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The map label for this gene is ndk

Identifier: 121998571

GI number: 121998571

Start: 1965540

End: 1965965

Strand: Reverse

Name: ndk

Synonym: Hhal_1792

Alternate gene names: 121998571

Gene position: 1965965-1965540 (Counterclockwise)

Preceding gene: 121998572

Following gene: 121998570

Centisome position: 73.4

GC content: 64.08

Gene sequence:

>426_bases
ATGGCCGTCGAGCGAACCCTTTCCATCATTAAACCGGATGCCGTCGCGCAGAACGCCATCGGCGAGATCCTTGCGCGCTT
CGAGCGCTCCGGGCTGCGTGTCGTGGCCGCGCGTATGGTGCGGCTGAGCACCGAGCAGGCCGAGAGCTTCTACGCCGTGC
ACAAGGAGCGCCCCTTCTTCAACGATCTGGTCGGCTTCATGACCTCCGGGCCGGTGATGGTGCAGGTCCTCGAGGGCGAG
GATGCCATCCGCAAGAACCGCGAGATCATGGGCGCCACCAACCCCAAGGAGGCCGCCGCCGGTACCCTGCGCCACGACTT
TGCCGAGAGCATCGACGCCAACGCGGTTCACGGATCGGATAGCCCCGAGACGGCGGAAAACGAGATCGAGTTCTTCTTTA
AGGCCGATGAGATCTGCTCCCGCTGA

Upstream 100 bases:

>100_bases
CGGTGCTGCCGGTGGGGGGTAGACTGTCAGGCTGCCCAAGGCGCCGCAGCACCTTAGCGCTGCGGCTTTTTTGTTGAAAG
CCAAACCGTCAGGAGATGTA

Downstream 100 bases:

>100_bases
CCACGAGGCGGTGCATGCCGAGCGCCGGTCGGGTCCGGTCGAGCTGCTAGGGCTCGATCGGCCCCGGTTGGCGGCCTTCT
TCGATACCCTGGGCGAGAAG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MAVERTLSIIKPDAVAQNAIGEILARFERSGLRVVAARMVRLSTEQAESFYAVHKERPFFNDLVGFMTSGPVMVQVLEGE
DAIRKNREIMGATNPKEAAAGTLRHDFAESIDANAVHGSDSPETAENEIEFFFKADEICSR

Sequences:

>Translated_141_residues
MAVERTLSIIKPDAVAQNAIGEILARFERSGLRVVAARMVRLSTEQAESFYAVHKERPFFNDLVGFMTSGPVMVQVLEGE
DAIRKNREIMGATNPKEAAAGTLRHDFAESIDANAVHGSDSPETAENEIEFFFKADEICSR
>Mature_140_residues
AVERTLSIIKPDAVAQNAIGEILARFERSGLRVVAARMVRLSTEQAESFYAVHKERPFFNDLVGFMTSGPVMVQVLEGED
AIRKNREIMGATNPKEAAAGTLRHDFAESIDANAVHGSDSPETAENEIEFFFKADEICSR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=137, Percent_Identity=46.7153284671533, Blast_Score=137, Evalue=2e-33,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=44.1176470588235, Blast_Score=131, Evalue=2e-31,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=44.1176470588235, Blast_Score=131, Evalue=2e-31,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=44.1176470588235, Blast_Score=131, Evalue=2e-31,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=44.1176470588235, Blast_Score=131, Evalue=2e-31,
Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=44.1176470588235, Blast_Score=131, Evalue=2e-31,
Organism=Homo sapiens, GI38045913, Length=136, Percent_Identity=41.9117647058824, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI4557797, Length=136, Percent_Identity=41.9117647058824, Blast_Score=123, Evalue=4e-29,
Organism=Homo sapiens, GI4826862, Length=137, Percent_Identity=38.6861313868613, Blast_Score=117, Evalue=4e-27,
Organism=Homo sapiens, GI37574614, Length=144, Percent_Identity=36.1111111111111, Blast_Score=95, Evalue=2e-20,
Organism=Homo sapiens, GI7019465, Length=144, Percent_Identity=36.1111111111111, Blast_Score=95, Evalue=2e-20,
Organism=Homo sapiens, GI4505413, Length=136, Percent_Identity=38.2352941176471, Blast_Score=84, Evalue=3e-17,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=36.0294117647059, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI30023828, Length=137, Percent_Identity=32.1167883211679, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI148839372, Length=137, Percent_Identity=29.9270072992701, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=56.7375886524823, Blast_Score=177, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=42.2222222222222, Blast_Score=121, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=44.1176470588235, Blast_Score=135, Evalue=2e-33,
Organism=Drosophila melanogaster, GI45549037, Length=137, Percent_Identity=41.6058394160584, Blast_Score=126, Evalue=4e-30,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=31.3432835820896, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24645457, Length=137, Percent_Identity=30.6569343065693, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_HALHL (A1WXZ4)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003358.1
- ProteinModelPortal:   A1WXZ4
- SMR:   A1WXZ4
- STRING:   A1WXZ4
- GeneID:   4710981
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1792
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- PhylomeDB:   A1WXZ4
- ProtClustDB:   PRK00668
- BioCyc:   HHAL349124:HHAL_1792-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15560; Mature: 15429

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVERTLSIIKPDAVAQNAIGEILARFERSGLRVVAARMVRLSTEQAESFYAVHKERPFF
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
NDLVGFMTSGPVMVQVLEGEDAIRKNREIMGATNPKEAAAGTLRHDFAESIDANAVHGSD
HHHHHHHCCCCEEEEEECCCHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
SPETAENEIEFFFKADEICSR
CCCCCHHHHHHEECHHHHHCC
>Mature Secondary Structure 
AVERTLSIIKPDAVAQNAIGEILARFERSGLRVVAARMVRLSTEQAESFYAVHKERPFF
CCHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
NDLVGFMTSGPVMVQVLEGEDAIRKNREIMGATNPKEAAAGTLRHDFAESIDANAVHGSD
HHHHHHHCCCCEEEEEECCCHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
SPETAENEIEFFFKADEICSR
CCCCCHHHHHHEECHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA