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The map label for this gene is clpP

Identifier: 121997404

GI number: 121997404

Start: 682493

End: 683125

Strand: Reverse

Name: clpP

Synonym: Hhal_0603

Alternate gene names: 121997404

Gene position: 683125-682493 (Counterclockwise)

Preceding gene: 121997405

Following gene: 121997403

Centisome position: 25.5

GC content: 65.4

Gene sequence:

>633_bases
ATGAGCGATACCCAGCAATCCGCCCCCGACATTTTCAACACCGGCCTGGTGCCGATGGTGGTCGAGCAGTCGGCGCGTGG
CGAGCGGGCCTACGACATCTTCTCGCGTCTGCTCAAGGAGCGCGTGATCTTTCTGGTCGGCCCGGTGGAGGACTACCAGG
CCAACCTGCTGGTGGCGCAGCTGCTGTTCCTCGAGTCCGAGAATCCGGATAAGGACGTGCACCTGTATATCAACTCGCCG
GGCGGCTCGGTCACTGCCGGGCTGGCGATCTACGACACCATGCAGTTCATCAAGCCCGATGTGGCCACGCTCTGCGTGGG
TCAGGCGGCGAGCATGGGCGCCCTGCTGCTGGCGGCTGGCGCGGAGGGCAAGCGCCACGCCCTGCCCAATTCGCGGATGA
TGATCCATCAGCCCCTCGGTGGTTTCCAGGGGCAGGCGACGGATATCGACATCCACGCCCGCGAGATCCTGAGCATGCGG
GATCGGCTCAACACCATCCTGGCGCACCACACCGGGCAGGATATCGAGACCATCCGGCAGGACACCGATCGGGACAACTT
CATGGCCGCCGAGGCGGCCGCGCAGTACGGCCTGATCGACCGGGTTCTGACCAGTCGCGGCGCCTCCGAGTGA

Upstream 100 bases:

>100_bases
GTGCAGACCGAAGACAAGACGCTGAGCTTCGACGAGCTCATGAACAGCGAGGACGGCGACCAGGCTTCGGCCTGAGTCGC
GGCCCCGGGAGGCCAACGGC

Downstream 100 bases:

>100_bases
GGCGCCGTGGGCTGGTTGCGTACCCGCTGAAAAGGGTGCATCGTTGATAAAGAATGATTCCAGTGCGCAAACCGAGGCCG
TGGCATGACTGATCGAACTC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MSDTQQSAPDIFNTGLVPMVVEQSARGERAYDIFSRLLKERVIFLVGPVEDYQANLLVAQLLFLESENPDKDVHLYINSP
GGSVTAGLAIYDTMQFIKPDVATLCVGQAASMGALLLAAGAEGKRHALPNSRMMIHQPLGGFQGQATDIDIHAREILSMR
DRLNTILAHHTGQDIETIRQDTDRDNFMAAEAAAQYGLIDRVLTSRGASE

Sequences:

>Translated_210_residues
MSDTQQSAPDIFNTGLVPMVVEQSARGERAYDIFSRLLKERVIFLVGPVEDYQANLLVAQLLFLESENPDKDVHLYINSP
GGSVTAGLAIYDTMQFIKPDVATLCVGQAASMGALLLAAGAEGKRHALPNSRMMIHQPLGGFQGQATDIDIHAREILSMR
DRLNTILAHHTGQDIETIRQDTDRDNFMAAEAAAQYGLIDRVLTSRGASE
>Mature_209_residues
SDTQQSAPDIFNTGLVPMVVEQSARGERAYDIFSRLLKERVIFLVGPVEDYQANLLVAQLLFLESENPDKDVHLYINSPG
GSVTAGLAIYDTMQFIKPDVATLCVGQAASMGALLLAAGAEGKRHALPNSRMMIHQPLGGFQGQATDIDIHAREILSMRD
RLNTILAHHTGQDIETIRQDTDRDNFMAAEAAAQYGLIDRVLTSRGASE

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=189, Percent_Identity=58.7301587301587, Blast_Score=244, Evalue=3e-65,
Organism=Escherichia coli, GI1786641, Length=191, Percent_Identity=70.1570680628272, Blast_Score=301, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17538017, Length=192, Percent_Identity=54.6875, Blast_Score=230, Evalue=3e-61,
Organism=Drosophila melanogaster, GI20129427, Length=196, Percent_Identity=61.2244897959184, Blast_Score=250, Evalue=4e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_HALHL (A1WUM7)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001002191.1
- ProteinModelPortal:   A1WUM7
- SMR:   A1WUM7
- STRING:   A1WUM7
- MEROPS:   S14.001
- GeneID:   4711550
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_0603
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   SPMEAQD
- PhylomeDB:   A1WUM7
- ProtClustDB:   PRK00277
- BioCyc:   HHAL349124:HHAL_0603-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22925; Mature: 22794

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 111-111 ACT_SITE 136-136

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTQQSAPDIFNTGLVPMVVEQSARGERAYDIFSRLLKERVIFLVGPVEDYQANLLVAQ
CCCCCCCCCHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHH
LLFLESENPDKDVHLYINSPGGSVTAGLAIYDTMQFIKPDVATLCVGQAASMGALLLAAG
HHHHCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHCCCHHHHHHCCHHHHCEEEEECC
AEGKRHALPNSRMMIHQPLGGFQGQATDIDIHAREILSMRDRLNTILAHHTGQDIETIRQ
CCCCCCCCCCCCEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DTDRDNFMAAEAAAQYGLIDRVLTSRGASE
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SDTQQSAPDIFNTGLVPMVVEQSARGERAYDIFSRLLKERVIFLVGPVEDYQANLLVAQ
CCCCCCCCHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHH
LLFLESENPDKDVHLYINSPGGSVTAGLAIYDTMQFIKPDVATLCVGQAASMGALLLAAG
HHHHCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHCCCHHHHHHCCHHHHCEEEEECC
AEGKRHALPNSRMMIHQPLGGFQGQATDIDIHAREILSMRDRLNTILAHHTGQDIETIRQ
CCCCCCCCCCCCEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DTDRDNFMAAEAAAQYGLIDRVLTSRGASE
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA