDMGGSAAVLGAAKALGAIKPKGLEIHFIVAACENMINGSA
VHPGDVVKASNGKTIEINNTDAEGRLTLADALTYASNLNPDSIIDLATLTGAIVVALGNDVAGFWSNNDDLANDLKAASA
QSGEKLWQMPLQKSYKEGLKSHIADMKNTGPRAGGSITAALFLEEFFDSEIKWAHIDIAGTCWTDKNKGINPSGATGFGV
KTLVQWIKNK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=447, Percent_Identity=35.3467561521253, Blast_Score=228, Evalue=9e-60,
Organism=Homo sapiens, GI47155554, Length=417, Percent_Identity=31.6546762589928, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1790710, Length=509, Percent_Identity=34.5776031434185, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI87082123, Length=329, Percent_Identity=37.0820668693009, Blast_Score=183, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=317, Percent_Identity=34.0694006309148, Blast_Score=143, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17565172, Length=255, Percent_Identity=30.9803921568627, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21355725, Length=318, Percent_Identity=33.6477987421384, Blast_Score=172, Evalue=7e-43,
Organism=Drosophila melanogaster, GI24661038, Length=316, Percent_Identity=33.8607594936709, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI20129969, Length=461, Percent_Identity=26.8980477223427, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI161077148, Length=457, Percent_Identity=27.5711159737418, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI20130057, Length=457, Percent_Identity=27.5711159737418, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24662227, Length=457, Percent_Identity=26.4770240700219, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI21355645, Length=453, Percent_Identity=26.4900662251656, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24662223, Length=453, Percent_Identity=26.4900662251656, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI20129963, Length=453, Percent_Identity=28.6975717439294, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI19922386, Length=450, Percent_Identity=26.2222222222222, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI21357381, Length=323, Percent_Identity=30.6501547987616, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI221379063, Length=323, Percent_Identity=30.6501547987616, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI221379062, Length=323, Percent_Identity=30.6501547987616, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24646701, Length=358, Percent_Identity=27.3743016759777, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24646703, Length=358, Percent_Identity=27.3743016759777, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI21358201, Length=358, Percent_Identity=27.3743016759777, Blast_Score=92, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53347; Mature: 53347

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFSTFQTNLDNWQGASLIFGVLEEEIASQLENIKFVVDPKLLLKKVTQKKFKGEKGKTL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHCCCCCCEE
SFEFLDQKLETLIIVGLGKSKDLNKSDIENSIGNLVRKTVDKNAKISILLPWELINSQLE
EHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHCCCHH
ITKLAESARLSAYKDNRFNKKKDEKKVLKEIEFLNLKQFENISFEETAQICEGVELARKL
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHH
VAAPPNSLTPQEMSLQASKIAKDHGLEVKILEAKDCEDLEMGAYLAVAKGSDLDPKFIHL
HCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCEEEEE
TLKSEGPIKEKIALVGKGLTFDSGGYNLKVGASQIEMMKYDMGGSAAVLGAAKALGAIKP
EECCCCCHHHHHHHHCCCCEECCCCCEEEECHHHEEEEEECCCCCHHHHHHHHHHCCCCC
KGLEIHFIVAACENMINGSAVHPGDVVKASNGKTIEINNTDAEGRLTLADALTYASNLNP
CCEEEEEHHHHHHHHCCCCCCCCCCEEECCCCCEEEEECCCCCCEEEHHHHHHHHCCCCH
DSIIDLATLTGAIVVALGNDVAGFWSNNDDLANDLKAASAQSGEKLWQMPLQKSYKEGLK
HHHHHHHHHHCEEEEEECCCEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
SHIADMKNTGPRAGGSITAALFLEEFFDSEIKWAHIDIAGTCWTDKNKGINPSGATGFGV
HHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCH
KTLVQWIKNK
HHHHHHHHCC
>Mature Secondary Structure
MQFSTFQTNLDNWQGASLIFGVLEEEIASQLENIKFVVDPKLLLKKVTQKKFKGEKGKTL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHCCCCCCEE
SFEFLDQKLETLIIVGLGKSKDLNKSDIENSIGNLVRKTVDKNAKISILLPWELINSQLE
EHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHCCCHH
ITKLAESARLSAYKDNRFNKKKDEKKVLKEIEFLNLKQFENISFEETAQICEGVELARKL
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHH
VAAPPNSLTPQEMSLQASKIAKDHGLEVKILEAKDCEDLEMGAYLAVAKGSDLDPKFIHL
HCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCEEEEE
TLKSEGPIKEKIALVGKGLTFDSGGYNLKVGASQIEMMKYDMGGSAAVLGAAKALGAIKP
EECCCCCHHHHHHHHCCCCEECCCCCEEEECHHHEEEEEECCCCCHHHHHHHHHHCCCCC
KGLEIHFIVAACENMINGSAVHPGDVVKASNGKTIEINNTDAEGRLTLADALTYASNLNP
CCEEEEEHHHHHHHHCCCCCCCCCCEEECCCCCEEEEECCCCCCEEEHHHHHHHHCCCCH
DSIIDLATLTGAIVVALGNDVAGFWSNNDDLANDLKAASAQSGEKLWQMPLQKSYKEGLK
HHHHHHHHHHCEEEEEECCCEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
SHIADMKNTGPRAGGSITAALFLEEFFDSEIKWAHIDIAGTCWTDKNKGINPSGATGFGV
HHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCH
KTLVQWIKNK
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA