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The map label for this gene is iscA [H]

Identifier: 121998572

GI number: 121998572

Start: 1966088

End: 1966411

Strand: Reverse

Name: iscA [H]

Synonym: Hhal_1793

Alternate gene names: 121998572

Gene position: 1966411-1966088 (Counterclockwise)

Preceding gene: 121998573

Following gene: 121998571

Centisome position: 73.42

GC content: 64.2

Gene sequence:

>324_bases
ATGCCAGTGACCCTGACCGAACGTGCCGCGCGGCATGTCGAGAAGATGCTCGCCAGCGAGGATGCCGCGCAGGGCCTGCG
CCTGGGCATCAAGGCGAGCGGCTGCTCCGGTTTCGCCTACGTGGTGGATTACGCCCAGGAGATCGGCGAGCAGGATCTGG
TCGTCGAGAACCACGGGGTGAAGGTGGTGGTGGCGCAGCAGCATCGGCCCTTCCTGGAAGGGACGGAGGTGGACTACGTC
CGTGACGGCATCAACTACCGTTTCGATTTCCGGAATCCGAACGTCCGGGATCTGTGTGGGTGCGGCGAGAGCTTTGCCGT
CTGA

Upstream 100 bases:

>100_bases
TGTGGCGAGCGCCCCGAGGACGCTTCCCGTTAGTTGCGCGGAGCCCCTAGAATGCAAACAGGCACGTTACCGCGGTGTGC
CCAGTGACAGGAGGCAAGCT

Downstream 100 bases:

>100_bases
GCGACGGGGCGCGCGGCGTTGTCGGTGCTGCCGGTGGGGGGTAGACTGTCAGGCTGCCCAAGGCGCCGCAGCACCTTAGC
GCTGCGGCTTTTTTGTTGAA

Product: iron-sulfur cluster assembly accessory protein

Products: NA

Alternate protein names: Iron-sulfur cluster assembly protein [H]

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MPVTLTERAARHVEKMLASEDAAQGLRLGIKASGCSGFAYVVDYAQEIGEQDLVVENHGVKVVVAQQHRPFLEGTEVDYV
RDGINYRFDFRNPNVRDLCGCGESFAV

Sequences:

>Translated_107_residues
MPVTLTERAARHVEKMLASEDAAQGLRLGIKASGCSGFAYVVDYAQEIGEQDLVVENHGVKVVVAQQHRPFLEGTEVDYV
RDGINYRFDFRNPNVRDLCGCGESFAV
>Mature_106_residues
PVTLTERAARHVEKMLASEDAAQGLRLGIKASGCSGFAYVVDYAQEIGEQDLVVENHGVKVVVAQQHRPFLEGTEVDYVR
DGINYRFDFRNPNVRDLCGCGESFAV

Specific function: Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that iscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transi

COG id: COG0316

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesB/iscA family [H]

Homologues:

Organism=Homo sapiens, GI52426768, Length=105, Percent_Identity=36.1904761904762, Blast_Score=90, Evalue=4e-19,
Organism=Homo sapiens, GI160420328, Length=96, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI1788877, Length=107, Percent_Identity=50.4672897196262, Blast_Score=116, Evalue=3e-28,
Organism=Escherichia coli, GI1787974, Length=105, Percent_Identity=47.6190476190476, Blast_Score=112, Evalue=5e-27,
Organism=Escherichia coli, GI1786351, Length=108, Percent_Identity=37.037037037037, Blast_Score=81, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI193209025, Length=105, Percent_Identity=39.0476190476191, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI25146411, Length=105, Percent_Identity=39.0476190476191, Blast_Score=96, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6323001, Length=105, Percent_Identity=38.0952380952381, Blast_Score=86, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24642263, Length=105, Percent_Identity=37.1428571428571, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000361
- InterPro:   IPR016092
- InterPro:   IPR017870
- InterPro:   IPR011302 [H]

Pfam domain/function: PF01521 Fe-S_biosyn [H]

EC number: NA

Molecular weight: Translated: 11832; Mature: 11701

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS01152 HESB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVTLTERAARHVEKMLASEDAAQGLRLGIKASGCSGFAYVVDYAQEIGEQDLVVENHGV
CCCCHHHHHHHHHHHHHHCCHHHCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCE
KVVVAQQHRPFLEGTEVDYVRDGINYRFDFRNPNVRDLCGCGESFAV
EEEEECCCCCCCCCCCCCEEECCCCEEEECCCCCHHHHHCCCCCCCC
>Mature Secondary Structure 
PVTLTERAARHVEKMLASEDAAQGLRLGIKASGCSGFAYVVDYAQEIGEQDLVVENHGV
CCCHHHHHHHHHHHHHHCCHHHCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCE
KVVVAQQHRPFLEGTEVDYVRDGINYRFDFRNPNVRDLCGCGESFAV
EEEEECCCCCCCCCCCCCEEECCCCEEEECCCCCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA