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The map label for this gene is clpX

Identifier: 121997403

GI number: 121997403

Start: 681128

End: 682408

Strand: Reverse

Name: clpX

Synonym: Hhal_0602

Alternate gene names: 121997403

Gene position: 682408-681128 (Counterclockwise)

Preceding gene: 121997404

Following gene: 121997402

Centisome position: 25.48

GC content: 64.56

Gene sequence:

>1281_bases
ATGACTGATCGAACTCAGAACAAGGGCGATGACAGCGGCAAGCTGCTGTACTGCTCCTTCTGCGGGAAGAGCCAGCACGA
GGTCCGCAAGCTCATCGCCGGGCCATCGGTGTTCATCTGTGACGAGTGCGTCGAGCTCTGCAACGACATCATCCGCGAGG
AGCTCCAGGAAGGTGCGGCGACGGAAGGCGGCGGGCTGCCCCGGCCCCACGAGATCAACCGCGAGCTCGACCAGTACGTC
ATTGGCCAGGAGCACGCCAAGAAGGTGCTCTCGGTGGCGGTGTACAACCACTACAAGCGCCTCGAGAGCCGGACCAGCCA
GGACGATGTGGAGCTGACCAAGAGCAACATCCTGCTCATCGGCCCCACCGGCTCGGGCAAGACGTTGCTCGCCGAGACCC
TGGCGCGGCTGCTCAACGTGCCGTTCACCATCGCCGACGCCACGACTCTGACCGAGGCCGGGTATGTCGGTGAGGATGTC
GAGAACATCATCCAGAAGTTGCTGCAGAAGTGCGATTACGACGTCGAGAAGGCGCAGCACGGCATCGTCTACATCGACGA
GATCGACAAGGTCTCGCGCAAGGCGGACAACCCGTCGATCACCCGGGACGTCTCCGGCGAGGGGGTGCAGCAGGCGCTGC
TCAAGCTGATCGAGGGGACCACGGCCTCGGTGCCCCCGCAGGGTGGGCGCAAGCACCCTCAGCAGGAGTTCGTGCAGGTC
GATACCAGCAACATGTTGTTCATCTGCGGCGGCGCTTTCGCCGGGCTCGACAAGGTCATCCAGGAGCGCTCCGAGCGGGG
CGGGATCGGCTTCTCGGCCGAGATCAAGGGCGAGGGCGAGCGAGCTAGCGTCGGCGAGACGCTGCAGACCGTTGAACCCA
GCGATCTGGTCCGCTACGGCCTGATCCCGGAGTTTGTCGGCCGGCTGCCGGTCATCGCGACCCTCAACGAGCTCGATCAG
GAGGCCCTGGTGCAGATCCTCCGCGAGCCGAAGAACGCGCTGGTTAAGCAGTACCAGAAGCTCTTTGAGATGGAGGGTGT
GGAGCTCGACCTGCGCGATGACGCCCTGCGGGCGGTGGCCGACAAGGCGATGGAGCGCAAGACCGGTGCCCGCGGGCTGC
GCACCATCATCGAGCAGGTGCTGCTCGAGACCATGTACGAGCTCCCGTCCATGGAGAATGTCAGCAAAGTGGTGGTCGAC
GAGTCGGTCATCGCCGGCGACAGCGACCCGTACATCGTCTACGCGGGCCCCGAGCATTCCAAGGCGGCGTCCGACGAGTA
G

Upstream 100 bases:

>100_bases
CGGCGCCTCCGAGTGAGGCGCCGTGGGCTGGTTGCGTACCCGCTGAAAAGGGTGCATCGTTGATAAAGAATGATTCCAGT
GCGCAAACCGAGGCCGTGGC

Downstream 100 bases:

>100_bases
GGCGCCGCCGACTCGGCGCACCTTGAAACCCGCCCGTATCACCCCCATTCCGAACCCAGAGGAGGGGCGCGCGGCCACCG
CCGCGCGCGTCCCGCCGTTC

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MTDRTQNKGDDSGKLLYCSFCGKSQHEVRKLIAGPSVFICDECVELCNDIIREELQEGAATEGGGLPRPHEINRELDQYV
IGQEHAKKVLSVAVYNHYKRLESRTSQDDVELTKSNILLIGPTGSGKTLLAETLARLLNVPFTIADATTLTEAGYVGEDV
ENIIQKLLQKCDYDVEKAQHGIVYIDEIDKVSRKADNPSITRDVSGEGVQQALLKLIEGTTASVPPQGGRKHPQQEFVQV
DTSNMLFICGGAFAGLDKVIQERSERGGIGFSAEIKGEGERASVGETLQTVEPSDLVRYGLIPEFVGRLPVIATLNELDQ
EALVQILREPKNALVKQYQKLFEMEGVELDLRDDALRAVADKAMERKTGARGLRTIIEQVLLETMYELPSMENVSKVVVD
ESVIAGDSDPYIVYAGPEHSKAASDE

Sequences:

>Translated_426_residues
MTDRTQNKGDDSGKLLYCSFCGKSQHEVRKLIAGPSVFICDECVELCNDIIREELQEGAATEGGGLPRPHEINRELDQYV
IGQEHAKKVLSVAVYNHYKRLESRTSQDDVELTKSNILLIGPTGSGKTLLAETLARLLNVPFTIADATTLTEAGYVGEDV
ENIIQKLLQKCDYDVEKAQHGIVYIDEIDKVSRKADNPSITRDVSGEGVQQALLKLIEGTTASVPPQGGRKHPQQEFVQV
DTSNMLFICGGAFAGLDKVIQERSERGGIGFSAEIKGEGERASVGETLQTVEPSDLVRYGLIPEFVGRLPVIATLNELDQ
EALVQILREPKNALVKQYQKLFEMEGVELDLRDDALRAVADKAMERKTGARGLRTIIEQVLLETMYELPSMENVSKVVVD
ESVIAGDSDPYIVYAGPEHSKAASDE
>Mature_425_residues
TDRTQNKGDDSGKLLYCSFCGKSQHEVRKLIAGPSVFICDECVELCNDIIREELQEGAATEGGGLPRPHEINRELDQYVI
GQEHAKKVLSVAVYNHYKRLESRTSQDDVELTKSNILLIGPTGSGKTLLAETLARLLNVPFTIADATTLTEAGYVGEDVE
NIIQKLLQKCDYDVEKAQHGIVYIDEIDKVSRKADNPSITRDVSGEGVQQALLKLIEGTTASVPPQGGRKHPQQEFVQVD
TSNMLFICGGAFAGLDKVIQERSERGGIGFSAEIKGEGERASVGETLQTVEPSDLVRYGLIPEFVGRLPVIATLNELDQE
ALVQILREPKNALVKQYQKLFEMEGVELDLRDDALRAVADKAMERKTGARGLRTIIEQVLLETMYELPSMENVSKVVVDE
SVIAGDSDPYIVYAGPEHSKAASDE

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=339, Percent_Identity=51.9174041297935, Blast_Score=322, Evalue=5e-88,
Organism=Escherichia coli, GI1786642, Length=427, Percent_Identity=74.9414519906323, Blast_Score=654, Evalue=0.0,
Organism=Escherichia coli, GI1790366, Length=99, Percent_Identity=46.4646464646465, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71982905, Length=315, Percent_Identity=43.8095238095238, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI71982908, Length=315, Percent_Identity=43.8095238095238, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI71988663, Length=403, Percent_Identity=36.7245657568238, Blast_Score=249, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI71988660, Length=263, Percent_Identity=38.4030418250951, Blast_Score=173, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6319704, Length=431, Percent_Identity=40.1392111368909, Blast_Score=282, Evalue=8e-77,
Organism=Drosophila melanogaster, GI24648289, Length=318, Percent_Identity=47.1698113207547, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24648291, Length=318, Percent_Identity=47.1698113207547, Blast_Score=290, Evalue=2e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_HALHL (A1WUM6)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001002190.1
- ProteinModelPortal:   A1WUM6
- STRING:   A1WUM6
- GeneID:   4709296
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_0602
- eggNOG:   COG1219
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- PhylomeDB:   A1WUM6
- ProtClustDB:   PRK05342
- BioCyc:   HHAL349124:HHAL_0602-MONOMER
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: NA

Molecular weight: Translated: 46805; Mature: 46673

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRTQNKGDDSGKLLYCSFCGKSQHEVRKLIAGPSVFICDECVELCNDIIREELQEGAA
CCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCC
TEGGGLPRPHEINRELDQYVIGQEHAKKVLSVAVYNHYKRLESRTSQDDVELTKSNILLI
CCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCEEEE
GPTGSGKTLLAETLARLLNVPFTIADATTLTEAGYVGEDVENIIQKLLQKCDYDVEKAQH
ECCCCCCHHHHHHHHHHHCCCEEEECHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHCC
GIVYIDEIDKVSRKADNPSITRDVSGEGVQQALLKLIEGTTASVPPQGGRKHPQQEFVQV
CEEEEECHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHEE
DTSNMLFICGGAFAGLDKVIQERSERGGIGFSAEIKGEGERASVGETLQTVEPSDLVRYG
CCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHC
LIPEFVGRLPVIATLNELDQEALVQILREPKNALVKQYQKLFEMEGVELDLRDDALRAVA
CCHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHH
DKAMERKTGARGLRTIIEQVLLETMYELPSMENVSKVVVDESVIAGDSDPYIVYAGPEHS
HHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHCCCCCCCEEEEECCCCC
KAASDE
CCCCCC
>Mature Secondary Structure 
TDRTQNKGDDSGKLLYCSFCGKSQHEVRKLIAGPSVFICDECVELCNDIIREELQEGAA
CCCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCC
TEGGGLPRPHEINRELDQYVIGQEHAKKVLSVAVYNHYKRLESRTSQDDVELTKSNILLI
CCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCEEEE
GPTGSGKTLLAETLARLLNVPFTIADATTLTEAGYVGEDVENIIQKLLQKCDYDVEKAQH
ECCCCCCHHHHHHHHHHHCCCEEEECHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHCC
GIVYIDEIDKVSRKADNPSITRDVSGEGVQQALLKLIEGTTASVPPQGGRKHPQQEFVQV
CEEEEECHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHEE
DTSNMLFICGGAFAGLDKVIQERSERGGIGFSAEIKGEGERASVGETLQTVEPSDLVRYG
CCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHC
LIPEFVGRLPVIATLNELDQEALVQILREPKNALVKQYQKLFEMEGVELDLRDDALRAVA
CCHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHH
DKAMERKTGARGLRTIIEQVLLETMYELPSMENVSKVVVDESVIAGDSDPYIVYAGPEHS
HHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHCCCCCCCEEEEECCCCC
KAASDE
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA