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The map label for this gene is dxr [H]

Identifier: 121998242

GI number: 121998242

Start: 1576410

End: 1577582

Strand: Reverse

Name: dxr [H]

Synonym: Hhal_1460

Alternate gene names: 121998242

Gene position: 1577582-1576410 (Counterclockwise)

Preceding gene: 121998243

Following gene: 121998241

Centisome position: 58.9

GC content: 68.63

Gene sequence:

>1173_bases
ATGCGGCTGGCAGTACTCGGGGCCACGGGGTCCATTGGTACGAGCACCCTGGATGTGGCAATCAGGCACCCCGAACGTTT
CGAGGTTCGGGCCGTGGCTGCAGGGCGCGATTGGGAAGGGTTGCTGCGGATCTGCCGTGCGCACCGCCCCAGCCGAGCCG
CGCTGGCCGATGAGCAGGCGGCGGCGCAGTTGCGCGATCGGCTTCAGGCCGAAGGCCTGGAGCACATCGAGGTCTCCGCG
GGCGAAGAGGGCGTGGCCGCGCTGGCGGCGGACGCCGACGTGGATGCAGTGGTCACGGCCGTGGTCGGGGCGGCGGGGCT
GGCCTCGTCCCTGGCGGCCTGCCGGGCCGGCAAGCGGATTCTCCTGGCCAACAAGGAGACGCTGGTCGTCGCCGGTGCCC
TGTTCATGGAGACGGCGCAGCGCCATGGGGCGCAGATCGTCCCGGTGGACAGTGAGCACAACGCCGTATTCCAGGGGCTG
CCGACCGGCACCGACGCCACGGCGGGGGTGGAGCGCATCGTGCTGACGGCATCCGGTGGCCCGTTCCGCGATCGGGATCC
CGACACCCTGGCCGCCGTGACCCCCGAGGAGGCCGTAGCCCATCCGAACTGGTCCATGGGCCGCAAGATCTCCGTCGATT
CAGCCACCATGATGAACAAGGGCCTTGAGGTGATCGAGGCCTGCCATCTCTTTGACCTGGAACCTCAGCGCGTCGATGTG
GTCATTCATCGACAGAGCTTGGTGCATGCGCTGGTGGGCTATCGCGACGGTTCCTATTTGGCGCAGGTCGGGTCGCCGGA
CATGCGAGTGCCGATCTCCTACGCCATGGGGTATCCCGAGCGGATCGCCTCGGGTGTGGATCTGGTGGATCTGGCGGCCG
CAGGGCGCCTCGACTTCGAAGCAGTGGACGAGCGCCGCTTCCCCTGCCTCCGACTGGCCTATCAGGCCCTGCGTACCGGC
GACGGCGCGTGCGCCGTACTCAATGCGGCCAATGAGATTGCGGTGGACGCCTTCCTCGACGGGCGTCTTCGTTTCGACCG
CATTGCACCTGTGATCGAGGACGCCCTGGCAGCGGAGACCCCTCCGCCGCCGAAGGATCTGGATTCGGCCCGCGCCATCG
ATGCGCAGGCCCGCCGTGTGGCCGAGGAGGCCGTGCGGCGCATCGCGGACTGA

Upstream 100 bases:

>100_bases
TCCTGCCGGGGCACGGCGGGATCCTTGACCGTATCGACAGTCTGACCGCGGCGGCGCCGGTTCTAGCAGCGGGGTTAGCG
TGGTGGCAGAGCGGAATGTG

Downstream 100 bases:

>100_bases
CTCGACTATGATGATCGTCTGGAGCGTCATCGCCTTCCTGGTCGCCATCGCCATCTTGGTGACCGTTCACGAGGCGGGCC
ATTTCTTCGTGGCCCGCTGG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MRLAVLGATGSIGTSTLDVAIRHPERFEVRAVAAGRDWEGLLRICRAHRPSRAALADEQAAAQLRDRLQAEGLEHIEVSA
GEEGVAALAADADVDAVVTAVVGAAGLASSLAACRAGKRILLANKETLVVAGALFMETAQRHGAQIVPVDSEHNAVFQGL
PTGTDATAGVERIVLTASGGPFRDRDPDTLAAVTPEEAVAHPNWSMGRKISVDSATMMNKGLEVIEACHLFDLEPQRVDV
VIHRQSLVHALVGYRDGSYLAQVGSPDMRVPISYAMGYPERIASGVDLVDLAAAGRLDFEAVDERRFPCLRLAYQALRTG
DGACAVLNAANEIAVDAFLDGRLRFDRIAPVIEDALAAETPPPPKDLDSARAIDAQARRVAEEAVRRIAD

Sequences:

>Translated_390_residues
MRLAVLGATGSIGTSTLDVAIRHPERFEVRAVAAGRDWEGLLRICRAHRPSRAALADEQAAAQLRDRLQAEGLEHIEVSA
GEEGVAALAADADVDAVVTAVVGAAGLASSLAACRAGKRILLANKETLVVAGALFMETAQRHGAQIVPVDSEHNAVFQGL
PTGTDATAGVERIVLTASGGPFRDRDPDTLAAVTPEEAVAHPNWSMGRKISVDSATMMNKGLEVIEACHLFDLEPQRVDV
VIHRQSLVHALVGYRDGSYLAQVGSPDMRVPISYAMGYPERIASGVDLVDLAAAGRLDFEAVDERRFPCLRLAYQALRTG
DGACAVLNAANEIAVDAFLDGRLRFDRIAPVIEDALAAETPPPPKDLDSARAIDAQARRVAEEAVRRIAD
>Mature_390_residues
MRLAVLGATGSIGTSTLDVAIRHPERFEVRAVAAGRDWEGLLRICRAHRPSRAALADEQAAAQLRDRLQAEGLEHIEVSA
GEEGVAALAADADVDAVVTAVVGAAGLASSLAACRAGKRILLANKETLVVAGALFMETAQRHGAQIVPVDSEHNAVFQGL
PTGTDATAGVERIVLTASGGPFRDRDPDTLAAVTPEEAVAHPNWSMGRKISVDSATMMNKGLEVIEACHLFDLEPQRVDV
VIHRQSLVHALVGYRDGSYLAQVGSPDMRVPISYAMGYPERIASGVDLVDLAAAGRLDFEAVDERRFPCLRLAYQALRTG
DGACAVLNAANEIAVDAFLDGRLRFDRIAPVIEDALAAETPPPPKDLDSARAIDAQARRVAEEAVRRIAD

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=396, Percent_Identity=48.4848484848485, Blast_Score=347, Evalue=1e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 41407; Mature: 41407

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLAVLGATGSIGTSTLDVAIRHPERFEVRAVAAGRDWEGLLRICRAHRPSRAALADEQA
CEEEEEECCCCCCCCEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHH
AAQLRDRLQAEGLEHIEVSAGEEGVAALAADADVDAVVTAVVGAAGLASSLAACRAGKRI
HHHHHHHHHHCCCCEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
LLANKETLVVAGALFMETAQRHGAQIVPVDSEHNAVFQGLPTGTDATAGVERIVLTASGG
EEECCCEEEEHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCCCCCCCCCEEEEEEECCC
PFRDRDPDTLAAVTPEEAVAHPNWSMGRKISVDSATMMNKGLEVIEACHLFDLEPQRVDV
CCCCCCCCCEEEECCHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEE
VIHRQSLVHALVGYRDGSYLAQVGSPDMRVPISYAMGYPERIASGVDLVDLAAAGRLDFE
EEEHHHHHHHHHCCCCCCEEEECCCCCCEEEHHHHCCCHHHHHCCCCEEHHHHCCCCCHH
AVDERRFPCLRLAYQALRTGDGACAVLNAANEIAVDAFLDGRLRFDRIAPVIEDALAAET
HHHHCCCHHHHHHHHHHHCCCCCEEEEECCCHHEEEEEECCCCCHHHHHHHHHHHHHCCC
PPPPKDLDSARAIDAQARRVAEEAVRRIAD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLAVLGATGSIGTSTLDVAIRHPERFEVRAVAAGRDWEGLLRICRAHRPSRAALADEQA
CEEEEEECCCCCCCCEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHH
AAQLRDRLQAEGLEHIEVSAGEEGVAALAADADVDAVVTAVVGAAGLASSLAACRAGKRI
HHHHHHHHHHCCCCEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
LLANKETLVVAGALFMETAQRHGAQIVPVDSEHNAVFQGLPTGTDATAGVERIVLTASGG
EEECCCEEEEHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCCCCCCCCCEEEEEEECCC
PFRDRDPDTLAAVTPEEAVAHPNWSMGRKISVDSATMMNKGLEVIEACHLFDLEPQRVDV
CCCCCCCCCEEEECCHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEE
VIHRQSLVHALVGYRDGSYLAQVGSPDMRVPISYAMGYPERIASGVDLVDLAAAGRLDFE
EEEHHHHHHHHHCCCCCCEEEECCCCCCEEEHHHHCCCHHHHHCCCCEEHHHHCCCCCHH
AVDERRFPCLRLAYQALRTGDGACAVLNAANEIAVDAFLDGRLRFDRIAPVIEDALAAET
HHHHCCCHHHHHHHHHHHCCCCCEEEEECCCHHEEEEEECCCCCHHHHHHHHHHHHHCCC
PPPPKDLDSARAIDAQARRVAEEAVRRIAD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA