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The map label for this gene is folK [H]

Identifier: 121999122

GI number: 121999122

Start: 2569530

End: 2570018

Strand: Reverse

Name: folK [H]

Synonym: Hhal_2344

Alternate gene names: 121999122

Gene position: 2570018-2569530 (Counterclockwise)

Preceding gene: 121999123

Following gene: 121999117

Centisome position: 95.95

GC content: 68.71

Gene sequence:

>489_bases
TTGAGACAGGCGTATCTGAGCATCGGCAGCAACATCGATCGCGACCGCAACATCCGTTCGGCCATGGCGGAACTGCGCGT
GCGCTGGCCGGACATGGTCTTCTCCACCGTCTACGAGACGGCGGCGGTGGGCTTCGAGGGCGAGGACTTCTACAACCTGG
TGGCTAGCTTCCGGGCCGAGGAGTCGCTGGAGGACGTCCTCGACACCCTGCGCGAGCTGGAAGACGCCCACGGCCGGCAC
CGTGCCGGCGGGAAGTTCTCGGCGCGGACCCTCGATCTGGACCTGCTGCTCTGGGGGGATGCGGTCATCGACGGCGATCC
GGTCACCCTGCCCCGGGGCGAGATCCTCCAGTTCGACTTCGTCCTCCGACCGCTGGCCGAACTGGCCCCCGAGGCCCGCC
ACCCGCTCAACGGCGAGTGCTTCCGCGACCTGTGGGCCGGCTTTACCGGCCACCCCTCCATCCGCCGTTCCGTGCCCCTG
GCCGACTAG

Upstream 100 bases:

>100_bases
ACGAGTTCGGCGTGGCGTGGCTGCGGCTCTCGGTGAGCAAGCCCGGCGCGCTGCGCGGCGCGGACGACGTAGGCGTGACC
ATCGAGCGAGGCGAGCGGCG

Downstream 100 bases:

>100_bases
CGCCTGCGCCCTGGCCGGGTGTAGGGGTTGGGGGCGTCGGGGTCGGGGCGCGTCTTGAAGCGGCGGTGCAGCCACAGGTA
CTGCTCCGGCGCCTGCCGGA

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MRQAYLSIGSNIDRDRNIRSAMAELRVRWPDMVFSTVYETAAVGFEGEDFYNLVASFRAEESLEDVLDTLRELEDAHGRH
RAGGKFSARTLDLDLLLWGDAVIDGDPVTLPRGEILQFDFVLRPLAELAPEARHPLNGECFRDLWAGFTGHPSIRRSVPL
AD

Sequences:

>Translated_162_residues
MRQAYLSIGSNIDRDRNIRSAMAELRVRWPDMVFSTVYETAAVGFEGEDFYNLVASFRAEESLEDVLDTLRELEDAHGRH
RAGGKFSARTLDLDLLLWGDAVIDGDPVTLPRGEILQFDFVLRPLAELAPEARHPLNGECFRDLWAGFTGHPSIRRSVPL
AD
>Mature_162_residues
MRQAYLSIGSNIDRDRNIRSAMAELRVRWPDMVFSTVYETAAVGFEGEDFYNLVASFRAEESLEDVLDTLRELEDAHGRH
RAGGKFSARTLDLDLLLWGDAVIDGDPVTLPRGEILQFDFVLRPLAELAPEARHPLNGECFRDLWAGFTGHPSIRRSVPL
AD

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=148, Percent_Identity=30.4054054054054, Blast_Score=70, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18260; Mature: 18260

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQAYLSIGSNIDRDRNIRSAMAELRVRWPDMVFSTVYETAAVGFEGEDFYNLVASFRAE
CCCCHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
ESLEDVLDTLRELEDAHGRHRAGGKFSARTLDLDLLLWGDAVIDGDPVTLPRGEILQFDF
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCEEECCCCCCCCCCCHHHHHH
VLRPLAELAPEARHPLNGECFRDLWAGFTGHPSIRRSVPLAD
HHHHHHHHCHHHCCCCCCHHHHHHHCCCCCCCCHHCCCCCCC
>Mature Secondary Structure
MRQAYLSIGSNIDRDRNIRSAMAELRVRWPDMVFSTVYETAAVGFEGEDFYNLVASFRAE
CCCCHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
ESLEDVLDTLRELEDAHGRHRAGGKFSARTLDLDLLLWGDAVIDGDPVTLPRGEILQFDF
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCEEECCCCCCCCCCCHHHHHH
VLRPLAELAPEARHPLNGECFRDLWAGFTGHPSIRRSVPLAD
HHHHHHHHCHHHCCCCCCHHHHHHHCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]