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The map label for this gene is atoC [H]

Identifier: 121998356

GI number: 121998356

Start: 1717469

End: 1718668

Strand: Reverse

Name: atoC [H]

Synonym: Hhal_1577

Alternate gene names: 121998356

Gene position: 1718668-1717469 (Counterclockwise)

Preceding gene: 121998357

Following gene: 121998355

Centisome position: 64.17

GC content: 66.0

Gene sequence:

>1200_bases
ATGGCCGTAGCGGAAAGTACCGAGGCCAGCTCCAGGGTCTGGTACCTCATTGAAGAGGGGCAGGGGTTGCGGGTGGGAAG
AGCGCGGTCGGCTGGTGCGACTTCGATCCCCCTTGAGGCGGGTTTCTACGTGGAGCCGGAAGCCGCCGCACCGCTGATCC
GGGCTGTGGAAAGGGCGCTTTCCGAAGGGGCGGATCCGGACCGGTATGAAGAGTCTGACGCACCGCTGGGCCGGGGGCGG
AGCCCATCTGGCGATGCGGGGCCACGCCGGCTGGGCTTGGTGACCGGTGACCCGCGCATGATCCAGCTTTGTCGGGATAC
GGAGCGGCTCGCTCCCTCGGATGCTACCGTCCTGCTTCTCGGTGAGAGTGGCACCGGGAAGGAGCTCTTTGCGAAGGCTC
TGCATGGGCTGAACCGAGTGCGATCCGCTGCTCCGCTGGAGGCGATTAACTGCGCCGCGATCCCTTCGGAACTGCTTGAG
AGTGAGCTGTTCGGGTTTGAGCGTGGCGCCTTTACGGGGGCCTACCGGGCCCGGGTGGGGCGGATCGAGCGTGCCAATGG
GGGAACCCTATTCCTCGACGAGATCGGAGAGTTGCCCCTGGAGGTTCAGGCGAAGCTGCTGCGCTTCCTGCAACAGCGGA
CGGTTCAGCGCTTGGGGGGGCGACGAGAGATCCCGGTGGACGTCCGGGTGGTTTGCGCGACCAACCGGGACTTGGTCGAG
CGGATGGGAGAGGGAGCGTTCCGTGACGACTTCTATTACCGGGTTGCCGAGGTTCAACTGCGGCTTCCGCCCCTGCGCGA
GCGGCCAGGAGATCCCGCACTGATTGCCCACGCGCTTCTCAAAGGAATGGTCCGGCAGCACAAGGCCCGAGCGCGGAAGC
TGGGCAGTGATGCCTTGGCCGTGATCGCCGCCTATCGCTGGCCTGGCAACGTTCGTGAACTGGAAAACGCGCTCCGGCGA
GCGGTGATCCTCTCGGAGGGAGGTGCCATTCGTGCCGAAGACCTCGGGCTGCCGCTGCCGCGTTCTCTGACCGTTCAGCG
GGATCTGCCCAGGTTGCGCGAGGTGCGCGATGAGGCGGAGCGACGCGTCGTCGCCGAGGCCTTGGGCCGGTGCAACGGGA
ACATCTCGCGCGCAGCGACGGAACTGGGAGTTACGCGGCCAACGATCTACGAGCTGCTGGCTAAGCACGGGATGCGCTAA

Upstream 100 bases:

>100_bases
AGCCGCCCAGTGCCATTCCCCTAGTATCTAGCGCGGGTTCTTGGCTCCGTTAACCGGGGACGTATTCCGGAGTGCGGACC
GCCAGGGAGGTCTCAAAGCG

Downstream 100 bases:

>100_bases
ATCCATTGGCCCACACATGCTCCCGAGCGGCAGGCTGCGTAGGCTGATACCCTCCGGCCGAAACATGCAAATGACTGGAG
TTTGCCTATGGGCAACCGCT

Product: sigma-54 dependent trancsriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MAVAESTEASSRVWYLIEEGQGLRVGRARSAGATSIPLEAGFYVEPEAAAPLIRAVERALSEGADPDRYEESDAPLGRGR
SPSGDAGPRRLGLVTGDPRMIQLCRDTERLAPSDATVLLLGESGTGKELFAKALHGLNRVRSAAPLEAINCAAIPSELLE
SELFGFERGAFTGAYRARVGRIERANGGTLFLDEIGELPLEVQAKLLRFLQQRTVQRLGGRREIPVDVRVVCATNRDLVE
RMGEGAFRDDFYYRVAEVQLRLPPLRERPGDPALIAHALLKGMVRQHKARARKLGSDALAVIAAYRWPGNVRELENALRR
AVILSEGGAIRAEDLGLPLPRSLTVQRDLPRLREVRDEAERRVVAEALGRCNGNISRAATELGVTRPTIYELLAKHGMR

Sequences:

>Translated_399_residues
MAVAESTEASSRVWYLIEEGQGLRVGRARSAGATSIPLEAGFYVEPEAAAPLIRAVERALSEGADPDRYEESDAPLGRGR
SPSGDAGPRRLGLVTGDPRMIQLCRDTERLAPSDATVLLLGESGTGKELFAKALHGLNRVRSAAPLEAINCAAIPSELLE
SELFGFERGAFTGAYRARVGRIERANGGTLFLDEIGELPLEVQAKLLRFLQQRTVQRLGGRREIPVDVRVVCATNRDLVE
RMGEGAFRDDFYYRVAEVQLRLPPLRERPGDPALIAHALLKGMVRQHKARARKLGSDALAVIAAYRWPGNVRELENALRR
AVILSEGGAIRAEDLGLPLPRSLTVQRDLPRLREVRDEAERRVVAEALGRCNGNISRAATELGVTRPTIYELLAKHGMR
>Mature_398_residues
AVAESTEASSRVWYLIEEGQGLRVGRARSAGATSIPLEAGFYVEPEAAAPLIRAVERALSEGADPDRYEESDAPLGRGRS
PSGDAGPRRLGLVTGDPRMIQLCRDTERLAPSDATVLLLGESGTGKELFAKALHGLNRVRSAAPLEAINCAAIPSELLES
ELFGFERGAFTGAYRARVGRIERANGGTLFLDEIGELPLEVQAKLLRFLQQRTVQRLGGRREIPVDVRVVCATNRDLVER
MGEGAFRDDFYYRVAEVQLRLPPLRERPGDPALIAHALLKGMVRQHKARARKLGSDALAVIAAYRWPGNVRELENALRRA
VILSEGGAIRAEDLGLPLPRSLTVQRDLPRLREVRDEAERRVVAEALGRCNGNISRAATELGVTRPTIYELLAKHGMR

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=313, Percent_Identity=43.4504792332268, Blast_Score=265, Evalue=4e-72,
Organism=Escherichia coli, GI87082117, Length=319, Percent_Identity=45.141065830721, Blast_Score=248, Evalue=4e-67,
Organism=Escherichia coli, GI1788905, Length=354, Percent_Identity=40.6779661016949, Blast_Score=244, Evalue=7e-66,
Organism=Escherichia coli, GI1790437, Length=309, Percent_Identity=44.9838187702265, Blast_Score=241, Evalue=4e-65,
Organism=Escherichia coli, GI1789087, Length=304, Percent_Identity=41.7763157894737, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1789233, Length=311, Percent_Identity=41.1575562700965, Blast_Score=224, Evalue=7e-60,
Organism=Escherichia coli, GI1790299, Length=369, Percent_Identity=38.2113821138211, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI87082152, Length=332, Percent_Identity=40.9638554216867, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI1786524, Length=392, Percent_Identity=39.030612244898, Blast_Score=201, Evalue=7e-53,
Organism=Escherichia coli, GI87081872, Length=319, Percent_Identity=39.8119122257053, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1787583, Length=310, Percent_Identity=38.7096774193548, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI87081858, Length=310, Percent_Identity=32.5806451612903, Blast_Score=147, Evalue=8e-37,
Organism=Escherichia coli, GI1789828, Length=249, Percent_Identity=36.5461847389558, Blast_Score=132, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 43687; Mature: 43555

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVAESTEASSRVWYLIEEGQGLRVGRARSAGATSIPLEAGFYVEPEAAAPLIRAVERAL
CCCCCCCCCCCEEEEEEECCCCCEECCCCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHH
SEGADPDRYEESDAPLGRGRSPSGDAGPRRLGLVTGDPRMIQLCRDTERLAPSDATVLLL
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEEEE
GESGTGKELFAKALHGLNRVRSAAPLEAINCAAIPSELLESELFGFERGAFTGAYRARVG
ECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHCCCCCCCCHHHHHHHC
RIERANGGTLFLDEIGELPLEVQAKLLRFLQQRTVQRLGGRREIPVDVRVVCATNRDLVE
CEEECCCCEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHH
RMGEGAFRDDFYYRVAEVQLRLPPLRERPGDPALIAHALLKGMVRQHKARARKLGSDALA
HHCCCCCCHHHHHEEEHHEEECCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
VIAAYRWPGNVRELENALRRAVILSEGGAIRAEDLGLPLPRSLTVQRDLPRLREVRDEAE
HHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
RRVVAEALGRCNGNISRAATELGVTRPTIYELLAKHGMR
HHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
AVAESTEASSRVWYLIEEGQGLRVGRARSAGATSIPLEAGFYVEPEAAAPLIRAVERAL
CCCCCCCCCCEEEEEEECCCCCEECCCCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHH
SEGADPDRYEESDAPLGRGRSPSGDAGPRRLGLVTGDPRMIQLCRDTERLAPSDATVLLL
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEEEE
GESGTGKELFAKALHGLNRVRSAAPLEAINCAAIPSELLESELFGFERGAFTGAYRARVG
ECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHCCCCCCCCHHHHHHHC
RIERANGGTLFLDEIGELPLEVQAKLLRFLQQRTVQRLGGRREIPVDVRVVCATNRDLVE
CEEECCCCEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHH
RMGEGAFRDDFYYRVAEVQLRLPPLRERPGDPALIAHALLKGMVRQHKARARKLGSDALA
HHCCCCCCHHHHHEEEHHEEECCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
VIAAYRWPGNVRELENALRRAVILSEGGAIRAEDLGLPLPRSLTVQRDLPRLREVRDEAE
HHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
RRVVAEALGRCNGNISRAATELGVTRPTIYELLAKHGMR
HHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]