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The map label for this gene is yrkA [H]

Identifier: 123967834

GI number: 123967834

Start: 273189

End: 274457

Strand: Reverse

Name: yrkA [H]

Synonym: A9601_02971

Alternate gene names: 123967834

Gene position: 274457-273189 (Counterclockwise)

Preceding gene: 123967837

Following gene: 123967832

Centisome position: 16.44

GC content: 31.28

Gene sequence:

>1269_bases
ATGAAAATAACTCTACTTTTTTTTCTTTTATTTTTACCAGCTTTTTTCGCAGCGAGTGAACTCTCTTTTTTATTAATAAG
GCCAAGTAAAGTTTTAAGGTTAATAGAAGAAAAAAAGAAAGGAGCTTTTTCAATTTTAAAAATTCAAAAACGCTTTAGAT
CTTCACTAATTGCTTCTCAATTTGGAGTAACAATTTCATTAGTTGCGATTGGATGGCTCAGCAATAACCTGGCTAATGAC
TATTGGAAAAGCAATAATTTATCAGATAGATTTTATGATCTTCTATTATTTTTATTTGTTGTTTTAGTTGTTACTCTTAT
TTCTGGACTAATTCCAAAAGCTTTAGTAATTAATAATCCAGAATCTGCTGCATTAAGGTTAACCACAATATTCGACGCCG
TGAGAAAATCTATGAATCCTATAGTGAAAACAATAGGATTCTTCGCTAGTGCCTGTTTAGGCTTGTTCAATTTAAATAAC
AAATGGGATTCTTTAAACTCGGGTTTATCTGCTGGAGAATTAGAAACTCTTATAGAAACAGATAACGTAACAGGTTTAAA
ACCAGATGAGAAGAATATTCTTGAAGGAGTTTTTGCTTTAAAAGATACACAAGTTAAAGAAGTGATGATTCCAAGATCCG
AAATGGTAACTTTGCCAAAAAATATAACCTTTTCAGAACTTATGAAACAAGTAGATAAAACTCGACATGCTCGCTTCTTT
GTAATTGGTGAGTCTTTAGATGATGTATTAGGTGTATTAGATTTGCGTTATCTAGCTAAGCCAATATCAAAAGGTGAAAT
GGAAGCCGATACATCATTAGAGCCATTCCTTTTACCCGTCACAAAAATAATAGAAACATGTTCACTAGCAGAAATATTTC
CAATAGTAAGAGACTACAATCCATTCTTACTGGTAGTTGATGAACACGGCGGGACAGAGGGACTAATAACTGCAGCTGAT
CTAAATGGCGAAATAGTTGGAGAGGAAATGCTTAATAATAGAATTTATTCAGACATGAGAATGTTAGATAATTTATCTAA
AAAATGGTCAATAGCTGGAAAATCAGAAATTATTGAAATCAATAAAAAGATAGGATGTTCTATTCCAGAAGGTATTGATT
ATCATACCCTTGCTGGATTTATGTTAGAAAAATTTCAAATGGTCCCAAAAATTGGCGACGTTTTAGATTTTAATAATATT
AAATTTGAAGTTATTTCTATGTCAGGTCCAAAAATTGATCGTGTTAAAATAATTCTTCCCAAAAGCTAA

Upstream 100 bases:

>100_bases
AATTTCCTTGGGGGTGTAGCAATCTGGTGAATGCACCAAACTCATAATTTGGCTAAGGCGAGTTCGATCCTCGCCACCCC
CATTATTCATTTGTCATAGA

Downstream 100 bases:

>100_bases
ATGTGACTCCCCATGGAGGATAATGATAATGAATATATGGATTTAAAATTATGCAACCAACCTCATCACCCGTAAAGGTT
GGAGTCATAGGTATAGGAAA

Product: hemolysin-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MKITLLFFLLFLPAFFAASELSFLLIRPSKVLRLIEEKKKGAFSILKIQKRFRSSLIASQFGVTISLVAIGWLSNNLAND
YWKSNNLSDRFYDLLLFLFVVLVVTLISGLIPKALVINNPESAALRLTTIFDAVRKSMNPIVKTIGFFASACLGLFNLNN
KWDSLNSGLSAGELETLIETDNVTGLKPDEKNILEGVFALKDTQVKEVMIPRSEMVTLPKNITFSELMKQVDKTRHARFF
VIGESLDDVLGVLDLRYLAKPISKGEMEADTSLEPFLLPVTKIIETCSLAEIFPIVRDYNPFLLVVDEHGGTEGLITAAD
LNGEIVGEEMLNNRIYSDMRMLDNLSKKWSIAGKSEIIEINKKIGCSIPEGIDYHTLAGFMLEKFQMVPKIGDVLDFNNI
KFEVISMSGPKIDRVKIILPKS

Sequences:

>Translated_422_residues
MKITLLFFLLFLPAFFAASELSFLLIRPSKVLRLIEEKKKGAFSILKIQKRFRSSLIASQFGVTISLVAIGWLSNNLAND
YWKSNNLSDRFYDLLLFLFVVLVVTLISGLIPKALVINNPESAALRLTTIFDAVRKSMNPIVKTIGFFASACLGLFNLNN
KWDSLNSGLSAGELETLIETDNVTGLKPDEKNILEGVFALKDTQVKEVMIPRSEMVTLPKNITFSELMKQVDKTRHARFF
VIGESLDDVLGVLDLRYLAKPISKGEMEADTSLEPFLLPVTKIIETCSLAEIFPIVRDYNPFLLVVDEHGGTEGLITAAD
LNGEIVGEEMLNNRIYSDMRMLDNLSKKWSIAGKSEIIEINKKIGCSIPEGIDYHTLAGFMLEKFQMVPKIGDVLDFNNI
KFEVISMSGPKIDRVKIILPKS
>Mature_422_residues
MKITLLFFLLFLPAFFAASELSFLLIRPSKVLRLIEEKKKGAFSILKIQKRFRSSLIASQFGVTISLVAIGWLSNNLAND
YWKSNNLSDRFYDLLLFLFVVLVVTLISGLIPKALVINNPESAALRLTTIFDAVRKSMNPIVKTIGFFASACLGLFNLNN
KWDSLNSGLSAGELETLIETDNVTGLKPDEKNILEGVFALKDTQVKEVMIPRSEMVTLPKNITFSELMKQVDKTRHARFF
VIGESLDDVLGVLDLRYLAKPISKGEMEADTSLEPFLLPVTKIIETCSLAEIFPIVRDYNPFLLVVDEHGGTEGLITAAD
LNGEIVGEEMLNNRIYSDMRMLDNLSKKWSIAGKSEIIEINKKIGCSIPEGIDYHTLAGFMLEKFQMVPKIGDVLDFNNI
KFEVISMSGPKIDRVKIILPKS

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=384, Percent_Identity=21.6145833333333, Blast_Score=99, Evalue=7e-21,
Organism=Escherichia coli, GI1790664, Length=435, Percent_Identity=22.9885057471264, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1786879, Length=288, Percent_Identity=27.4305555555556, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI145693175, Length=419, Percent_Identity=24.8210023866348, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI87082033, Length=259, Percent_Identity=25.0965250965251, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788119, Length=235, Percent_Identity=21.7021276595745, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 47224; Mature: 47224

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITLLFFLLFLPAFFAASELSFLLIRPSKVLRLIEEKKKGAFSILKIQKRFRSSLIASQ
CCHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
FGVTISLVAIGWLSNNLANDYWKSNNLSDRFYDLLLFLFVVLVVTLISGLIPKALVINNP
HCCEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
ESAALRLTTIFDAVRKSMNPIVKTIGFFASACLGLFNLNNKWDSLNSGLSAGELETLIET
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHCC
DNVTGLKPDEKNILEGVFALKDTQVKEVMIPRSEMVTLPKNITFSELMKQVDKTRHARFF
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCHHHEECCCCCCHHHHHHHHHHHHCCEEE
VIGESLDDVLGVLDLRYLAKPISKGEMEADTSLEPFLLPVTKIIETCSLAEIFPIVRDYN
EECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
PFLLVVDEHGGTEGLITAADLNGEIVGEEMLNNRIYSDMRMLDNLSKKWSIAGKSEIIEI
CEEEEEECCCCCCCEEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEE
NKKIGCSIPEGIDYHTLAGFMLEKFQMVPKIGDVLDFNNIKFEVISMSGPKIDRVKIILP
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEEEEEC
KS
CC
>Mature Secondary Structure
MKITLLFFLLFLPAFFAASELSFLLIRPSKVLRLIEEKKKGAFSILKIQKRFRSSLIASQ
CCHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
FGVTISLVAIGWLSNNLANDYWKSNNLSDRFYDLLLFLFVVLVVTLISGLIPKALVINNP
HCCEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
ESAALRLTTIFDAVRKSMNPIVKTIGFFASACLGLFNLNNKWDSLNSGLSAGELETLIET
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHCC
DNVTGLKPDEKNILEGVFALKDTQVKEVMIPRSEMVTLPKNITFSELMKQVDKTRHARFF
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCHHHEECCCCCCHHHHHHHHHHHHCCEEE
VIGESLDDVLGVLDLRYLAKPISKGEMEADTSLEPFLLPVTKIIETCSLAEIFPIVRDYN
EECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
PFLLVVDEHGGTEGLITAADLNGEIVGEEMLNNRIYSDMRMLDNLSKKWSIAGKSEIIEI
CEEEEEECCCCCCCEEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEE
NKKIGCSIPEGIDYHTLAGFMLEKFQMVPKIGDVLDFNNIKFEVISMSGPKIDRVKIILP
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEEEEEC
KS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 8969508; 7608059 [H]