Click here to switch to the map view.

The map label for this gene is folB [H]

Identifier: 121999123

GI number: 121999123

Start: 2570015

End: 2570371

Strand: Reverse

Name: folB [H]

Synonym: Hhal_2345

Alternate gene names: 121999123

Gene position: 2570371-2570015 (Counterclockwise)

Preceding gene: 121999130

Following gene: 121999122

Centisome position: 95.96

GC content: 66.11

Gene sequence:

>357_bases
ATGGATACCGTCTTCATTCGCGGCCTGCAGGTCGAGACCGTCATCGGCATCTTCGAGTGGGAACGGCGCATCCGCCAGCG
GGTGCGTATTGACCTGGAGATGTCCGCCGACGTCGCTCGGGCTGCGGCTACCGACTCCATCGACGACGCCCTCGATTACA
AGGCCATCGGCAAGCGGATCATCGGGTTCGTCGGGGAGAGTGAGTTCCTGCTCGTGGAGACGCTGGCCGAGGAAGTGGCG
AAGATCGTTCGCGACGAGTTCGGCGTGGCGTGGCTGCGGCTCTCGGTGAGCAAGCCCGGCGCGCTGCGCGGCGCGGACGA
CGTAGGCGTGACCATCGAGCGAGGCGAGCGGCGTTGA

Upstream 100 bases:

>100_bases
TGCCGCCGGGTTGCTTCTAGCCGCTGTTGAGTGTCGTGGCCGGGGCGGGGGTGCTGACGCGGCTTGCAAGTTGCCATCTG
CAACCGGAGACTGTGCGCCC

Downstream 100 bases:

>100_bases
GACAGGCGTATCTGAGCATCGGCAGCAACATCGATCGCGACCGCAACATCCGTTCGGCCATGGCGGAACTGCGCGTGCGC
TGGCCGGACATGGTCTTCTC

Product: dihydroneopterin aldolase

Products: NA

Alternate protein names: DHNA [H]

Number of amino acids: Translated: 118; Mature: 118

Protein sequence:

>118_residues
MDTVFIRGLQVETVIGIFEWERRIRQRVRIDLEMSADVARAAATDSIDDALDYKAIGKRIIGFVGESEFLLVETLAEEVA
KIVRDEFGVAWLRLSVSKPGALRGADDVGVTIERGERR

Sequences:

>Translated_118_residues
MDTVFIRGLQVETVIGIFEWERRIRQRVRIDLEMSADVARAAATDSIDDALDYKAIGKRIIGFVGESEFLLVETLAEEVA
KIVRDEFGVAWLRLSVSKPGALRGADDVGVTIERGERR
>Mature_118_residues
MDTVFIRGLQVETVIGIFEWERRIRQRVRIDLEMSADVARAAATDSIDDALDYKAIGKRIIGFVGESEFLLVETLAEEVA
KIVRDEFGVAWLRLSVSKPGALRGADDVGVTIERGERR

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimeriza

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

Organism=Escherichia coli, GI87082204, Length=117, Percent_Identity=43.5897435897436, Blast_Score=102, Evalue=5e-24,
Organism=Escherichia coli, GI1788641, Length=107, Percent_Identity=34.5794392523364, Blast_Score=69, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: =4.1.2.25 [H]

Molecular weight: Translated: 13221; Mature: 13221

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTVFIRGLQVETVIGIFEWERRIRQRVRIDLEMSADVARAAATDSIDDALDYKAIGKRI
CCCEEEECEEHHHHHHHHHHHHHHHHHHEECEECCCHHHHHHHCCCHHHHHHHHHHHHHH
IGFVGESEFLLVETLAEEVAKIVRDEFGVAWLRLSVSKPGALRGADDVGVTIERGERR
HHHCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCEEECCCCCC
>Mature Secondary Structure
MDTVFIRGLQVETVIGIFEWERRIRQRVRIDLEMSADVARAAATDSIDDALDYKAIGKRI
CCCEEEECEEHHHHHHHHHHHHHHHHHHEECEECCCHHHHHHHCCCHHHHHHHHHHHHHH
IGFVGESEFLLVETLAEEVAKIVRDEFGVAWLRLSVSKPGALRGADDVGVTIERGERR
HHHCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]