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The map label for this gene is lon [H]

Identifier: 121997402

GI number: 121997402

Start: 678541

End: 681003

Strand: Reverse

Name: lon [H]

Synonym: Hhal_0601

Alternate gene names: 121997402

Gene position: 681003-678541 (Counterclockwise)

Preceding gene: 121997403

Following gene: 121997401

Centisome position: 25.43

GC content: 65.81

Gene sequence:

>2463_bases
ATGGCTGAGCCAACCGCTCACAATCCCGAATCCCCGCAGACCGTCACCCAGGCGCCGGTTTTGCCGCTGCGCGACGTGGT
GGTCTATCCGCACATGGTCATCCCGCTGTTCGTTGGGCGGGAACGCTCCATCCACGCCCTCGAGGCGGCCATGGAGCAGG
ACAAGCGGATCTTCCTGATCGCCCAGCGCAGCGCCGAGGTCGATGACCCGGGTGTCGAAGAACTCTATGGCTACGGCACC
GTGGCCTCGATCCTGCAGATGCTCAAGCTCCCCGACGGTACGGTGAAGGTGCTGGTCGAGGGCGGGGAGCGGGCGCGCCT
GGTCGAGCTGCTCGATAGCGGCGAATACCTCTCGGCCCATCTGGTTACGGTGCCCGAGCCGCAGCCCAGCGACGAGGACC
GCGAGCTGGAGGTGGTGGCGCGGTCCGCGACCAACGTGTTTGAGCAGTACGTCAAGCTCAACAAGAAGATCCCGCCGGAG
ATTCTCTCTTCGCTTTCCGGGATCGAGGAGCCCGGCCGACTGGCTGACACCATTGCTGCGCACATGGCGCTGAAGGTCGA
GGAGAAGCAGAAGGTCCTCGAGATGGAGGGCCCGCGCGAGCGCCTCGAGCACCTGATGGGCCTGATCGAGGGGGAGATCG
ACATCCTCCAGATCGAGAAGCGCATCCGCGGGCGCGTCAAGCAGCAGATGGAGAAATCCCAGCGGGAGTACTACCTCAAT
GAGCAGATGAAGGCCATCCAGAAGGAGCTGGGTGAGCTGGAGGACGTGCCCAACGAGGTCGAGGACCTCGAGAACAAGAT
CGACCAGGCCGGGATGCCGCAGCAGGCCCTGGACAAGGCGAAGCAGGAGCTGAACAAGCTCAAGATGATGTCGCCGATGT
CCGCCGAGGCCACCGTGGTGCGCAATTACCTCGACTGGCTGGTGAGCCTGCCCTGGAAGGACAAGACGCGCGTGCGGCAC
GATCTCAAGCACGCCGCCAAGGTCCTCGATCAAGACCACTACGGCTTGGACAAGGTCAAGGAGCGCATCCTCGAGTACCT
GGCCGTGCAGCGACGGGTGCGCAAGCTCAAGGGGCCGATCCTCTGTTTGGTTGGGCCGCCGGGTGTCGGCAAGACGTCGC
TGGGGCAGTCCATCGCCCGGGCCACCAACCGCAAGTTCACCCGCATGTCCCTCGGTGGTGTGCGCGACGAGGCAGAGATC
CGTGGCCACCGCCGCACCTACATCGGCTCGCTGCCGGGCAAGATTGTGCAGAACCTGAGCAAGGCGGGTAAGCGCAACCC
GCTGTTCCTGCTCGATGAGGTGGACAAGATGGCCATGGACTTCCGGGGCGACCCGTCCTCGGCCCTGTTGGAGGTCCTGG
ATCCGGAGCAGAACAGCAGCTTCAGCGACCACTACCTTGAGGTCGACTTCGATCTCTCCGACGTGATGTTCGTCTGCACG
GCGAACACCATGAACATCCCGGCGCCGCTGCTCGACCGCATGGAGGTCATCCGCCTGCCGGGCTACACCGAGGAGGAGAA
GCTCGCCATCGCGCAGAGCTATCTGCTGCCCAAGCAGATGAAGGCCAACGGCATCCGCAAGGGCGAGCTGGACGTCAAGG
AGAGTGCCATCCGCGACGTCATCCGCTACTACACCCGTGAGGCCGGCGTGCGAAATCTGGAGCGGGAGCTGGCGACGGTC
TGCCGCAAGGTGGTCAAGGGGCTGGTCGAGGGCGAGTCCAAGGGCCGCAAGCGCAGCGCCGGCGTGCAGGTGACCCGCCG
CAATATCGACAAGTACCTCGGGGTGCGCCGCTACCGCTTCGGGGTCGCCGAGACCGAGGATCGCATCGGCCAGTCCACCG
GTCTGGCCTGGACCGAGGTCGGTGGCGAGTTGCTGACCATCGAGGTGGCTGTGGTGCCCGGCAAGGGGCGGGCGACGCAG
ACCGGACAGCTCGGCGACGTCATGAAGGAGTCCATCGACGCTGCCACCACCGTGGTGCGCAGCCGGGCCCGCACCCTGGG
ACTGGATCCGGAGTTCTACACCAAGAACGACTACCACATCCACGTCCCCGAGGGGGCCATCCCCAAGGACGGTCCGTCGG
CTGGCACTGGCATGTGTGTCGCCCTGGTCTCGGCCTTGACCGGCATCCCGGTGCGGGCGGGCGTGGGCATGACCGGTGAG
ATCACCCTGCGCGGCGAGGTGTTGCCCATCGGTGGGCTCAAGGAGAAGCTTCTGGCCGCCCTGCGGGGCGGCATCGACAC
GGTGCTGATCCCGTCGGAGAACGAAAAGGATCTGGCGGATGTGCCCAAGGACGTGAAGTCGAAGCTCGACATCCGGCCGG
TGCGCTGGATCGACGAGGTCCTCGAGGTGGCCCTGACCCGTCAGCCTGAACCGCTCCCGGCCCCGGAGGGTGAAGGCGAT
GCCGACGCGGCCACGCGCGTGGCAGTCGGCGAGGGGGAGGGTGACCCCAAGCGGCCACACTGA

Upstream 100 bases:

>100_bases
GAAACCCGCCCGTATCACCCCCATTCCGAACCCAGAGGAGGGGCGCGCGGCCACCGCCGCGCGCGTCCCGCCGTTCGCAC
GCCAATGAGGTTCGCATCCA

Downstream 100 bases:

>100_bases
GGCGGTGCCGCCCATTTGACAGTCTGGAAAAGCCGCTGCTATAACGCCGGCAACTGGGCGCCCGGGCCCCGAAGCCCGGG
GCGGCGACGTCGGCGCTGCC

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 820; Mature: 819

Protein sequence:

>820_residues
MAEPTAHNPESPQTVTQAPVLPLRDVVVYPHMVIPLFVGRERSIHALEAAMEQDKRIFLIAQRSAEVDDPGVEELYGYGT
VASILQMLKLPDGTVKVLVEGGERARLVELLDSGEYLSAHLVTVPEPQPSDEDRELEVVARSATNVFEQYVKLNKKIPPE
ILSSLSGIEEPGRLADTIAAHMALKVEEKQKVLEMEGPRERLEHLMGLIEGEIDILQIEKRIRGRVKQQMEKSQREYYLN
EQMKAIQKELGELEDVPNEVEDLENKIDQAGMPQQALDKAKQELNKLKMMSPMSAEATVVRNYLDWLVSLPWKDKTRVRH
DLKHAAKVLDQDHYGLDKVKERILEYLAVQRRVRKLKGPILCLVGPPGVGKTSLGQSIARATNRKFTRMSLGGVRDEAEI
RGHRRTYIGSLPGKIVQNLSKAGKRNPLFLLDEVDKMAMDFRGDPSSALLEVLDPEQNSSFSDHYLEVDFDLSDVMFVCT
ANTMNIPAPLLDRMEVIRLPGYTEEEKLAIAQSYLLPKQMKANGIRKGELDVKESAIRDVIRYYTREAGVRNLERELATV
CRKVVKGLVEGESKGRKRSAGVQVTRRNIDKYLGVRRYRFGVAETEDRIGQSTGLAWTEVGGELLTIEVAVVPGKGRATQ
TGQLGDVMKESIDAATTVVRSRARTLGLDPEFYTKNDYHIHVPEGAIPKDGPSAGTGMCVALVSALTGIPVRAGVGMTGE
ITLRGEVLPIGGLKEKLLAALRGGIDTVLIPSENEKDLADVPKDVKSKLDIRPVRWIDEVLEVALTRQPEPLPAPEGEGD
ADAATRVAVGEGEGDPKRPH

Sequences:

>Translated_820_residues
MAEPTAHNPESPQTVTQAPVLPLRDVVVYPHMVIPLFVGRERSIHALEAAMEQDKRIFLIAQRSAEVDDPGVEELYGYGT
VASILQMLKLPDGTVKVLVEGGERARLVELLDSGEYLSAHLVTVPEPQPSDEDRELEVVARSATNVFEQYVKLNKKIPPE
ILSSLSGIEEPGRLADTIAAHMALKVEEKQKVLEMEGPRERLEHLMGLIEGEIDILQIEKRIRGRVKQQMEKSQREYYLN
EQMKAIQKELGELEDVPNEVEDLENKIDQAGMPQQALDKAKQELNKLKMMSPMSAEATVVRNYLDWLVSLPWKDKTRVRH
DLKHAAKVLDQDHYGLDKVKERILEYLAVQRRVRKLKGPILCLVGPPGVGKTSLGQSIARATNRKFTRMSLGGVRDEAEI
RGHRRTYIGSLPGKIVQNLSKAGKRNPLFLLDEVDKMAMDFRGDPSSALLEVLDPEQNSSFSDHYLEVDFDLSDVMFVCT
ANTMNIPAPLLDRMEVIRLPGYTEEEKLAIAQSYLLPKQMKANGIRKGELDVKESAIRDVIRYYTREAGVRNLERELATV
CRKVVKGLVEGESKGRKRSAGVQVTRRNIDKYLGVRRYRFGVAETEDRIGQSTGLAWTEVGGELLTIEVAVVPGKGRATQ
TGQLGDVMKESIDAATTVVRSRARTLGLDPEFYTKNDYHIHVPEGAIPKDGPSAGTGMCVALVSALTGIPVRAGVGMTGE
ITLRGEVLPIGGLKEKLLAALRGGIDTVLIPSENEKDLADVPKDVKSKLDIRPVRWIDEVLEVALTRQPEPLPAPEGEGD
ADAATRVAVGEGEGDPKRPH
>Mature_819_residues
AEPTAHNPESPQTVTQAPVLPLRDVVVYPHMVIPLFVGRERSIHALEAAMEQDKRIFLIAQRSAEVDDPGVEELYGYGTV
ASILQMLKLPDGTVKVLVEGGERARLVELLDSGEYLSAHLVTVPEPQPSDEDRELEVVARSATNVFEQYVKLNKKIPPEI
LSSLSGIEEPGRLADTIAAHMALKVEEKQKVLEMEGPRERLEHLMGLIEGEIDILQIEKRIRGRVKQQMEKSQREYYLNE
QMKAIQKELGELEDVPNEVEDLENKIDQAGMPQQALDKAKQELNKLKMMSPMSAEATVVRNYLDWLVSLPWKDKTRVRHD
LKHAAKVLDQDHYGLDKVKERILEYLAVQRRVRKLKGPILCLVGPPGVGKTSLGQSIARATNRKFTRMSLGGVRDEAEIR
GHRRTYIGSLPGKIVQNLSKAGKRNPLFLLDEVDKMAMDFRGDPSSALLEVLDPEQNSSFSDHYLEVDFDLSDVMFVCTA
NTMNIPAPLLDRMEVIRLPGYTEEEKLAIAQSYLLPKQMKANGIRKGELDVKESAIRDVIRYYTREAGVRNLERELATVC
RKVVKGLVEGESKGRKRSAGVQVTRRNIDKYLGVRRYRFGVAETEDRIGQSTGLAWTEVGGELLTIEVAVVPGKGRATQT
GQLGDVMKESIDAATTVVRSRARTLGLDPEFYTKNDYHIHVPEGAIPKDGPSAGTGMCVALVSALTGIPVRAGVGMTGEI
TLRGEVLPIGGLKEKLLAALRGGIDTVLIPSENEKDLADVPKDVKSKLDIRPVRWIDEVLEVALTRQPEPLPAPEGEGDA
DAATRVAVGEGEGDPKRPH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=564, Percent_Identity=46.2765957446808, Blast_Score=501, Evalue=1e-141,
Organism=Homo sapiens, GI21396489, Length=631, Percent_Identity=41.838351822504, Blast_Score=500, Evalue=1e-141,
Organism=Escherichia coli, GI1786643, Length=782, Percent_Identity=67.2634271099744, Blast_Score=1072, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=711, Percent_Identity=38.2559774964838, Blast_Score=476, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17556486, Length=545, Percent_Identity=41.4678899082569, Blast_Score=430, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6319449, Length=706, Percent_Identity=39.5184135977337, Blast_Score=492, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24666867, Length=632, Percent_Identity=42.5632911392405, Blast_Score=496, Evalue=1e-140,
Organism=Drosophila melanogaster, GI221513036, Length=632, Percent_Identity=42.5632911392405, Blast_Score=495, Evalue=1e-140,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 90916; Mature: 90785

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEPTAHNPESPQTVTQAPVLPLRDVVVYPHMVIPLFVGRERSIHALEAAMEQDKRIFLI
CCCCCCCCCCCCCHHHHCCCCCHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHCCCEEEEE
AQRSAEVDDPGVEELYGYGTVASILQMLKLPDGTVKVLVEGGERARLVELLDSGEYLSAH
EECCCCCCCCCHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCCEEEEE
LVTVPEPQPSDEDRELEVVARSATNVFEQYVKLNKKIPPEILSSLSGIEEPGRLADTIAA
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHH
HMALKVEEKQKVLEMEGPRERLEHLMGLIEGEIDILQIEKRIRGRVKQQMEKSQREYYLN
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQMKAIQKELGELEDVPNEVEDLENKIDQAGMPQQALDKAKQELNKLKMMSPMSAEATVV
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
RNYLDWLVSLPWKDKTRVRHDLKHAAKVLDQDHYGLDKVKERILEYLAVQRRVRKLKGPI
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCE
LCLVGPPGVGKTSLGQSIARATNRKFTRMSLGGVRDEAEIRGHRRTYIGSLPGKIVQNLS
EEEECCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCHHHHCCCHHHHHHCCHHHHHHHHH
KAGKRNPLFLLDEVDKMAMDFRGDPSSALLEVLDPEQNSSFSDHYLEVDFDLSDVMFVCT
HCCCCCCEEEEHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCEEEEECCHHHEEEEEE
ANTMNIPAPLLDRMEVIRLPGYTEEEKLAIAQSYLLPKQMKANGIRKGELDVKESAIRDV
CCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHH
IRYYTREAGVRNLERELATVCRKVVKGLVEGESKGRKRSAGVQVTRRNIDKYLGVRRYRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHC
GVAETEDRIGQSTGLAWTEVGGELLTIEVAVVPGKGRATQTGQLGDVMKESIDAATTVVR
CCCCCHHHCCHHCCCCHHHCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
SRARTLGLDPEFYTKNDYHIHVPEGAIPKDGPSAGTGMCVALVSALTGIPVRAGVGMTGE
HHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEE
ITLRGEVLPIGGLKEKLLAALRGGIDTVLIPSENEKDLADVPKDVKSKLDIRPVRWIDEV
EEEECEEEECCCHHHHHHHHHHCCCCEEEECCCCCCHHHHCCHHHHHCCCCCHHHHHHHH
LEVALTRQPEPLPAPEGEGDADAATRVAVGEGEGDPKRPH
HHHHHCCCCCCCCCCCCCCCCCHHHEEEEECCCCCCCCCC
>Mature Secondary Structure 
AEPTAHNPESPQTVTQAPVLPLRDVVVYPHMVIPLFVGRERSIHALEAAMEQDKRIFLI
CCCCCCCCCCCCHHHHCCCCCHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHCCCEEEEE
AQRSAEVDDPGVEELYGYGTVASILQMLKLPDGTVKVLVEGGERARLVELLDSGEYLSAH
EECCCCCCCCCHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCCEEEEE
LVTVPEPQPSDEDRELEVVARSATNVFEQYVKLNKKIPPEILSSLSGIEEPGRLADTIAA
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHH
HMALKVEEKQKVLEMEGPRERLEHLMGLIEGEIDILQIEKRIRGRVKQQMEKSQREYYLN
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQMKAIQKELGELEDVPNEVEDLENKIDQAGMPQQALDKAKQELNKLKMMSPMSAEATVV
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
RNYLDWLVSLPWKDKTRVRHDLKHAAKVLDQDHYGLDKVKERILEYLAVQRRVRKLKGPI
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCE
LCLVGPPGVGKTSLGQSIARATNRKFTRMSLGGVRDEAEIRGHRRTYIGSLPGKIVQNLS
EEEECCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCHHHHCCCHHHHHHCCHHHHHHHHH
KAGKRNPLFLLDEVDKMAMDFRGDPSSALLEVLDPEQNSSFSDHYLEVDFDLSDVMFVCT
HCCCCCCEEEEHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCEEEEECCHHHEEEEEE
ANTMNIPAPLLDRMEVIRLPGYTEEEKLAIAQSYLLPKQMKANGIRKGELDVKESAIRDV
CCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHH
IRYYTREAGVRNLERELATVCRKVVKGLVEGESKGRKRSAGVQVTRRNIDKYLGVRRYRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHC
GVAETEDRIGQSTGLAWTEVGGELLTIEVAVVPGKGRATQTGQLGDVMKESIDAATTVVR
CCCCCHHHCCHHCCCCHHHCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
SRARTLGLDPEFYTKNDYHIHVPEGAIPKDGPSAGTGMCVALVSALTGIPVRAGVGMTGE
HHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEE
ITLRGEVLPIGGLKEKLLAALRGGIDTVLIPSENEKDLADVPKDVKSKLDIRPVRWIDEV
EEEECEEEECCCHHHHHHHHHHCCCCEEEECCCCCCHHHHCCHHHHHCCCCCHHHHHHHH
LEVALTRQPEPLPAPEGEGDADAATRVAVGEGEGDPKRPH
HHHHHCCCCCCCCCCCCCCCCCHHHEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]