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The map label for this gene is argH

Identifier: 121997815

GI number: 121997815

Start: 1097640

End: 1099037

Strand: Reverse

Name: argH

Synonym: Hhal_1024

Alternate gene names: 121997815

Gene position: 1099037-1097640 (Counterclockwise)

Preceding gene: 121997820

Following gene: 121997814

Centisome position: 41.03

GC content: 70.31

Gene sequence:

>1398_bases
ATGAGCCAGAATGACGCAGCCCCCGGCCAGCAGCTGTGGACCGGCCGCTTCACCGAGGCGACCGACGCCTTCGTCGAGCG
CTTCTCGGCCTCCGTGCAGTTCGACGCGCGCCTCGCCCTGCAGGATATCCAGGGCTCCGAGGCCCACGCCCGCATGCTCG
CCGCGCGTGGCGTGCTGACCGAGGCGGAGCGCGACGCCATCCTCCAGGGGCTGGCCGAGATCCGCCAAGAGGTGGTCGAG
GAGCGCTTCCCGTGGTCGCCGCAGCTCGAGGATGTGCACATGAACATCGAGCATCGGCTGACCCAGCGCATCGGCGAGGC
CGGCAAGAAGCTGCACACCGGCCGCTCGCGCAACGATCAGATCGCCACCGACGTGCGCCTCTTCCTGCGCGAGGCCATCG
ATACCATCCGTGCCGAGTTGGCCCGCTTCCAGCACGGGCTGGTGGAACTGGCCGAGCGCGAGGCCGACACCATCATGCCC
GGCTTCACCCACCTGCAGGTGGCGCAGCCGGTGACCTTCGGGCACCACATGCTGGCCTGGTACGAGATGCTCGAGCGCGA
CCGCGACCGCCTGGCGGACTGCCGGCGGCGCCTGAACCAGTGTCCGCTCGGCGCGGCGGCGCTGGCGGGGACGTCGTTCC
CCATCGACCGCGAGGCGACCGCCCGGGAGCTGGGCTTCGACGCGCCGACGCGCAACTCCCTGGACTCGGTCAGCGATCGC
GATTTCGCCATCGAATTCTGTGCCGACGCCAGCCTGATCCTCGTCCACCTCTCGCGCATGGCCGAGGAGCTGGTGCTGTG
GACCTCTCAGCAGTTCGGCTTCATCGAGCTGCCGGATCGCTTCTGCACCGGTTCTTCGATCATGCCGCAGAAGAAGAACC
CGGACGTGGCGGAGCTGGTGCGGGGCAAGGCGGCCCGTGCCCAGGGCAGCCTGGTCCAGCTGCTGACCCTGATGAAAGGC
CAGCCGTTGGCCTATAACCGGGACAACCAGGAGGACAAGGAGCCGCTTTTCGACGCCGTGGACACGGCGCGGGATGCGCT
GACCGCCTTCGCCGACATGGTCCCGGCGCTGAGCGTCAACCGCGAGCGTTGCCGCGCGGCGGCCCGGGCCGGCTTCGCCA
CGGCCACCGACCTGGCCGACTACCTGGTCCGCCAGGGGCTGGCCTTCCGCGACGCCCACGAGGTGGTCGGCCGTGCCGTG
CGTTACGCCACCGAAGCCGATCGGGATCTCGCCGAGCTCAGCCTTGAGGAGCTCCAGCAGTTCTCCACCGCCATCGGGGA
CGACGTCTTCGCCGTGCTCACCCTCGACGGCTCGGTCGCGGCGCGCTCCCACGTTGGCGGCACGGCGCCGGAGCAGGTCC
GTGCCCAGGCCCAGGCGGCCCGGGAGCGCCTGGCTTGA

Upstream 100 bases:

>100_bases
TCGGCACTACAATGGCGAGCGCGCCGGCGGCCCCGTCGGGCGGGGTGGCCGACCATCGACCCGTTTTTGTCCACCAAACC
ATCGACCGTGAGCACCCGCT

Downstream 100 bases:

>100_bases
GCCATCGCCCACGCAAGCGCTTCGGGCAGAACTTCCTCCGCGACCCGGCGGTCATCCAGCGTATGGTCACGGCCATCGCC
CCGCGGGAGGGGGAGACGCT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MSQNDAAPGQQLWTGRFTEATDAFVERFSASVQFDARLALQDIQGSEAHARMLAARGVLTEAERDAILQGLAEIRQEVVE
ERFPWSPQLEDVHMNIEHRLTQRIGEAGKKLHTGRSRNDQIATDVRLFLREAIDTIRAELARFQHGLVELAEREADTIMP
GFTHLQVAQPVTFGHHMLAWYEMLERDRDRLADCRRRLNQCPLGAAALAGTSFPIDREATARELGFDAPTRNSLDSVSDR
DFAIEFCADASLILVHLSRMAEELVLWTSQQFGFIELPDRFCTGSSIMPQKKNPDVAELVRGKAARAQGSLVQLLTLMKG
QPLAYNRDNQEDKEPLFDAVDTARDALTAFADMVPALSVNRERCRAAARAGFATATDLADYLVRQGLAFRDAHEVVGRAV
RYATEADRDLAELSLEELQQFSTAIGDDVFAVLTLDGSVAARSHVGGTAPEQVRAQAQAARERLA

Sequences:

>Translated_465_residues
MSQNDAAPGQQLWTGRFTEATDAFVERFSASVQFDARLALQDIQGSEAHARMLAARGVLTEAERDAILQGLAEIRQEVVE
ERFPWSPQLEDVHMNIEHRLTQRIGEAGKKLHTGRSRNDQIATDVRLFLREAIDTIRAELARFQHGLVELAEREADTIMP
GFTHLQVAQPVTFGHHMLAWYEMLERDRDRLADCRRRLNQCPLGAAALAGTSFPIDREATARELGFDAPTRNSLDSVSDR
DFAIEFCADASLILVHLSRMAEELVLWTSQQFGFIELPDRFCTGSSIMPQKKNPDVAELVRGKAARAQGSLVQLLTLMKG
QPLAYNRDNQEDKEPLFDAVDTARDALTAFADMVPALSVNRERCRAAARAGFATATDLADYLVRQGLAFRDAHEVVGRAV
RYATEADRDLAELSLEELQQFSTAIGDDVFAVLTLDGSVAARSHVGGTAPEQVRAQAQAARERLA
>Mature_464_residues
SQNDAAPGQQLWTGRFTEATDAFVERFSASVQFDARLALQDIQGSEAHARMLAARGVLTEAERDAILQGLAEIRQEVVEE
RFPWSPQLEDVHMNIEHRLTQRIGEAGKKLHTGRSRNDQIATDVRLFLREAIDTIRAELARFQHGLVELAEREADTIMPG
FTHLQVAQPVTFGHHMLAWYEMLERDRDRLADCRRRLNQCPLGAAALAGTSFPIDREATARELGFDAPTRNSLDSVSDRD
FAIEFCADASLILVHLSRMAEELVLWTSQQFGFIELPDRFCTGSSIMPQKKNPDVAELVRGKAARAQGSLVQLLTLMKGQ
PLAYNRDNQEDKEPLFDAVDTARDALTAFADMVPALSVNRERCRAAARAGFATATDLADYLVRQGLAFRDAHEVVGRAVR
YATEADRDLAELSLEELQQFSTAIGDDVFAVLTLDGSVAARSHVGGTAPEQVRAQAQAARERLA

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=459, Percent_Identity=43.7908496732026, Blast_Score=374, Evalue=1e-103,
Organism=Homo sapiens, GI68303542, Length=459, Percent_Identity=43.7908496732026, Blast_Score=374, Evalue=1e-103,
Organism=Homo sapiens, GI68303547, Length=459, Percent_Identity=41.8300653594771, Blast_Score=345, Evalue=4e-95,
Organism=Homo sapiens, GI68303549, Length=459, Percent_Identity=41.3943355119826, Blast_Score=340, Evalue=2e-93,
Organism=Escherichia coli, GI1790398, Length=460, Percent_Identity=48.695652173913, Blast_Score=425, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6321806, Length=458, Percent_Identity=41.703056768559, Blast_Score=362, Evalue=1e-101,
Organism=Drosophila melanogaster, GI221473854, Length=460, Percent_Identity=39.7826086956522, Blast_Score=331, Evalue=5e-91,
Organism=Drosophila melanogaster, GI78706858, Length=460, Percent_Identity=39.7826086956522, Blast_Score=331, Evalue=5e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_HALHL (A1WVT8)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001002602.1
- ProteinModelPortal:   A1WVT8
- SMR:   A1WVT8
- STRING:   A1WVT8
- GeneID:   4709218
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1024
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- PhylomeDB:   A1WVT8
- ProtClustDB:   PRK00855
- BioCyc:   HHAL349124:HHAL_1024-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51582; Mature: 51450

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQNDAAPGQQLWTGRFTEATDAFVERFSASVQFDARLALQDIQGSEAHARMLAARGVLT
CCCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
EAERDAILQGLAEIRQEVVEERFPWSPQLEDVHMNIEHRLTQRIGEAGKKLHTGRSRNDQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
IATDVRLFLREAIDTIRAELARFQHGLVELAEREADTIMPGFTHLQVAQPVTFGHHMLAW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHH
YEMLERDRDRLADCRRRLNQCPLGAAALAGTSFPIDREATARELGFDAPTRNSLDSVSDR
HHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCC
DFAIEFCADASLILVHLSRMAEELVLWTSQQFGFIELPDRFCTGSSIMPQKKNPDVAELV
CHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHCCCCCCCCCCCCCCHHHHH
RGKAARAQGSLVQLLTLMKGQPLAYNRDNQEDKEPLFDAVDTARDALTAFADMVPALSVN
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RERCRAAARAGFATATDLADYLVRQGLAFRDAHEVVGRAVRYATEADRDLAELSLEELQQ
HHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSTAIGDDVFAVLTLDGSVAARSHVGGTAPEQVRAQAQAARERLA
HHHHHCCCEEEEEEECCCHHHHHCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SQNDAAPGQQLWTGRFTEATDAFVERFSASVQFDARLALQDIQGSEAHARMLAARGVLT
CCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
EAERDAILQGLAEIRQEVVEERFPWSPQLEDVHMNIEHRLTQRIGEAGKKLHTGRSRNDQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
IATDVRLFLREAIDTIRAELARFQHGLVELAEREADTIMPGFTHLQVAQPVTFGHHMLAW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHH
YEMLERDRDRLADCRRRLNQCPLGAAALAGTSFPIDREATARELGFDAPTRNSLDSVSDR
HHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCC
DFAIEFCADASLILVHLSRMAEELVLWTSQQFGFIELPDRFCTGSSIMPQKKNPDVAELV
CHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHCCCCCCCCCCCCCCHHHHH
RGKAARAQGSLVQLLTLMKGQPLAYNRDNQEDKEPLFDAVDTARDALTAFADMVPALSVN
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RERCRAAARAGFATATDLADYLVRQGLAFRDAHEVVGRAVRYATEADRDLAELSLEELQQ
HHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSTAIGDDVFAVLTLDGSVAARSHVGGTAPEQVRAQAQAARERLA
HHHHHCCCEEEEEEECCCHHHHHCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA