Click here to switch to the map view.

The map label for this gene is pyrG

Identifier: 121998221

GI number: 121998221

Start: 1550176

End: 1551831

Strand: Reverse

Name: pyrG

Synonym: Hhal_1439

Alternate gene names: 121998221

Gene position: 1551831-1550176 (Counterclockwise)

Preceding gene: 121998222

Following gene: 121998220

Centisome position: 57.94

GC content: 65.4

Gene sequence:

>1656_bases
ATGACGCGTTATCTATTTATTACTGGTGGCGTGGTTTCCTCCCTGGGTAAGGGCATCTCGGCCGCTTCCCTGGGGACCAT
CCTGCAGGCGCGCGGTCTGAGCGTGACCCTGATCAAGCTCGACCCCTACATCAACGTCGACCCGGGTACCATGAGCCCGT
TCCAGCACGGCGAGGTCTACGTCACTGACGACGGTGCGGAGACGGACCTGGATCTGGGGCACTACGAGCGGTTCGTCCGC
GCCCCGGTCAGCCGTCGCAACAACTTCACCACCGGTCGGATCTACGAGAGCGTGATCCGCAAGGAGCGCCGCGGCGACTA
CCTCGGCGGGACGGTGCAGGTCATCCCCCACGTAACCGACGAGATCAAGCGGTGCATCCAGGAGGGGGCCGACGACGTCG
ACGTCGCGCTGGTGGAGATTGGCGGCACGGTGGGCGACATCGAGTCGCTGCCCTTCCTCGAGGCGATTCGCCAGATGGGG
ACCGAACTCGGGCGCGAGCGGTGCATGTTCATGCATCTGACCCTGGTGCCGTTCATCGGCACGGCTGGGGAGATGAAGAC
CAAGCCGACTCAGCACTCCGTCAAGGAGCTGCGCTCGATCGGCATCCAGCCGGATATTCTGGTCTGCCGCGCGGCGCACC
CGATCCCGGAGGAGGAGCGCCGGAAGATCGCGCTGTTCACCAATGTCGAGCCGCGGGCGGTGATCGCCGCGCTCGACGTG
CCGAACATCTACCAGATCCCCGAGGAATTGCACCAGCAGGGCCTGGACCATATTGTCGCCGAGAAGTGGGGCTTGGAGCT
GCCTCCGGCCAACCTGGCGGATTGGCACCGGGTGGTGGAGATCATGTCCAACCCGGAGGGGGAGGTCACGGTGGCCATGG
TCGGCAAGTATGTCGACCTCACGGACGCCTACATGTCCCTCAACGAGGCGCTGCGCCATGCTGGTATCCAGACGCGTCAG
CGGGTGAATATCCGCTACGTGGATTCGGAATCCCTGGAGCGCGAGGGGTGTTCGGCGCTGGAGGGGGCGGATGCCATCCT
GGTGCCGGGCGGTTTCGGGCAGCGCGGCATCGAGGGCAAGATCGAGGCCGTGCGCTTCGCGCGTGAAAGCCGGATCCCCT
ATCTCGGCATCTGCCTGGGCATGCAGTTGGCGGTGATCGAGTATGCGCGGCACCAGGCGGGGCTGGAGAACGCTCACAGC
ACCGAGTTCGTCCGGCACCCGCACCATCCGGTGATCGGCCTGATCACCGAGTGGATGACCGACGAAGGCGAGGTGGAGCA
GCGCGACGAGGCCGATGACCTGGGCGGCACCATGCGCTTGGGTGGGCAGCCGTGCCGCCTGGCTGCCGGGACCCTGATCA
ACCAAGTCTACGGCAAGGATCGCATCGTCGAGCGTCACCGCCACCGGTACGAGTTCAACAACCACTACCGCGAGCGCCTG
GCCGAGGCCGGCCTGAGCTTCTCGGGGTGGTCCCAGGACGGTCGCCTGGTCGAAGTGGTGGAACTGCCCGAGCATCCCTG
GTTTATTGGCTGCCAGTTCCACCCGGAGTTCACATCCACGCCACGGGATGGGCACCCGCTGTTCGCAAGCTTCCTGCGGG
CGGCGATCGCCCACCGCGATGGCACTGCGCAGGCATTCAACCATGAGCAGCATTGA

Upstream 100 bases:

>100_bases
GGACTCCTGACCGATCCGTGCGTTGTGGGCCTACCCCCCTTCTGGTAAGGTTCCGCCATTCTGTTTCCCGGTCCATCCTT
CCCTCAGCCTGGCTCTGTCC

Downstream 100 bases:

