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The map label for this gene is aroK

Identifier: 121999037

GI number: 121999037

Start: 2480417

End: 2480950

Strand: Reverse

Name: aroK

Synonym: Hhal_2258

Alternate gene names: 121999037

Gene position: 2480950-2480417 (Counterclockwise)

Preceding gene: 121999040

Following gene: 121999036

Centisome position: 92.63

GC content: 71.16

Gene sequence:

>534_bases
ATGGCACACTGGAGAACACCGTCGCGGATCTTTCTGGTCGGCCCCATGGGGGCAGGCAAGAGCACTGTAGGGCGCGAGCT
GGCCAACCTGCTGGGTCTGGAGTTCATCGATAGCGATGCCGCCATCGAGGCGCGCACCGGGGTGAGCATCCCGTGGATCT
TCGATATCGAGGGCGAGGCCGGGTTCCGGGCCCGCGAAGCGGCAGTGATCGACGAGCTGACGGGCCGGGACGGCGTCGTG
GTGGCCACCGGCGGCGGTGCGGTCACGACGCCGGCCAACCGTGACCTGCTGGGCGCGCGGGGGGTGGTGGTCTACCTGTA
CACGCCGGTATCGGTGCAGCTGCAGCGCACCCGCCACGACACCAACCGTCCGCTCCTGCAGAGTGACGACCCCGAGGCGC
GGCTGCAGAGCCTGCTCGCCGAGCGGGATCCGCTCTACCGGGAGGTGGCCGACGTGGTGGTGGAGACGACCGGCGGGCGG
GCGCGGAGCGTGGCGCGGCGGATCGTCGAGGCGCTGCAGGGGCAGCCCTCCTAG

Upstream 100 bases:

>100_bases
TCGAAGAGGATGTGCTGACGGCCTTGGCGCGTTTGTTGCGGATCCATGGCCGCCTACTCTGCCATACCGAGCCCCGTGTC
GGTGGTGGTAAAGTGCCGTC

Downstream 100 bases:

>100_bases
TCGATGACGATGAGACGGATGAACGAGAGCGGACAGGCAGCAGGAGCGGGCATGCGGACACAATGGGTCGAGCTCGGGGA
GCGCAGTTACCCGATCTACA

Product: shikimate kinase

Products: NA

Alternate protein names: SK

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MAHWRTPSRIFLVGPMGAGKSTVGRELANLLGLEFIDSDAAIEARTGVSIPWIFDIEGEAGFRAREAAVIDELTGRDGVV
VATGGGAVTTPANRDLLGARGVVVYLYTPVSVQLQRTRHDTNRPLLQSDDPEARLQSLLAERDPLYREVADVVVETTGGR
ARSVARRIVEALQGQPS

Sequences:

>Translated_177_residues
MAHWRTPSRIFLVGPMGAGKSTVGRELANLLGLEFIDSDAAIEARTGVSIPWIFDIEGEAGFRAREAAVIDELTGRDGVV
VATGGGAVTTPANRDLLGARGVVVYLYTPVSVQLQRTRHDTNRPLLQSDDPEARLQSLLAERDPLYREVADVVVETTGGR
ARSVARRIVEALQGQPS
>Mature_176_residues
AHWRTPSRIFLVGPMGAGKSTVGRELANLLGLEFIDSDAAIEARTGVSIPWIFDIEGEAGFRAREAAVIDELTGRDGVVV
ATGGGAVTTPANRDLLGARGVVVYLYTPVSVQLQRTRHDTNRPLLQSDDPEARLQSLLAERDPLYREVADVVVETTGGRA
RSVARRIVEALQGQPS

Specific function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate

COG id: COG0703

COG function: function code E; Shikimate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate kinase family

Homologues:

Organism=Escherichia coli, GI87082255, Length=174, Percent_Identity=53.448275862069, Blast_Score=182, Evalue=1e-47,
Organism=Escherichia coli, GI1786587, Length=152, Percent_Identity=40.7894736842105, Blast_Score=113, Evalue=7e-27,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): AROK_HALHL (A1WZB0)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003824.1
- ProteinModelPortal:   A1WZB0
- SMR:   A1WZB0
- STRING:   A1WZB0
- GeneID:   4709140
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_2258
- eggNOG:   COG0703
- HOGENOM:   HBG335815
- OMA:   VIYLRAN
- PhylomeDB:   A1WZB0
- ProtClustDB:   CLSK727722
- BioCyc:   HHAL349124:HHAL_2258-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00109
- InterPro:   IPR000623
- InterPro:   IPR023000
- PRINTS:   PR01100

Pfam domain/function: PF01202 SKI

EC number: =2.7.1.71

Molecular weight: Translated: 19060; Mature: 18929

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS01128 SHIKIMATE_KINASE

Important sites: BINDING 39-39 BINDING 63-63 BINDING 85-85 BINDING 123-123 BINDING 142-142 BINDING 160-160

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHWRTPSRIFLVGPMGAGKSTVGRELANLLGLEFIDSDAAIEARTGVSIPWIFDIEGEA
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEECCCCCEEECCCCCCCEEEEECCCC
GFRAREAAVIDELTGRDGVVVATGGGAVTTPANRDLLGARGVVVYLYTPVSVQLQRTRHD
CCCHHHHHHHHHHCCCCCEEEEECCCEEECCCCCCCCCCCCEEEEEECCCEEEEEECCCC
TNRPLLQSDDPEARLQSLLAERDPLYREVADVVVETTGGRARSVARRIVEALQGQPS
CCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AHWRTPSRIFLVGPMGAGKSTVGRELANLLGLEFIDSDAAIEARTGVSIPWIFDIEGEA
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEECCCCCEEECCCCCCCEEEEECCCC
GFRAREAAVIDELTGRDGVVVATGGGAVTTPANRDLLGARGVVVYLYTPVSVQLQRTRHD
CCCHHHHHHHHHHCCCCCEEEEECCCEEECCCCCCCCCCCCEEEEEECCCEEEEEECCCC
TNRPLLQSDDPEARLQSLLAERDPLYREVADVVVETTGGRARSVARRIVEALQGQPS
CCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA