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The map label for this gene is htpX

Identifier: 121998760

GI number: 121998760

Start: 2182649

End: 2183542

Strand: Reverse

Name: htpX

Synonym: Hhal_1981

Alternate gene names: 121998760

Gene position: 2183542-2182649 (Counterclockwise)

Preceding gene: 121998761

Following gene: 121998758

Centisome position: 81.52

GC content: 64.32

Gene sequence:

>894_bases
ATGCTGACCCGGATCGCGTTACTGTTGGCGACCAACATCGCTGTGGTGTTGGTGCTGTCGATCATCCTCAACCTGCTCGG
CGTTGAGCAGTTCCTCCGCGAGCAAGGCATCGACGCGGAGATGGTCACGCTGCTGATCTTCGCCGCCGGCATCGGCTTTG
CCGGCTCCTTCATCTCGCTGGCCATGTCCAAGTACATGGCGATGAAGATGATGGGTGCCAAGCCCATCGAGAGCCCGCGC
GGCGAGCAGGAGCAGTGGCTGGTGGAGACCGTCCGCCGCTTCGCCCAGCGCGAGGGCATCGGCATGCCCGATGTGGCAAT
CTACGACGCCCCGGAGATCAACGCCTTTGCCACCGGTGCCCGGCGCAACAGCGCCCTAGTGGCGGTCAGCTCGGGGCTGC
TGCAGAACATGACCCGCGACGAGGCCGAGGCGGTCATCGCCCACGAGGTGGCCCACGTCTCCAACGGTGACATGGTCACT
CTGACCCTGATCCAGGGCGTGGTGAACACCTTCGTGATCTTCCTCTCGCACGTTGCCGGGCGCTTCGTCGATCGGGTGGT
GTTCAAGAATGAGGGCGGTCACGGCCCCGGCTTCTGGATCACCATGATCTTCGCTCAGATGGTCCTCGGCGTGCTGGCGT
CGATGATCACCATGTACTTCTCGCGCAAGCGCGAGTTCCGGGCGGATAGCGGTGCCGCCAAGCTGGCCGGGCGCGACAAG
ATGATCGCCGCGCTGGAGAAGCTTAAGCGCTCGGTGGAGCCGCAGAACATGCCGGACGAGATGGAGGCCTTCGGCATCAA
CGGCCGGATGGGCGGCTCGTCGATCAAACGGCTGTTCATGTCGCACCCGCCGCTGGATGAGCGCATCGAGGCGCTCAAGG
GGCGTCCGGTGTAA

Upstream 100 bases:

>100_bases
TTGAGCGGATCGACCCGGTCTTGAAACCCTGGTCGCCCAACCCAATCCAAGCGCTAGGGAGTAGGTTCCGCAGCTTGATG
AAAGAGGAGCGTTCTTAACG

Downstream 100 bases:

>100_bases
TCACCGTCTTGGCCGCCGCGCCGGGCTCCTCGCGGGCTAGGCGCGGCACCAGATAACCGGGCAAGCTCCGGGCCAGTTCC
GCCCAGAGCCGCTGCCCGGT

Product: peptidase M48, Ste24p

Products: NA

Alternate protein names: Heat shock protein HtpX

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MLTRIALLLATNIAVVLVLSIILNLLGVEQFLREQGIDAEMVTLLIFAAGIGFAGSFISLAMSKYMAMKMMGAKPIESPR
GEQEQWLVETVRRFAQREGIGMPDVAIYDAPEINAFATGARRNSALVAVSSGLLQNMTRDEAEAVIAHEVAHVSNGDMVT
LTLIQGVVNTFVIFLSHVAGRFVDRVVFKNEGGHGPGFWITMIFAQMVLGVLASMITMYFSRKREFRADSGAAKLAGRDK
MIAALEKLKRSVEPQNMPDEMEAFGINGRMGGSSIKRLFMSHPPLDERIEALKGRPV

Sequences:

>Translated_297_residues
MLTRIALLLATNIAVVLVLSIILNLLGVEQFLREQGIDAEMVTLLIFAAGIGFAGSFISLAMSKYMAMKMMGAKPIESPR
GEQEQWLVETVRRFAQREGIGMPDVAIYDAPEINAFATGARRNSALVAVSSGLLQNMTRDEAEAVIAHEVAHVSNGDMVT
LTLIQGVVNTFVIFLSHVAGRFVDRVVFKNEGGHGPGFWITMIFAQMVLGVLASMITMYFSRKREFRADSGAAKLAGRDK
MIAALEKLKRSVEPQNMPDEMEAFGINGRMGGSSIKRLFMSHPPLDERIEALKGRPV
>Mature_297_residues
MLTRIALLLATNIAVVLVLSIILNLLGVEQFLREQGIDAEMVTLLIFAAGIGFAGSFISLAMSKYMAMKMMGAKPIESPR
GEQEQWLVETVRRFAQREGIGMPDVAIYDAPEINAFATGARRNSALVAVSSGLLQNMTRDEAEAVIAHEVAHVSNGDMVT
LTLIQGVVNTFVIFLSHVAGRFVDRVVFKNEGGHGPGFWITMIFAQMVLGVLASMITMYFSRKREFRADSGAAKLAGRDK
MIAALEKLKRSVEPQNMPDEMEAFGINGRMGGSSIKRLFMSHPPLDERIEALKGRPV

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=298, Percent_Identity=53.6912751677852, Blast_Score=304, Evalue=5e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_HALHL (A1WYI3)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003547.1
- ProteinModelPortal:   A1WYI3
- SMR:   A1WYI3
- STRING:   A1WYI3
- GeneID:   4710448
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1981
- eggNOG:   COG0501
- HOGENOM:   HBG739460
- OMA:   QSANEDY
- PhylomeDB:   A1WYI3
- BioCyc:   HHAL349124:HHAL_1981-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 32504; Mature: 32504

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 149-149

Signals:

None

Transmembrane regions:

HASH(0x1b73b388)-; HASH(0x1bf02250)-; HASH(0x1ba3a3bc)-; HASH(0x1b6367d8)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.4 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.4 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTRIALLLATNIAVVLVLSIILNLLGVEQFLREQGIDAEMVTLLIFAAGIGFAGSFISL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
AMSKYMAMKMMGAKPIESPRGEQEQWLVETVRRFAQREGIGMPDVAIYDAPEINAFATGA
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHCCC
RRNSALVAVSSGLLQNMTRDEAEAVIAHEVAHVSNGDMVTLTLIQGVVNTFVIFLSHVAG
CCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHH
RFVDRVVFKNEGGHGPGFWITMIFAQMVLGVLASMITMYFSRKREFRADSGAAKLAGRDK
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHH
MIAALEKLKRSVEPQNMPDEMEAFGINGRMGGSSIKRLFMSHPPLDERIEALKGRPV
HHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCH
>Mature Secondary Structure
MLTRIALLLATNIAVVLVLSIILNLLGVEQFLREQGIDAEMVTLLIFAAGIGFAGSFISL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
AMSKYMAMKMMGAKPIESPRGEQEQWLVETVRRFAQREGIGMPDVAIYDAPEINAFATGA
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHCCC
RRNSALVAVSSGLLQNMTRDEAEAVIAHEVAHVSNGDMVTLTLIQGVVNTFVIFLSHVAG
CCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHH
RFVDRVVFKNEGGHGPGFWITMIFAQMVLGVLASMITMYFSRKREFRADSGAAKLAGRDK
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHH
MIAALEKLKRSVEPQNMPDEMEAFGINGRMGGSSIKRLFMSHPPLDERIEALKGRPV
HHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA