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The map label for this gene is trpF

Identifier: 121998584

GI number: 121998584

Start: 1977183

End: 1977806

Strand: Reverse

Name: trpF

Synonym: Hhal_1805

Alternate gene names: 121998584

Gene position: 1977806-1977183 (Counterclockwise)

Preceding gene: 121998585

Following gene: 121998583

Centisome position: 73.84

GC content: 68.27

Gene sequence:

>624_bases
GTGCGCACGCGCGTCAAGATCTGCGGGGTTACCCGCCCGGAAGATGCCGCAGCCGCTGTCGAGCTGGGTGCCGATGCCAT
CGGTCTGGTGTTTTGCGATGCCAGCCCGCGTGCCGTGGACATGAAAGAGGCCCGAGCCATTGTGGCGGCCGTCCCGGCCT
TCGTCTCGGTGGTCGGTCTGTTCGTCGATCCCAAGCCGGGGCAGGTGGAGGTGGCCGTGGAAGGCCTGCACTTGGATACC
CTGCAGTTCCACGGCAACGAGGCGCCGGAACTTTGCCGCCACTACGAGCGTCGCTACGTGAAGGCGGTGCCCATGGGGGG
CGGGGCGGATCCGTCCGAGTACGTGGCGGCCTATCCGGATGCCAGCGGGTTTCTGTTCGATAGCCACCGCGTCGGCGAGC
GCGGGGGTCGGGGTGAGTCCTTCGACCACGACACCATCCCGGGCGGCGTGCGCGGGCTCACGGTGGCTGGCGGTCTGAGC
GCCGAGAATGTGGCGGAGGTGGTGCGCAAGGTGCGCCCCTTCGCCGTGGATGTTAGCAGCGGCGTCGAGTCGGAGCCGGG
GATCAAGGACCGGGAGCGCATAGCCCGGTTTCTCGCGGAGGTGGAACGTGGCGATGAGACCTGA

Upstream 100 bases:

>100_bases
CGGCCTCCCGACCCGGGGGCAGTGGCCGTTTTTGGCGTAAAGCTCGCCCACGCGGTAACATTTGCGCTTTCCTTGGAGCC
GCTGAAGGGGGACGCCGAGC

Downstream 100 bases:

>100_bases
GCAGGACGGCGGCGGCCCCGCCGAGGAGCATGATGGGCACTTCGGCCGGTTCGGGGGGCGGTTCGTCTCCGAGACCCTGG
TCGGGCCGCTCGAGGAGTTG

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MRTRVKICGVTRPEDAAAAVELGADAIGLVFCDASPRAVDMKEARAIVAAVPAFVSVVGLFVDPKPGQVEVAVEGLHLDT
LQFHGNEAPELCRHYERRYVKAVPMGGGADPSEYVAAYPDASGFLFDSHRVGERGGRGESFDHDTIPGGVRGLTVAGGLS
AENVAEVVRKVRPFAVDVSSGVESEPGIKDRERIARFLAEVERGDET

Sequences:

>Translated_207_residues
MRTRVKICGVTRPEDAAAAVELGADAIGLVFCDASPRAVDMKEARAIVAAVPAFVSVVGLFVDPKPGQVEVAVEGLHLDT
LQFHGNEAPELCRHYERRYVKAVPMGGGADPSEYVAAYPDASGFLFDSHRVGERGGRGESFDHDTIPGGVRGLTVAGGLS
AENVAEVVRKVRPFAVDVSSGVESEPGIKDRERIARFLAEVERGDET
>Mature_207_residues
MRTRVKICGVTRPEDAAAAVELGADAIGLVFCDASPRAVDMKEARAIVAAVPAFVSVVGLFVDPKPGQVEVAVEGLHLDT
LQFHGNEAPELCRHYERRYVKAVPMGGGADPSEYVAAYPDASGFLFDSHRVGERGGRGESFDHDTIPGGVRGLTVAGGLS
AENVAEVVRKVRPFAVDVSSGVESEPGIKDRERIARFLAEVERGDET

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=199, Percent_Identity=33.1658291457286, Blast_Score=85, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320210, Length=224, Percent_Identity=28.125, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_HALHL (A1WY07)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003371.1
- ProteinModelPortal:   A1WY07
- SMR:   A1WY07
- STRING:   A1WY07
- GeneID:   4710988
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1805
- eggNOG:   COG0135
- HOGENOM:   HBG554803
- OMA:   SKICGIT
- PhylomeDB:   A1WY07
- ProtClustDB:   PRK01222
- BioCyc:   HHAL349124:HHAL_1805-MONOMER
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 22016; Mature: 22016

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTRVKICGVTRPEDAAAAVELGADAIGLVFCDASPRAVDMKEARAIVAAVPAFVSVVGL
CCCEEEEECCCCCCHHHHHHHCCCCEEEEEEECCCCCEECHHHHHHHHHHHHHHHHHHHH
FVDPKPGQVEVAVEGLHLDTLQFHGNEAPELCRHYERRYVKAVPMGGGADPSEYVAAYPD
EECCCCCEEEEEEECEEEEEEEECCCCCHHHHHHHHHHHEEEECCCCCCCHHHHEEECCC
ASGFLFDSHRVGERGGRGESFDHDTIPGGVRGLTVAGGLSAENVAEVVRKVRPFAVDVSS
CCCEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCEEEECCC
GVESEPGIKDRERIARFLAEVERGDET
CCCCCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRTRVKICGVTRPEDAAAAVELGADAIGLVFCDASPRAVDMKEARAIVAAVPAFVSVVGL
CCCEEEEECCCCCCHHHHHHHCCCCEEEEEEECCCCCEECHHHHHHHHHHHHHHHHHHHH
FVDPKPGQVEVAVEGLHLDTLQFHGNEAPELCRHYERRYVKAVPMGGGADPSEYVAAYPD
EECCCCCEEEEEEECEEEEEEEECCCCCHHHHHHHHHHHEEEECCCCCCCHHHHEEECCC
ASGFLFDSHRVGERGGRGESFDHDTIPGGVRGLTVAGGLSAENVAEVVRKVRPFAVDVSS
CCCEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCEEEECCC
GVESEPGIKDRERIARFLAEVERGDET
CCCCCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA