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The map label for this gene is accB [H]

Identifier: 123967563

GI number: 123967563

Start: 27779

End: 28285

Strand: Direct

Name: accB [H]

Synonym: A9601_00261

Alternate gene names: 123967563

Gene position: 27779-28285 (Clockwise)

Preceding gene: 123967562

Following gene: 123967566

Centisome position: 1.66

GC content: 35.7

Gene sequence:

>507_bases
ATGGCTATGAAATTAGATCATGAAGACTTAAATCGCTTAATAGAGAAAATCTCTGCAAGTGATATACAAGAGTTCTCGCT
AGAGGGAGAAGATTTTAAACTCGAAATAAAAAGGAATCTATATGATCAGAACCAAGTTTTAAATAATTTAGTTTCTAATA
CTTCATTTGATAAGCAAACAAATGCTAATCAAAAAACTATTAACGATAATATTCCAGCTGTTAATGAGCCTGAAGTACCT
CTGGTAGCGCCCCCAGGAAGCTCTGACCTAACTGAAATCACATCTCCTATGGTTGGTACATTTTATAGGGCTGCAGCGCC
TGGTGAGGAGCCATTCGTCGAAGTAGGAAATAATGTTAAGGTTGGCCAAACTATTTGTATTTTGGAAGCAATGAAGTTAA
TGAATGAAATTGAATCTGAATTTAATGCTGAAATTGTAGAGATTCTCGTTGAAAATGGGACGCCAGTTGAATTTGGTCAA
GTTCTAATGCGTGTTAAGCAATCTTGA

Upstream 100 bases:

>100_bases
TAGAGACAGGTGCTCAAGTTATGGTTCCTTTATTTATTTCTGTGGGAGAAATGATTAGAGTTGATACTCGTAATGACAGT
TACCTAGGACGTGAAAATTA

Downstream 100 bases:

>100_bases
ATTTTTAGTCATTTCTATTGCAGTCTTTATAGCCTCAATCATGCTTTGAGATTGAGCAATTCCTTTGCCAGCAATATCAA
ATCCCGTTCCATGATCTGGA

Product: biotin / lipoyl attachment:Acetyl-CoA biotin carboxyl carrier subunit

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MAMKLDHEDLNRLIEKISASDIQEFSLEGEDFKLEIKRNLYDQNQVLNNLVSNTSFDKQTNANQKTINDNIPAVNEPEVP
LVAPPGSSDLTEITSPMVGTFYRAAAPGEEPFVEVGNNVKVGQTICILEAMKLMNEIESEFNAEIVEILVENGTPVEFGQ
VLMRVKQS

Sequences:

>Translated_168_residues
MAMKLDHEDLNRLIEKISASDIQEFSLEGEDFKLEIKRNLYDQNQVLNNLVSNTSFDKQTNANQKTINDNIPAVNEPEVP
LVAPPGSSDLTEITSPMVGTFYRAAAPGEEPFVEVGNNVKVGQTICILEAMKLMNEIESEFNAEIVEILVENGTPVEFGQ
VLMRVKQS
>Mature_167_residues
AMKLDHEDLNRLIEKISASDIQEFSLEGEDFKLEIKRNLYDQNQVLNNLVSNTSFDKQTNANQKTINDNIPAVNEPEVPL
VAPPGSSDLTEITSPMVGTFYRAAAPGEEPFVEVGNNVKVGQTICILEAMKLMNEIESEFNAEIVEILVENGTPVEFGQV
LMRVKQS

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789653, Length=166, Percent_Identity=34.3373493975904, Blast_Score=90, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: NA

Molecular weight: Translated: 18684; Mature: 18553

Theoretical pI: Translated: 4.06; Mature: 4.06

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMKLDHEDLNRLIEKISASDIQEFSLEGEDFKLEIKRNLYDQNQVLNNLVSNTSFDKQT
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHCHHHHHHHHHHHCCCCCCCC
NANQKTINDNIPAVNEPEVPLVAPPGSSDLTEITSPMVGTFYRAAAPGEEPFVEVGNNVK
CCCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCC
VGQTICILEAMKLMNEIESEFNAEIVEILVENGTPVEFGQVLMRVKQS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
AMKLDHEDLNRLIEKISASDIQEFSLEGEDFKLEIKRNLYDQNQVLNNLVSNTSFDKQT
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHCHHHHHHHHHHHCCCCCCCC
NANQKTINDNIPAVNEPEVPLVAPPGSSDLTEITSPMVGTFYRAAAPGEEPFVEVGNNVK
CCCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCC
VGQTICILEAMKLMNEIESEFNAEIVEILVENGTPVEFGQVLMRVKQS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]