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The map label for this gene is hisC [H]

Identifier: 121611288

GI number: 121611288

Start: 4825060

End: 4826250

Strand: Direct

Name: hisC [H]

Synonym: Veis_4374

Alternate gene names: 121611288

Gene position: 4825060-4826250 (Clockwise)

Preceding gene: 121611287

Following gene: 121611289

Centisome position: 86.68

GC content: 68.09

Gene sequence:

>1191_bases
ATGGCTTTTTGCAGCCCGCCACGCTTGGCTGCTTGCCGCACCCCGATTCAGCCCGCGCACTGCAGACTCCCCCGAATGCC
CGCTCCATCCCCGACCCCCCTGACCCATATCCGCCCCGATGTGCGCGCCATGCGCGCATACCATGTGCAGCCGGCCACCG
GCATGCTCAAGATGGACGCGATGGAAAACCCGTTCCGGCTGCCGGCCGATCTGCAAACCGCGCTCGGCCAGCGCCTGGGC
GCTCTGGCGCTCAACCGCTACCCGAGCGACGCGCGCCTGGCCGAGCTGCAGGCCGCGCTGGCGCGCTACGCCGGCCTGCC
CGAAGGCCATCGCATCATGCTCGGCAATGGCTCGGACGAACTCATCGCGCTGCTGGCCCTGGCCTGCGCCCGGCCCGGCA
GCGGCGAGCGCCCCGGCGTGCTGGCTCCGCTGCCCGGCTTTGTGATGTATGCGTTGAGCGCGCAATTGCAGGGCCTGGAC
TTCGTCGGCGTGCCGCTGACGGCCGATTTCGAGCTGGACGAGCCGGCGATGCTGGCCGCCATCGCCCGGCACCGGCCCGC
GCTCACCTACATCGCCTACCCCAACAACCCCACGGCCACGCTGTGGGACGAAGGCGCGGTGCAGCGCATCATCGACGCGG
TCGGCACGCAGGGCGGCATCGTGGTGATGGATGAAGCCTATCAGCCCTTTGCCTGCCGTAGCTGGATCGGGCGCCTGCAC
GCCGAACCCGGGCGCAATGCCCATGTGCTGCTGATGCGCACGCTCAGCAAGTTCGGCCTGGCCGGTGTGCGCCTGGGCTA
CCTGATCGGCCCGGCGGCCCTGGTCAACGAGATCGACAAGGTGCGCCCGCCCTACAACGTGAACCTGCTCAGTTGCGAAA
CCGCGCTGTTTGCGCTCGAACATGCCCCGGTGTTCGCCGCCCAGGCGGCCGAACTGCGCACCCAGCGCGACCTGCTGATC
GGTGCGCTGCGCCAGTTGCCCGGCATCGCAAAATGCTGGGACAGCCAGGCCAACATGGTGCTGGTGCGGGTGGCCGATGC
CAGCCGCACCTACGAGGGCATGAAAACCCTGAAGGTCTTGGTCCGGAACGTTTCTACAATGCACCCCTTGCTGAGCAACT
GCCTGCGCCTGACGGTCGGCAGTGCCGACGACAACGCACAAATGCTGGCTGCACTCCAGGCCTCTTCATGA

Upstream 100 bases:

>100_bases
TGCATGTGCACGCGCGAAGTGGCATCCGGACCAGGGCAGACCGCGACACCGGCCGATAGCCACAGGCAGGAACGCAACGC
AGCGGCTGCGCCATGGAACA

Downstream 100 bases:

>100_bases
CCTCCTCCGCCCTCGTGCCCTCGGGCCTGCCCGGTTCGCTCGACCGCATCGCCGAGGTCAGCCGCAACACCGCCGAGACC
CGCGTCAGCGTGCGCGTCAA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MAFCSPPRLAACRTPIQPAHCRLPRMPAPSPTPLTHIRPDVRAMRAYHVQPATGMLKMDAMENPFRLPADLQTALGQRLG
ALALNRYPSDARLAELQAALARYAGLPEGHRIMLGNGSDELIALLALACARPGSGERPGVLAPLPGFVMYALSAQLQGLD
FVGVPLTADFELDEPAMLAAIARHRPALTYIAYPNNPTATLWDEGAVQRIIDAVGTQGGIVVMDEAYQPFACRSWIGRLH
AEPGRNAHVLLMRTLSKFGLAGVRLGYLIGPAALVNEIDKVRPPYNVNLLSCETALFALEHAPVFAAQAAELRTQRDLLI
GALRQLPGIAKCWDSQANMVLVRVADASRTYEGMKTLKVLVRNVSTMHPLLSNCLRLTVGSADDNAQMLAALQASS

Sequences:

>Translated_396_residues
MAFCSPPRLAACRTPIQPAHCRLPRMPAPSPTPLTHIRPDVRAMRAYHVQPATGMLKMDAMENPFRLPADLQTALGQRLG
ALALNRYPSDARLAELQAALARYAGLPEGHRIMLGNGSDELIALLALACARPGSGERPGVLAPLPGFVMYALSAQLQGLD
FVGVPLTADFELDEPAMLAAIARHRPALTYIAYPNNPTATLWDEGAVQRIIDAVGTQGGIVVMDEAYQPFACRSWIGRLH
AEPGRNAHVLLMRTLSKFGLAGVRLGYLIGPAALVNEIDKVRPPYNVNLLSCETALFALEHAPVFAAQAAELRTQRDLLI
GALRQLPGIAKCWDSQANMVLVRVADASRTYEGMKTLKVLVRNVSTMHPLLSNCLRLTVGSADDNAQMLAALQASS
>Mature_395_residues
AFCSPPRLAACRTPIQPAHCRLPRMPAPSPTPLTHIRPDVRAMRAYHVQPATGMLKMDAMENPFRLPADLQTALGQRLGA
LALNRYPSDARLAELQAALARYAGLPEGHRIMLGNGSDELIALLALACARPGSGERPGVLAPLPGFVMYALSAQLQGLDF
VGVPLTADFELDEPAMLAAIARHRPALTYIAYPNNPTATLWDEGAVQRIIDAVGTQGGIVVMDEAYQPFACRSWIGRLHA
EPGRNAHVLLMRTLSKFGLAGVRLGYLIGPAALVNEIDKVRPPYNVNLLSCETALFALEHAPVFAAQAAELRTQRDLLIG
ALRQLPGIAKCWDSQANMVLVRVADASRTYEGMKTLKVLVRNVSTMHPLLSNCLRLTVGSADDNAQMLAALQASS

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=366, Percent_Identity=29.7814207650273, Blast_Score=132, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6322075, Length=345, Percent_Identity=26.9565217391304, Blast_Score=108, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 42711; Mature: 42580

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFCSPPRLAACRTPIQPAHCRLPRMPAPSPTPLTHIRPDVRAMRAYHVQPATGMLKMDA
CCCCCCCCCHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEECC
MENPFRLPADLQTALGQRLGALALNRYPSDARLAELQAALARYAGLPEGHRIMLGNGSDE
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCHH
LIALLALACARPGSGERPGVLAPLPGFVMYALSAQLQGLDFVGVPLTADFELDEPAMLAA
HHHHHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHCCCEEECCCEEECCCCCCHHHHHH
IARHRPALTYIAYPNNPTATLWDEGAVQRIIDAVGTQGGIVVMDEAYQPFACRSWIGRLH
HHHCCCCEEEEEECCCCCEEECCCHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHC
AEPGRNAHVLLMRTLSKFGLAGVRLGYLIGPAALVNEIDKVRPPYNVNLLSCETALFALE
CCCCCCCEEHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHH
HAPVFAAQAAELRTQRDLLIGALRQLPGIAKCWDSQANMVLVRVADASRTYEGMKTLKVL
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHH
VRNVSTMHPLLSNCLRLTVGSADDNAQMLAALQASS
HHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
AFCSPPRLAACRTPIQPAHCRLPRMPAPSPTPLTHIRPDVRAMRAYHVQPATGMLKMDA
CCCCCCCCHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEECC
MENPFRLPADLQTALGQRLGALALNRYPSDARLAELQAALARYAGLPEGHRIMLGNGSDE
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCHH
LIALLALACARPGSGERPGVLAPLPGFVMYALSAQLQGLDFVGVPLTADFELDEPAMLAA
HHHHHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHCCCEEECCCEEECCCCCCHHHHHH
IARHRPALTYIAYPNNPTATLWDEGAVQRIIDAVGTQGGIVVMDEAYQPFACRSWIGRLH
HHHCCCCEEEEEECCCCCEEECCCHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHC
AEPGRNAHVLLMRTLSKFGLAGVRLGYLIGPAALVNEIDKVRPPYNVNLLSCETALFALE
CCCCCCCEEHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHH
HAPVFAAQAAELRTQRDLLIGALRQLPGIAKCWDSQANMVLVRVADASRTYEGMKTLKVL
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHH
VRNVSTMHPLLSNCLRLTVGSADDNAQMLAALQASS
HHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA