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The map label for this gene is bioC [H]

Identifier: 121997751

GI number: 121997751

Start: 1032123

End: 1033010

Strand: Reverse

Name: bioC [H]

Synonym: Hhal_0960

Alternate gene names: 121997751

Gene position: 1033010-1032123 (Counterclockwise)

Preceding gene: 121997752

Following gene: 121997750

Centisome position: 38.57

GC content: 73.99

Gene sequence:

>888_bases
GTGAACCCAGGCGACGCCCAGTCGATTGATCGCCGCTGCGTGCGACGCAGCTTCGACGCCTCGGCGGAGCGCTACGACGA
GGTCGCCGTGCTCCAGCGCGAGGTCGCCGATCGCCTGCTCGAGCGGCTCGAGCCGGTCCGGGTCCATCCGCGCCGGGTCC
TCGACCTCGGCGCGGGCACCGGCTACGCCACGCGCGGGCTCCTGCGACGCTACCGCAAGGCCGAGGTCCACGCCGTGGAT
CTGGCCCCGGCCATGCTGCAGCGTGTGCGCCGCCGGGCCCCCTGGCTGCGCCGTCCGCGGTGCGTCTGCGCCGATCTTCA
CGCCCTGCCGTACCCCGACGACAGCTTCGAGCTGGTCTTCTCCAACCTGGCCCTGCAGTGGGCAGAGGACCTGCCCACCG
CCCTGCGCGAACTGCAGCGGGTGACGGCCCCGGAGGGGGCGGTGATGTTCGCCACCTTCGGGCCGGAGACCCTGCACGAG
CTGCGCGGAGCCTGGGCCGAGGTGGGGGATCAGGCCCGCGTCCACCGGTTTGCGGACAAGCACGACGTGGGCGACCGCAT
GCTCGAGGCGGGCTTCGTCGATCCGGTCCTCGACGGCGAGTCGTTCACGCTGACCTACGCCCAGCCGCGCGAGGTGATGC
GCGATCTCAAGGCCCTGGGGGCCTCCAACGCCGACCCCGGCCGCCCCCGCGGCCTGCTCTCGCCCCACCGCCTGGCCCGC
GTGGAGGCTGCCTACCGTCTGGCCTGGCGCCAGCCCGACGGCCGTGTGCCGGCCACCTACGAGGTGGTCTACGGGCACGC
CTGGGGGATGGGCGGAACCCCGCAGCGGGCCGATGACACCGGCGAGGTCCGGCTCGACGTCCACGGCATCCGGCGGAGGC
GGCGATGA

Upstream 100 bases:

>100_bases
GCCAGCTGCGGATCCTGGAGGGGGCCGGGCATCTGCCCCACTGCACCCACGCCACCGCAGTGGCGCAGACGATCCACGCT
TTCCTTGAGGAGATCTGACC

Downstream 100 bases:

>100_bases
GCGCGGGGCAGGCGCACGGCGCTGATCCGGCCGGGGTGTTCATCACCGGCACCGACACCGGCGTCGGCAAGACGGTCTAC
GCCGGCGGGCTGATCCGTCT

Product: biotin biosynthesis protein BioC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MNPGDAQSIDRRCVRRSFDASAERYDEVAVLQREVADRLLERLEPVRVHPRRVLDLGAGTGYATRGLLRRYRKAEVHAVD
LAPAMLQRVRRRAPWLRRPRCVCADLHALPYPDDSFELVFSNLALQWAEDLPTALRELQRVTAPEGAVMFATFGPETLHE
LRGAWAEVGDQARVHRFADKHDVGDRMLEAGFVDPVLDGESFTLTYAQPREVMRDLKALGASNADPGRPRGLLSPHRLAR
VEAAYRLAWRQPDGRVPATYEVVYGHAWGMGGTPQRADDTGEVRLDVHGIRRRRR

Sequences:

>Translated_295_residues
MNPGDAQSIDRRCVRRSFDASAERYDEVAVLQREVADRLLERLEPVRVHPRRVLDLGAGTGYATRGLLRRYRKAEVHAVD
LAPAMLQRVRRRAPWLRRPRCVCADLHALPYPDDSFELVFSNLALQWAEDLPTALRELQRVTAPEGAVMFATFGPETLHE
LRGAWAEVGDQARVHRFADKHDVGDRMLEAGFVDPVLDGESFTLTYAQPREVMRDLKALGASNADPGRPRGLLSPHRLAR
VEAAYRLAWRQPDGRVPATYEVVYGHAWGMGGTPQRADDTGEVRLDVHGIRRRRR
>Mature_295_residues
MNPGDAQSIDRRCVRRSFDASAERYDEVAVLQREVADRLLERLEPVRVHPRRVLDLGAGTGYATRGLLRRYRKAEVHAVD
LAPAMLQRVRRRAPWLRRPRCVCADLHALPYPDDSFELVFSNLALQWAEDLPTALRELQRVTAPEGAVMFATFGPETLHE
LRGAWAEVGDQARVHRFADKHDVGDRMLEAGFVDPVLDGESFTLTYAQPREVMRDLKALGASNADPGRPRGLLSPHRLAR
VEAAYRLAWRQPDGRVPATYEVVYGHAWGMGGTPQRADDTGEVRLDVHGIRRRRR

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI40018642, Length=245, Percent_Identity=31.4285714285714, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI86792933, Length=152, Percent_Identity=33.5526315789474, Blast_Score=88, Evalue=8e-18,
Organism=Escherichia coli, GI1786994, Length=258, Percent_Identity=34.1085271317829, Blast_Score=123, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17535003, Length=269, Percent_Identity=22.6765799256506, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI19922210, Length=264, Percent_Identity=29.1666666666667, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 33395; Mature: 33395

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPGDAQSIDRRCVRRSFDASAERYDEVAVLQREVADRLLERLEPVRVHPRRVLDLGAGT
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCC
GYATRGLLRRYRKAEVHAVDLAPAMLQRVRRRAPWLRRPRCVCADLHALPYPDDSFELVF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHCCCCCCCCCHHHHHH
SNLALQWAEDLPTALRELQRVTAPEGAVMFATFGPETLHELRGAWAEVGDQARVHRFADK
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHH
HDVGDRMLEAGFVDPVLDGESFTLTYAQPREVMRDLKALGASNADPGRPRGLLSPHRLAR
HHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
VEAAYRLAWRQPDGRVPATYEVVYGHAWGMGGTPQRADDTGEVRLDVHGIRRRRR
HHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCEEEEHHHHHHCCC
>Mature Secondary Structure
MNPGDAQSIDRRCVRRSFDASAERYDEVAVLQREVADRLLERLEPVRVHPRRVLDLGAGT
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCC
GYATRGLLRRYRKAEVHAVDLAPAMLQRVRRRAPWLRRPRCVCADLHALPYPDDSFELVF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHCCCCCCCCCHHHHHH
SNLALQWAEDLPTALRELQRVTAPEGAVMFATFGPETLHELRGAWAEVGDQARVHRFADK
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHH
HDVGDRMLEAGFVDPVLDGESFTLTYAQPREVMRDLKALGASNADPGRPRGLLSPHRLAR
HHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
VEAAYRLAWRQPDGRVPATYEVVYGHAWGMGGTPQRADDTGEVRLDVHGIRRRRR
HHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCEEEEHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8250549 [H]