Click here to switch to the map view.

The map label for this gene is lysA [H]

Identifier: 123968729

GI number: 123968729

Start: 1012803

End: 1014176

Strand: Direct

Name: lysA [H]

Synonym: A9601_11961

Alternate gene names: 123968729

Gene position: 1012803-1014176 (Clockwise)

Preceding gene: 123968724

Following gene: 123968730

Centisome position: 60.65

GC content: 33.11

Gene sequence:

>1374_bases
ATGGATGAAAAAGAATCTTTTTTAAAACAGAAAATTGACTTGGAAAGTCCCAATAAAAATATAGTGCCCATTACTACCTC
AATTGGAGGAGATGGGAAATTGTCAGTTGGTGGATGTTCAATTGAAGAATTAGTTAAAAAATATGATTCTCCTCTCTATA
TTTTGGATGAAACCACATTGAGAATGTCTTGTAGAGCTTATAAAAAAGCATTAGAAAAATACTATCCAGGAGAAACACTC
CCGATATATGCATCCAAGGCTAATAGCTCTATATTTATGAGTAACCTTGTTTCCTCAGAAGGTTTAGGACTTGATGCAGT
TTCGGAGGGGGAATTATTAACTGCCCTAAAGGGTGGGGTGCCAAATGAAAAAATTGTTTTTCATGGGAACAATAAATCTG
ACAAAGAAATAGATTTCGCGATTAAAAATAACATAAAAATAATTGTAGATAATGACTATGACTTAAAAAGATTAGAGGAA
GTATCAAACTCATTAAATCATGACTTAGAAATAATGATTCGCTTTACTCCTGGAATAGAATGCCATACACATGAATACAT
AAGAACAGGTTCATTTGATAGCAAATTTGGTTTTGGAATCGAATATCTGAATAATTTATTTGCCAACATAAGCGACACTA
AACATTTAAAGTTAAGAGGAATACATGCTCATATTGGTTCCCAAATTTTTGAACTAGAACCTCATAAGGATCTAGGCGAA
ATAATGGTAAAGGTTATTTTGGACGCCAAGAAATTTGGCCACAATATTAAGGAACTTAATGTTGGTGGAGGATTAGGCAT
TAAATATACAAAAAATGACGATCCACCTTCTATTGATGAATGGGTAAAAACAATTTCCACCTCTGTAGTTGAAGCTTGTA
AAAAACACAATTTAGATTTACCTAAGTTAATGTGTGAACCTGGAAGATCCATCGTATCTACAGCAGGCATAACAATTTAC
AAAATTGGGGCTTTCAAAGAAATTCCTGGAATCAGAACCTATTTGTCTGTTGATGGTGGGATGAGTGATAATCCAAGGCC
CATAACATATCAATCAAATTATTCTGCATGTTTGGTAAAAAACCCCTTAAACATTAATTCAAAAAATAAATATACTATTG
CTGGAAAACATTGCGAATCAGGAGATGTATTGTTGAAGGAGATAGAGCTAGCAAATTGTAAAACAGGAGATCTTATATGT
GTTTTTGGTACTGGTGCATATAATGTTTCAATGAGTTCTAACTACAACAGAATTCCAAGGCCCGCAGCTCTTTTAGTTTG
TGATGGAGAAGCAGAGATTATTCAAAAAAGAGAAAGTCCATTTGATCTTTTAAGATATGATGTTTTGCCTGATCGCTTTA
TTAAACAAAATTAG

Upstream 100 bases:

>100_bases
AATAGATATCATTTTATTATGTATTTATATTTATAAAGTTCAAATCTAGAGTCATTATAAAATATGGCTGTTTTGGCAAA
ACTTTATTTAAAGTTCTCTT

Downstream 100 bases:

>100_bases
GTACATTTAAATTAATGTTGTTTTTAGTGTGAATTTCTGGGGAATTATAAATTTAAAGCTTTTATTAGATGTCTTATTTG
CTGTTGGTTTCGGACTTTTA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MDEKESFLKQKIDLESPNKNIVPITTSIGGDGKLSVGGCSIEELVKKYDSPLYILDETTLRMSCRAYKKALEKYYPGETL
PIYASKANSSIFMSNLVSSEGLGLDAVSEGELLTALKGGVPNEKIVFHGNNKSDKEIDFAIKNNIKIIVDNDYDLKRLEE
VSNSLNHDLEIMIRFTPGIECHTHEYIRTGSFDSKFGFGIEYLNNLFANISDTKHLKLRGIHAHIGSQIFELEPHKDLGE
IMVKVILDAKKFGHNIKELNVGGGLGIKYTKNDDPPSIDEWVKTISTSVVEACKKHNLDLPKLMCEPGRSIVSTAGITIY
KIGAFKEIPGIRTYLSVDGGMSDNPRPITYQSNYSACLVKNPLNINSKNKYTIAGKHCESGDVLLKEIELANCKTGDLIC
VFGTGAYNVSMSSNYNRIPRPAALLVCDGEAEIIQKRESPFDLLRYDVLPDRFIKQN

Sequences:

>Translated_457_residues
MDEKESFLKQKIDLESPNKNIVPITTSIGGDGKLSVGGCSIEELVKKYDSPLYILDETTLRMSCRAYKKALEKYYPGETL
PIYASKANSSIFMSNLVSSEGLGLDAVSEGELLTALKGGVPNEKIVFHGNNKSDKEIDFAIKNNIKIIVDNDYDLKRLEE
VSNSLNHDLEIMIRFTPGIECHTHEYIRTGSFDSKFGFGIEYLNNLFANISDTKHLKLRGIHAHIGSQIFELEPHKDLGE
IMVKVILDAKKFGHNIKELNVGGGLGIKYTKNDDPPSIDEWVKTISTSVVEACKKHNLDLPKLMCEPGRSIVSTAGITIY
KIGAFKEIPGIRTYLSVDGGMSDNPRPITYQSNYSACLVKNPLNINSKNKYTIAGKHCESGDVLLKEIELANCKTGDLIC
VFGTGAYNVSMSSNYNRIPRPAALLVCDGEAEIIQKRESPFDLLRYDVLPDRFIKQN
>Mature_457_residues
MDEKESFLKQKIDLESPNKNIVPITTSIGGDGKLSVGGCSIEELVKKYDSPLYILDETTLRMSCRAYKKALEKYYPGETL
PIYASKANSSIFMSNLVSSEGLGLDAVSEGELLTALKGGVPNEKIVFHGNNKSDKEIDFAIKNNIKIIVDNDYDLKRLEE
VSNSLNHDLEIMIRFTPGIECHTHEYIRTGSFDSKFGFGIEYLNNLFANISDTKHLKLRGIHAHIGSQIFELEPHKDLGE
IMVKVILDAKKFGHNIKELNVGGGLGIKYTKNDDPPSIDEWVKTISTSVVEACKKHNLDLPKLMCEPGRSIVSTAGITIY
KIGAFKEIPGIRTYLSVDGGMSDNPRPITYQSNYSACLVKNPLNINSKNKYTIAGKHCESGDVLLKEIELANCKTGDLIC
VFGTGAYNVSMSSNYNRIPRPAALLVCDGEAEIIQKRESPFDLLRYDVLPDRFIKQN

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=413, Percent_Identity=27.3607748184019, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1789307, Length=278, Percent_Identity=23.3812949640288, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24586472, Length=398, Percent_Identity=23.3668341708543, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24586474, Length=385, Percent_Identity=24.1558441558442, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 50756; Mature: 50756

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEKESFLKQKIDLESPNKNIVPITTSIGGDGKLSVGGCSIEELVKKYDSPLYILDETTL
CCHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEECCCCHHHHHHHCCCCEEEEECCHH
RMSCRAYKKALEKYYPGETLPIYASKANSSIFMSNLVSSEGLGLDAVSEGELLTALKGGV
HHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEHHHHHCCCCCCCCCCCCCCEEHHHHCCC
PNEKIVFHGNNKSDKEIDFAIKNNIKIIVDNDYDLKRLEEVSNSLNHDLEIMIRFTPGIE
CCCEEEEECCCCCCCEEEEEEECCEEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCE
CHTHEYIRTGSFDSKFGFGIEYLNNLFANISDTKHLKLRGIHAHIGSQIFELEPHKDLGE
ECCCHHEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEHHHHCCEEEEECCCCCHHH
IMVKVILDAKKFGHNIKELNVGGGLGIKYTKNDDPPSIDEWVKTISTSVVEACKKHNLDL
HHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
PKLMCEPGRSIVSTAGITIYKIGAFKEIPGIRTYLSVDGGMSDNPRPITYQSNYSACLVK
HHHHHCCCCHHHHHCCEEEEEECCHHCCCCCEEEEEECCCCCCCCCEEEECCCCCEEEEE
NPLNINSKNKYTIAGKHCESGDVLLKEIELANCKTGDLICVFGTGAYNVSMSSNYNRIPR
CCCCCCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCEEEEEECCEEEEEECCCCCCCCC
PAALLVCDGEAEIIQKRESPFDLLRYDVLPDRFIKQN
CEEEEEECCCHHHHHCCCCCHHHHHHHCCCHHHHCCC
>Mature Secondary Structure
MDEKESFLKQKIDLESPNKNIVPITTSIGGDGKLSVGGCSIEELVKKYDSPLYILDETTL
CCHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEECCCCHHHHHHHCCCCEEEEECCHH
RMSCRAYKKALEKYYPGETLPIYASKANSSIFMSNLVSSEGLGLDAVSEGELLTALKGGV
HHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEHHHHHCCCCCCCCCCCCCCEEHHHHCCC
PNEKIVFHGNNKSDKEIDFAIKNNIKIIVDNDYDLKRLEEVSNSLNHDLEIMIRFTPGIE
CCCEEEEECCCCCCCEEEEEEECCEEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCE
CHTHEYIRTGSFDSKFGFGIEYLNNLFANISDTKHLKLRGIHAHIGSQIFELEPHKDLGE
ECCCHHEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEHHHHCCEEEEECCCCCHHH
IMVKVILDAKKFGHNIKELNVGGGLGIKYTKNDDPPSIDEWVKTISTSVVEACKKHNLDL
HHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
PKLMCEPGRSIVSTAGITIYKIGAFKEIPGIRTYLSVDGGMSDNPRPITYQSNYSACLVK
HHHHHCCCCHHHHHCCEEEEEECCHHCCCCCEEEEEECCCCCCCCCEEEECCCCCEEEEE
NPLNINSKNKYTIAGKHCESGDVLLKEIELANCKTGDLICVFGTGAYNVSMSSNYNRIPR
CCCCCCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCEEEEEECCEEEEEECCCCCCCCC
PAALLVCDGEAEIIQKRESPFDLLRYDVLPDRFIKQN
CEEEEEECCCHHHHHCCCCCHHHHHHHCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]