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The map label for this gene is kdsA [H]

Identifier: 121998220

GI number: 121998220

Start: 1549353

End: 1550189

Strand: Reverse

Name: kdsA [H]

Synonym: Hhal_1438

Alternate gene names: 121998220

Gene position: 1550189-1549353 (Counterclockwise)

Preceding gene: 121998221

Following gene: 121998219

Centisome position: 57.88

GC content: 67.5

Gene sequence:

>837_bases
ATGAGCAGCATTGAGCTCTGCGGTTTTCGGGCCGGCATCGAGCAGCCGCTGTTCCTGATCGCCGGCCCGTGCGTGGTCGA
GTCCGAGGCGCTGGCCCTGGAGAGCGCCCTGGAGCTGCGTGATCTCTGCGCTGAGCTCGGGGTGCCGCTGATCTACAAAT
CCTCTTTCGACAAGGCCAACCGCTCATCGGCGCAGAGCTATCGTGGCCCCGGGATGGAGGCAGGTCTGCGCGTGCTGGAG
CGCGTGCGCCGCGAGGTTGGGGTGCCCGTGGTCACCGATGTCCACGAGGATACCCCGCTCGACGAGGTGGCCTCGGTGGT
CGATGTGCTCCAGACCCCCGCGTTCCTCTGCCGTCAGACCAACTTTATCCAGCGGGTGGCTGCCTGCGGGCTGCCAGTCA
ACCTGAAAAAGGGCCAGTTCCTTGCCCCTTGGGACATGACCCATGTCGTCGACAAGGCGCGCGCGACCGGCAATGAGCAC
ATCCTGGTTTGCGAGCGCGGGGTGTCTTTCGGCTACAACAACCTGATCTCCGACATGCGGGCGCTGGCGGTGATGCGCCA
GACCGGGGCGCCGGTGGTCTTCGACGCGACCCACTCGGTGCAGCTGCCCGGGGGGCAGGGCCACGCCTCGGGGGGGCAGC
GGGAGTTCGTGCCCGTGCTGGCGCGCGCCGCGGTGGCCGCGGGCGTGTCGGGGCTGTTCATGGAAACCCATCCGGATCCC
GATGCCGCGCTGTCCGATGGCCCCAATGCGTGGCCGCTGGATCGTATGCGCGAACTCCTCGCGACGCTGATCGCGCTGGA
TCGCGTCGTCAAGGAGCAGGGATTCGCCGAGCAATGA

Upstream 100 bases:

>100_bases
CCGGAGTTCACATCCACGCCACGGGATGGGCACCCGCTGTTCGCAAGCTTCCTGCGGGCGGCGATCGCCCACCGCGATGG
CACTGCGCAGGCATTCAACC

Downstream 100 bases:

>100_bases
AGGAGCGACTGAATCATGGCGAACATCGAGCGTGTCATCGGCCGCGAGGTCCTCGACTCTCGCGGTAACCCGACCGTCGA
GGCCGACGTCTGGCTGGACG

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase [H]

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MSSIELCGFRAGIEQPLFLIAGPCVVESEALALESALELRDLCAELGVPLIYKSSFDKANRSSAQSYRGPGMEAGLRVLE
RVRREVGVPVVTDVHEDTPLDEVASVVDVLQTPAFLCRQTNFIQRVAACGLPVNLKKGQFLAPWDMTHVVDKARATGNEH
ILVCERGVSFGYNNLISDMRALAVMRQTGAPVVFDATHSVQLPGGQGHASGGQREFVPVLARAAVAAGVSGLFMETHPDP
DAALSDGPNAWPLDRMRELLATLIALDRVVKEQGFAEQ

Sequences:

>Translated_278_residues
MSSIELCGFRAGIEQPLFLIAGPCVVESEALALESALELRDLCAELGVPLIYKSSFDKANRSSAQSYRGPGMEAGLRVLE
RVRREVGVPVVTDVHEDTPLDEVASVVDVLQTPAFLCRQTNFIQRVAACGLPVNLKKGQFLAPWDMTHVVDKARATGNEH
ILVCERGVSFGYNNLISDMRALAVMRQTGAPVVFDATHSVQLPGGQGHASGGQREFVPVLARAAVAAGVSGLFMETHPDP
DAALSDGPNAWPLDRMRELLATLIALDRVVKEQGFAEQ
>Mature_277_residues
SSIELCGFRAGIEQPLFLIAGPCVVESEALALESALELRDLCAELGVPLIYKSSFDKANRSSAQSYRGPGMEAGLRVLER
VRREVGVPVVTDVHEDTPLDEVASVVDVLQTPAFLCRQTNFIQRVAACGLPVNLKKGQFLAPWDMTHVVDKARATGNEHI
LVCERGVSFGYNNLISDMRALAVMRQTGAPVVFDATHSVQLPGGQGHASGGQREFVPVLARAAVAAGVSGLFMETHPDPD
AALSDGPNAWPLDRMRELLATLIALDRVVKEQGFAEQ

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=264, Percent_Identity=45.0757575757576, Blast_Score=249, Evalue=2e-67,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 29931; Mature: 29799

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSIELCGFRAGIEQPLFLIAGPCVVESEALALESALELRDLCAELGVPLIYKSSFDKAN
CCCCCCCHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
RSSAQSYRGPGMEAGLRVLERVRREVGVPVVTDVHEDTPLDEVASVVDVLQTPAFLCRQT
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHCHHHHHHHH
NFIQRVAACGLPVNLKKGQFLAPWDMTHVVDKARATGNEHILVCERGVSFGYNNLISDMR
HHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHH
ALAVMRQTGAPVVFDATHSVQLPGGQGHASGGQREFVPVLARAAVAAGVSGLFMETHPDP
HHHHHHHCCCCEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHCHHHCEEECCCCC
DAALSDGPNAWPLDRMRELLATLIALDRVVKEQGFAEQ
CCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SSIELCGFRAGIEQPLFLIAGPCVVESEALALESALELRDLCAELGVPLIYKSSFDKAN
CCCCCCHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
RSSAQSYRGPGMEAGLRVLERVRREVGVPVVTDVHEDTPLDEVASVVDVLQTPAFLCRQT
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHCHHHHHHHH
NFIQRVAACGLPVNLKKGQFLAPWDMTHVVDKARATGNEHILVCERGVSFGYNNLISDMR
HHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHH
ALAVMRQTGAPVVFDATHSVQLPGGQGHASGGQREFVPVLARAAVAAGVSGLFMETHPDP
HHHHHHHCCCCEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHCHHHCEEECCCCC
DAALSDGPNAWPLDRMRELLATLIALDRVVKEQGFAEQ
CCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA