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The map label for this gene is aroB

Identifier: 121999036

GI number: 121999036

Start: 2479301

End: 2480365

Strand: Reverse

Name: aroB

Synonym: Hhal_2257

Alternate gene names: 121999036

Gene position: 2480365-2479301 (Counterclockwise)

Preceding gene: 121999037

Following gene: 121999032

Centisome position: 92.6

GC content: 69.39

Gene sequence:

>1065_bases
ATGCGGACACAATGGGTCGAGCTCGGGGAGCGCAGTTACCCGATCTACATCGGGGACGGAGTGCTGGATCAGGGGGTGCT
GGCCGAGCATCTGGTGGCGGATCGGGCGCTGCTGGTCAGCAACGAGACCGTGGCACCGCTCTACGCCGAGCGCCTGGCCG
TTCCGGGTGCCGAGGTGCAGTCGGTGACCCTGCACGACGGCGAGCGCTACAAGACCCTGCAGACCTGTGAGCAGGTCTAT
GACGCCTTGATCGAGGGGCGCTTCGACCGTTCGGCCACGGTGATCGCCCTCGGCGGTGGCGTGGTCGGTGATATGGCCGG
CTTCTGTGCGGCTACCTACCAGCGCGGGGTGGGCTACATCCAGGTGCCCACGACGCTGTTGGCCCAGGTCGACTCCTCGG
TGGGCGGCAAGACCGGGGTCAACCATCCGCGTGGCAAGAACATGATCGGCGCCTTCCACCAGCCGCGTGCCGTGGTGGCG
GATACGGGGGTCCTCGCCACCCTGCCCGAGCGCGAATACAACGCCGGCCTGGCCGAGGTCGTCAAGTACGGCCTGATCCG
CGATCCCGCCTTCTTCGACTGGCTCGAGGCGCATGTCGATGCCCTGCGGCGCCGCGACCCCGAGGCCCTGGCCCACGCCG
TGGCCGAGTCGTGCCGCAACAAGGCCGAGGTGGTCGCCGCTGACGAGCGGGAGGCCGGTGAGCGTGCGCTGCTCAACCTC
GGCCACACCTTCGGCCACGCCATCGAGACCTACACCGACTACTGCACCTGGCTCCACGGCGAGGCCGTGGCGGCCGGGAT
GGTCATGGCGGCGCGCATGTCGGTGCGCCTGGGTTGGCTGCAGCGCAACGGGCTGGAGCGCACCATCGCCCTGCTTGAGG
CCTTCGGCCTGCCCACGCGGCCGCCCGCCATCCCCGAGGCCCGCTTCCGTGAGCTGATGAGTGTCGACAAGAAGAACCGG
GGTGGCCAGTTGCGCCTGGTGCTCCTGCGCAGTGTCGGCGATGCCGTGGTCACCGGCGAGTTTGCCCCGGAGGCGCTGAC
CGACACCCTGGTCGAGGCGGTCTAG

Upstream 100 bases:

>100_bases
GAGCGTGGCGCGGCGGATCGTCGAGGCGCTGCAGGGGCAGCCCTCCTAGTCGATGACGATGAGACGGATGAACGAGAGCG
GACAGGCAGCAGGAGCGGGC

Downstream 100 bases:

>100_bases
GTCAGCTCCTCGGGGCGGAACAGCCGGCGATACTCTTCGATGGCGAACCGGTCGGTCATGCCGGCGATGTAATCGGCCAC
GGCACGGGCCCGTCCGGGCA

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MRTQWVELGERSYPIYIGDGVLDQGVLAEHLVADRALLVSNETVAPLYAERLAVPGAEVQSVTLHDGERYKTLQTCEQVY
DALIEGRFDRSATVIALGGGVVGDMAGFCAATYQRGVGYIQVPTTLLAQVDSSVGGKTGVNHPRGKNMIGAFHQPRAVVA
DTGVLATLPEREYNAGLAEVVKYGLIRDPAFFDWLEAHVDALRRRDPEALAHAVAESCRNKAEVVAADEREAGERALLNL
GHTFGHAIETYTDYCTWLHGEAVAAGMVMAARMSVRLGWLQRNGLERTIALLEAFGLPTRPPAIPEARFRELMSVDKKNR
GGQLRLVLLRSVGDAVVTGEFAPEALTDTLVEAV

Sequences:

>Translated_354_residues
MRTQWVELGERSYPIYIGDGVLDQGVLAEHLVADRALLVSNETVAPLYAERLAVPGAEVQSVTLHDGERYKTLQTCEQVY
DALIEGRFDRSATVIALGGGVVGDMAGFCAATYQRGVGYIQVPTTLLAQVDSSVGGKTGVNHPRGKNMIGAFHQPRAVVA
DTGVLATLPEREYNAGLAEVVKYGLIRDPAFFDWLEAHVDALRRRDPEALAHAVAESCRNKAEVVAADEREAGERALLNL
GHTFGHAIETYTDYCTWLHGEAVAAGMVMAARMSVRLGWLQRNGLERTIALLEAFGLPTRPPAIPEARFRELMSVDKKNR
GGQLRLVLLRSVGDAVVTGEFAPEALTDTLVEAV
>Mature_354_residues
MRTQWVELGERSYPIYIGDGVLDQGVLAEHLVADRALLVSNETVAPLYAERLAVPGAEVQSVTLHDGERYKTLQTCEQVY
DALIEGRFDRSATVIALGGGVVGDMAGFCAATYQRGVGYIQVPTTLLAQVDSSVGGKTGVNHPRGKNMIGAFHQPRAVVA
DTGVLATLPEREYNAGLAEVVKYGLIRDPAFFDWLEAHVDALRRRDPEALAHAVAESCRNKAEVVAADEREAGERALLNL
GHTFGHAIETYTDYCTWLHGEAVAAGMVMAARMSVRLGWLQRNGLERTIALLEAFGLPTRPPAIPEARFRELMSVDKKNR
GGQLRLVLLRSVGDAVVTGEFAPEALTDTLVEAV

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=354, Percent_Identity=53.3898305084746, Blast_Score=328, Evalue=4e-91,
Organism=Saccharomyces cerevisiae, GI6320332, Length=341, Percent_Identity=38.41642228739, Blast_Score=202, Evalue=6e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_HALHL (A1WZA9)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003823.1
- ProteinModelPortal:   A1WZA9
- SMR:   A1WZA9
- STRING:   A1WZA9
- GeneID:   4709139
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_2257
- eggNOG:   COG0337
- HOGENOM:   HBG632303
- OMA:   CEIKAEV
- PhylomeDB:   A1WZA9
- BioCyc:   HHAL349124:HHAL_2257-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 38390; Mature: 38390

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTQWVELGERSYPIYIGDGVLDQGVLAEHLVADRALLVSNETVAPLYAERLAVPGAEVQ
CCCCHHHCCCCCCCEEECCCCCCCHHHHHHHHHCCCEEECCCCCHHHHHHHHCCCCCCEE
SVTLHDGERYKTLQTCEQVYDALIEGRFDRSATVIALGGGVVGDMAGFCAATYQRGVGYI
EEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEE
QVPTTLLAQVDSSVGGKTGVNHPRGKNMIGAFHQPRAVVADTGVLATLPEREYNAGLAEV
EHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEECCCCHHCCCHHHH
VKYGLIRDPAFFDWLEAHVDALRRRDPEALAHAVAESCRNKAEVVAADEREAGERALLNL
HHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHH
GHTFGHAIETYTDYCTWLHGEAVAAGMVMAARMSVRLGWLQRNGLERTIALLEAFGLPTR
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
PPAIPEARFRELMSVDKKNRGGQLRLVLLRSVGDAVVTGEFAPEALTDTLVEAV
CCCCCHHHHHHHHHHHCCCCCCCEEEEEEHHCCCEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure
MRTQWVELGERSYPIYIGDGVLDQGVLAEHLVADRALLVSNETVAPLYAERLAVPGAEVQ
CCCCHHHCCCCCCCEEECCCCCCCHHHHHHHHHCCCEEECCCCCHHHHHHHHCCCCCCEE
SVTLHDGERYKTLQTCEQVYDALIEGRFDRSATVIALGGGVVGDMAGFCAATYQRGVGYI
EEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEE
QVPTTLLAQVDSSVGGKTGVNHPRGKNMIGAFHQPRAVVADTGVLATLPEREYNAGLAEV
EHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEECCCCHHCCCHHHH
VKYGLIRDPAFFDWLEAHVDALRRRDPEALAHAVAESCRNKAEVVAADEREAGERALLNL
HHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHH
GHTFGHAIETYTDYCTWLHGEAVAAGMVMAARMSVRLGWLQRNGLERTIALLEAFGLPTR
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
PPAIPEARFRELMSVDKKNRGGQLRLVLLRSVGDAVVTGEFAPEALTDTLVEAV
CCCCCHHHHHHHHHHHCCCCCCCEEEEEEHHCCCEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA