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The map label for this gene is parC [H]

Identifier: 121998761

GI number: 121998761

Start: 2183639

End: 2185891

Strand: Reverse

Name: parC [H]

Synonym: Hhal_1982

Alternate gene names: 121998761

Gene position: 2185891-2183639 (Counterclockwise)

Preceding gene: 121998762

Following gene: 121998760

Centisome position: 81.61

GC content: 69.68

Gene sequence:

>2253_bases
ATGTCCGAAAACGCTGCCTCCGACTTCGAGACGCAACCGCTCCGCGAGTTCACCGAGCGGGCCTACCTCGACTACTCGAT
GTACGTCATCCTCGACCGTGCGCTGCCCCACGTCTCCGACGGGCTCAAGCCGGTGCAGCGGCGGATCGTCTACGCCATGT
CCGAACTCGGGTTGTCGGCGGCGGCGAAGTACAAGAAATCGGCCCGTACCGTCGGCGACGTGCTCGGCAAGTACCACCCG
CACGGCGACGCGGCCTGCTACGAGGCCATGGTCCACATGGCCCAGCCGTTCACCTATCGCTATCCGTTGATCGACGGCCA
GGGCAACTGGGGCTCTCCGGACGATCCGAAATCCTTCGCCGCCATGCGCTACACCGAGGCGCGCCTGACCCCCTACGCCC
GCGTGCTGCTCAACGAGTTGGGGCAGGGGACAGTGGAGTGGATTCCCAACTTCGACGGCGCCCTGCAGGAGCCGGAACGC
CTGCCGGCGCGGCTGCCGAACGTGTTGCTCAACGGCGGTTCGGGGATCGCCGTGGGCATGGCCACGGATATCCCGCCCCA
CAACCTGCGCGAGGTGGTCGATGCCTGCGTCCACCTCCTCGATCGGCCCGAGGCCACCACGGCGGAGCTCTGTGAGCACG
TGCCGGCGCCGGACTTCCCCACCGCCTCGGACGTGATCACGCCGCGCGAGGAGCTGCGCACCATCTACGAGCGGGGCCAC
GGTACCGTCCGCGCGCGGGCCCGCTGGGAGTATGAGCGGGAGCAGGCGCAGATCGTCATCCACGCACTCCCTTACCAGGT
GGCCGGCGCCAAGGTCATGGAGCAGATCGCCGCCCAGATCCAGTCGCGCAAGCTGCCCATGGTCGAGGATCTGCGCGATG
AGTCGGACCACGACGCGCCGGTGCGCATCGTCGTCCAGCTCCGCTCCCGGCGCCAGGATCCGGAGCGGGTCATGGATCAC
CTGTTCGCCACCACGGATCTCGAGCGCGGCTACCGCGTCCACCTGAACGTCATCGGCCTCGACGGTCGGCCGCGGGTCTT
CTCCCTGCGCGACCTTCTGGCCGAGTGGCTGAGCTTCCGCACCGAGACGGTCCGCCGTCGCCTGACTTGGCGCTTGGAGA
AGGTGGAGGATCGGCTCCATATCCTCGAGGGCCTGCTCACCGCGTATCTGAACATCGATGAGGTCATCGCCATCATCCGC
GAGGAGGACGAGCCCAAGCCGGTGCTCATGGAGCGCTTCGGGCTCAGTGATGCCCAGGCCGAGGCGATCCTCGAGCTGCG
CCTGCGCCACTTGGCCCGTCTGGAGGAGATGAAGATCCGCGGCGAGCAGGGCGATCTGGAGCGTGAGCGCGACGAGCTGC
GCGCCACCCTTGGCGACGCCGCCCGGCTGCGCGAGCAGGTCAAGAGCGAGCTCCTCGGTGATGCCGAGGCCCACGGGGAC
GAGCGCCGCTCGCCGCTGGTCCAGCGCGGTCCGGCGCGGGCCATGGACGAGACCGAGCTGATGCCCAGCGAGCCGGTCAC
CGTGGTGCTCTCGGAGAAGGGCTGGGTCCGCGCCGCCAAGGGCCACGAGGTCGATGCGACCGGGCTCTCCTACAAGGCCG
GCGACGGCTACCTGGATCACGCCCTGGGCCGGTCGAACCAGCCGGCCATCTTCCTCGACTCCACCGGTCGGGCCTACGCG
GTCCCGGCGCATACCCTGCCGTCGGCGCGCAGCCAGGGGGAGCCGCTGACCAAGCGGCTCACGCCCCCGGAGAAGGCCCG
CTTCCAGTCGGTCCTCGCCGGCGATTCGGAGTCGCGCTGGTTGCTCGCCTCCGATGCCGGCTACGGCTTCCGTGTCCCCC
TGCGCGAGCTCTTCTCGCGCAATCGCTCCGGGAAGGCGGTGCTGACCCTGCCGGATGGGGCGGCTGTGCTCCCGCCCGTA
ACGGTGCCCGCGGAGGCCGATGGTGCCGAGGTGGTGGTGGCCAGTTCCGATGGCCGACTGCTGGTCTTCCCCCTTGAGGA
GCTGCCGGAGATGGCGCGAGGCAAGGGCAACAAGCTCATTGGCATCCCTGCCCAGCGCCTGCGCGATCGCGAGGAGGTGG
TGGTCGCCGTGGCCGTGCTGCCCGCCGGCGCAGCGCTGCGTGTGGAGGCCGGCAAGACCGGCAAGCGGCTGAGCCACAGC
GATCTGGAGGCGTTCCGCGCCGCCCGGGGCCGGCGCGGTGTTCAGTTGCCGCGCGGGCTGCGCCAGATCCGTGGGCTCCA
CGTGGAGAATTGA

Upstream 100 bases:

>100_bases
GCGCCGCAGCCCAGCGCCGCGAGTGGCTGGAGAGCAAGGGCAACCTGGCGGAAATCGTCCTTTGACCCCCTGACTACTAA
GCGCCGAACAGCAAACGACT

Downstream 100 bases:

>100_bases
GCGGATCGACCCGGTCTTGAAACCCTGGTCGCCCAACCCAATCCAAGCGCTAGGGAGTAGGTTCCGCAGCTTGATGAAAG
AGGAGCGTTCTTAACGATGC

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 750; Mature: 749

Protein sequence:

>750_residues
MSENAASDFETQPLREFTERAYLDYSMYVILDRALPHVSDGLKPVQRRIVYAMSELGLSAAAKYKKSARTVGDVLGKYHP
HGDAACYEAMVHMAQPFTYRYPLIDGQGNWGSPDDPKSFAAMRYTEARLTPYARVLLNELGQGTVEWIPNFDGALQEPER
LPARLPNVLLNGGSGIAVGMATDIPPHNLREVVDACVHLLDRPEATTAELCEHVPAPDFPTASDVITPREELRTIYERGH
GTVRARARWEYEREQAQIVIHALPYQVAGAKVMEQIAAQIQSRKLPMVEDLRDESDHDAPVRIVVQLRSRRQDPERVMDH
LFATTDLERGYRVHLNVIGLDGRPRVFSLRDLLAEWLSFRTETVRRRLTWRLEKVEDRLHILEGLLTAYLNIDEVIAIIR
EEDEPKPVLMERFGLSDAQAEAILELRLRHLARLEEMKIRGEQGDLERERDELRATLGDAARLREQVKSELLGDAEAHGD
ERRSPLVQRGPARAMDETELMPSEPVTVVLSEKGWVRAAKGHEVDATGLSYKAGDGYLDHALGRSNQPAIFLDSTGRAYA
VPAHTLPSARSQGEPLTKRLTPPEKARFQSVLAGDSESRWLLASDAGYGFRVPLRELFSRNRSGKAVLTLPDGAAVLPPV
TVPAEADGAEVVVASSDGRLLVFPLEELPEMARGKGNKLIGIPAQRLRDREEVVVAVAVLPAGAALRVEAGKTGKRLSHS
DLEAFRAARGRRGVQLPRGLRQIRGLHVEN

Sequences:

>Translated_750_residues
MSENAASDFETQPLREFTERAYLDYSMYVILDRALPHVSDGLKPVQRRIVYAMSELGLSAAAKYKKSARTVGDVLGKYHP
HGDAACYEAMVHMAQPFTYRYPLIDGQGNWGSPDDPKSFAAMRYTEARLTPYARVLLNELGQGTVEWIPNFDGALQEPER
LPARLPNVLLNGGSGIAVGMATDIPPHNLREVVDACVHLLDRPEATTAELCEHVPAPDFPTASDVITPREELRTIYERGH
GTVRARARWEYEREQAQIVIHALPYQVAGAKVMEQIAAQIQSRKLPMVEDLRDESDHDAPVRIVVQLRSRRQDPERVMDH
LFATTDLERGYRVHLNVIGLDGRPRVFSLRDLLAEWLSFRTETVRRRLTWRLEKVEDRLHILEGLLTAYLNIDEVIAIIR
EEDEPKPVLMERFGLSDAQAEAILELRLRHLARLEEMKIRGEQGDLERERDELRATLGDAARLREQVKSELLGDAEAHGD
ERRSPLVQRGPARAMDETELMPSEPVTVVLSEKGWVRAAKGHEVDATGLSYKAGDGYLDHALGRSNQPAIFLDSTGRAYA
VPAHTLPSARSQGEPLTKRLTPPEKARFQSVLAGDSESRWLLASDAGYGFRVPLRELFSRNRSGKAVLTLPDGAAVLPPV
TVPAEADGAEVVVASSDGRLLVFPLEELPEMARGKGNKLIGIPAQRLRDREEVVVAVAVLPAGAALRVEAGKTGKRLSHS
DLEAFRAARGRRGVQLPRGLRQIRGLHVEN
>Mature_749_residues
SENAASDFETQPLREFTERAYLDYSMYVILDRALPHVSDGLKPVQRRIVYAMSELGLSAAAKYKKSARTVGDVLGKYHPH
GDAACYEAMVHMAQPFTYRYPLIDGQGNWGSPDDPKSFAAMRYTEARLTPYARVLLNELGQGTVEWIPNFDGALQEPERL
PARLPNVLLNGGSGIAVGMATDIPPHNLREVVDACVHLLDRPEATTAELCEHVPAPDFPTASDVITPREELRTIYERGHG
TVRARARWEYEREQAQIVIHALPYQVAGAKVMEQIAAQIQSRKLPMVEDLRDESDHDAPVRIVVQLRSRRQDPERVMDHL
FATTDLERGYRVHLNVIGLDGRPRVFSLRDLLAEWLSFRTETVRRRLTWRLEKVEDRLHILEGLLTAYLNIDEVIAIIRE
EDEPKPVLMERFGLSDAQAEAILELRLRHLARLEEMKIRGEQGDLERERDELRATLGDAARLREQVKSELLGDAEAHGDE
RRSPLVQRGPARAMDETELMPSEPVTVVLSEKGWVRAAKGHEVDATGLSYKAGDGYLDHALGRSNQPAIFLDSTGRAYAV
PAHTLPSARSQGEPLTKRLTPPEKARFQSVLAGDSESRWLLASDAGYGFRVPLRELFSRNRSGKAVLTLPDGAAVLPPVT
VPAEADGAEVVVASSDGRLLVFPLEELPEMARGKGNKLIGIPAQRLRDREEVVVAVAVLPAGAALRVEAGKTGKRLSHSD
LEAFRAARGRRGVQLPRGLRQIRGLHVEN

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=378, Percent_Identity=24.6031746031746, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI19913408, Length=173, Percent_Identity=28.9017341040462, Blast_Score=71, Evalue=5e-12,
Organism=Escherichia coli, GI1789396, Length=738, Percent_Identity=60.7046070460705, Blast_Score=937, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=761, Percent_Identity=35.611038107753, Blast_Score=416, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI212645845, Length=499, Percent_Identity=23.8476953907816, Blast_Score=78, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=399, Percent_Identity=22.5563909774436, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 83561; Mature: 83430

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENAASDFETQPLREFTERAYLDYSMYVILDRALPHVSDGLKPVQRRIVYAMSELGLSA
CCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHH
AAKYKKSARTVGDVLGKYHPHGDAACYEAMVHMAQPFTYRYPLIDGQGNWGSPDDPKSFA
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEECCEECCCCCCCCCCCCHHHH
AMRYTEARLTPYARVLLNELGQGTVEWIPNFDGALQEPERLPARLPNVLLNGGSGIAVGM
HHHHHHHHCCHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHCCHHEEECCCEEEEEE
ATDIPPHNLREVVDACVHLLDRPEATTAELCEHVPAPDFPTASDVITPREELRTIYERGH
ECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCC
GTVRARARWEYEREQAQIVIHALPYQVAGAKVMEQIAAQIQSRKLPMVEDLRDESDHDAP
CEEEEHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCH
VRIVVQLRSRRQDPERVMDHLFATTDLERGYRVHLNVIGLDGRPRVFSLRDLLAEWLSFR
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHH
TETVRRRLTWRLEKVEDRLHILEGLLTAYLNIDEVIAIIREEDEPKPVLMERFGLSDAQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHCCCCHHHH
EAILELRLRHLARLEEMKIRGEQGDLERERDELRATLGDAARLREQVKSELLGDAEAHGD
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
ERRSPLVQRGPARAMDETELMPSEPVTVVLSEKGWVRAAKGHEVDATGLSYKAGDGYLDH
HHCCCHHHCCCCCCCCCCCCCCCCCEEEEECCCCCEEECCCCCCCCCCCCEECCCCHHHH
ALGRSNQPAIFLDSTGRAYAVPAHTLPSARSQGEPLTKRLTPPEKARFQSVLAGDSESRW
HCCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHCCCCCCCE
LLASDAGYGFRVPLRELFSRNRSGKAVLTLPDGAAVLPPVTVPAEADGAEVVVASSDGRL
EEEECCCCCEECCHHHHHCCCCCCCEEEECCCCCEECCCCCCCCCCCCCEEEEECCCCCE
LVFPLEELPEMARGKGNKLIGIPAQRLRDREEVVVAVAVLPAGAALRVEAGKTGKRLSHS
EEECHHHHHHHHCCCCCEEECCCHHHHCCHHHEEEEEEEECCCCEEEEECCCCCCCCCHH
DLEAFRAARGRRGVQLPRGLRQIRGLHVEN
HHHHHHHHCCCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SENAASDFETQPLREFTERAYLDYSMYVILDRALPHVSDGLKPVQRRIVYAMSELGLSA
CCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHH
AAKYKKSARTVGDVLGKYHPHGDAACYEAMVHMAQPFTYRYPLIDGQGNWGSPDDPKSFA
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEECCEECCCCCCCCCCCCHHHH
AMRYTEARLTPYARVLLNELGQGTVEWIPNFDGALQEPERLPARLPNVLLNGGSGIAVGM
HHHHHHHHCCHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHCCHHEEECCCEEEEEE
ATDIPPHNLREVVDACVHLLDRPEATTAELCEHVPAPDFPTASDVITPREELRTIYERGH
ECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCC
GTVRARARWEYEREQAQIVIHALPYQVAGAKVMEQIAAQIQSRKLPMVEDLRDESDHDAP
CEEEEHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCH
VRIVVQLRSRRQDPERVMDHLFATTDLERGYRVHLNVIGLDGRPRVFSLRDLLAEWLSFR
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHH
TETVRRRLTWRLEKVEDRLHILEGLLTAYLNIDEVIAIIREEDEPKPVLMERFGLSDAQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHCCCCHHHH
EAILELRLRHLARLEEMKIRGEQGDLERERDELRATLGDAARLREQVKSELLGDAEAHGD
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
ERRSPLVQRGPARAMDETELMPSEPVTVVLSEKGWVRAAKGHEVDATGLSYKAGDGYLDH
HHCCCHHHCCCCCCCCCCCCCCCCCEEEEECCCCCEEECCCCCCCCCCCCEECCCCHHHH
ALGRSNQPAIFLDSTGRAYAVPAHTLPSARSQGEPLTKRLTPPEKARFQSVLAGDSESRW
HCCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHCCCCCCCE
LLASDAGYGFRVPLRELFSRNRSGKAVLTLPDGAAVLPPVTVPAEADGAEVVVASSDGRL
EEEECCCCCEECCHHHHHCCCCCCCEEEECCCCCEECCCCCCCCCCCCCEEEEECCCCCE
LVFPLEELPEMARGKGNKLIGIPAQRLRDREEVVVAVAVLPAGAALRVEAGKTGKRLSHS
EEECHHHHHHHHCCCCCEEECCCHHHHCCHHHEEEEEEEECCCCEEEEECCCCCCCCCHH
DLEAFRAARGRRGVQLPRGLRQIRGLHVEN
HHHHHHHHCCCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]