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The map label for this gene is ribH

Identifier: 121997688

GI number: 121997688

Start: 973291

End: 973761

Strand: Reverse

Name: ribH

Synonym: Hhal_0897

Alternate gene names: 121997688

Gene position: 973761-973291 (Counterclockwise)

Preceding gene: 121997689

Following gene: 121997687

Centisome position: 36.36

GC content: 69.85

Gene sequence:

>471_bases
ATGCAAGTAACCGAAGGACAACTCGTCGCGCTGCAGGATGCGCGATTCGCCCTTGTGGCGGCGCGCTTCAACGATCTCAT
CGTCGACCGGCTGATCGACGGCGCCGCCGATACCCTGCGGCGCCACGGGGTGCCGGAGGAACACCTGGAGCTGATCCGCG
TGCCCGGTTCCTTTGAGCTGCCGCTGGCGGTCCAGCGCGTGGCCGACGCCGGCCGGGCCGACGCCGTGATCGCCCTCGGC
GCGGTGATCCGCGGTGGTACCGACCACCACCAGTACGTGGCCGCCGAGTGCACCAAGGGCGTCGCCCAGGCGATGATGGG
CTCCGGCGTGCCGGTCTCCTACGGCGTGCTCACCGTCGAGACTGTCGAGCAGGCCATCGAGCGTGCCGGGACCAAGGCCG
GCAACAAGGGCGCCGAGGCGGCGCTCTCGGCCCTGGAGATGGTCGATCTGATGCGGCAGCTCGAGGCGTAA

Upstream 100 bases:

>100_bases
TTGATCACCAGCGCTTGCGGGGCGCCCGCCGGGCTTGTAGTTTAACGCCGGAACCCGCGCAAGCGCCGGTCCTACCGAAA
CTTTCTTCAGGAAACCAGGC

Downstream 100 bases:

>100_bases
TGGCGGCTTCAGGGGAAGGCAAGCGCCGCTCGCGGGCCCGATCCAAGCTCGTCCAGGCGCTCTATCAGTACGCGGTCACC
GGCGCGTCGGCGGAGGATAT

Product: 6,7-dimethyl-8-ribityllumazine synthase

Products: NA

Alternate protein names: DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MQVTEGQLVALQDARFALVAARFNDLIVDRLIDGAADTLRRHGVPEEHLELIRVPGSFELPLAVQRVADAGRADAVIALG
AVIRGGTDHHQYVAAECTKGVAQAMMGSGVPVSYGVLTVETVEQAIERAGTKAGNKGAEAALSALEMVDLMRQLEA

Sequences:

>Translated_156_residues
MQVTEGQLVALQDARFALVAARFNDLIVDRLIDGAADTLRRHGVPEEHLELIRVPGSFELPLAVQRVADAGRADAVIALG
AVIRGGTDHHQYVAAECTKGVAQAMMGSGVPVSYGVLTVETVEQAIERAGTKAGNKGAEAALSALEMVDLMRQLEA
>Mature_156_residues
MQVTEGQLVALQDARFALVAARFNDLIVDRLIDGAADTLRRHGVPEEHLELIRVPGSFELPLAVQRVADAGRADAVIALG
AVIRGGTDHHQYVAAECTKGVAQAMMGSGVPVSYGVLTVETVEQAIERAGTKAGNKGAEAALSALEMVDLMRQLEA

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes

COG id: COG0054

COG function: function code H; Riboflavin synthase beta-chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DMRL synthase family

Homologues:

Organism=Escherichia coli, GI1786617, Length=157, Percent_Identity=54.140127388535, Blast_Score=169, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6324429, Length=155, Percent_Identity=33.5483870967742, Blast_Score=84, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RISB_HALHL (A1WVG1)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001002475.1
- ProteinModelPortal:   A1WVG1
- SMR:   A1WVG1
- STRING:   A1WVG1
- GeneID:   4709763
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_0897
- eggNOG:   COG0054
- HOGENOM:   HBG311126
- OMA:   KAGNKGW
- PhylomeDB:   A1WVG1
- ProtClustDB:   PRK00061
- BioCyc:   HHAL349124:HHAL_0897-MONOMER
- HAMAP:   MF_00178
- InterPro:   IPR002180
- Gene3D:   G3DSA:3.40.50.960
- PANTHER:   PTHR21058
- TIGRFAMs:   TIGR00114

Pfam domain/function: PF00885 DMRL_synthase; SSF52121 DMRL_synthase

EC number: =2.5.1.9

Molecular weight: Translated: 16457; Mature: 16457

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVTEGQLVALQDARFALVAARFNDLIVDRLIDGAADTLRRHGVPEEHLELIRVPGSFEL
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEEECCCCCCC
PLAVQRVADAGRADAVIALGAVIRGGTDHHQYVAAECTKGVAQAMMGSGVPVSYGVLTVE
HHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
TVEQAIERAGTKAGNKGAEAALSALEMVDLMRQLEA
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQVTEGQLVALQDARFALVAARFNDLIVDRLIDGAADTLRRHGVPEEHLELIRVPGSFEL
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEEECCCCCCC
PLAVQRVADAGRADAVIALGAVIRGGTDHHQYVAAECTKGVAQAMMGSGVPVSYGVLTVE
HHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
TVEQAIERAGTKAGNKGAEAALSALEMVDLMRQLEA
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA