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The map label for this gene is truA [H]

Identifier: 121998585

GI number: 121998585

Start: 1977867

End: 1978667

Strand: Reverse

Name: truA [H]

Synonym: Hhal_1806

Alternate gene names: 121998585

Gene position: 1978667-1977867 (Counterclockwise)

Preceding gene: 121998586

Following gene: 121998584

Centisome position: 73.87

GC content: 70.66

Gene sequence:

>801_bases
GTGGCGGAACGAGGGGCAGAGCAACGCATTGCCCTGGTGCTGGAGTACGACGGCACCGGCTTCAGCGGCTGGCAGCGACA
GGACGACGCCCCGTCGGTGCAGGAGGCCCTCGAGGGGGCTGTGTCGCGGATCGCCAATCACCCGGTGGCGGTGGTCTGTG
CCGGCCGCACCGATGCCGGGGTTCACGCCGCCGCCCAAGTGGTCCACTTCGATACCACCGCATCGCGGCCGCTGCACGCC
TGGGTGCTGGGCACCAATGCGCAGCTACCCGAGACGGTCAGCGTCCGTTCGGCCCACGCCGTCGATGCGGATTTCCACGC
GCGCTATCAAGCGCAGCGGCGGGGGTACCGCTATGTCTTCCTGTGCCGGCGGGCCCGCCCGGCGCTTCTGCGTCACCGCG
TGGCCTGGACCCACCACGAGCTGGATGAGGGGCGCATGCATCGGGCCGCCCAGGCCCTGGTTGGCGAGCACGATTTCTCG
GCCTTCCGGGCCGCCGCCTGCCAGGCGCCCCACGCGGTGCGGGAGGTCTATCGGCTCGATGTGCACCGCCACGGCGAGCT
GCTGTTCATCGACATCGAGGCCAACGCCTTCGTGCACCATATGGTGCGCAATATCGCCGGCACCCTGATGGCCGTGGGAA
CCGGCGAGCAGCCTGAGCATTGGCCCGCGGGATTGCTCGCCGCCGGCGACCGGACCCGCAGCGGGATGACGGCCCCGGCG
GCCGGGCTCTACCTGACCCGCGTGGTCTACCCGTCGCATTACGGCCTCCCGACCCGGGGGCAGTGGCCGTTTTTGGCGTA
A

Upstream 100 bases:

>100_bases
GCAGCCTGCTGGAGGAGGTCCTGGAGGAAGGTACCGAGTCGCAGCGCGAGAGTGCCCGGCAGATCCTGGCTGAGCTCAGC
GGCGAGTAGGCGGGCAGGCG

Downstream 100 bases:

>100_bases
AGCTCGCCCACGCGGTAACATTTGCGCTTTCCTTGGAGCCGCTGAAGGGGGACGCCGAGCGTGCGCACGCGCGTCAAGAT
CTGCGGGGTTACCCGCCCGG

Product: tRNA pseudouridine synthase A

Products: NA

Alternate protein names: tRNA pseudouridylate synthase I; tRNA-uridine isomerase I [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MAERGAEQRIALVLEYDGTGFSGWQRQDDAPSVQEALEGAVSRIANHPVAVVCAGRTDAGVHAAAQVVHFDTTASRPLHA
WVLGTNAQLPETVSVRSAHAVDADFHARYQAQRRGYRYVFLCRRARPALLRHRVAWTHHELDEGRMHRAAQALVGEHDFS
AFRAAACQAPHAVREVYRLDVHRHGELLFIDIEANAFVHHMVRNIAGTLMAVGTGEQPEHWPAGLLAAGDRTRSGMTAPA
AGLYLTRVVYPSHYGLPTRGQWPFLA

Sequences:

>Translated_266_residues
MAERGAEQRIALVLEYDGTGFSGWQRQDDAPSVQEALEGAVSRIANHPVAVVCAGRTDAGVHAAAQVVHFDTTASRPLHA
WVLGTNAQLPETVSVRSAHAVDADFHARYQAQRRGYRYVFLCRRARPALLRHRVAWTHHELDEGRMHRAAQALVGEHDFS
AFRAAACQAPHAVREVYRLDVHRHGELLFIDIEANAFVHHMVRNIAGTLMAVGTGEQPEHWPAGLLAAGDRTRSGMTAPA
AGLYLTRVVYPSHYGLPTRGQWPFLA
>Mature_265_residues
AERGAEQRIALVLEYDGTGFSGWQRQDDAPSVQEALEGAVSRIANHPVAVVCAGRTDAGVHAAAQVVHFDTTASRPLHAW
VLGTNAQLPETVSVRSAHAVDADFHARYQAQRRGYRYVFLCRRARPALLRHRVAWTHHELDEGRMHRAAQALVGEHDFSA
FRAAACQAPHAVREVYRLDVHRHGELLFIDIEANAFVHHMVRNIAGTLMAVGTGEQPEHWPAGLLAAGDRTRSGMTAPAA
GLYLTRVVYPSHYGLPTRGQWPFLA

Specific function: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs [H]

COG id: COG0101

COG function: function code J; Pseudouridylate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tRNA pseudouridine synthase truA family [H]

Homologues:

Organism=Homo sapiens, GI23503259, Length=273, Percent_Identity=32.2344322344322, Blast_Score=97, Evalue=1e-20,
Organism=Escherichia coli, GI1788657, Length=259, Percent_Identity=55.2123552123552, Blast_Score=277, Evalue=4e-76,
Organism=Drosophila melanogaster, GI116007752, Length=305, Percent_Identity=29.1803278688525, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020103
- InterPro:   IPR001406
- InterPro:   IPR020097
- InterPro:   IPR020095
- InterPro:   IPR020094 [H]

Pfam domain/function: PF01416 PseudoU_synth_1 [H]

EC number: =5.4.99.12 [H]

Molecular weight: Translated: 29323; Mature: 29192

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERGAEQRIALVLEYDGTGFSGWQRQDDAPSVQEALEGAVSRIANHPVAVVCAGRTDAG
CCCCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCC
VHAAAQVVHFDTTASRPLHAWVLGTNAQLPETVSVRSAHAVDADFHARYQAQRRGYRYVF
HHHHEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEE
LCRRARPALLRHRVAWTHHELDEGRMHRAAQALVGEHDFSAFRAAACQAPHAVREVYRLD
EECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHH
VHRHGELLFIDIEANAFVHHMVRNIAGTLMAVGTGEQPEHWPAGLLAAGDRTRSGMTAPA
HCCCCCEEEEEECCCHHHHHHHHHHHHHEEEECCCCCCCCCCCCEEECCCCCCCCCCCCH
AGLYLTRVVYPSHYGLPTRGQWPFLA
HHHEEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AERGAEQRIALVLEYDGTGFSGWQRQDDAPSVQEALEGAVSRIANHPVAVVCAGRTDAG
CCCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCC
VHAAAQVVHFDTTASRPLHAWVLGTNAQLPETVSVRSAHAVDADFHARYQAQRRGYRYVF
HHHHEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEE
LCRRARPALLRHRVAWTHHELDEGRMHRAAQALVGEHDFSAFRAAACQAPHAVREVYRLD
EECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHH
VHRHGELLFIDIEANAFVHHMVRNIAGTLMAVGTGEQPEHWPAGLLAAGDRTRSGMTAPA
HCCCCCEEEEEECCCHHHHHHHHHHHHHEEEECCCCCCCCCCCCEEECCCCCCCCCCCCH
AGLYLTRVVYPSHYGLPTRGQWPFLA
HHHEEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA