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The map label for this gene is hisD

Identifier: 121998891

GI number: 121998891

Start: 2317180

End: 2318499

Strand: Reverse

Name: hisD

Synonym: Hhal_2112

Alternate gene names: 121998891

Gene position: 2318499-2317180 (Counterclockwise)

Preceding gene: 121998892

Following gene: 121998890

Centisome position: 86.56

GC content: 70.08

Gene sequence:

>1320_bases
ATGGTCGACATCAAGCGGCTGAGCACCACACAACCCGATTTCTGGGACAGCCTGGACGCCCTGACGAGCTGGGGGAGCCA
CCCGGGCGCCTCCATTGAGCAGCGCGTCGCCGAGGTGGTCGAGGGGGTTCGCACCGGCGGTGATGCGGCCCTGCTGGATT
ACACGCGGCGTTTCGACGGCCGCGAGGCCGATTCGGTGGCCGCGCTGGAGATCCCGACCGAGCAGGTGGTCGCGGCCCAC
GAACAGATCGCCCCGGAGATGCGCGAGGCGCTGGAGCAGGCGGCCGCGCGGATCCGCGACTACGCGCAGCGTCAGCGCCT
GGAGTCCTGGGAGTACCAGGACGCCGACGGTAACCGCCTCGGGCAGCAGGTCACCGCCCTCGACCGGGTCGGGGTCTACG
TCCCCGGCGGCAAGGCCGCCTATCCCTCATCGGTGCTGATGAACGCCGTGCCGGCCCGGGTGGCCGGCGTGCAGGAGATC
ATCATGACCGTCCCGGCCCCCGGGGGGGAGCTCTCACCACTGGTGCTGGCCGCTGCCCATGTGGCGGGCGTGGATCGCAT
CTTCACCTTGGGCGGGGCGCAGGCGGTGGCGGCCCTGGCCTACGGGACCGAGACCGTACCCGCCGTGGACAAGATCGTCG
GCCCCGGTAACGCCTATGTTGCCGAGGCCAAGCGCCGCGTCTACGGGGTGGTGGGCATCGACATGATCGCCGGCCCCTCC
GAGGTGCTGGTCATCAGCGACGGCCAGGCCGATCCCGAGTGGATCGCCATGGACCTGTTCTCCCAGGCCGAGCACGACGA
GGAGGCGCAGGCCCTGCTGGTCTGCCCGGACTTCGTCTTCCTCGATCAGGTCCAGGCGGCCATGGAGCGCCTGCTGCCGG
ATATGGAGCGTTCGGAGATCATCCGCACCTCGCTGGCGGAGCGGGGGGCGTTGATCTGTGTCCGCGATCTGGAAGAGGCG
CAGCAGGTGGCCAACTATGTCGCTCCGGAACACCTGGAGCTCTCCGTGGCCGAGCCCGATCGACTGGCCGAGGGCATCCG
TCACGCCGGGGCGATCTTCCTCGGCCATTACAGCGCCGAGTCACTGGGTGATTACTGTGCCGGCCCCAACCACACGCTGC
CGACGTCGCGGACCGCGCGGTTCGCATCGCCGTTGGGTGTCTACGACTTCCAGAAGCGTTCCACCACGCTGGCCTGCTCA
CCCGCCGGCGCCGCAGCACTGGCCGGGACCGCCGCGGTGATGGCACGGGGCGAGGGACTGACCGCCCATGCCCGCTCAGC
GGAGTACCGCGGCCAGGGGGAGGAGCGCAGCGGTGACTGA

Upstream 100 bases:

>100_bases
CCCTGAAGACCAGCCCCGACCGTCTGGGGACGCTGATCGACGATCTGGCGGCGGCGGCGCGCGCCAAGGACACCAGTTAG
CTTTATCGCGAGAGGAAAGC

Downstream 100 bases:

>100_bases
GGTCGAGGCGCGGGTCGCCCGCTGGGTGCGGCCACAGGTGCAGGCCCTGGAGGCCTATCAGGTGGCCGAGCCGGGCAAGG
CCATCAAGCTCGATGCCATG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MVDIKRLSTTQPDFWDSLDALTSWGSHPGASIEQRVAEVVEGVRTGGDAALLDYTRRFDGREADSVAALEIPTEQVVAAH
EQIAPEMREALEQAAARIRDYAQRQRLESWEYQDADGNRLGQQVTALDRVGVYVPGGKAAYPSSVLMNAVPARVAGVQEI
IMTVPAPGGELSPLVLAAAHVAGVDRIFTLGGAQAVAALAYGTETVPAVDKIVGPGNAYVAEAKRRVYGVVGIDMIAGPS
EVLVISDGQADPEWIAMDLFSQAEHDEEAQALLVCPDFVFLDQVQAAMERLLPDMERSEIIRTSLAERGALICVRDLEEA
QQVANYVAPEHLELSVAEPDRLAEGIRHAGAIFLGHYSAESLGDYCAGPNHTLPTSRTARFASPLGVYDFQKRSTTLACS
PAGAAALAGTAAVMARGEGLTAHARSAEYRGQGEERSGD

Sequences:

>Translated_439_residues
MVDIKRLSTTQPDFWDSLDALTSWGSHPGASIEQRVAEVVEGVRTGGDAALLDYTRRFDGREADSVAALEIPTEQVVAAH
EQIAPEMREALEQAAARIRDYAQRQRLESWEYQDADGNRLGQQVTALDRVGVYVPGGKAAYPSSVLMNAVPARVAGVQEI
IMTVPAPGGELSPLVLAAAHVAGVDRIFTLGGAQAVAALAYGTETVPAVDKIVGPGNAYVAEAKRRVYGVVGIDMIAGPS
EVLVISDGQADPEWIAMDLFSQAEHDEEAQALLVCPDFVFLDQVQAAMERLLPDMERSEIIRTSLAERGALICVRDLEEA
QQVANYVAPEHLELSVAEPDRLAEGIRHAGAIFLGHYSAESLGDYCAGPNHTLPTSRTARFASPLGVYDFQKRSTTLACS
PAGAAALAGTAAVMARGEGLTAHARSAEYRGQGEERSGD
>Mature_439_residues
MVDIKRLSTTQPDFWDSLDALTSWGSHPGASIEQRVAEVVEGVRTGGDAALLDYTRRFDGREADSVAALEIPTEQVVAAH
EQIAPEMREALEQAAARIRDYAQRQRLESWEYQDADGNRLGQQVTALDRVGVYVPGGKAAYPSSVLMNAVPARVAGVQEI
IMTVPAPGGELSPLVLAAAHVAGVDRIFTLGGAQAVAALAYGTETVPAVDKIVGPGNAYVAEAKRRVYGVVGIDMIAGPS
EVLVISDGQADPEWIAMDLFSQAEHDEEAQALLVCPDFVFLDQVQAAMERLLPDMERSEIIRTSLAERGALICVRDLEEA
QQVANYVAPEHLELSVAEPDRLAEGIRHAGAIFLGHYSAESLGDYCAGPNHTLPTSRTARFASPLGVYDFQKRSTTLACS
PAGAAALAGTAAVMARGEGLTAHARSAEYRGQGEERSGD

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=403, Percent_Identity=40.9429280397022, Blast_Score=292, Evalue=3e-80,
Organism=Saccharomyces cerevisiae, GI6319819, Length=411, Percent_Identity=38.1995133819951, Blast_Score=258, Evalue=9e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46804; Mature: 46804

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDIKRLSTTQPDFWDSLDALTSWGSHPGASIEQRVAEVVEGVRTGGDAALLDYTRRFDG
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
READSVAALEIPTEQVVAAHEQIAPEMREALEQAAARIRDYAQRQRLESWEYQDADGNRL
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
GQQVTALDRVGVYVPGGKAAYPSSVLMNAVPARVAGVQEIIMTVPAPGGELSPLVLAAAH
HHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
VAGVDRIFTLGGAQAVAALAYGTETVPAVDKIVGPGNAYVAEAKRRVYGVVGIDMIAGPS
HHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHEEEEEHHEECCCC
EVLVISDGQADPEWIAMDLFSQAEHDEEAQALLVCPDFVFLDQVQAAMERLLPDMERSEI
CEEEEECCCCCHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCHHHHH
IRTSLAERGALICVRDLEEAQQVANYVAPEHLELSVAEPDRLAEGIRHAGAIFLGHYSAE
HHHHHHHCCCEEEEHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCEEEEECCCHH
SLGDYCAGPNHTLPTSRTARFASPLGVYDFQKRSTTLACSPAGAAALAGTAAVMARGEGL
HHHHHCCCCCCCCCCCCHHHHCCCCCCCCHHCCCCEEEECCCCHHHHHHHHHHHCCCCCC
TAHARSAEYRGQGEERSGD
EECCCCCHHCCCCCCCCCC
>Mature Secondary Structure
MVDIKRLSTTQPDFWDSLDALTSWGSHPGASIEQRVAEVVEGVRTGGDAALLDYTRRFDG
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
READSVAALEIPTEQVVAAHEQIAPEMREALEQAAARIRDYAQRQRLESWEYQDADGNRL
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
GQQVTALDRVGVYVPGGKAAYPSSVLMNAVPARVAGVQEIIMTVPAPGGELSPLVLAAAH
HHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
VAGVDRIFTLGGAQAVAALAYGTETVPAVDKIVGPGNAYVAEAKRRVYGVVGIDMIAGPS
HHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHEEEEEHHEECCCC
EVLVISDGQADPEWIAMDLFSQAEHDEEAQALLVCPDFVFLDQVQAAMERLLPDMERSEI
CEEEEECCCCCHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCHHHHH
IRTSLAERGALICVRDLEEAQQVANYVAPEHLELSVAEPDRLAEGIRHAGAIFLGHYSAE
HHHHHHHCCCEEEEHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCEEEEECCCHH
SLGDYCAGPNHTLPTSRTARFASPLGVYDFQKRSTTLACSPAGAAALAGTAAVMARGEGL
HHHHHCCCCCCCCCCCCHHHHCCCCCCCCHHCCCCEEEECCCCHHHHHHHHHHHCCCCCC
TAHARSAEYRGQGEERSGD
EECCCCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA