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The map label for this gene is ribB [H]

Identifier: 121997689

GI number: 121997689

Start: 973858

End: 974991

Strand: Reverse

Name: ribB [H]

Synonym: Hhal_0898

Alternate gene names: 121997689

Gene position: 974991-973858 (Counterclockwise)

Preceding gene: 121997690

Following gene: 121997688

Centisome position: 36.4

GC content: 69.22

Gene sequence:

>1134_bases
ATGGATGAACGAATGAGCGAGACGGTGCAGTTCAACAGTATCGAGGAGATCATCGAGGACCTGCGCCAGGGGCGCATGGC
GGTCGTCCTCGATGACGAAGACCGGGAGAACGAAGGCGACCTGGTGATGCCGGCGAGCCTGATCCGCCCCGAGGACATCA
ACTTCATGGCCCGCTACGGCCGGGGGCTGATCTGCCTGACCCTCACCCGGGAGCGCTGTGAGCAGCTGCGCCTGCCGTTG
ATGGTCCATAACAACGACGAGAAAAACACCACGAACTTCACGGTTTCCATCGAGGCGGCGGAGGGGGTGACCACCGGCAT
CTCGGCCGCCGACCGGGCGCGCACCGTTCAGGCGGCGGTGGCCCCCGGCGCCCGCCCCGAGGATCTGGTCCAGCCCGGGC
ACATCTTCCCGCTGATGGCCCAGCCCGGCGGCGTGCTTACCCGCGCCGGGCACACCGAGGCCGGCTGCGACCTGGCCCGG
CTGGCCGGTTTCGCCCCGGCGGCGGTGATCGTCGAGATCCTCAACGAGGACGGCACCATGGCCCGGCGCGACGACCTCAT
GGCGTTCGCTCGCACCCACGGGTTGAAGATCGGCACCGTGGCCGATCTCATCGCCTATCGGGTGCGCAACGAGCGCTCGG
TGGAGCACGTCGGTGCCTGCGAGCTGCCCACCGAGTACGGCACGTTCCGTATGCACACTTACCAGGACAACGTCAGCGGT
GCGCTGCACTTCGCCCTGCTCGCCGGCCAGGTGGACGAGGAAACCCCGGCCCTGGTGCGCGTGCATCTCGAGAACCCGCT
GGCCGACCTGCTCGGCGCCACCGGGCCGCGCTGCGGCTGGCCGTTGCGCTCGGCGCTGCGCCAGGTGGCCGAGGCCGAAT
CGGGTGTGGTGGTGGTGCTGCGCAACGCCGATGCCAACGACGACATCCTCGAGCACATGCGCTGCTATCAGGGCGGTGGC
TGCAGCGAGGAGGCCGGCGGCGTGCCGCTGGATCTGCGCACCTACGGCATCGGCGCGCAGATCCTCACCGACCTCGGGGT
GCGCCGCATGCGCGTGCTCAGCGCCCCGCGGCGCATGCACGCCCTGTCCGGATTCGGCATGGAAGTGGTGGAGTACGTCA
CCCCCGAGGCTTGA

Upstream 100 bases:

>100_bases
CTGGTGGCCCGTTACGTCGAGCGGCTGCTCAGCGCCGGTGCCGACAGTGGCGACGGCGGGGGGCTGACCCTGGAGCAGCT
ACGACAGGCCGGATTCGGCA

Downstream 100 bases:

>100_bases
TCACCAGCGCTTGCGGGGCGCCCGCCGGGCTTGTAGTTTAACGCCGGAACCCGCGCAAGCGCCGGTCCTACCGAAACTTT
CTTCAGGAAACCAGGCATGC

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: DHBP synthase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MDERMSETVQFNSIEEIIEDLRQGRMAVVLDDEDRENEGDLVMPASLIRPEDINFMARYGRGLICLTLTRERCEQLRLPL
MVHNNDEKNTTNFTVSIEAAEGVTTGISAADRARTVQAAVAPGARPEDLVQPGHIFPLMAQPGGVLTRAGHTEAGCDLAR
LAGFAPAAVIVEILNEDGTMARRDDLMAFARTHGLKIGTVADLIAYRVRNERSVEHVGACELPTEYGTFRMHTYQDNVSG
ALHFALLAGQVDEETPALVRVHLENPLADLLGATGPRCGWPLRSALRQVAEAESGVVVVLRNADANDDILEHMRCYQGGG
CSEEAGGVPLDLRTYGIGAQILTDLGVRRMRVLSAPRRMHALSGFGMEVVEYVTPEA

Sequences:

>Translated_377_residues
MDERMSETVQFNSIEEIIEDLRQGRMAVVLDDEDRENEGDLVMPASLIRPEDINFMARYGRGLICLTLTRERCEQLRLPL
MVHNNDEKNTTNFTVSIEAAEGVTTGISAADRARTVQAAVAPGARPEDLVQPGHIFPLMAQPGGVLTRAGHTEAGCDLAR
LAGFAPAAVIVEILNEDGTMARRDDLMAFARTHGLKIGTVADLIAYRVRNERSVEHVGACELPTEYGTFRMHTYQDNVSG
ALHFALLAGQVDEETPALVRVHLENPLADLLGATGPRCGWPLRSALRQVAEAESGVVVVLRNADANDDILEHMRCYQGGG
CSEEAGGVPLDLRTYGIGAQILTDLGVRRMRVLSAPRRMHALSGFGMEVVEYVTPEA
>Mature_377_residues
MDERMSETVQFNSIEEIIEDLRQGRMAVVLDDEDRENEGDLVMPASLIRPEDINFMARYGRGLICLTLTRERCEQLRLPL
MVHNNDEKNTTNFTVSIEAAEGVTTGISAADRARTVQAAVAPGARPEDLVQPGHIFPLMAQPGGVLTRAGHTEAGCDLAR
LAGFAPAAVIVEILNEDGTMARRDDLMAFARTHGLKIGTVADLIAYRVRNERSVEHVGACELPTEYGTFRMHTYQDNVSG
ALHFALLAGQVDEETPALVRVHLENPLADLLGATGPRCGWPLRSALRQVAEAESGVVVVLRNADANDDILEHMRCYQGGG
CSEEAGGVPLDLRTYGIGAQILTDLGVRRMRVLSAPRRMHALSGFGMEVVEYVTPEA

Specific function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=203, Percent_Identity=55.1724137931034, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1787533, Length=168, Percent_Identity=31.547619047619, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320695, Length=204, Percent_Identity=40.6862745098039, Blast_Score=171, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12 [H]

Molecular weight: Translated: 41097; Mature: 41097

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDERMSETVQFNSIEEIIEDLRQGRMAVVLDDEDRENEGDLVMPASLIRPEDINFMARYG
CCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEECHHHCCCCCCHHHHHHC
RGLICLTLTRERCEQLRLPLMVHNNDEKNTTNFTVSIEAAEGVTTGISAADRARTVQAAV
CCEEEEEECHHHHHHCCCCEEEECCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHH
APGARPEDLVQPGHIFPLMAQPGGVLTRAGHTEAGCDLARLAGFAPAAVIVEILNEDGTM
CCCCCHHHHCCCCCEEEEEECCCCEEEECCCCCCCCCHHHHHCCCHHHHHHHHHCCCCCC
ARRDDLMAFARTHGLKIGTVADLIAYRVRNERSVEHVGACELPTEYGTFRMHTYQDNVSG
HHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCEEEEEECCCCCH
ALHFALLAGQVDEETPALVRVHLENPLADLLGATGPRCGWPLRSALRQVAEAESGVVVVL
HHHHHHHHCCCCCCCCEEEEEEECCCHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEE
RNADANDDILEHMRCYQGGGCSEEAGGVPLDLRTYGIGAQILTDLGVRRMRVLSAPRRMH
ECCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCHHHHH
ALSGFGMEVVEYVTPEA
HHHCCCHHHHHHCCCCC
>Mature Secondary Structure
MDERMSETVQFNSIEEIIEDLRQGRMAVVLDDEDRENEGDLVMPASLIRPEDINFMARYG
CCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEECHHHCCCCCCHHHHHHC
RGLICLTLTRERCEQLRLPLMVHNNDEKNTTNFTVSIEAAEGVTTGISAADRARTVQAAV
CCEEEEEECHHHHHHCCCCEEEECCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHH
APGARPEDLVQPGHIFPLMAQPGGVLTRAGHTEAGCDLARLAGFAPAAVIVEILNEDGTM
CCCCCHHHHCCCCCEEEEEECCCCEEEECCCCCCCCCHHHHHCCCHHHHHHHHHCCCCCC
ARRDDLMAFARTHGLKIGTVADLIAYRVRNERSVEHVGACELPTEYGTFRMHTYQDNVSG
HHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCEEEEEECCCCCH
ALHFALLAGQVDEETPALVRVHLENPLADLLGATGPRCGWPLRSALRQVAEAESGVVVVL
HHHHHHHHCCCCCCCCEEEEEEECCCHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEE
RNADANDDILEHMRCYQGGGCSEEAGGVPLDLRTYGIGAQILTDLGVRRMRVLSAPRRMH
ECCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCHHHHH
ALSGFGMEVVEYVTPEA
HHHCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]