>100_bases
GCTCTGCGGTTTTCGGGCCGGCATCGAGCAGCCGCTGTTCCTGATCGCCGGCCCGTGCGTGGTCGAGTCCGAGGCGCTGG
CCCTGGAGAGCGCCCTGGAG

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 551; Mature: 550

Protein sequence:

>551_residues
MTRYLFITGGVVSSLGKGISAASLGTILQARGLSVTLIKLDPYINVDPGTMSPFQHGEVYVTDDGAETDLDLGHYERFVR
APVSRRNNFTTGRIYESVIRKERRGDYLGGTVQVIPHVTDEIKRCIQEGADDVDVALVEIGGTVGDIESLPFLEAIRQMG
TELGRERCMFMHLTLVPFIGTAGEMKTKPTQHSVKELRSIGIQPDILVCRAAHPIPEEERRKIALFTNVEPRAVIAALDV
PNIYQIPEELHQQGLDHIVAEKWGLELPPANLADWHRVVEIMSNPEGEVTVAMVGKYVDLTDAYMSLNEALRHAGIQTRQ
RVNIRYVDSESLEREGCSALEGADAILVPGGFGQRGIEGKIEAVRFARESRIPYLGICLGMQLAVIEYARHQAGLENAHS
TEFVRHPHHPVIGLITEWMTDEGEVEQRDEADDLGGTMRLGGQPCRLAAGTLINQVYGKDRIVERHRHRYEFNNHYRERL
AEAGLSFSGWSQDGRLVEVVELPEHPWFIGCQFHPEFTSTPRDGHPLFASFLRAAIAHRDGTAQAFNHEQH

Sequences:

>Translated_551_residues
MTRYLFITGGVVSSLGKGISAASLGTILQARGLSVTLIKLDPYINVDPGTMSPFQHGEVYVTDDGAETDLDLGHYERFVR
APVSRRNNFTTGRIYESVIRKERRGDYLGGTVQVIPHVTDEIKRCIQEGADDVDVALVEIGGTVGDIESLPFLEAIRQMG
TELGRERCMFMHLTLVPFIGTAGEMKTKPTQHSVKELRSIGIQPDILVCRAAHPIPEEERRKIALFTNVEPRAVIAALDV
PNIYQIPEELHQQGLDHIVAEKWGLELPPANLADWHRVVEIMSNPEGEVTVAMVGKYVDLTDAYMSLNEALRHAGIQTRQ
RVNIRYVDSESLEREGCSALEGADAILVPGGFGQRGIEGKIEAVRFARESRIPYLGICLGMQLAVIEYARHQAGLENAHS
TEFVRHPHHPVIGLITEWMTDEGEVEQRDEADDLGGTMRLGGQPCRLAAGTLINQVYGKDRIVERHRHRYEFNNHYRERL
AEAGLSFSGWSQDGRLVEVVELPEHPWFIGCQFHPEFTSTPRDGHPLFASFLRAAIAHRDGTAQAFNHEQH
>Mature_550_residues
TRYLFITGGVVSSLGKGISAASLGTILQARGLSVTLIKLDPYINVDPGTMSPFQHGEVYVTDDGAETDLDLGHYERFVRA
PVSRRNNFTTGRIYESVIRKERRGDYLGGTVQVIPHVTDEIKRCIQEGADDVDVALVEIGGTVGDIESLPFLEAIRQMGT
ELGRERCMFMHLTLVPFIGTAGEMKTKPTQHSVKELRSIGIQPDILVCRAAHPIPEEERRKIALFTNVEPRAVIAALDVP
NIYQIPEELHQQGLDHIVAEKWGLELPPANLADWHRVVEIMSNPEGEVTVAMVGKYVDLTDAYMSLNEALRHAGIQTRQR
VNIRYVDSESLEREGCSALEGADAILVPGGFGQRGIEGKIEAVRFARESRIPYLGICLGMQLAVIEYARHQAGLENAHST
EFVRHPHHPVIGLITEWMTDEGEVEQRDEADDLGGTMRLGGQPCRLAAGTLINQVYGKDRIVERHRHRYEFNNHYRERLA
EAGLSFSGWSQDGRLVEVVELPEHPWFIGCQFHPEFTSTPRDGHPLFASFLRAAIAHRDGTAQAFNHEQH

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=559, Percent_Identity=43.2915921288014, Blast_Score=472, Evalue=1e-133,
Organism=Homo sapiens, GI28559085, Length=568, Percent_Identity=42.7816901408451, Blast_Score=465, Evalue=1e-131,
Organism=Homo sapiens, GI28559083, Length=568, Percent_Identity=42.7816901408451, Blast_Score=465, Evalue=1e-131,
Organism=Homo sapiens, GI221316689, Length=568, Percent_Identity=42.7816901408451, Blast_Score=465, Evalue=1e-131,
Organism=Escherichia coli, GI1789142, Length=534, Percent_Identity=64.6067415730337, Blast_Score=715, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25148299, Length=632, Percent_Identity=37.5, Blast_Score=417, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6322563, Length=573, Percent_Identity=41.7102966841187, Blast_Score=442, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6319432, Length=573, Percent_Identity=40.4886561954625, Blast_Score=430, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24664469, Length=558, Percent_Identity=43.3691756272401, Blast_Score=457, Evalue=1e-129,
Organism=Drosophila melanogaster, GI21357815, Length=504, Percent_Identity=41.6666666666667, Blast_Score=382, Evalue=1e-106,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_HALHL (A1WWZ4)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003008.1
- ProteinModelPortal:   A1WWZ4
- SMR:   A1WWZ4
- STRING:   A1WWZ4
- GeneID:   4709176
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1439
- eggNOG:   COG0504
- HOGENOM:   HBG597806
- OMA:   IIHAGAN
- PhylomeDB:   A1WWZ4
- ProtClustDB:   PRK05380
- BioCyc:   HHAL349124:HHAL_1439-MONOMER
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 61465; Mature: 61333

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 378-378 ACT_SITE 514-514 ACT_SITE 516-516

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRYLFITGGVVSSLGKGISAASLGTILQARGLSVTLIKLDPYINVDPGTMSPFQHGEVY
CCEEEEEECHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFVRAPVSRRNNFTTGRIYESVIRKERRGDYLGGTVQVIPHVTD
EECCCCCCCCCHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCHHHH
EIKRCIQEGADDVDVALVEIGGTVGDIESLPFLEAIRQMGTELGRERCMFMHLTLVPFIG
HHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEHHHHHCC
TAGEMKTKPTQHSVKELRSIGIQPDILVCRAAHPIPEEERRKIALFTNVEPRAVIAALDV
CCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHCCEEEEEECCCCCEEEEECCC
PNIYQIPEELHQQGLDHIVAEKWGLELPPANLADWHRVVEIMSNPEGEVTVAMVGKYVDL
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCHHHH
TDAYMSLNEALRHAGIQTRQRVNIRYVDSESLEREGCSALEGADAILVPGGFGQRGIEGK
HHHHHHHHHHHHHCCCCHHHEEEEEEECCHHHHHCCCCHHCCCCEEEECCCCCCCCCCCH
IEAVRFARESRIPYLGICLGMQLAVIEYARHQAGLENAHSTEFVRHPHHPVIGLITEWMT
HHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHCC
DEGEVEQRDEADDLGGTMRLGGQPCRLAAGTLINQVYGKDRIVERHRHRYEFNNHYRERL
CCCCCCCCCCHHHCCCEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
AEAGLSFSGWSQDGRLVEVVELPEHPWFIGCQFHPEFTSTPRDGHPLFASFLRAAIAHRD
HHCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCC
GTAQAFNHEQH
CCHHCCCCCCC
>Mature Secondary Structure 
TRYLFITGGVVSSLGKGISAASLGTILQARGLSVTLIKLDPYINVDPGTMSPFQHGEVY
CEEEEEECHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFVRAPVSRRNNFTTGRIYESVIRKERRGDYLGGTVQVIPHVTD
EECCCCCCCCCHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCHHHH
EIKRCIQEGADDVDVALVEIGGTVGDIESLPFLEAIRQMGTELGRERCMFMHLTLVPFIG
HHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEHHHHHCC
TAGEMKTKPTQHSVKELRSIGIQPDILVCRAAHPIPEEERRKIALFTNVEPRAVIAALDV
CCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHCCEEEEEECCCCCEEEEECCC
PNIYQIPEELHQQGLDHIVAEKWGLELPPANLADWHRVVEIMSNPEGEVTVAMVGKYVDL
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCHHHH
TDAYMSLNEALRHAGIQTRQRVNIRYVDSESLEREGCSALEGADAILVPGGFGQRGIEGK
HHHHHHHHHHHHHCCCCHHHEEEEEEECCHHHHHCCCCHHCCCCEEEECCCCCCCCCCCH
IEAVRFARESRIPYLGICLGMQLAVIEYARHQAGLENAHSTEFVRHPHHPVIGLITEWMT
HHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHCC
DEGEVEQRDEADDLGGTMRLGGQPCRLAAGTLINQVYGKDRIVERHRHRYEFNNHYRERL
CCCCCCCCCCHHHCCCEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
AEAGLSFSGWSQDGRLVEVVELPEHPWFIGCQFHPEFTSTPRDGHPLFASFLRAAIAHRD
HHCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCC
GTAQAFNHEQH
CCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA