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The map label for this gene is hisG

Identifier: 121998892

GI number: 121998892

Start: 2318520

End: 2319164

Strand: Reverse

Name: hisG

Synonym: Hhal_2113

Alternate gene names: 121998892

Gene position: 2319164-2318520 (Counterclockwise)

Preceding gene: 121998893

Following gene: 121998891

Centisome position: 86.59

GC content: 70.23

Gene sequence:

>645_bases
ATGAGCCGAACCCTGACCCTGGCCCTGTCCAAGGGGCGCATCCTGGAAGAGACCCTGCCGCTGCTGGCGCGCTGCGGGAT
TGAGCCCGCCGAGGATCCGGACGCCAGCCGCAAGCTGATCATCGGTACCAACCGCGAGGACGTCCGGCTGCTGGTCGTGC
GCGCCTCGGACGTGCCGACCTACGTCGAGCACGGCGGCGCCGACCTCGGTGTGGCCGGTCGGGACGTGCTCCTGGAGCAC
GGCGGCGATGGTCTCTACGACCCGGTGGATCTGGGGATCGCCCGGTGCCGGCTGATGGTGGCCGGACCGCCGGACGGACC
GCCGCCCGGGCGCCGCCCGCGCGTGGCGACCAAGTTCGTACATCTGGCCCGGCAACACTTCGCTGCGCAGGGCCGGCAGG
CCGAGATCATCAAGCTCTACGGCTCTATGGAGCTGGCGCCGCTGGTCGGCATGGCCGATCTCATCGTGGACCTGGTCGAC
ACCGGGAACACCCTGCGCGCCAACGGGCTTGCGCCGCTCGAGGAGATCATGCCGATCAGCTCGCGGCTGGTCGTCAACAA
GGCCTCCCTGAAGACCAGCCCCGACCGTCTGGGGACGCTGATCGACGATCTGGCGGCGGCGGCGCGCGCCAAGGACACCA
GTTAG

Upstream 100 bases:

>100_bases
CACATCGACCGCGGCTACGAGTGCATCGAGGAGAAGCTCGCCCAGCTCGGTGCCGATATCCAGCGCGTCCCCGACTGACG
ACGGAGACCGATCGAATACC

Downstream 100 bases:

>100_bases
CTTTATCGCGAGAGGAAAGCATGGTCGACATCAAGCGGCTGAGCACCACACAACCCGATTTCTGGGACAGCCTGGACGCC
CTGACGAGCTGGGGGAGCCA

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 214; Mature: 213

Protein sequence:

>214_residues
MSRTLTLALSKGRILEETLPLLARCGIEPAEDPDASRKLIIGTNREDVRLLVVRASDVPTYVEHGGADLGVAGRDVLLEH
GGDGLYDPVDLGIARCRLMVAGPPDGPPPGRRPRVATKFVHLARQHFAAQGRQAEIIKLYGSMELAPLVGMADLIVDLVD
TGNTLRANGLAPLEEIMPISSRLVVNKASLKTSPDRLGTLIDDLAAAARAKDTS

Sequences:

>Translated_214_residues
MSRTLTLALSKGRILEETLPLLARCGIEPAEDPDASRKLIIGTNREDVRLLVVRASDVPTYVEHGGADLGVAGRDVLLEH
GGDGLYDPVDLGIARCRLMVAGPPDGPPPGRRPRVATKFVHLARQHFAAQGRQAEIIKLYGSMELAPLVGMADLIVDLVD
TGNTLRANGLAPLEEIMPISSRLVVNKASLKTSPDRLGTLIDDLAAAARAKDTS
>Mature_213_residues
SRTLTLALSKGRILEETLPLLARCGIEPAEDPDASRKLIIGTNREDVRLLVVRASDVPTYVEHGGADLGVAGRDVLLEHG
GDGLYDPVDLGIARCRLMVAGPPDGPPPGRRPRVATKFVHLARQHFAAQGRQAEIIKLYGSMELAPLVGMADLIVDLVDT
GNTLRANGLAPLEEIMPISSRLVVNKASLKTSPDRLGTLIDDLAAAARAKDTS

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=206, Percent_Identity=34.9514563106796, Blast_Score=92, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320896, Length=152, Percent_Identity=34.2105263157895, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_HALHL (A1WYW5)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003679.1
- ProteinModelPortal:   A1WYW5
- SMR:   A1WYW5
- STRING:   A1WYW5
- GeneID:   4711266
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_2113
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- BioCyc:   HHAL349124:HHAL_2113-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 22808; Mature: 22676

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRTLTLALSKGRILEETLPLLARCGIEPAEDPDASRKLIIGTNREDVRLLVVRASDVPT
CCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCH
YVEHGGADLGVAGRDVLLEHGGDGLYDPVDLGIARCRLMVAGPPDGPPPGRRPRVATKFV
HHHCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHEEEEEECCCCCCCCCCCCHHHHHHH
HLARQHFAAQGRQAEIIKLYGSMELAPLVGMADLIVDLVDTGNTLRANGLAPLEEIMPIS
HHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHCCCC
SRLVVNKASLKTSPDRLGTLIDDLAAAARAKDTS
HHEEEEHHHCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SRTLTLALSKGRILEETLPLLARCGIEPAEDPDASRKLIIGTNREDVRLLVVRASDVPT
CCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCH
YVEHGGADLGVAGRDVLLEHGGDGLYDPVDLGIARCRLMVAGPPDGPPPGRRPRVATKFV
HHHCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHEEEEEECCCCCCCCCCCCHHHHHHH
HLARQHFAAQGRQAEIIKLYGSMELAPLVGMADLIVDLVDTGNTLRANGLAPLEEIMPIS
HHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHCCCC
SRLVVNKASLKTSPDRLGTLIDDLAAAARAKDTS
HHEEEEHHHCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA