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The map label for this gene is maeB [H]

Identifier: 121997820

GI number: 121997820

Start: 1104071

End: 1106365

Strand: Reverse

Name: maeB [H]

Synonym: Hhal_1029

Alternate gene names: 121997820

Gene position: 1106365-1104071 (Counterclockwise)

Preceding gene: 121997821

Following gene: 121997815

Centisome position: 41.31

GC content: 67.36

Gene sequence:

>2295_bases
ATGTCCGACGACTTCAAAGAAGCCGCGCTCGAATACCATCGGCAGCCGACCCCCGGGAAGATCGAGGTCATCCCCAGCAA
GCCGCTGGCCAACCAGCGTGACCTCGCCCTGGCCTACTCCCCCGGGGTTGCCTCGGCCTGCGAAGCCATCGTCAACGACC
CGCGCGAGGCGGCCGCCATGACCGCCCGGGGCAACCTGGTGGCGGTCATCACCAACGGTTCCGCCGTGCTCGGCCTGGGT
AACATCGGTCCACTGGCGTCGAAACCGGTGATGGAGGGCAAGGGTGTCCTGTTCAAGAAGTTCGCCGGAATCGATGTCTT
CGACATCGAGGTCGACGAGCCGGACGCCGAGCGCTTCGTCGACATCGTCTCCGCTCTGGAGCCGACCTTCGGCGGCATCA
ATCTGGAGGACATCAAGGCCCCGGAGTGCTTCGAGATCGAGGAGGCCCTCAAGCGCCGGATGAACATCCCGGTGTTCCAC
GATGATCAGCACGGCACCGCCATCATCACTGCTGCGGCTATCCGCAATGGCCTGCGCGTGGTGGGCAAGCGGCTCGAGGA
CGTCACCCTGGTCTGCTCCGGCGCCGGTGCCGCGGCCATCGCCTGCCTCGACCTGCTGGTGGCCATGGGGCTGCCCAAGG
AGCAGATCACCGTCACCGATCGCAAGGGCGTGGTCTACAAGGGGCGCAAGGAGTACATGGACCCGCGTAAGGAAGGCTAT
GCCCGGGAGACGGCCTCCCGCAGTCTGCGCGAGGTGATCGAGGGCGCGGACATCTTCCTCGGGCTGTCGGCACCGGGGGT
GCTGAATGCCGAGATGGTCCACCTGATGGCCGATCAGCCGATCATCATGGCGTTGGCCAATCCGGTTCCCGAGATCCTCC
CCGAGGAGGTGCGCGAGGCCCGGCCCGATGCGGTGATCGCCACCGGCCGCTCGGATTACCCCAACCAGGTGAACAACGTC
CTCTGCTTCCCGTTCATCTTCCGCGGGGCGCTGGATGTGGGCGCCAGCGCCATCAACGAGGCGATGAAGATCGCCGCGGT
GGAGGCCATCGCCGACCTGGCTACCGAGGAGTCGTCCGAGGAGGTGGTGGCAGCCTACGGCGGCCGGCCCTGGAGCTTCG
GCCCCGAGTACCTGATTCCCAAGCCCTTCGACCCCCGACTGATCAGCCGCGTGGCGCCGGCGGTGGCCCAAGCCGCCATG
GAGAGCGGGGTGGCTTGCCGGCCGATCGCGGACTTCGAGGCCTACCGCCTGCAGCTGCAGCAGTACGTGTTCCAGTCCGG
GCTGGTCATGAAGCCGATTTTCGAGCGCGCCCGGGAGCAGCCCAAGCGGGTGGTCTACACCGACGGCGAAGAGGAGCGGA
TCCTCCGTGCCGTGCAGCTGGTGGTCGACGAACAGCTTGCGCGGCCCATCGTCGTCGGGCGCCGGCGCGTGGTGGAGAAG
CGGCTGCGCCAGCTCGGTTTGCGGGTACAGATCGACGAGGATTTCGAGCTGGTCGACCCCGAGGGCGACCCCCGCTACCG
CGACTATTGGCAGGCGTACTACCAGCTGATGGCCCGGCGCGGCGTGACGCCGGCCCGGGCGCGGACGGTGGTGCGTACCC
GCAACACGGTCATCGGCGCACTGATGGTCCATCTAGGCGACGCCGACGCCCTGGTCGGCGGTATCGAGGGGCGCTATCAG
CGGCAGATGCAGCACGTTCAGGACGTTATCGGCCGTCGCCGCGGGGTGCGCAACCTGGCGGCGATGAACGTGCTGATCAT
GCCCAAGGGGACCTTCTTCCTGGCGGACACCTACGTCAACCAGGATCCGAACCCCCACGAGATCGCCGAGATGACCTTGT
TGGCTGCGGACGAGGTGCGCCGTTTCGGAACGGTGCCGAAGGTGGCGCTGCTCTCGCACTCGAACTTCGGTACCTCGTCG
CAGCCCTCGGCGGAGAAGATGCGCCACGCCCTGGAGCTGATCCAGGACCGGGACCCGGCCCTCGAGGTGGAGGGCGAGAT
GCACGGCGACGCAGCGATCTCCGAGGAGGTGCGACGGCGCATCTTCCCCGATGCGCAGCTCGAGGGGGAGGCGAACCTGC
TGATCATGCCGGGGCTCGACGCCGCCAACATCTCGTTCAACCTGCTCAAGGCGACCACCGACAGCGTCTCTGTCGGGCCG
ATCCTGCTCGGGACCGCGAAACCGGCCCACCTGCTCACCCCGTCGTCCACCGTTCGGGCCATCGTCAACCTCACCGCCCT
GTCCGTGGTCGAGGCGCAGATGACCGATGCGGTGGAGCCGGAGAGGCATCCGTAG

Upstream 100 bases:

>100_bases
TTCCTGGCGCACGCCTATCCGGCGCGGTGACGCCACCACCCTGGCAGCAAGCCTGAAGCTCACCCTATACTGGGCTGATC
CAATACCCAAGGGATTTTAT

Downstream 100 bases:

>100_bases
CGCCGACGCTAGCAGGCGGAGGTGCAACGAGAAAGGCCCCGGGCCGATAACGGCCCGGGGCCTTTTCTCATCCCCCGTCA
GGGTGTCCGCCTGCAGGGCC

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 764; Mature: 763

Protein sequence:

>764_residues
MSDDFKEAALEYHRQPTPGKIEVIPSKPLANQRDLALAYSPGVASACEAIVNDPREAAAMTARGNLVAVITNGSAVLGLG
NIGPLASKPVMEGKGVLFKKFAGIDVFDIEVDEPDAERFVDIVSALEPTFGGINLEDIKAPECFEIEEALKRRMNIPVFH
DDQHGTAIITAAAIRNGLRVVGKRLEDVTLVCSGAGAAAIACLDLLVAMGLPKEQITVTDRKGVVYKGRKEYMDPRKEGY
ARETASRSLREVIEGADIFLGLSAPGVLNAEMVHLMADQPIIMALANPVPEILPEEVREARPDAVIATGRSDYPNQVNNV
LCFPFIFRGALDVGASAINEAMKIAAVEAIADLATEESSEEVVAAYGGRPWSFGPEYLIPKPFDPRLISRVAPAVAQAAM
ESGVACRPIADFEAYRLQLQQYVFQSGLVMKPIFERAREQPKRVVYTDGEEERILRAVQLVVDEQLARPIVVGRRRVVEK
RLRQLGLRVQIDEDFELVDPEGDPRYRDYWQAYYQLMARRGVTPARARTVVRTRNTVIGALMVHLGDADALVGGIEGRYQ
RQMQHVQDVIGRRRGVRNLAAMNVLIMPKGTFFLADTYVNQDPNPHEIAEMTLLAADEVRRFGTVPKVALLSHSNFGTSS
QPSAEKMRHALELIQDRDPALEVEGEMHGDAAISEEVRRRIFPDAQLEGEANLLIMPGLDAANISFNLLKATTDSVSVGP
ILLGTAKPAHLLTPSSTVRAIVNLTALSVVEAQMTDAVEPERHP

Sequences:

>Translated_764_residues
MSDDFKEAALEYHRQPTPGKIEVIPSKPLANQRDLALAYSPGVASACEAIVNDPREAAAMTARGNLVAVITNGSAVLGLG
NIGPLASKPVMEGKGVLFKKFAGIDVFDIEVDEPDAERFVDIVSALEPTFGGINLEDIKAPECFEIEEALKRRMNIPVFH
DDQHGTAIITAAAIRNGLRVVGKRLEDVTLVCSGAGAAAIACLDLLVAMGLPKEQITVTDRKGVVYKGRKEYMDPRKEGY
ARETASRSLREVIEGADIFLGLSAPGVLNAEMVHLMADQPIIMALANPVPEILPEEVREARPDAVIATGRSDYPNQVNNV
LCFPFIFRGALDVGASAINEAMKIAAVEAIADLATEESSEEVVAAYGGRPWSFGPEYLIPKPFDPRLISRVAPAVAQAAM
ESGVACRPIADFEAYRLQLQQYVFQSGLVMKPIFERAREQPKRVVYTDGEEERILRAVQLVVDEQLARPIVVGRRRVVEK
RLRQLGLRVQIDEDFELVDPEGDPRYRDYWQAYYQLMARRGVTPARARTVVRTRNTVIGALMVHLGDADALVGGIEGRYQ
RQMQHVQDVIGRRRGVRNLAAMNVLIMPKGTFFLADTYVNQDPNPHEIAEMTLLAADEVRRFGTVPKVALLSHSNFGTSS
QPSAEKMRHALELIQDRDPALEVEGEMHGDAAISEEVRRRIFPDAQLEGEANLLIMPGLDAANISFNLLKATTDSVSVGP
ILLGTAKPAHLLTPSSTVRAIVNLTALSVVEAQMTDAVEPERHP
>Mature_763_residues
SDDFKEAALEYHRQPTPGKIEVIPSKPLANQRDLALAYSPGVASACEAIVNDPREAAAMTARGNLVAVITNGSAVLGLGN
IGPLASKPVMEGKGVLFKKFAGIDVFDIEVDEPDAERFVDIVSALEPTFGGINLEDIKAPECFEIEEALKRRMNIPVFHD
DQHGTAIITAAAIRNGLRVVGKRLEDVTLVCSGAGAAAIACLDLLVAMGLPKEQITVTDRKGVVYKGRKEYMDPRKEGYA
RETASRSLREVIEGADIFLGLSAPGVLNAEMVHLMADQPIIMALANPVPEILPEEVREARPDAVIATGRSDYPNQVNNVL
CFPFIFRGALDVGASAINEAMKIAAVEAIADLATEESSEEVVAAYGGRPWSFGPEYLIPKPFDPRLISRVAPAVAQAAME
SGVACRPIADFEAYRLQLQQYVFQSGLVMKPIFERAREQPKRVVYTDGEEERILRAVQLVVDEQLARPIVVGRRRVVEKR
LRQLGLRVQIDEDFELVDPEGDPRYRDYWQAYYQLMARRGVTPARARTVVRTRNTVIGALMVHLGDADALVGGIEGRYQR
QMQHVQDVIGRRRGVRNLAAMNVLIMPKGTFFLADTYVNQDPNPHEIAEMTLLAADEVRRFGTVPKVALLSHSNFGTSSQ
PSAEKMRHALELIQDRDPALEVEGEMHGDAAISEEVRRRIFPDAQLEGEANLLIMPGLDAANISFNLLKATTDSVSVGPI
LLGTAKPAHLLTPSSTVRAIVNLTALSVVEAQMTDAVEPERHP

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=406, Percent_Identity=24.6305418719212, Blast_Score=90, Evalue=1e-17,
Organism=Homo sapiens, GI62420882, Length=403, Percent_Identity=25.5583126550869, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI62420880, Length=403, Percent_Identity=25.5583126550869, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI239049447, Length=403, Percent_Identity=25.5583126550869, Blast_Score=81, Evalue=4e-15,
Organism=Escherichia coli, GI1788806, Length=755, Percent_Identity=62.1192052980132, Blast_Score=963, Evalue=0.0,
Organism=Escherichia coli, GI1788800, Length=331, Percent_Identity=30.5135951661631, Blast_Score=139, Evalue=8e-34,
Organism=Escherichia coli, GI1788635, Length=320, Percent_Identity=27.1875, Blast_Score=135, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6322823, Length=268, Percent_Identity=27.9850746268657, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281362674, Length=396, Percent_Identity=26.2626262626263, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI281362672, Length=396, Percent_Identity=26.2626262626263, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI21356279, Length=396, Percent_Identity=26.2626262626263, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24646388, Length=402, Percent_Identity=27.8606965174129, Blast_Score=87, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24646386, Length=402, Percent_Identity=27.363184079602, Blast_Score=86, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 83543; Mature: 83412

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDFKEAALEYHRQPTPGKIEVIPSKPLANQRDLALAYSPGVASACEAIVNDPREAAAM
CCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHCCCHHHHHE
TARGNLVAVITNGSAVLGLGNIGPLASKPVMEGKGVLFKKFAGIDVFDIEVDEPDAERFV
EECCCEEEEEECCCEEEEECCCCCCCCCCCCCCCCCEEEHHCCCEEEEEEECCCCHHHHH
DIVSALEPTFGGINLEDIKAPECFEIEEALKRRMNIPVFHDDQHGTAIITAAAIRNGLRV
HHHHHHCCCCCCCCHHHCCCCCCHHHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHHH
VGKRLEDVTLVCSGAGAAAIACLDLLVAMGLPKEQITVTDRKGVVYKGRKEYMDPRKEGY
HHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHEEEECCCCCEECCHHHHCCCHHHCH
ARETASRSLREVIEGADIFLGLSAPGVLNAEMVHLMADQPIIMALANPVPEILPEEVREA
HHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHCCCCEEEECCCCCHHCCHHHHHHC
RPDAVIATGRSDYPNQVNNVLCFPFIFRGALDVGASAINEAMKIAAVEAIADLATEESSE
CCCEEEECCCCCCCHHHHCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EVVAAYGGRPWSFGPEYLIPKPFDPRLISRVAPAVAQAAMESGVACRPIADFEAYRLQLQ
CEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
QYVFQSGLVMKPIFERAREQPKRVVYTDGEEERILRAVQLVVDEQLARPIVVGRRRVVEK
HHHHHCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
RLRQLGLRVQIDEDFELVDPEGDPRYRDYWQAYYQLMARRGVTPARARTVVRTRNTVIGA
HHHHCCCEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LMVHLGDADALVGGIEGRYQRQMQHVQDVIGRRRGVRNLAAMNVLIMPKGTFFLADTYVN
HHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHCEEEEECCCCEEEEEECCC
QDPNPHEIAEMTLLAADEVRRFGTVPKVALLSHSNFGTSSQPSAEKMRHALELIQDRDPA
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCC
LEVEGEMHGDAAISEEVRRRIFPDAQLEGEANLLIMPGLDAANISFNLLKATTDSVSVGP
EEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCEEEEEEECCCCCEECE
ILLGTAKPAHLLTPSSTVRAIVNLTALSVVEAQMTDAVEPERHP
EEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SDDFKEAALEYHRQPTPGKIEVIPSKPLANQRDLALAYSPGVASACEAIVNDPREAAAM
CCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHCCCHHHHHE
TARGNLVAVITNGSAVLGLGNIGPLASKPVMEGKGVLFKKFAGIDVFDIEVDEPDAERFV
EECCCEEEEEECCCEEEEECCCCCCCCCCCCCCCCCEEEHHCCCEEEEEEECCCCHHHHH
DIVSALEPTFGGINLEDIKAPECFEIEEALKRRMNIPVFHDDQHGTAIITAAAIRNGLRV
HHHHHHCCCCCCCCHHHCCCCCCHHHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHHH
VGKRLEDVTLVCSGAGAAAIACLDLLVAMGLPKEQITVTDRKGVVYKGRKEYMDPRKEGY
HHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHEEEECCCCCEECCHHHHCCCHHHCH
ARETASRSLREVIEGADIFLGLSAPGVLNAEMVHLMADQPIIMALANPVPEILPEEVREA
HHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHCCCCEEEECCCCCHHCCHHHHHHC
RPDAVIATGRSDYPNQVNNVLCFPFIFRGALDVGASAINEAMKIAAVEAIADLATEESSE
CCCEEEECCCCCCCHHHHCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EVVAAYGGRPWSFGPEYLIPKPFDPRLISRVAPAVAQAAMESGVACRPIADFEAYRLQLQ
CEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
QYVFQSGLVMKPIFERAREQPKRVVYTDGEEERILRAVQLVVDEQLARPIVVGRRRVVEK
HHHHHCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
RLRQLGLRVQIDEDFELVDPEGDPRYRDYWQAYYQLMARRGVTPARARTVVRTRNTVIGA
HHHHCCCEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LMVHLGDADALVGGIEGRYQRQMQHVQDVIGRRRGVRNLAAMNVLIMPKGTFFLADTYVN
HHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHCEEEEECCCCEEEEEECCC
QDPNPHEIAEMTLLAADEVRRFGTVPKVALLSHSNFGTSSQPSAEKMRHALELIQDRDPA
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCC
LEVEGEMHGDAAISEEVRRRIFPDAQLEGEANLLIMPGLDAANISFNLLKATTDSVSVGP
EEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCEEEEEEECCCCCEECE
ILLGTAKPAHLLTPSSTVRAIVNLTALSVVEAQMTDAVEPERHP
EEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]