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The map label for this gene is macA [H]

Identifier: 121998695

GI number: 121998695

Start: 2110855

End: 2112060

Strand: Reverse

Name: macA [H]

Synonym: Hhal_1916

Alternate gene names: 121998695

Gene position: 2112060-2110855 (Counterclockwise)

Preceding gene: 121998696

Following gene: 121998694

Centisome position: 78.85

GC content: 74.05

Gene sequence:

>1206_bases
ATGCATCCACGCTGGAAGCCCATCATCGGCTGGGCACTGACCGGTCTCGCGGTCCTCGGGCTGCTCGTCCTGCTGCTGCG
GCCGGCGCCGATCCTCGTCGATACCGAGACGGTCAGCCGTGGCCCCCTGGAGGTCACCCTCGAGGAGGAGGGCAAGACCC
GCGTGGCGGACCGGTACGTCCTCTCGGCCCCGGCCGCGGCCCAGGCCCGCCGGATCACCCTGGAACCGGGTGACCGGGTC
GAGGCCGGGGAGGTGCTCGCCACCCTTGATCCGATGGCGGTGCCGGTGCTCGATGCCCGTGCCCGGGATCAGGCCCGGGC
CCAGCTCGAAGCGGCGCACTCGGCGCTGGGGGCGGCCCGCGAGGAGGCCGAGGCGGCGCAGGCAGCAGCGGAGTCGGCGG
CCGACGAGTACCGTCGGCTGGCGGCTCTGGGTGAGGAGGGAGTGGTCGCGGAGCGGGAGGTGGAGCGTGCCGATGCCGAG
CGACGGCGGGCCTTGGCCGGGTGGCGCTCGGCGCAGTTCCGGGTGGCCACCGCCGAGGCGCAGCGCGACCAGGCCGAGGC
CGTCCTGCGCTGGGAGGGGGAGGACGCCCTGGCGCCCGGGGACATCGAGCCGATCCGTCTGCGCGCCCCGATCGATGGCG
CGATCCTTAAGCGCCACTTCGATAGCGCCCGGGTGGTGCAGCCCGGGGAGCCGATCCTGGAGATGGCCGATCTCGGGCGG
CTGGAGGTCGAGGTGGAGGTGCGTTCGGCGGATGCGGTGCGTATCACGCCGGGGATGACGGTGCGGCTGGAGCGCTGGGG
CGATGAGGCCCCCCTGGAGGCGGTCGTACGCCGGGTGGAGCCCTACGGCTTCGAGTACATTACCGCCCTCGGCGTGGAAG
AGCGGCGGGTGCGGGTCATTGCCGATCTGGCATCGCCGCGGGAAGCCTGGGAGCGCCTCGGCGACGGCTATCGGGTCAAC
GCCGTCTTCGTGCTCTGGTCGGCGGAGGACGTGCTGCGGGTGCCGACCAGCGCCCTGTTCCGCCACGATGACGGCTGGGC
GGTCCTGGTCGCAGAGCAGGGGCGGGCGCGGCTGCGGTCGGTGGAGATCGGGGAGCGGGGTGCCCGCCAGACCCGCCTCC
GTTCCGGCCTGGAGGACGGGGAGGCCGTGGTGGTGCATCCGCCCCGGGAACTCGGCGACGGCGACCGCCTGGAGGTGCGC
CGCTGA

Upstream 100 bases:

>100_bases
CCCTGGTGATCCTCGCCGTTGCCGGCCTCTCGGCGTGGGTGGTGCGGCGCCGGCTGGACCGGCTGGACATGGTCGAGGCC
CTGAAATCGAGGGAGTAGCG

Downstream 100 bases:

>100_bases
CCGCGCAAGGCGCGGTTGCGAGCATTGTCCGATGAACCGGAAATCCCTAGTCTAGCCGGGCTTGGTTCACGGGGAGCGAG
CGGTGAAAGAGGTCCGACAA

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MHPRWKPIIGWALTGLAVLGLLVLLLRPAPILVDTETVSRGPLEVTLEEEGKTRVADRYVLSAPAAAQARRITLEPGDRV
EAGEVLATLDPMAVPVLDARARDQARAQLEAAHSALGAAREEAEAAQAAAESAADEYRRLAALGEEGVVAEREVERADAE
RRRALAGWRSAQFRVATAEAQRDQAEAVLRWEGEDALAPGDIEPIRLRAPIDGAILKRHFDSARVVQPGEPILEMADLGR
LEVEVEVRSADAVRITPGMTVRLERWGDEAPLEAVVRRVEPYGFEYITALGVEERRVRVIADLASPREAWERLGDGYRVN
AVFVLWSAEDVLRVPTSALFRHDDGWAVLVAEQGRARLRSVEIGERGARQTRLRSGLEDGEAVVVHPPRELGDGDRLEVR
R

Sequences:

>Translated_401_residues
MHPRWKPIIGWALTGLAVLGLLVLLLRPAPILVDTETVSRGPLEVTLEEEGKTRVADRYVLSAPAAAQARRITLEPGDRV
EAGEVLATLDPMAVPVLDARARDQARAQLEAAHSALGAAREEAEAAQAAAESAADEYRRLAALGEEGVVAEREVERADAE
RRRALAGWRSAQFRVATAEAQRDQAEAVLRWEGEDALAPGDIEPIRLRAPIDGAILKRHFDSARVVQPGEPILEMADLGR
LEVEVEVRSADAVRITPGMTVRLERWGDEAPLEAVVRRVEPYGFEYITALGVEERRVRVIADLASPREAWERLGDGYRVN
AVFVLWSAEDVLRVPTSALFRHDDGWAVLVAEQGRARLRSVEIGERGARQTRLRSGLEDGEAVVVHPPRELGDGDRLEVR
R
>Mature_401_residues
MHPRWKPIIGWALTGLAVLGLLVLLLRPAPILVDTETVSRGPLEVTLEEEGKTRVADRYVLSAPAAAQARRITLEPGDRV
EAGEVLATLDPMAVPVLDARARDQARAQLEAAHSALGAAREEAEAAQAAAESAADEYRRLAALGEEGVVAEREVERADAE
RRRALAGWRSAQFRVATAEAQRDQAEAVLRWEGEDALAPGDIEPIRLRAPIDGAILKRHFDSARVVQPGEPILEMADLGR
LEVEVEVRSADAVRITPGMTVRLERWGDEAPLEAVVRRVEPYGFEYITALGVEERRVRVIADLASPREAWERLGDGYRVN
AVFVLWSAEDVLRVPTSALFRHDDGWAVLVAEQGRARLRSVEIGERGARQTRLRSGLEDGEAVVVHPPRELGDGDRLEVR
R

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=381, Percent_Identity=24.1469816272966, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 44106; Mature: 44106

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPRWKPIIGWALTGLAVLGLLVLLLRPAPILVDTETVSRGPLEVTLEEEGKTRVADRYV
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEECCCCCCCHHHHHE
LSAPAAAQARRITLEPGDRVEAGEVLATLDPMAVPVLDARARDQARAQLEAAHSALGAAR
ECCCCHHHCEEEEECCCCCCCCCCCHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHH
EEAEAAQAAAESAADEYRRLAALGEEGVVAEREVERADAERRRALAGWRSAQFRVATAEA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECHH
QRDQAEAVLRWEGEDALAPGDIEPIRLRAPIDGAILKRHFDSARVVQPGEPILEMADLGR
HHHHHCEEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHCCCCCEECCCCHHHHHHCCCC
LEVEVEVRSADAVRITPGMTVRLERWGDEAPLEAVVRRVEPYGFEYITALGVEERRVRVI
EEEEEEEECCCEEEECCCCEEEEECCCCCCCHHHHHHHCCCCCEEEEEECCCCHHHEEHH
ADLASPREAWERLGDGYRVNAVFVLWSAEDVLRVPTSALFRHDDGWAVLVAEQGRARLRS
HHHCCHHHHHHHHCCCEEEEEEEEEECCCHHHHCCCHHHEEECCCCEEEEECCCCCHHHE
VEIGERGARQTRLRSGLEDGEAVVVHPPRELGDGDRLEVRR
ECCCCCCHHHHHHHCCCCCCCEEEEECCHHCCCCCCEEECC
>Mature Secondary Structure
MHPRWKPIIGWALTGLAVLGLLVLLLRPAPILVDTETVSRGPLEVTLEEEGKTRVADRYV
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEECCCCCCCHHHHHE
LSAPAAAQARRITLEPGDRVEAGEVLATLDPMAVPVLDARARDQARAQLEAAHSALGAAR
ECCCCHHHCEEEEECCCCCCCCCCCHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHH
EEAEAAQAAAESAADEYRRLAALGEEGVVAEREVERADAERRRALAGWRSAQFRVATAEA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECHH
QRDQAEAVLRWEGEDALAPGDIEPIRLRAPIDGAILKRHFDSARVVQPGEPILEMADLGR
HHHHHCEEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHCCCCCEECCCCHHHHHHCCCC
LEVEVEVRSADAVRITPGMTVRLERWGDEAPLEAVVRRVEPYGFEYITALGVEERRVRVI
EEEEEEEECCCEEEECCCCEEEEECCCCCCCHHHHHHHCCCCCEEEEEECCCCHHHEEHH
ADLASPREAWERLGDGYRVNAVFVLWSAEDVLRVPTSALFRHDDGWAVLVAEQGRARLRS
HHHCCHHHHHHHHCCCEEEEEEEEEECCCHHHHCCCHHHEEECCCCEEEEECCCCCHHHE
VEIGERGARQTRLRSGLEDGEAVVVHPPRELGDGDRLEVRR
ECCCCCCHHHHHHHCCCCCCCEEEEECCHHCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]